An efficient system for the evolution of aminoacyl-tRNA synthetase specificity

Nature Biotechnology

Volumn 20, Issue 10, 2002, Pages 1044-1048

  Santoro, Stephen W ^a   Wang, Lei ^a   Herberich, Brad ^a   King, David S ^b   Schultz, Peter G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ESCHERICHIA COLI; FLUORESCENCE; RNA;

PLASMIDS;

ENZYMES;

AMINO ACID DERIVATIVE; AMINOACYL TRANSFER RNA; BACTERIAL ENZYME; CHLORAMPHENICOL; ENZYME VARIANT; SYNTHETASE; TRANSFER RNA;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EVOLUTION; FLUORESCENCE ACTIVATED CELL SORTING; FLUOROMETRY; GENETIC SCREENING; GENETIC SELECTION; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

AMINO ACIDS; AMINO ACYL-TRNA SYNTHETASES; CELL LINE; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; PROTEIN ENGINEERING; QUALITY CONTROL; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; TYROSINE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0036787635     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt742     Document Type: Article

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