In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors

Journal of the American Chemical Society

Volumn 134, Issue 25, 2012, Pages 10469-10477

  Guillen Schlippe, Yollete V ^a   Hartman, Matthew C T ^a,b   Josephson, Kristopher ^a,c   Szostak, Jack W ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Ra Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVE MOLECULES; BIOLOGIC DRUGS; CYCLIC PEPTIDES; HIGH SPECIFICITY; IN-VITRO; ISOLATION AND CHARACTERIZATION; MACRO-CYCLIZATION; MACROCYCLICS; MRNA-DISPLAY; NANOMOLAR AFFINITY; NANOMOLAR RANGE; RIBOSOMAL PEPTIDES; SMALL MOLECULES; SMALL-MOLECULE DRUGS; THERAPEUTIC MOLECULES; TIGHT BINDING;

AMINO ACIDS; BIOCHEMISTRY; ENZYMES; LIBRARIES; MOLECULES;

PEPTIDES;

AMINO ACID; CYCLOPEPTIDE; MACROCYCLIC COMPOUND; MESSENGER RNA; PROTEINASE; THROMBIN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG ISOLATION; IN VITRO STUDY;

AMINO ACID SEQUENCE; ANTITHROMBINS; BINDING SITES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN BINDING; SEQUENCE ALIGNMENT; SMALL MOLECULE LIBRARIES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THROMBIN;

EID: 84863434152     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja301017y     Document Type: Article

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