Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease

Protein Science

Volumn 16, Issue 8, 2007, Pages 1535-1542

  Cheng, Lin ^a   Naumann, Todd A ^a,b   Horswill, Alexander R ^a,c   Hong, Sue Jean ^a,d   Venters, Bryan J ^a   Tomsho, John W ^a   Benkovic, Stephen J ^a   Keiler, Kenneth C ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Antibacterial; ClpXP protease; Cyclic peptide; Protease inhibitor; SICLOPPS

Indexed keywords

CYCLOPEPTIDE;

ARTICLE; BACTERICIDAL ACTIVITY; ENZYME ACTIVITY; ESCHERICHIA COLI; FLUORESCENCE ACTIVATED CELL SORTING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CAULOBACTER CRESCENTUS; ENDOPEPTIDASE CLP; LUMINESCENT PROTEINS; MODELS, BIOLOGICAL; PEPTIDE LIBRARY; PEPTIDES, CYCLIC; PROTEASE INHIBITORS; SUBSTRATE SPECIFICITY;

CAULOBACTER VIBRIOIDES; ESCHERICHIA COLI;

EID: 34547561306     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.072933007     Document Type: Article

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