Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization

Angewandte Chemie - International Edition

Volumn 44, Issue 18, 2005, Pages 2760-2763

  Tavassoli, Ali ^a   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Bioorganic chemistry; Enzymes; Inhibitors; Library biosynthesis; Peptides

Indexed keywords

BIOSYNTHESIS; DIMERIZATION; GENETIC ENGINEERING; PROTEINS;

BIOSYNTHESIZED LIBRARY; CYCLIC-PEPTIDE INHIBITORS; HOMODIMERIZATION; PROTEIN-PROTEIN INTERACTIONS;

ENZYME INHIBITION;

CYCLOPEPTIDE; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PURINE; PURINE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; DIMERIZATION; DRUG EFFECT; GENETICS; METABOLISM; PROTEIN QUATERNARY STRUCTURE; SACCHAROMYCES CEREVISIAE;

AMINO ACID SEQUENCE; CATALYSIS; DIMERIZATION; PEPTIDES, CYCLIC; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PROTEIN STRUCTURE, QUATERNARY; PURINES; SACCHAROMYCES CEREVISIAE;

EID: 18844408408     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500417     Document Type: Article

References (18)

1. L. Ni, K. Guan, H. Zalkin, J. E. Dixon, Gene 1991, 106, 197.
2. S. E. Greasley, P. Horton, J. Ramcharan, G. P. Beardsley, S. J. Benkovic, I. A. Wilson, Nat. Struct. Biol. 2001, 8, 402.
3. R. C. Jackson, R. J. Harkrader in Nucleosides and Cancer Treatment (Eds.: M. H. N. Tattersall, R. M. Fox), Academic Press, Sydney, 1981, p. 18.
4. P. Gadangi, M. Longaker, D. Naime, R. I. Levin, P. A. Recht, M. C. Montesinos, M. T. Buckley, G. Carlin, B. N. Cronstein, J. Immunol. 1996, 156, 1937.
5. R. Zutshi, M. Brickner, J. Chmielewski, Curr. Opin. Chem. Biol. 1998, 2, 62.
6. C. P. Scott, E. Abel-Santos, A. D. Jones, S. J. Benkovic, Chem. Biol. 2001, 8, 801.
7. A. R. Horswill, S. N. Savinov, S. J. Benkovic, Proc. Natl. Acad. Sci. USA 2004, 101, 15591.
8. Y. Q. Tang, J. Yuan, G. Osapay, K. Osapay, D. Tran, C. J. Miller, A. J. Ouellette, M. E. Selsted, Science 1999, 286, 498.
9. J. C. Hu, E. K. O'Shea, P. S. Kim, R. T. Sauer, Science 1990, 250, 1400.
10. J. K. Joung, E. I. Ramm, C. O. Pabo, Proc. Natl. Acad. Sci. USA 2000, 97, 7382.
11. P. Kuzmic, Anal. Biochem. 1996, 237, 260.
12. S. R. Stone, H. J. Fromm, Biochemistry 1980, 19, 620.
13. M. Bauer, H. Griengl, W. Steiner, Biotechnol. Bioeng. 1999, 62, 20.
14. C. Frieden, Trends Biochem. Sci. 1993, 18, 58.
15. J. M. Vergis, K. G. Bulock, K. G. Fleming, G. P. Beardsley, J. Biol. Chem. 2001, 276, 7727.
16. K. G. Bulock, G. P. Beardsley, K. S. Anderson, J. Biol. Chem. 2002, 277, 22168.
17. S. A. Andronati, T. L. Karaseva, A. A. Krysko, Curr. Med. Chem. 2004, 11, 1183.
18. C. G. Cheong, D. W. Wolan, S. E. Greasley, P. A. Horton, G. P. Beardsley, I. A. Wilson, J. Biol. Chem. 2004, 279, 18034.