Discovery of macrocyclic peptides armed with a mechanism-based warhead: Isoform-selective inhibition of human deacetylase SIRT2

Angewandte Chemie - International Edition

Volumn 51, Issue 14, 2012, Pages 3423-3427

  Morimoto, Jumpei ^a   Hayashi, Yuuki ^a   Suga, Hiroaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

FIT system; inhibitors; macrocyclic peptides; peptides; RaPID system

Indexed keywords

DEACETYLASE; FIT SYSTEM; MACROCYCLICS; NANOMOLAR; RAPID SYSTEM;

CATALYSIS; CHEMISTRY; CORROSION INHIBITORS;

PEPTIDES;

ENZYME INHIBITOR; ISOPROTEIN; PEPTIDE; SIRT2 PROTEIN, HUMAN; SIRTUIN 2;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; CYCLIZATION; DRUG ANTAGONISM; ELECTRON SPIN RESONANCE; HUMAN; KINETICS; METABOLISM; PROTEIN BINDING; SYNTHESIS;

AMINO ACID SEQUENCE; CYCLIZATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; HUMANS; KINETICS; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; SIRTUIN 2;

EID: 84859239807     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201108118     Document Type: Article

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