Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation

Journal of the American Chemical Society

Volumn 133, Issue 30, 2011, Pages 11418-11421

  Nguyen, Duy P ^a   Elliott, Thomas ^a   Holt, Matthew ^b   Muir, Tom W ^b   Chin, Jason W ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN LABELING; RECOMBINANT PROTEIN; SITE-SPECIFIC; SYNTHETASES;

AMINO ACIDS; CONDENSATION; ESCHERICHIA COLI; PROBES;

PROTEINS;

1,2 AMINOTHIOL; AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; AMINOTHIOL; BENZOTHIAZOLE DERIVATIVE; CYCLOBENZOTHIAZOLE; LYSINE DERIVATIVE; RECOMBINANT PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; METHANOSARCINA; NONHUMAN; SYNTHESIS; WESTERN BLOTTING;

AMINO ACYL-TRNA SYNTHETASES; BENZOTHIAZOLES; BINDING SITES; LYSINE; METHANOSARCINA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STAINING AND LABELING; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS;

EID: 79960883438     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja203111c     Document Type: Article

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