메뉴 건너뛰기




Volumn 20, Issue 8, 2015, Pages 1040-1051

A Perspective on the Future of High-Throughput RNAi Screening: Will CRISPR Cut Out the Competition or Can RNAi Help Guide the Way?

Author keywords

CRISPR Cas; functional genomics; precise genome editing; RNAi; screening

Indexed keywords

CRISPR CAS SYSTEM; FUNCTIONAL GENOMICS; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA INTERFERENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; GENETICS; GENOMICS; PROCEDURES; RNA EDITING;

EID: 84939784406     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057115590069     Document Type: Review
Times cited : (33)

References (106)
  • 1
    • 36048953476 scopus 로고    scopus 로고
    • Yeast Genomics and Drug Target Identification
    • Bharucha N., Kumar A., Yeast Genomics and Drug Target Identification. Comb. Chem. High Through. Screen. 2007, 10 (8), 618-634.
    • (2007) Comb. Chem. High Through. Screen , vol.10 , Issue.8 , pp. 618-634
    • Bharucha, N.1    Kumar, A.2
  • 2
    • 5544315049 scopus 로고    scopus 로고
    • High-Throughput RNAi in Caenorhabditis elegans: Genome-Wide Screens and Functional Genomics
    • Sugimoto A., High-Throughput RNAi in Caenorhabditis elegans: Genome-Wide Screens and Functional Genomics. Differentiation. 2004, 72 (2-3), 81-91.
    • (2004) Differentiation , vol.72 , Issue.2-3 , pp. 81-91
    • Sugimoto, A.1
  • 3
    • 84901364818 scopus 로고    scopus 로고
    • Resources for Functional Genomics Studies in Drosophila melanogaster
    • Mohr S. E., Hu Y., Kim K.,. Resources for Functional Genomics Studies in Drosophila melanogaster. Genetics. 2014, 197 (1), 1-18.
    • (2014) Genetics , vol.197 , Issue.1 , pp. 1-18
    • Mohr, S.E.1    Hu, Y.2    Kim, K.3
  • 4
    • 84867118591 scopus 로고    scopus 로고
    • Functional Genomics in Drosophila Models of Human Disease
    • Chen K. F., Crowther D. C., Functional Genomics in Drosophila Models of Human Disease. Brief. Funct. Genom. 2012, 11 (5), 405-415.
    • (2012) Brief. Funct. Genom , vol.11 , Issue.5 , pp. 405-415
    • Chen, K.F.1    Crowther, D.C.2
  • 5
    • 79960342425 scopus 로고    scopus 로고
    • Fishing for Function: Zebrafish BAC Transgenics for Functional Genomics
    • Chatterjee S., Lufkin T., Fishing for Function: Zebrafish BAC Transgenics for Functional Genomics. Molec. bioSystems. 2011, 7 (8), 2345-2351.
    • (2011) Molec. BioSystems , vol.7 , Issue.8 , pp. 2345-2351
    • Chatterjee, S.1    Lufkin, T.2
  • 6
    • 0030879562 scopus 로고    scopus 로고
    • Functional Genomics in Mice by Tagged Sequence Mutagenesis
    • Hicks G. G., Shi E. G., Li X. M.,. Functional Genomics in Mice by Tagged Sequence Mutagenesis. Nature Genet. 1997, 16 (4), 338-344.
    • (1997) Nature Genet , vol.16 , Issue.4 , pp. 338-344
    • Hicks, G.G.1    Shi, E.G.2    Li, X.M.3
  • 7
    • 8844232706 scopus 로고    scopus 로고
    • Functional Genomics to New Drug Targets
    • Kramer R., Cohen D., Functional Genomics to New Drug Targets. Nature Rev. Drug Disc. 2004, 3 (11), 965-972.
    • (2004) Nature Rev. Drug Disc , vol.3 , Issue.11 , pp. 965-972
    • Kramer, R.1    Cohen, D.2
  • 8
    • 84866884932 scopus 로고    scopus 로고
    • Functional Genomic and High-Content Screening for Target Discovery and Deconvolution
    • Heynen-Genel S., Pache L., Chanda S. K.,. Functional Genomic and High-Content Screening for Target Discovery and Deconvolution. Expert Opin. Drug Disc. 2012, 7 (10), 955-968.
    • (2012) Expert Opin. Drug Disc , vol.7 , Issue.10 , pp. 955-968
    • Heynen-Genel, S.1    Pache, L.2    Chanda, S.K.3
  • 9
    • 77953205629 scopus 로고    scopus 로고
    • Functional Genomics and Cancer Drug Target Discovery
    • Moody S. E., Boehm J. S., Barbie D. A.,. Functional Genomics and Cancer Drug Target Discovery. Curr. Opin. Molec. Ther. 2010, 12 (3), 284-293.
    • (2010) Curr. Opin. Molec. Ther , vol.12 , Issue.3 , pp. 284-293
    • Moody, S.E.1    Boehm, J.S.2    Barbie, D.A.3
  • 10
    • 0035487038 scopus 로고    scopus 로고
    • Gene-Trap Mutagenesis: Past, Present and beyond
    • Stanford W. L., Cohn J. B., Cordes S. P., Gene-Trap Mutagenesis: Past, Present and Beyond. Nat. Rev. Genet. 2001, 2 (10), 756-768.
    • (2001) Nat. Rev. Genet , vol.2 , Issue.10 , pp. 756-768
    • Stanford, W.L.1    Cohn, J.B.2    Cordes, S.P.3
  • 11
    • 0342449328 scopus 로고    scopus 로고
    • Ten Years of Gene Targeting: Targeted Mouse Mutants, from Vector Design to Phenotype Analysis
    • Müller U., Ten Years of Gene Targeting: Targeted Mouse Mutants, from Vector Design to Phenotype Analysis. Mech. Dev. 1999, 82 (1-2), 3-21.
    • (1999) Mech. Dev , vol.82 , Issue.1-2 , pp. 3-21
    • Müller, U.1
  • 12
    • 61449196773 scopus 로고    scopus 로고
    • Northern Blot Analysis for Detection and Quantification of RNA in Pancreatic Cancer Cells and Tissues
    • Streit S., Michalski C. W., Erkan M.,. Northern Blot Analysis for Detection and Quantification of RNA in Pancreatic Cancer Cells and Tissues. Nat. Protoc. 2009, 4 (1), 37-43.
    • (2009) Nat. Protoc , vol.4 , Issue.1 , pp. 37-43
    • Streit, S.1    Michalski, C.W.2    Erkan, M.3
  • 13
    • 41649115887 scopus 로고    scopus 로고
    • Discovery of Novel Targets with High Throughput RNA Interference Screening
    • Kassner P. D., Discovery of Novel Targets with High Throughput RNA Interference Screening. Comb. Chem. High Through. Screen. 2008, 11 (3), 175-184.
    • (2008) Comb. Chem. High Through. Screen , vol.11 , Issue.3 , pp. 175-184
    • Kassner, P.D.1
  • 14
    • 84906702408 scopus 로고    scopus 로고
    • RNAi Screening Comes of Age: Improved Techniques and Complementary Approaches
    • Mohr S. E., Smith J. A., Shamu C. E.,. RNAi Screening Comes of Age: Improved Techniques and Complementary Approaches. Nature Rev. Molec. Cell Biol. 2014, 15 (9), 591-600.
    • (2014) Nature Rev. Molec. Cell Biol , vol.15 , Issue.9 , pp. 591-600
    • Mohr, S.E.1    Smith, J.A.2    Shamu, C.E.3
  • 15
    • 0032545933 scopus 로고    scopus 로고
    • Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M. K.,. Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis elegans. Nature. 1998, 391 (6669), 806-811.
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3
  • 16
    • 14544280255 scopus 로고    scopus 로고
    • The Silent Revolution: RNA Interference as Basic Biology, Research Tool, and Therapeutic
    • Dykxhoorn D. M., Lieberman J., The Silent Revolution: RNA Interference as Basic Biology, Research Tool, and Therapeutic. Annu. Rev. Med. 2005, 56, 401-423.
    • (2005) Annu. Rev. Med , vol.56 , pp. 401-423
    • Dykxhoorn, D.M.1    Lieberman, J.2
  • 17
    • 84873566518 scopus 로고    scopus 로고
    • Beyond RNAi: Antiviral Defense Strategies in Drosophila and Mosquito
    • Merkling S. H., van Rij R. P., Beyond RNAi: Antiviral Defense Strategies in Drosophila and Mosquito. J. Insect Physiol. 2013, 59 (2), 159-170.
    • (2013) J. Insect Physiol , vol.59 , Issue.2 , pp. 159-170
    • Merkling, S.H.1    Van Rij, R.P.2
  • 18
    • 65749088084 scopus 로고    scopus 로고
    • SiRNA vs. ShRNA: Similarities and Differences
    • Rao D. D., Vorhies J. S., Senzer N.,. siRNA vs. shRNA: Similarities and Differences. Adv. Drug Deliv. Rev. 2009, 61 (9), 746-759.
    • (2009) Adv. Drug Deliv. Rev , vol.61 , Issue.9 , pp. 746-759
    • Rao, D.D.1    Vorhies, J.S.2    Senzer, N.3
  • 19
    • 79955416113 scopus 로고    scopus 로고
    • A Kinase shRNA Screen Links LATS2 and the pRB Tumor Suppressor
    • Tschöp K., Conery A. R., Litovchick L.,. A Kinase shRNA Screen Links LATS2 and the pRB Tumor Suppressor. Genes Dev. 2011, 25 (8), 814-830.
    • (2011) Genes Dev , vol.25 , Issue.8 , pp. 814-830
    • Tschöp, K.1    Conery, A.R.2    Litovchick, L.3
  • 20
    • 34547124106 scopus 로고    scopus 로고
    • An RNAi-Based Genetic Screen for Oxidative Stress Resistance Reveals Retinol Saturase as a Mediator of Stress Resistance
    • Nagaoka-Yasuda R., Matsuo N., Perkins B.,. An RNAi-Based Genetic Screen for Oxidative Stress Resistance Reveals Retinol Saturase as a Mediator of Stress Resistance. Free Radic. Biol. Med. 2007, 43 (5), 781-788.
    • (2007) Free Radic. Biol. Med , vol.43 , Issue.5 , pp. 781-788
    • Nagaoka-Yasuda, R.1    Matsuo, N.2    Perkins, B.3
  • 21
    • 46749137231 scopus 로고    scopus 로고
    • Systems Analysis of Quantitative shRNA-Library Screens Identifies Regulators of Cell Adhesion
    • Huang X., Wang J. Y. J., Lu X., Systems Analysis of Quantitative shRNA-Library Screens Identifies Regulators of Cell Adhesion. BMC Syst. Biol. 2008, 2, 49.
    • (2008) BMC Syst. Biol , vol.2 , pp. 49
    • Huang, X.1    Wang, J.Y.J.2    Lu, X.3
  • 22
    • 66149091940 scopus 로고    scopus 로고
    • A Genome-Wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
    • Luo J., Emanuele M. J., Li D.,. A Genome-Wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene. Cell. 2009, 137 (5), 835-848.
    • (2009) Cell , vol.137 , Issue.5 , pp. 835-848
    • Luo, J.1    Emanuele, M.J.2    Li, D.3
  • 23
    • 62849106294 scopus 로고    scopus 로고
    • A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway
    • Mullenders J., Fabius A. W. M., Madiredjo M.,. A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway. PLoS One. 2009, 4 (3), e4798.
    • (2009) PLoS One , vol.4 , Issue.3 , pp. e4798
    • Mullenders, J.1    Fabius, A.W.M.2    Madiredjo, M.3
  • 24
    • 67749148923 scopus 로고    scopus 로고
    • A Genome-Wide Short Hairpin RNA Screening of Jurkat T-Cells for Human Proteins Contributing to Productive HIV-1 Replication
    • Yeung M. L., Houzet L., Yedavalli V. S. R. K.,. A Genome-Wide Short Hairpin RNA Screening of Jurkat T-Cells for Human Proteins Contributing to Productive HIV-1 Replication. J. Biol. Chem. 2009, 284 (29), 19463-19473.
    • (2009) J. Biol. Chem , vol.284 , Issue.29 , pp. 19463-19473
    • Yeung, M.L.1    Houzet, L.2    Yedavalli, V.S.R.K.3
  • 25
    • 52649118681 scopus 로고    scopus 로고
    • A Functional Genome-Wide RNAi Screen Identifies TAF1 as a Regulator for Apoptosis in Response to Genotoxic Stress
    • Kimura J., Nguyen S. T., Liu H.,. A Functional Genome-Wide RNAi Screen Identifies TAF1 as a Regulator for Apoptosis in Response to Genotoxic Stress. Nucleic Acids Res. 2008, 36 (16), 5250-5259.
    • (2008) Nucleic Acids Res , vol.36 , Issue.16 , pp. 5250-5259
    • Kimura, J.1    Nguyen, S.T.2    Liu, H.3
  • 26
    • 77649248469 scopus 로고    scopus 로고
    • Genome-Wide siRNA Screen Identifies SMCX, EP400, and Brd4 as E2-Dependent Regulators of Human Papillomavirus Oncogene Expression
    • Smith J. A., White E. A., Sowa M. E.,. Genome-Wide siRNA Screen Identifies SMCX, EP400, and Brd4 as E2-Dependent Regulators of Human Papillomavirus Oncogene Expression. Proc. Natl. Acad. Sci. USA. 2010, 107 (8), 3752-3757.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.8 , pp. 3752-3757
    • Smith, J.A.1    White, E.A.2    Sowa, M.E.3
  • 27
    • 76749090540 scopus 로고    scopus 로고
    • Genome-Wide RNAi Screen Identifies Human Host Factors Crucial for Influenza Virus Replication
    • Karlas A., Machuy N., Shin Y.,. Genome-Wide RNAi Screen Identifies Human Host Factors Crucial for Influenza Virus Replication. Nature. 2010, 463 (7282), 818-822.
    • (2010) Nature , vol.463 , Issue.7282 , pp. 818-822
    • Karlas, A.1    Machuy, N.2    Shin, Y.3
  • 28
    • 33749537857 scopus 로고    scopus 로고
    • Genome-Wide Functional Analysis of Human Cell-Cycle Regulators
    • Mukherji M., Bell R., Supekova L.,. Genome-Wide Functional Analysis of Human Cell-Cycle Regulators. Proc. Natl. Acad. Sci. USA. 2006, 103 (40), 14819-14824.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.40 , pp. 14819-14824
    • Mukherji, M.1    Bell, R.2    Supekova, L.3
  • 29
    • 80054744229 scopus 로고    scopus 로고
    • High-Throughput RNA Interference Screening Using Pooled shRNA Libraries and Next Generation Sequencing
    • Sims D., Mendes-Pereira A. M., Frankum J.,. High-Throughput RNA Interference Screening Using Pooled shRNA Libraries and Next Generation Sequencing. Genome Biol. 2011, 12 (10), R104.
    • (2011) Genome Biol , vol.12 , Issue.10 , pp. R104
    • Sims, D.1    Mendes-Pereira, A.M.2    Frankum, J.3
  • 30
    • 47749131756 scopus 로고    scopus 로고
    • SiRNA Screening of the Cell Cycle with Two Dynamic GFP Sensors
    • Kenrick M., Hancock S., Stubbs S.,. siRNA Screening of the Cell Cycle with Two Dynamic GFP Sensors. Discovery. 2005, 1, 1-19.
    • (2005) Discovery , vol.1 , pp. 1-19
    • Kenrick, M.1    Hancock, S.2    Stubbs, S.3
  • 31
    • 17844387370 scopus 로고    scopus 로고
    • A Computational Study of Off-Target Effects of RNA Interference
    • Qiu S., Adema C. M., Lane T., A Computational Study of Off-Target Effects of RNA Interference. Nucleic Acids Res. 2005, 33 (6), 1834-1847.
    • (2005) Nucleic Acids Res , vol.33 , Issue.6 , pp. 1834-1847
    • Qiu, S.1    Adema, C.M.2    Lane, T.3
  • 32
    • 84887881978 scopus 로고    scopus 로고
    • Systematic Analysis of RNAi Reports Identifies Dismal Commonality at Gene-Level and Reveals an Unprecedented Enrichment in Pooled shRNA Screens
    • Bhinder B., Djaballah H., Systematic Analysis of RNAi Reports Identifies Dismal Commonality at Gene-Level and Reveals an Unprecedented Enrichment in Pooled shRNA Screens. Comb. Chem. High Throughput Screen. 2013, 16 (9), 665-681.
    • (2013) Comb. Chem. High Throughput Screen , vol.16 , Issue.9 , pp. 665-681
    • Bhinder, B.1    Djaballah, H.2
  • 33
    • 0023600057 scopus 로고
    • Nucleotide Sequence of the IAP Gene, Responsible for Alkaline Phosphatase Isozyme Conversion in Escherichia coli, and Identification of the Gene Product
    • Ishino Y., Shinagawa H., Makino K.,. Nucleotide Sequence of the IAP Gene, Responsible for Alkaline Phosphatase Isozyme Conversion in Escherichia coli, and Identification of the Gene Product. J. Bacteriol. 1987, 169 (12), 5429-5433.
    • (1987) J. Bacteriol , vol.169 , Issue.12 , pp. 5429-5433
    • Ishino, Y.1    Shinagawa, H.2    Makino, K.3
  • 34
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex Genome Engineering Using CRISPR/Cas Systems
    • Cong L., Ran F. A., Cox D.,. Multiplex Genome Engineering Using CRISPR/Cas Systems. Science. 2013, 339 (6121), 819-823.
    • (2013) Science , vol.339 , Issue.6121 , pp. 819-823
    • Cong, L.1    Ran, F.A.2    Cox, D.3
  • 35
    • 84873734105 scopus 로고    scopus 로고
    • RNA-Guided Human Genome Engineering via Cas9
    • Mali P., Yang L., Esvelt K. M.,. RNA-Guided Human Genome Engineering via Cas9. Science. 2013, 339 (6121), 823-826.
    • (2013) Science , vol.339 , Issue.6121 , pp. 823-826
    • Mali, P.1    Yang, L.2    Esvelt, K.M.3
  • 36
    • 84875963894 scopus 로고    scopus 로고
    • Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs
    • Ding Q., Regan S. N., Xia Y.,. Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs. Cell Stem Cell. 2013, 12 (4), 393-394.
    • (2013) Cell Stem Cell , vol.12 , Issue.4 , pp. 393-394
    • Ding, Q.1    Regan, S.N.2    Xia, Y.3
  • 37
    • 79956157571 scopus 로고    scopus 로고
    • Evolution and Classification of the CRISPR-Cas Systems
    • Makarova K. S., Haft D. H., Barrangou R.,. Evolution and Classification of the CRISPR-Cas Systems. Nat. Rev. Microbiol. 2011, 9 (6), 467-477.
    • (2011) Nat. Rev. Microbiol , vol.9 , Issue.6 , pp. 467-477
    • Makarova, K.S.1    Haft, D.H.2    Barrangou, R.3
  • 38
    • 84878936806 scopus 로고    scopus 로고
    • CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
    • Sorek R., Lawrence C. M., Wiedenheft B., CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea. Annu. Rev. Biochem. 2013, 82, 237-266.
    • (2013) Annu. Rev. Biochem , vol.82 , pp. 237-266
    • Sorek, R.1    Lawrence, C.M.2    Wiedenheft, B.3
  • 39
    • 84887010498 scopus 로고    scopus 로고
    • Genome Engineering Using the CRISPR-Cas9 System
    • Ran F. A., Hsu P. D., Wright J.,. Genome Engineering Using the CRISPR-Cas9 System. Nat. Protoc. 2013, 8 (11), 2281-2308.
    • (2013) Nat. Protoc , vol.8 , Issue.11 , pp. 2281-2308
    • Ran, F.A.1    Hsu, P.D.2    Wright, J.3
  • 41
    • 84871519181 scopus 로고    scopus 로고
    • TALENs: A Widely Applicable Technology for Targeted Genome Editing
    • Keith Joung J., Sander J. D., TALENs: A Widely Applicable Technology for Targeted Genome Editing. Nat. Rev. Mol. Cell Biol. 2012, 14 (1), 49-55.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.14 , Issue.1 , pp. 49-55
    • Keith Joung, J.1    Sander, J.D.2
  • 42
    • 59849095820 scopus 로고    scopus 로고
    • Proprietary Science, Open Science and the Role of Patent Disclosure: The Case of Zinc-Finger Proteins
    • Chandrasekharan S., Kumar S., Valley C. M.,. Proprietary Science, Open Science and the Role of Patent Disclosure: The Case of Zinc-Finger Proteins. Nat. Biotechnol. 2009, 27 (2), 140-144.
    • (2009) Nat. Biotechnol , vol.27 , Issue.2 , pp. 140-144
    • Chandrasekharan, S.1    Kumar, S.2    Valley, C.M.3
  • 43
    • 84861990434 scopus 로고    scopus 로고
    • Precision Genome Engineering with Programmable DNA-Nicking Enzymes
    • Kim E., Kim S., Kim D. H.,. Precision Genome Engineering with Programmable DNA-Nicking Enzymes. Genome Res. 2012, 22 (7), 1327-1333.
    • (2012) Genome Res , vol.22 , Issue.7 , pp. 1327-1333
    • Kim, E.1    Kim, S.2    Kim, D.H.3
  • 44
    • 84863275797 scopus 로고    scopus 로고
    • Targeted Chromosomal Duplications and Inversions in the Human Genome Using Zinc Finger Nucleases
    • Lee H. J., Kweon J., Kim E.,. Targeted Chromosomal Duplications and Inversions in the Human Genome Using Zinc Finger Nucleases. Genome Res. 2012, 22 (3), 539-548.
    • (2012) Genome Res , vol.22 , Issue.3 , pp. 539-548
    • Lee, H.J.1    Kweon, J.2    Kim, E.3
  • 45
    • 84908190503 scopus 로고    scopus 로고
    • CRISPR-Mediated Direct Mutation of Cancer Genes in the Mouse Liver
    • Xue W., Chen S., Yin H.,. CRISPR-Mediated Direct Mutation of Cancer Genes in the Mouse Liver. Nature. 2014, 514 (7522), 380-384.
    • (2014) Nature , vol.514 , Issue.7522 , pp. 380-384
    • Xue, W.1    Chen, S.2    Yin, H.3
  • 46
    • 84907200149 scopus 로고    scopus 로고
    • Prevention of Muscular Dystrophy in Mice by CRISPR/Cas9-Mediated Editing of Germline DNA
    • Long C., McAnally J. R., Shelton J. M.,. Prevention of Muscular Dystrophy in Mice by CRISPR/Cas9-Mediated Editing of Germline DNA. Science. 2014, 345 (6201), 1184-1188.
    • (2014) Science , vol.345 , Issue.6201 , pp. 1184-1188
    • Long, C.1    McAnally, J.R.2    Shelton, J.M.3
  • 47
    • 84911422892 scopus 로고    scopus 로고
    • Generation of Mouse Models of Myeloid Malignancy with Combinatorial Genetic Lesions Using CRISPR-Cas9 Genome Editing
    • Heckl D., Kowalczyk M. S., Yudovich D.,. Generation of Mouse Models of Myeloid Malignancy with Combinatorial Genetic Lesions Using CRISPR-Cas9 Genome Editing. Nat. Biotechnol. 2014, 32 (9), 941-946.
    • (2014) Nat. Biotechnol , vol.32 , Issue.9 , pp. 941-946
    • Heckl, D.1    Kowalczyk, M.S.2    Yudovich, D.3
  • 48
    • 84892749369 scopus 로고    scopus 로고
    • Genetic Screens in Human Cells Using the CRISPR-Cas9 System
    • Wang T., Wei J. J., Sabatini D. M.,. Genetic Screens in Human Cells Using the CRISPR-Cas9 System. Science. 2014, 343 (6166), 80-84.
    • (2014) Science , vol.343 , Issue.6166 , pp. 80-84
    • Wang, T.1    Wei, J.J.2    Sabatini, D.M.3
  • 49
    • 84900861730 scopus 로고    scopus 로고
    • High-Throughput Screening of a CRISPR/Cas9 Library for Functional Genomics in Human Cells
    • Zhou Y., Zhu S., Cai C.,. High-Throughput Screening of a CRISPR/Cas9 Library for Functional Genomics in Human Cells. Nature. 2014, 509 (7501), 487-491.
    • (2014) Nature , vol.509 , Issue.7501 , pp. 487-491
    • Zhou, Y.1    Zhu, S.2    Cai, C.3
  • 50
    • 84898665052 scopus 로고    scopus 로고
    • Genome-Wide Recessive Genetic Screening in Mammalian Cells with a Lentiviral CRISPR-Guide RNA Library
    • Koike-Yusa H., Li Y., Tan E. P.,. Genome-Wide Recessive Genetic Screening in Mammalian Cells with a Lentiviral CRISPR-Guide RNA Library. Nat. Biotechnol. 2014, 32 (3), 267-273.
    • (2014) Nat. Biotechnol , vol.32 , Issue.3 , pp. 267-273
    • Koike-Yusa, H.1    Li, Y.2    Tan, E.P.3
  • 51
    • 84892765883 scopus 로고    scopus 로고
    • Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
    • Shalem O., Sanjana N. E., Hartenian E.,. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells. Science. 2014, 343 (6166), 84-87.
    • (2014) Science , vol.343 , Issue.6166 , pp. 84-87
    • Shalem, O.1    Sanjana, N.E.2    Hartenian, E.3
  • 52
    • 84884288934 scopus 로고    scopus 로고
    • Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
    • Ran F. A., Hsu P. D., Lin C.-Y.,. Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell. 2013, 154 (6), 1380-1389.
    • (2013) Cell , vol.154 , Issue.6 , pp. 1380-1389
    • Ran, F.A.1    Hsu, P.D.2    Lin, C.-Y.3
  • 53
    • 48249095920 scopus 로고    scopus 로고
    • Single-Strand Break Repair and Genetic Disease
    • Caldecott K. W., Single-Strand Break Repair and Genetic Disease. Nature Rev. Genet. 2008, 9 (8), 619-631.
    • (2008) Nature Rev. Genet , vol.9 , Issue.8 , pp. 619-631
    • Caldecott, K.W.1
  • 54
    • 84908593807 scopus 로고    scopus 로고
    • DNA Single-Strand Break Repair
    • Caldecott K. W., DNA Single-Strand Break Repair. Exper. Cell Res. 2014, 329 (1), 2-8.
    • (2014) Exper. Cell Res , vol.329 , Issue.1 , pp. 2-8
    • Caldecott, K.W.1
  • 55
    • 84876016461 scopus 로고    scopus 로고
    • Mammalian Base Excision Repair: The Forgotten Archangel
    • Dianov G. L., Hubscher U., Mammalian Base Excision Repair: The Forgotten Archangel. Nucleic Acids Res. 2013, 41 (6), 3483-3490.
    • (2013) Nucleic Acids Res , vol.41 , Issue.6 , pp. 3483-3490
    • Dianov, G.L.1    Hubscher, U.2
  • 56
    • 84885398906 scopus 로고    scopus 로고
    • A CRISPR CASe for High-Throughput Silencing
    • Heintze J., Luft C., Ketteler R., A CRISPR CASe for High-Throughput Silencing. Front. Genet. 2013, 4, 193.
    • (2013) Front. Genet , vol.4 , pp. 193
    • Heintze, J.1    Luft, C.2    Ketteler, R.3
  • 57
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
    • Qi L. S., Larson M. H., Gilbert L. A.,. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression. Cell. 2013, 152 (5), 1173-1183.
    • (2013) Cell , vol.152 , Issue.5 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3
  • 58
    • 84886993480 scopus 로고    scopus 로고
    • CRISPR Interference (CRISPRi) for Sequence-Specific Control of Gene Expression
    • Larson M. H., Gilbert L. A., Wang X.,. CRISPR Interference (CRISPRi) for Sequence-Specific Control of Gene Expression. Nat. Protoc. 2013, 8 (11), 2180-2196.
    • (2013) Nat. Protoc , vol.8 , Issue.11 , pp. 2180-2196
    • Larson, M.H.1    Gilbert, L.A.2    Wang, X.3
  • 59
    • 84885180675 scopus 로고    scopus 로고
    • Multiplexed Activation of Endogenous Genes by CRISPR-on, an RNA-Guided Transcriptional Activator System
    • Cheng A. W., Wang H., Yang H.,. Multiplexed Activation of Endogenous Genes by CRISPR-on, an RNA-Guided Transcriptional Activator System. Cell Res. 2013, 23 (10), 1163-1171.
    • (2013) Cell Res , vol.23 , Issue.10 , pp. 1163-1171
    • Cheng, A.W.1    Wang, H.2    Yang, H.3
  • 60
    • 84880571335 scopus 로고    scopus 로고
    • CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
    • Gilbert L. A., Larson M. H., Morsut L.,. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes. Cell. 2013, 154 (2), 442-451.
    • (2013) Cell , vol.154 , Issue.2 , pp. 442-451
    • Gilbert, L.A.1    Larson, M.H.2    Morsut, L.3
  • 61
    • 84908352138 scopus 로고    scopus 로고
    • Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
    • Gilbert L. A., Horlbeck M. A., Adamson B.,. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 2014, 159 (3), 647-661.
    • (2014) Cell , vol.159 , Issue.3 , pp. 647-661
    • Gilbert, L.A.1    Horlbeck, M.A.2    Adamson, B.3
  • 62
    • 84908328232 scopus 로고    scopus 로고
    • A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging
    • Tanenbaum M. E., Gilbert L. A., Qi L. S.,. A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging. Cell. 2014, 159 (3), 635-646.
    • (2014) Cell , vol.159 , Issue.3 , pp. 635-646
    • Tanenbaum, M.E.1    Gilbert, L.A.2    Qi, L.S.3
  • 63
    • 84888781186 scopus 로고    scopus 로고
    • Repurposing CRISPR/Cas9 for in Situ Functional Assays
    • Malina A., Mills J. R., Cencic R.,. Repurposing CRISPR/Cas9 for In Situ Functional Assays. Genes Dev. 2013, 27 (23), 2602-2614.
    • (2013) Genes Dev , vol.27 , Issue.23 , pp. 2602-2614
    • Malina, A.1    Mills, J.R.2    Cencic, R.3
  • 64
    • 84912101598 scopus 로고    scopus 로고
    • CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
    • Platt R. J., Chen S., Zhou Y.,. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. Cell. 2014, 159 (2), 440-455.
    • (2014) Cell , vol.159 , Issue.2 , pp. 440-455
    • Platt, R.J.1    Chen, S.2    Zhou, Y.3
  • 65
    • 77950627707 scopus 로고    scopus 로고
    • Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression
    • Woodcock S. A., Rushton H. J., Castaneda-Saucedo E.,. Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression. Curr. Biol. 2010, 20 (7), 669-675.
    • (2010) Curr. Biol , vol.20 , Issue.7 , pp. 669-675
    • Woodcock, S.A.1    Rushton, H.J.2    Castaneda-Saucedo, E.3
  • 66
    • 33747799289 scopus 로고    scopus 로고
    • Enhancing and Confirming the Specificity of RNAi Experiments
    • Cullen B. R., Enhancing and Confirming the Specificity of RNAi Experiments. Nature Meth. 2006, 3 (9), 677-681.
    • (2006) Nature Meth , vol.3 , Issue.9 , pp. 677-681
    • Cullen, B.R.1
  • 67
    • 84879026965 scopus 로고    scopus 로고
    • Protospacer Recognition Motifs: Mixed Identities and Functional Diversity
    • Shah S. A., Erdmann S., Mojica F. J. M.,. Protospacer Recognition Motifs: Mixed Identities and Functional Diversity. RNA Biol. 2013, 10 (5), 891-899.
    • (2013) RNA Biol , vol.10 , Issue.5 , pp. 891-899
    • Shah, S.A.1    Erdmann, S.2    Mojica, F.J.M.3
  • 68
    • 84884165315 scopus 로고    scopus 로고
    • DNA Targeting Specificity of RNA-Guided Cas9 Nucleases
    • Hsu P. D., Scott D. A., Weinstein J. A.,. DNA Targeting Specificity of RNA-Guided Cas9 Nucleases. Nat. Biotechnol. 2013, 31 (9), 827-832.
    • (2013) Nat. Biotechnol , vol.31 , Issue.9 , pp. 827-832
    • Hsu, P.D.1    Scott, D.A.2    Weinstein, J.A.3
  • 69
    • 84907331721 scopus 로고    scopus 로고
    • Expansion of the CRISPR-Cas9 Genome Targeting Space through the Use of H1 Promoter-Expressed Guide RNAs
    • Ranganathan V., Wahlin K., Maruotti J.,. Expansion of the CRISPR-Cas9 Genome Targeting Space through the Use of H1 Promoter-Expressed Guide RNAs. Nat. Commun. 2014, 5, 4516.
    • (2014) Nat. Commun , vol.5 , pp. 4516
    • Ranganathan, V.1    Wahlin, K.2    Maruotti, J.3
  • 70
    • 84895832944 scopus 로고    scopus 로고
    • Phylogeny of Cas9 Determines Functional Exchangeability of Dual-RNA and Cas9 among Orthologous Type II CRISPR-Cas systems
    • Fonfara I., Le Rhun A., Chylinski K.,. Phylogeny of Cas9 Determines Functional Exchangeability of Dual-RNA and Cas9 among Orthologous Type II CRISPR-Cas systems. Nucleic Acids Res. 2014, 42 (4), 2577-2590.
    • (2014) Nucleic Acids Res , vol.42 , Issue.4 , pp. 2577-2590
    • Fonfara, I.1    Le Rhun, A.2    Chylinski, K.3
  • 71
    • 84884663630 scopus 로고    scopus 로고
    • Efficient Genome Engineering in Human Pluripotent Stem Cells Using Cas9 from Neisseria meningitidis
    • Hou Z., Zhang Y., Propson N. E.,. Efficient Genome Engineering in Human Pluripotent Stem Cells Using Cas9 from Neisseria meningitidis. Proc. Natl. Acad. Sci. USA. 2013, 110 (39), 15644-15649.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , Issue.39 , pp. 15644-15649
    • Hou, Z.1    Zhang, Y.2    Propson, N.E.3
  • 72
    • 84903200702 scopus 로고    scopus 로고
    • Comparison of Non-Canonical PAMs for CRISPR/Cas9-Mediated DNA Cleavage in Human Cells
    • Zhang Y., Ge X., Yang F.,. Comparison of Non-Canonical PAMs for CRISPR/Cas9-Mediated DNA Cleavage in Human Cells. Sci. Rep. 2014, 4, 5405.
    • (2014) Sci. Rep , vol.4 , pp. 5405
    • Zhang, Y.1    Ge, X.2    Yang, F.3
  • 73
    • 33745614074 scopus 로고    scopus 로고
    • Position-Specific Chemical Modification of siRNAs Reduces off-Target Transcript Silencing
    • Jackson A. L., Burchard J., Leake D.,. Position-Specific Chemical Modification of siRNAs Reduces ;Off-Target; Transcript Silencing. RNA. 2006, 12 (7), 1197-1205.
    • (2006) RNA , vol.12 , Issue.7 , pp. 1197-1205
    • Jackson, A.L.1    Burchard, J.2    Leake, D.3
  • 74
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA off-Target Transcript Silencing Mediated by Seed Region Sequence Complementarity
    • Jackson A. L., Burchard J., Schelter J.,. Widespread siRNA 'Off-Target' Transcript Silencing Mediated by Seed Region Sequence Complementarity. RNA. 2006, 12 (7), 1179-1187.
    • (2006) RNA , vol.12 , Issue.7 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3
  • 75
    • 84902301560 scopus 로고    scopus 로고
    • Online GESS: Prediction of miRNA-Like Off-Target Effects in Large-Scale RNAi Screen Data by Seed Region Analysis
    • Yilmazel B., Hu Y., Sigoillot F.,. Online GESS: Prediction of miRNA-Like Off-Target Effects in Large-Scale RNAi Screen Data by Seed Region Analysis. BMC Bioinformatics. 2014, 15, 192.
    • (2014) BMC Bioinformatics , vol.15 , pp. 192
    • Yilmazel, B.1    Hu, Y.2    Sigoillot, F.3
  • 76
    • 84861752176 scopus 로고    scopus 로고
    • SiRNA Off-Target Effects in Genome-Wide Screens Identify Signaling Pathway Members
    • Buehler E., Khan A. A., Marine S.,. siRNA Off-Target Effects in Genome-Wide Screens Identify Signaling Pathway Members. Sci. Rep. 2012, 2, 428.
    • (2012) Sci. Rep , vol.2 , pp. 428
    • Buehler, E.1    Khan, A.A.2    Marine, S.3
  • 77
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and Avoiding siRNA Off-Target Effects for Target Identification and Therapeutic Application
    • Jackson A. L., Linsley P. S., Recognizing and Avoiding siRNA Off-Target Effects for Target Identification and Therapeutic Application. Nat. Rev. Drug Discov. 2010, 9 (1), 57-67.
    • (2010) Nat. Rev. Drug Discov , vol.9 , Issue.1 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 78
    • 84897954175 scopus 로고    scopus 로고
    • Efficient Genome Modification by CRISPR-Cas9 Nickase with Minimal Off-Target Effects
    • Shen B., Zhang W., Zhang J.,. Efficient Genome Modification by CRISPR-Cas9 Nickase with Minimal Off-Target Effects. Nat. Methods. 2014, 11 (4), 399-402.
    • (2014) Nat. Methods , vol.11 , Issue.4 , pp. 399-402
    • Shen, B.1    Zhang, W.2    Zhang, J.3
  • 79
    • 84904010334 scopus 로고    scopus 로고
    • Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
    • Veres A., Gosis B. S., Ding Q.,. Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing. Cell Stem Cell. 2014, 15 (1), 27-30.
    • (2014) Cell Stem Cell , vol.15 , Issue.1 , pp. 27-30
    • Veres, A.1    Gosis, B.S.2    Ding, Q.3
  • 80
    • 84884155038 scopus 로고    scopus 로고
    • High-Throughput Profiling of Off-Target DNA Cleavage Reveals RNA-Programmed Cas9 Nuclease Specificity
    • Pattanayak V., Lin S., Guilinger J. P.,. High-Throughput Profiling of Off-Target DNA Cleavage Reveals RNA-Programmed Cas9 Nuclease Specificity. Nat. Biotechnol. 2013, 31 (9), 839-843.
    • (2013) Nat. Biotechnol , vol.31 , Issue.9 , pp. 839-843
    • Pattanayak, V.1    Lin, S.2    Guilinger, J.P.3
  • 81
    • 84884950106 scopus 로고    scopus 로고
    • CRISPR/Cas9 Systems Targeting '-Globin and CCR5 Genes Have Substantial Off-Target Activity
    • Cradick T. J., Fine E. J., Antico C. J.,. CRISPR/Cas9 Systems Targeting '-Globin and CCR5 Genes Have Substantial Off-Target Activity. Nucleic Acids Res. 2013, 41 (20), 9584-9592.
    • (2013) Nucleic Acids Res , vol.41 , Issue.20 , pp. 9584-9592
    • Cradick, T.J.1    Fine, E.J.2    Antico, C.J.3
  • 82
    • 84880570576 scopus 로고    scopus 로고
    • High-Frequency Off-Target Mutagenesis Induced by CRISPR-Cas Nucleases in Human Cells
    • Fu Y., Foden J. A., Khayter C.,. High-Frequency Off-Target Mutagenesis Induced by CRISPR-Cas Nucleases in Human Cells. Nat. Biotechnol. 2013, 31 (9), 822-826.
    • (2013) Nat. Biotechnol , vol.31 , Issue.9 , pp. 822-826
    • Fu, Y.1    Foden, J.A.2    Khayter, C.3
  • 83
    • 84895871173 scopus 로고    scopus 로고
    • DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9
    • Sternberg S. H., Redding S., Jinek M.,. DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9. Nature. 2014, 507 (7490), 62-67.
    • (2014) Nature , vol.507 , Issue.7490 , pp. 62-67
    • Sternberg, S.H.1    Redding, S.2    Jinek, M.3
  • 84
    • 84902095352 scopus 로고    scopus 로고
    • Genome-Wide Binding of the CRISPR Endonuclease Cas9 in Mammalian Cells
    • Wu X., Scott D. A., Kriz A. J.,. Genome-Wide Binding of the CRISPR Endonuclease Cas9 in Mammalian Cells. Nat. Biotechnol. 2014, 32 (7), 670-676.
    • (2014) Nat. Biotechnol , vol.32 , Issue.7 , pp. 670-676
    • Wu, X.1    Scott, D.A.2    Kriz, A.J.3
  • 85
    • 84903545084 scopus 로고    scopus 로고
    • Genome-Wide Analysis Reveals Characteristics of Off-Target Sites Bound by the Cas9 Endonuclease
    • Kuscu C., Arslan S., Singh R.,. Genome-Wide Analysis Reveals Characteristics of Off-Target Sites Bound by the Cas9 Endonuclease. Nat. Biotechnol. 2014, 32 (7), 677-683.
    • (2014) Nat. Biotechnol , vol.32 , Issue.7 , pp. 677-683
    • Kuscu, C.1    Arslan, S.2    Singh, R.3
  • 86
    • 84874608929 scopus 로고    scopus 로고
    • RNA-Guided Editing of Bacterial Genomes Using CRISPR-Cas Systems
    • Jiang W., Bikard D., Cox D.,. RNA-Guided Editing of Bacterial Genomes Using CRISPR-Cas Systems. Nat. Biotechnol. 2013, 31 (3), 233-239.
    • (2013) Nat. Biotechnol , vol.31 , Issue.3 , pp. 233-239
    • Jiang, W.1    Bikard, D.2    Cox, D.3
  • 87
    • 84934439082 scopus 로고    scopus 로고
    • Designing Functional siRNA with Reduced Off-Target Effects
    • Naito Y., Ui-Tei K., Designing Functional siRNA with Reduced Off-Target Effects. siRNA Design. 2012, 942, 57-68.
    • (2012) SiRNA Design , vol.942 , pp. 57-68
    • Naito, Y.1    Ui-Tei, K.2
  • 88
    • 77950634611 scopus 로고    scopus 로고
    • Multi-Task Learning for Cross-Platform siRNA Efficacy Prediction: An In-Silico Study
    • Liu Q., Xu Q., Zheng V. W.,. Multi-Task Learning for Cross-Platform siRNA Efficacy Prediction: An In-Silico Study. BMC Bioinformatics. 2010, 11, 181.
    • (2010) BMC Bioinformatics , vol.11 , pp. 181
    • Liu, Q.1    Xu, Q.2    Zheng, V.W.3
  • 89
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas Nuclease Specificity Using Truncated Guide RNAs
    • Fu Y., Sander J. D., Reyon D.,. Improving CRISPR-Cas Nuclease Specificity Using Truncated Guide RNAs. Nat. Biotechnol. 2014, 32 (3), 279-284.
    • (2014) Nat. Biotechnol , vol.32 , Issue.3 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3
  • 90
    • 84893819419 scopus 로고    scopus 로고
    • Sequence-Specific Inhibition of microRNA via CRISPR/CRISPRi System
    • Zhao Y., Dai Z., Liang Y.,. Sequence-Specific Inhibition of microRNA via CRISPR/CRISPRi System. Sci. Rep. 2014, 4, 3943.
    • (2014) Sci. Rep , vol.4 , pp. 3943
    • Zhao, Y.1    Dai, Z.2    Liang, Y.3
  • 91
    • 84877612139 scopus 로고    scopus 로고
    • The Genomic and Transcriptomic Landscape of a HeLa Cell Line
    • Landry J. J. M., Pyl P. T., Rausch T.,. The Genomic and Transcriptomic Landscape of a HeLa Cell Line. Genes Genom. Genet. 2013, 3 (8), 1213-1224.
    • (2013) Genes Genom. Genet , vol.3 , Issue.8 , pp. 1213-1224
    • Landry, J.J.M.1    Pyl, P.T.2    Rausch, T.3
  • 92
    • 61849165129 scopus 로고    scopus 로고
    • Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure
    • Carralot J.-P., Kim T.-K., Lenseigne B.,. Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure. J. Biomol. Screen. 2009, 14 (2), 151-160.
    • (2009) J. Biomol. Screen , vol.14 , Issue.2 , pp. 151-160
    • Carralot, J.-P.1    Kim, T.-K.2    Lenseigne, B.3
  • 93
    • 0035146798 scopus 로고    scopus 로고
    • Quantitative Study of Electroporation-Mediated Molecular Uptake and Cell Viability
    • Canatella P. J., Karr J. F., Petros J. A.,. Quantitative Study of Electroporation-Mediated Molecular Uptake and Cell Viability. Biophys. J. 2001, 80 (2), 755-764.
    • (2001) Biophys. J , vol.80 , Issue.2 , pp. 755-764
    • Canatella, P.J.1    Karr, J.F.2    Petros, J.A.3
  • 94
    • 0037434885 scopus 로고    scopus 로고
    • Nucleoporation of Dendritic Cells: Efficient Gene Transfer by Electroporation into Human Monocyte-Derived Dendritic Cells
    • Lenz P., Bacot S. M., Frazier-Jessen M. R.,. Nucleoporation of Dendritic Cells: Efficient Gene Transfer by Electroporation into Human Monocyte-Derived Dendritic Cells. FEBS Lett. 2003, 538 (1-3), 149-154.
    • (2003) FEBS Lett , vol.538 , Issue.1-3 , pp. 149-154
    • Lenz, P.1    Bacot, S.M.2    Frazier-Jessen, M.R.3
  • 95
    • 0036635919 scopus 로고    scopus 로고
    • Comparison of the Efficiency and Safety of Non-Viral Vector-Mediated Gene Transfer into a Wide Range of Human Cells
    • Uchida E., Mizuguchi H., Ishii-Watabe A.,. Comparison of the Efficiency and Safety of Non-Viral Vector-Mediated Gene Transfer into a Wide Range of Human Cells. Biol. Pharm. Bull. 2002, 25 (7), 891-897.
    • (2002) Biol. Pharm. Bull , vol.25 , Issue.7 , pp. 891-897
    • Uchida, E.1    Mizuguchi, H.2    Ishii-Watabe, A.3
  • 96
    • 84901843996 scopus 로고    scopus 로고
    • Gene Disruption by Cell-Penetrating Peptide-Mediated Delivery of Cas9 Protein and Guide RNA
    • Ramakrishna S., Kwaku Dad A.-B., Beloor J.,. Gene Disruption by Cell-Penetrating Peptide-Mediated Delivery of Cas9 Protein and Guide RNA. Genome Res. 2014, 24 (6), 1020-1027.
    • (2014) Genome Res , vol.24 , Issue.6 , pp. 1020-1027
    • Ramakrishna, S.1    Kwaku Dad, A.-B.2    Beloor, J.3
  • 97
    • 67349230238 scopus 로고    scopus 로고
    • Cellular siRNA Delivery Using Cell-Penetrating Peptides Modified for Endosomal Escape
    • Endoh T., Ohtsuki T., Cellular siRNA Delivery Using Cell-Penetrating Peptides Modified for Endosomal Escape. Adv. Drug Deliv. Rev. 2009, 61 (9), 704-709.
    • (2009) Adv. Drug Deliv. Rev , vol.61 , Issue.9 , pp. 704-709
    • Endoh, T.1    Ohtsuki, T.2
  • 98
    • 84907573408 scopus 로고    scopus 로고
    • CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems
    • Zhu L. J., Holmes B. R., Aronin N.,. CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems. PLoS One. 2014, 9 (9), e108424.
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e108424
    • Zhu, L.J.1    Holmes, B.R.2    Aronin, N.3
  • 99
    • 84925855176 scopus 로고    scopus 로고
    • Advances in Genome Editing Technology and Its Promising Application in Evolutionary and Ecological Studies
    • Chen L., Tang L., Xiang H.,. Advances in Genome Editing Technology and Its Promising Application in Evolutionary and Ecological Studies. GigaScience. 2014, 3, 24.
    • (2014) GigaScience , vol.3 , pp. 24
    • Chen, L.1    Tang, L.2    Xiang, H.3
  • 100
    • 84890831873 scopus 로고    scopus 로고
    • RNA-Guided Genome Editing for Target Gene Mutations in Wheat
    • Upadhyay S. K., Kumar J., Alok A.,. RNA-Guided Genome Editing for Target Gene Mutations in Wheat. Genes Genom. Genet. 2013, 3 (12), 2233-2238.
    • (2013) Genes Genom. Genet , vol.3 , Issue.12 , pp. 2233-2238
    • Upadhyay, S.K.1    Kumar, J.2    Alok, A.3
  • 101
    • 84921934205 scopus 로고    scopus 로고
    • Simultaneous Editing of Three Homoeoalleles in Hexaploid Bread Wheat Confers Heritable Resistance to Powdery Mildew
    • Wang Y., Cheng X., Shan Q.,. Simultaneous Editing of Three Homoeoalleles in Hexaploid Bread Wheat Confers Heritable Resistance to Powdery Mildew. Nature Biotech. 2014, 32 (9), 947-951.
    • (2014) Nature Biotech , vol.32 , Issue.9 , pp. 947-951
    • Wang, Y.1    Cheng, X.2    Shan, Q.3
  • 102
    • 84906069052 scopus 로고    scopus 로고
    • Using RNA-seq and Targeted Nucleases to Identify Mechanisms of Drug Resistance in Acute Myeloid Leukemia
    • Rathe S. K., Moriarity B. S., Stoltenberg C. B.,. Using RNA-seq and Targeted Nucleases to Identify Mechanisms of Drug Resistance in Acute Myeloid Leukemia. Sci. Rep. 2014, 4, 6048.
    • (2014) Sci. Rep , vol.4 , pp. 6048
    • Rathe, S.K.1    Moriarity, B.S.2    Stoltenberg, C.B.3
  • 103
    • 12344288635 scopus 로고    scopus 로고
    • Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets
    • Eggert U. S., Kiger A. A., Richter C.,. Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets. PLoS Biol. 2004, 2 (12), e379.
    • (2004) PLoS Biol , vol.2 , Issue.12 , pp. e379
    • Eggert, U.S.1    Kiger, A.A.2    Richter, C.3
  • 104
    • 79955046668 scopus 로고    scopus 로고
    • An RNAi-Based Chemical Genetic Screen Identifies Three Small-Molecule Inhibitors of the Wnt/Wingless Signaling Pathway
    • Gonsalves F. C., Klein K., Carson B. B.,. An RNAi-Based Chemical Genetic Screen Identifies Three Small-Molecule Inhibitors of the Wnt/Wingless Signaling Pathway. Proc. Natl. Acad. Sci. USA. 2011, 108 (15), 5954-5963.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , Issue.15 , pp. 5954-5963
    • Gonsalves, F.C.1    Klein, K.2    Carson, B.B.3
  • 105
    • 5444234179 scopus 로고    scopus 로고
    • RNA Interference: From Model Organisms towards Therapy for Neural and Neuromuscular Disorders
    • Buckingham S. D., Esmaeili B., Wood M.,. RNA Interference: From Model Organisms towards Therapy for Neural and Neuromuscular Disorders. Human Molec. Genet. 2004, 13 (Spec. No. 2), R275-R288.
    • (2004) Human Molec. Genet , vol.13 , Issue.SPEC. NO. 2 , pp. R275-R288
    • Buckingham, S.D.1    Esmaeili, B.2    Wood, M.3
  • 106
    • 33646950387 scopus 로고    scopus 로고
    • Glial Cell Line-Derived Neurotrophic Factor and Its Receptor RET Is a Novel Ligand-Receptor Complex Critical for Survival Response during Podocyte Injury
    • Tsui C. C., Shankland S. J., Pierchala B. A., Glial Cell Line-Derived Neurotrophic Factor and Its Receptor RET Is a Novel Ligand-Receptor Complex Critical for Survival Response during Podocyte Injury. J. Amer. Soc. Nephrol. 2006, 17 (6), 1543-1552.
    • (2006) J. Amer. Soc. Nephrol , vol.17 , Issue.6 , pp. 1543-1552
    • Tsui, C.C.1    Shankland, S.J.2    Pierchala, B.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.