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Volumn 7, Issue 1, 2015, Pages

RNA interference approaches for treatment of HIV-1 infection

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; SMALL INTERFERING RNA;

EID: 84939267265     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-015-0174-y     Document Type: Article
Times cited : (72)

References (183)
  • 1
    • 0001707601 scopus 로고
    • 3'-Azido-3"-deoxythymidine (BW A509U). an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
    • Mitsuya H, Weinhold KJ, Furman PA, St Clair MH, Lehrman SN, Gallo RC, et al. 3'-Azido-3"-deoxythymidine (BW A509U). an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A. 1985;82:7096-100.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 7096-7100
    • Mitsuya, H.1    Weinhold, K.J.2    Furman, P.A.3    St Clair, M.H.4    Lehrman, S.N.5    Gallo, R.C.6
  • 3
    • 79551614790 scopus 로고    scopus 로고
    • HIV infection, inflammation, immunosenescence, and aging
    • Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62:141-55.
    • (2011) Annu Rev Med. , vol.62 , pp. 141-155
    • Deeks, S.G.1
  • 6
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 1997;278:1295-300.
    • (1997) Science. , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3    Carruth, L.M.4    Buck, C.5    Chaisson, R.E.6
  • 7
    • 78549245806 scopus 로고    scopus 로고
    • Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
    • Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS. 2010;24:2451-60.
    • (2010) AIDS. , vol.24 , pp. 2451-2460
    • Yukl, S.A.1    Shergill, A.K.2    McQuaid, K.3    Gianella, S.4    Lampiris, H.5    Hare, C.B.6
  • 8
    • 84901804676 scopus 로고    scopus 로고
    • Global Report: UNAIDS report on the global AIDS epidemic
    • UNAIDS. Global Report: UNAIDS report on the global AIDS epidemic 2013. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf. Accessed 15 Apr 2015.
    • (2013)
  • 9
    • 79952699891 scopus 로고    scopus 로고
    • Coreceptors and HIV-1 pathogenesis
    • Gorry PR, Ancuta P. Coreceptors and HIV-1 pathogenesis. Curr HIV/AIDS Rep. 2011;8:45-53.
    • (2011) Curr HIV/AIDS Rep. , vol.8 , pp. 45-53
    • Gorry, P.R.1    Ancuta, P.2
  • 10
    • 0027494083 scopus 로고
    • Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity
    • Purcell DF, Martin MA. Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. J Virol. 1993;67:6365-78.
    • (1993) J Virol. , vol.67 , pp. 6365-6378
    • Purcell, D.F.1    Martin, M.A.2
  • 11
    • 80053962808 scopus 로고    scopus 로고
    • Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane
    • Hogue IB, Grover JR, Soheilian F, Nagashima K, Ono A. Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane. J Virol. 2011;85:9749-66.
    • (2011) J Virol. , vol.85 , pp. 9749-9766
    • Hogue, I.B.1    Grover, J.R.2    Soheilian, F.3    Nagashima, K.4    Ono, A.5
  • 12
    • 0035923525 scopus 로고    scopus 로고
    • Plasma membrane rafts play a critical role in HIV-1 assembly and release
    • Ono A, Freed EO. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc Natl Acad Sci U S A. 2001;98:13925-30.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , pp. 13925-13930
    • Ono, A.1    Freed, E.O.2
  • 14
    • 84875420616 scopus 로고    scopus 로고
    • Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
    • Maier DA, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, et al. Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Hum Gene Ther. 2013;24:245-58.
    • (2013) Hum Gene Ther. , vol.24 , pp. 245-258
    • Maier, D.A.1    Brennan, A.L.2    Jiang, S.3    Binder-Scholl, G.K.4    Lee, G.5    Plesa, G.6
  • 15
    • 84862777608 scopus 로고    scopus 로고
    • Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment
    • Yuan J, Wang J, Crain K, Fearns C, Kim KA, Hua KL, et al. Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment. Mol Ther. 2012;20:849-59.
    • (2012) Mol Ther. , vol.20 , pp. 849-859
    • Yuan, J.1    Wang, J.2    Crain, K.3    Fearns, C.4    Kim, K.A.5    Hua, K.L.6
  • 16
    • 84891772031 scopus 로고    scopus 로고
    • Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
    • Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, et al. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood. 2014;123:61-9.
    • (2014) Blood. , vol.123 , pp. 61-69
    • Didigu, C.A.1    Wilen, C.B.2    Wang, J.3    Duong, J.4    Secreto, A.J.5    Danet-Desnoyers, G.A.6
  • 17
    • 79955785236 scopus 로고    scopus 로고
    • Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases
    • Wilen CB, Wang J, Tilton JC, Miller JC, Kim KA, Rebar EJ, et al. Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases. PLoS Pathog. 2011;7, e1002020.
    • (2011) PLoS Pathog. , vol.7
    • Wilen, C.B.1    Wang, J.2    Tilton, J.C.3    Miller, J.C.4    Kim, K.A.5    Rebar, E.J.6
  • 18
    • 78650735673 scopus 로고    scopus 로고
    • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    • Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28:839-47.
    • (2010) Nat Biotechnol. , vol.28 , pp. 839-847
    • Holt, N.1    Wang, J.2    Kim, K.3    Friedman, G.4    Wang, X.5    Taupin, V.6
  • 19
    • 84878528467 scopus 로고    scopus 로고
    • Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
    • Li L, Krymskaya L, Wang J, Henley J, Rao A, Cao LF, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013;21:1259-69.
    • (2013) Mol Ther. , vol.21 , pp. 1259-1269
    • Li, L.1    Krymskaya, L.2    Wang, J.3    Henley, J.4    Rao, A.5    Cao, L.F.6
  • 20
    • 84895487305 scopus 로고    scopus 로고
    • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
    • Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014;370:901-10.
    • (2014) N Engl J Med. , vol.370 , pp. 901-910
    • Tebas, P.1    Stein, D.2    Tang, W.W.3    Frank, I.4    Wang, S.Q.5    Lee, G.6
  • 21
    • 46949095221 scopus 로고    scopus 로고
    • Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
    • Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 2008;26:808-16.
    • (2008) Nat Biotechnol. , vol.26 , pp. 808-816
    • Perez, E.E.1    Wang, J.2    Miller, J.C.3    Jouvenot, Y.4    Kim, K.A.5    Liu, O.6
  • 22
    • 84903729497 scopus 로고    scopus 로고
    • Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Delta32 mutation confers resistance to HIV infection
    • Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, et al. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Delta32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014;111:9591-6.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , pp. 9591-9596
    • Ye, L.1    Wang, J.2    Beyer, A.I.3    Teque, F.4    Cradick, T.J.5    Qi, Z.6
  • 23
    • 84867061435 scopus 로고    scopus 로고
    • Coupling endonucleases with DNA end-processing enzymes to drive gene disruption
    • Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, et al. Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nat Methods. 2012;9:973-5.
    • (2012) Nat Methods. , vol.9 , pp. 973-975
    • Certo, M.T.1    Gwiazda, K.S.2    Kuhar, R.3    Sather, B.4    Curinga, G.5    Mandt, T.6
  • 24
    • 80053145141 scopus 로고    scopus 로고
    • Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids
    • Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, et al. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011;18:1189-98.
    • (2011) Chem Biol. , vol.18 , pp. 1189-1198
    • Schleifman, E.B.1    Bindra, R.2    Leif, J.3    Campo, J.4    Rogers, F.A.5    Uchil, P.6
  • 25
    • 84884950106 scopus 로고    scopus 로고
    • CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity
    • Cradick TJ, Fine EJ, Antico CJ, Bao G. CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res. 2013;41:9584-92.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 9584-9592
    • Cradick, T.J.1    Fine, E.J.2    Antico, C.J.3    Bao, G.4
  • 26
    • 84874624936 scopus 로고    scopus 로고
    • Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    • Cho SW, Kim S, Kim JM, Kim JS. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol. 2013;31:230-2.
    • (2013) Nat Biotechnol. , vol.31 , pp. 230-232
    • Cho, S.W.1    Kim, S.2    Kim, J.M.3    Kim, J.S.4
  • 27
    • 84905643812 scopus 로고    scopus 로고
    • RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
    • Hu W, Kaminski R, Yang F, Zhang Y, Cosentino L, Li F, et al. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A. 2014;111:11461-6.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , pp. 11461-11466
    • Hu, W.1    Kaminski, R.2    Yang, F.3    Zhang, Y.4    Cosentino, L.5    Li, F.6
  • 28
    • 84883305437 scopus 로고    scopus 로고
    • Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
    • Ebina H, Misawa N, Kanemura Y, Koyanagi Y. Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep. 2013;3:2510.
    • (2013) Sci Rep. , vol.3 , pp. 2510
    • Ebina, H.1    Misawa, N.2    Kanemura, Y.3    Koyanagi, Y.4
  • 29
    • 79951783813 scopus 로고    scopus 로고
    • Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI
    • Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR. Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. PLoS One. 2011;6, e16825.
    • (2011) PLoS One. , vol.6
    • Aubert, M.1    Ryu, B.Y.2    Banks, L.3    Rawlings, D.J.4    Scharenberg, A.M.5    Jerome, K.R.6
  • 31
    • 34347398120 scopus 로고    scopus 로고
    • HIV-1 proviral DNA excision using an evolved recombinase
    • Sarkar I, Hauber I, Hauber J, Buchholz F. HIV-1 proviral DNA excision using an evolved recombinase. Science. 2007;316:1912-5.
    • (2007) Science. , vol.316 , pp. 1912-1915
    • Sarkar, I.1    Hauber, I.2    Hauber, J.3    Buchholz, F.4
  • 32
    • 78651503825 scopus 로고    scopus 로고
    • In vitro evolution and analysis of HIV-1 LTR-specific recombinases
    • Buchholz F, Hauber J. In vitro evolution and analysis of HIV-1 LTR-specific recombinases. Methods. 2011;53:102-9.
    • (2011) Methods. , vol.53 , pp. 102-109
    • Buchholz, F.1    Hauber, J.2
  • 33
    • 85019237824 scopus 로고    scopus 로고
    • Long-term transgene expression and inhibition of HIV-1 replication by a Cre/loxP-EBNA-1/oriP HIV-1-dependent ribozyme vector: applications for HIV-1 gene therapy
    • Nagawa T, Habu Y, Matsumoto N, Miyano-Kurosaki N, Takaku H. Long-term transgene expression and inhibition of HIV-1 replication by a Cre/loxP-EBNA-1/oriP HIV-1-dependent ribozyme vector: applications for HIV-1 gene therapy. J RNAi Gene Silencing. 2006;2:146-53.
    • (2006) J RNAi Gene Silencing. , vol.2 , pp. 146-153
    • Nagawa, T.1    Habu, Y.2    Matsumoto, N.3    Miyano-Kurosaki, N.4    Takaku, H.5
  • 34
    • 0029655644 scopus 로고    scopus 로고
    • RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo
    • Symensma TL, Giver L, Zapp M, Takle GB, Ellington AD. RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo. J Virol. 1996;70:179-87.
    • (1996) J Virol. , vol.70 , pp. 179-187
    • Symensma, T.L.1    Giver, L.2    Zapp, M.3    Takle, G.B.4    Ellington, A.D.5
  • 35
    • 0034687063 scopus 로고    scopus 로고
    • Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication
    • Konopka K, Lee NS, Rossi J, Duzgunes N. Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication. Gene. 2000;255:235-44.
    • (2000) Gene. , vol.255 , pp. 235-244
    • Konopka, K.1    Lee, N.S.2    Rossi, J.3    Duzgunes, N.4
  • 37
    • 77949418266 scopus 로고    scopus 로고
    • A dual function TAR decoy serves as an anti-HIV siRNA delivery vehicle
    • Unwalla HJ, Rossi JJ. A dual function TAR decoy serves as an anti-HIV siRNA delivery vehicle. Virol J. 2010;7:33.
    • (2010) Virol J. , vol.7 , pp. 33
    • Unwalla, H.J.1    Rossi, J.J.2
  • 38
    • 77955608799 scopus 로고    scopus 로고
    • RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.
    • DiGiusto DL, Krishnan A, Li L, Li H, Li S, Rao A, et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med. 2010;2:36ra43.
    • (2010) Sci Transl Med. , vol.2 , pp. 36-43
    • DiGiusto, D.L.1    Krishnan, A.2    Li, L.3    Li, H.4    Li, S.5    Rao, A.6
  • 39
    • 84888150047 scopus 로고    scopus 로고
    • Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice
    • DiGiusto DL, Stan R, Krishnan A, Li H, Rossi JJ, Zaia JA. Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice. Viruses. 2013;5:2898-919.
    • (2013) Viruses. , vol.5 , pp. 2898-2919
    • DiGiusto, D.L.1    Stan, R.2    Krishnan, A.3    Li, H.4    Rossi, J.J.5    Zaia, J.A.6
  • 40
    • 80052777732 scopus 로고    scopus 로고
    • Phase I/II clinical trials using gene-modified adult hematopoietic stem cells for HIV: lessons learnt
    • Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP. Phase I/II clinical trials using gene-modified adult hematopoietic stem cells for HIV: lessons learnt. Stem Cells Int. 2011;2011:393698.
    • (2011) Stem Cells Int. , vol.2011 , pp. 393698
    • Mitsuyasu, R.T.1    Zack, J.A.2    Macpherson, J.L.3    Symonds, G.P.4
  • 42
    • 0032211255 scopus 로고    scopus 로고
    • A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
    • Wong-Staal F, Poeschla EM, Looney DJ. A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther. 1998;9:2407-25.
    • (1998) Hum Gene Ther. , vol.9 , pp. 2407-2425
    • Wong-Staal, F.1    Poeschla, E.M.2    Looney, D.J.3
  • 43
    • 21144470101 scopus 로고    scopus 로고
    • Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients
    • Macpherson JL, Boyd MP, Arndt AJ, Todd AV, Fanning GC, Ely JA, et al. Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients. J Gene Med. 2005;7:552-64.
    • (2005) J Gene Med. , vol.7 , pp. 552-564
    • Macpherson, J.L.1    Boyd, M.P.2    Arndt, A.J.3    Todd, A.V.4    Fanning, G.C.5    Ely, J.A.6
  • 44
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-11.
    • (1998) Nature. , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 46
    • 84911471417 scopus 로고    scopus 로고
    • The role of antisense long noncoding RNA in small RNA-triggered gene activation
    • Zhang X, Li H, Burnett JC, Rossi JJ. The role of antisense long noncoding RNA in small RNA-triggered gene activation. RNA. 2014;20:1916-28.
    • (2014) RNA. , vol.20 , pp. 1916-1928
    • Zhang, X.1    Li, H.2    Burnett, J.C.3    Rossi, J.J.4
  • 47
    • 31044433795 scopus 로고    scopus 로고
    • The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
    • Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, Chen ZX, et al. The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA. 2006;12:256-62.
    • (2006) RNA. , vol.12 , pp. 256-262
    • Weinberg, M.S.1    Villeneuve, L.M.2    Ehsani, A.3    Amarzguioui, M.4    Aagaard, L.5    Chen, Z.X.6
  • 48
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • Siomi H, Siomi MC. Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell. 2010;38:323-32.
    • (2010) Mol Cell. , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 49
    • 66149125689 scopus 로고    scopus 로고
    • The role of RNAi and microRNAs in animal virus replication and antiviral immunity
    • Umbach JL, Cullen BR. The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev. 2009;23:1151-64.
    • (2009) Genes Dev. , vol.23 , pp. 1151-1164
    • Umbach, J.L.1    Cullen, B.R.2
  • 50
    • 77649239548 scopus 로고    scopus 로고
    • Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
    • Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, et al. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010;6, e1000764.
    • (2010) PLoS Pathog. , vol.6
    • Parameswaran, P.1    Sklan, E.2    Wilkins, C.3    Burgon, T.4    Samuel, M.A.5    Lu, R.6
  • 51
    • 78650575533 scopus 로고    scopus 로고
    • Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system
    • Bivalkar-Mehla S, Vakharia J, Mehla R, Abreha M, Kanwar JR, Tikoo A, et al. Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system. Virus Res. 2011;155:1-9.
    • (2011) Virus Res. , vol.155 , pp. 1-9
    • Bivalkar-Mehla, S.1    Vakharia, J.2    Mehla, R.3    Abreha, M.4    Kanwar, J.R.5    Tikoo, A.6    Chauhan, A.7
  • 52
    • 84865123875 scopus 로고    scopus 로고
    • Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism
    • Backes S, Shapiro JS, Sabin LR, Pham AM, Reyes I, Moss B, et al. Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism. Cell Host Microbe. 2012;12:200-10.
    • (2012) Cell Host Microbe. , vol.12 , pp. 200-210
    • Backes, S.1    Shapiro, J.S.2    Sabin, L.R.3    Pham, A.M.4    Reyes, I.5    Moss, B.6
  • 54
    • 84885635441 scopus 로고    scopus 로고
    • RNA interference functions as an antiviral immunity mechanism in mammals
    • Li Y, Lu J, Han Y, Fan X, Ding SW. RNA interference functions as an antiviral immunity mechanism in mammals. Science. 2013;342:231-4.
    • (2013) Science. , vol.342 , pp. 231-234
    • Li, Y.1    Lu, J.2    Han, Y.3    Fan, X.4    Ding, S.W.5
  • 56
    • 84904600856 scopus 로고    scopus 로고
    • Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs
    • Bogerd HP, Skalsky RL, Kennedy EM, Furuse Y, Whisnant AW, Flores O, et al. Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs. J Virol. 2014;88:8065-76.
    • (2014) J Virol. , vol.88 , pp. 8065-8076
    • Bogerd, H.P.1    Skalsky, R.L.2    Kennedy, E.M.3    Furuse, Y.4    Whisnant, A.W.5    Flores, O.6
  • 57
    • 84857784900 scopus 로고    scopus 로고
    • Progress toward in vivo use of siRNAs-II
    • Rettig GR, Behlke MA. Progress toward in vivo use of siRNAs-II. Mol Ther. 2012;20:483-512.
    • (2012) Mol Ther. , vol.20 , pp. 483-512
    • Rettig, G.R.1    Behlke, M.A.2
  • 58
    • 84876030403 scopus 로고    scopus 로고
    • Dicer-independent processing of short hairpin RNAs
    • Liu YP, Schopman NC, Berkhout B. Dicer-independent processing of short hairpin RNAs. Nucleic Acids Res. 2013;41:3723-33.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 3723-3733
    • Liu, Y.P.1    Schopman, N.C.2    Berkhout, B.3
  • 59
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell. 2003;115:209-16.
    • (2003) Cell. , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 62
    • 36148933344 scopus 로고    scopus 로고
    • Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect
    • Kubo T, Zhelev Z, Ohba H, Bakalova R. Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect. Biochem Biophys Res Commun. 2008;365:54-61.
    • (2008) Biochem Biophys Res Commun. , vol.365 , pp. 54-61
    • Kubo, T.1    Zhelev, Z.2    Ohba, H.3    Bakalova, R.4
  • 63
    • 54549084606 scopus 로고    scopus 로고
    • Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
    • Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S. Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res. 2008;36:5812-21.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5812-5821
    • Sano, M.1    Sierant, M.2    Miyagishi, M.3    Nakanishi, M.4    Takagi, Y.5    Sutou, S.6
  • 67
    • 84880213957 scopus 로고    scopus 로고
    • Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared to other siRNA variants
    • Snead NM, Wu X, Li A, Cui Q, Sakurai K, Burnett JC, et al. Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared to other siRNA variants. Nucleic Acids Res. 2013. doi:10.1093/nar/gkt200.
    • (2013) Nucleic Acids Res
    • Snead, N.M.1    Wu, X.2    Li, A.3    Cui, Q.4    Sakurai, K.5    Burnett, J.C.6    Rossi, J.J.7
  • 68
    • 84868350874 scopus 로고    scopus 로고
    • Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on Dicing polarity, strand selectivity, and RNA editing of siRNAs
    • Zhou J, Song MS, Jacobi AM, Behlke MA, Wu X, Rossi JJ. Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on Dicing polarity, strand selectivity, and RNA editing of siRNAs. Mol Ther Nucleic Acids. 2012;1, e17.
    • (2012) Mol Ther Nucleic Acids. , vol.1
    • Zhou, J.1    Song, M.S.2    Jacobi, A.M.3    Behlke, M.A.4    Wu, X.5    Rossi, J.J.6
  • 69
    • 84863418151 scopus 로고    scopus 로고
    • Action and reaction: the biological response to siRNA and its delivery vehicles
    • Kanasty RL, Whitehead KA, Vegas AJ, Anderson DG. Action and reaction: the biological response to siRNA and its delivery vehicles. Mol Ther. 2012;20:513-24.
    • (2012) Mol Ther. , vol.20 , pp. 513-524
    • Kanasty, R.L.1    Whitehead, K.A.2    Vegas, A.J.3    Anderson, D.G.4
  • 70
    • 64549120295 scopus 로고    scopus 로고
    • Targeted delivery of antisense oligonucleotides and siRNAs into mammalian cells
    • Sioud M. Targeted delivery of antisense oligonucleotides and siRNAs into mammalian cells. Methods Mol Biol. 2009;487:61-82.
    • (2009) Methods Mol Biol. , vol.487 , pp. 61-82
    • Sioud, M.1
  • 71
    • 84878601356 scopus 로고    scopus 로고
    • Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I
    • Karlsen TA, Brinchmann JE. Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I. Mol Ther. 2013;21:1169-81.
    • (2013) Mol Ther. , vol.21 , pp. 1169-1181
    • Karlsen, T.A.1    Brinchmann, J.E.2
  • 72
    • 84891784472 scopus 로고    scopus 로고
    • siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway.
    • Sui H, Zhou M, Chen Q, Lane HC, Imamichi T. siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway. Nucleic Acids Res. 2014;42:583-98.
    • (2014) Nucleic Acids Res. , vol.42 , pp. 583-598
    • Sui, H.1    Zhou, M.2    Chen, Q.3    Lane, H.C.4    Imamichi, T.5
  • 73
    • 84555187756 scopus 로고    scopus 로고
    • Control of the interferon response in RNAi experiments
    • Nejepinska J, Flemr M, Svoboda P. Control of the interferon response in RNAi experiments. Methods Mol Biol. 2012;820:133-61.
    • (2012) Methods Mol Biol. , vol.820 , pp. 133-161
    • Nejepinska, J.1    Flemr, M.2    Svoboda, P.3
  • 75
    • 78650904206 scopus 로고    scopus 로고
    • Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors
    • Eekels JJ, Geerts D, Jeeninga RE, Berkhout B. Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors. Antiviral Res. 2011;89:43-53.
    • (2011) Antiviral Res. , vol.89 , pp. 43-53
    • Eekels, J.J.1    Geerts, D.2    Jeeninga, R.E.3    Berkhout, B.4
  • 76
    • 84892472993 scopus 로고    scopus 로고
    • Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA
    • Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, et al. Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. J Antimicrob Chemother. 2014;69:404-15.
    • (2014) J Antimicrob Chemother. , vol.69 , pp. 404-415
    • Singh, A.1    Palanichamy, J.K.2    Ramalingam, P.3    Kassab, M.A.4    Bhagat, M.5    Andrabi, R.6
  • 77
    • 68149158913 scopus 로고    scopus 로고
    • Long-term RNA interference and its application to hepatitis B virus
    • Pan JS, Wang XZ, Ren JL. Long-term RNA interference and its application to hepatitis B virus. J Dig Dis. 2009;10:165-71.
    • (2009) J Dig Dis. , vol.10 , pp. 165-171
    • Pan, J.S.1    Wang, X.Z.2    Ren, J.L.3
  • 78
    • 84875311939 scopus 로고    scopus 로고
    • Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors
    • Boutimah F, Eekels JJ, Liu YP, Berkhout B. Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors. Antiviral Res. 2013;98:121-9.
    • (2013) Antiviral Res. , vol.98 , pp. 121-129
    • Boutimah, F.1    Eekels, J.J.2    Liu, Y.P.3    Berkhout, B.4
  • 81
    • 70349302043 scopus 로고    scopus 로고
    • Progress towards therapeutic application of RNA interference for HIV infection
    • Singh SK, Gaur RK. Progress towards therapeutic application of RNA interference for HIV infection. BioDrugs. 2009;23:269-76.
    • (2009) BioDrugs. , vol.23 , pp. 269-276
    • Singh, S.K.1    Gaur, R.K.2
  • 82
    • 77957268423 scopus 로고    scopus 로고
    • The therapeutic potential of RNA interference in controlling HIV-1 replication
    • Soejitno A, Wihandani DM, Kuswardhani T. The therapeutic potential of RNA interference in controlling HIV-1 replication. Acta Med Indones. 2009;41:215-21.
    • (2009) Acta Med Indones. , vol.41 , pp. 215-221
    • Soejitno, A.1    Wihandani, D.M.2    Kuswardhani, T.3
  • 84
    • 53149132028 scopus 로고    scopus 로고
    • Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region
    • Suzuki K, Juelich T, Lim H, Ishida T, Watanebe T, Cooper DA, et al. Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region. J Biol Chem. 2008;283:23353-63.
    • (2008) J Biol Chem. , vol.283 , pp. 23353-23363
    • Suzuki, K.1    Juelich, T.2    Lim, H.3    Ishida, T.4    Watanebe, T.5    Cooper, D.A.6
  • 86
    • 79959931148 scopus 로고    scopus 로고
    • siRNA off-target effects can be reduced at concentrations that match their individual potency.
    • Caffrey DR, Zhao J, Song Z, Schaffer ME, Haney SA, Subramanian RR, et al. siRNA off-target effects can be reduced at concentrations that match their individual potency. PLoS One. 2011;6:e21503.
    • (2011) PLoS One , vol.6
    • Caffrey, D.R.1    Zhao, J.2    Song, Z.3    Schaffer, M.E.4    Haney, S.A.5    Subramanian, R.R.6
  • 87
    • 84868672935 scopus 로고    scopus 로고
    • Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells
    • Green VA, Arbuthnot P, Weinberg MS. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Virol J. 2012;9:272.
    • (2012) Virol J. , vol.9 , pp. 272
    • Green, V.A.1    Arbuthnot, P.2    Weinberg, M.S.3
  • 88
    • 33845668311 scopus 로고    scopus 로고
    • RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapy
    • Li M, Li H, Rossi JJ. RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapy. Ann N Y Acad Sci. 2006;1082:172-9.
    • (2006) Ann N Y Acad Sci. , vol.1082 , pp. 172-179
    • Li, M.1    Li, H.2    Rossi, J.J.3
  • 89
    • 80051882660 scopus 로고    scopus 로고
    • Toward a durable treatment of HIV-1 infection using RNA interference
    • Eekels JJ, Berkhout B. Toward a durable treatment of HIV-1 infection using RNA interference. Prog Mol Biol Transl Sci. 2011;102:141-63.
    • (2011) Prog Mol Biol Transl Sci. , vol.102 , pp. 141-163
    • Eekels, J.J.1    Berkhout, B.2
  • 90
    • 84939261536 scopus 로고    scopus 로고
    • Los Alamos National Laboratory
    • Accessed 15 Apr
    • HIV Databases. Los Alamos National Laboratory. http://www.hiv.lanl.gov. Accessed 15 Apr 2015.
    • (2015)
  • 91
    • 34250821095 scopus 로고    scopus 로고
    • Suppression of HIV replication using RNA interference against HIV-1 integrase
    • Lau TS, Li Y, Kameoka M, Ng TB, Wan DC. Suppression of HIV replication using RNA interference against HIV-1 integrase. FEBS Lett. 2007;581:3253-9.
    • (2007) FEBS Lett. , vol.581 , pp. 3253-3259
    • Lau, T.S.1    Li, Y.2    Kameoka, M.3    Ng, T.B.4    Wan, D.C.5
  • 92
    • 13844320402 scopus 로고    scopus 로고
    • HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome
    • Westerhout EM, Ooms M, Vink M, Das AT, Berkhout B. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res. 2005;33:796-804.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 796-804
    • Westerhout, E.M.1    Ooms, M.2    Vink, M.3    Das, A.T.4    Berkhout, B.5
  • 95
    • 27744453385 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol
    • Morris KV, Chung CH, Witke W, Looney DJ. Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol. RNA Biol. 2005;2:17-20.
    • (2005) RNA Biol. , vol.2 , pp. 17-20
    • Morris, K.V.1    Chung, C.H.2    Witke, W.3    Looney, D.J.4
  • 96
    • 23044517213 scopus 로고    scopus 로고
    • Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV
    • Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, et al. Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood. 2005;106:818-26.
    • (2005) Blood. , vol.106 , pp. 818-826
    • Lee, S.K.1    Dykxhoorn, D.M.2    Kumar, P.3    Ranjbar, S.4    Song, E.5    Maliszewski, L.E.6
  • 98
    • 81255176941 scopus 로고    scopus 로고
    • Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific
    • Suzuki K, Ishida T, Yamagishi M, Ahlenstiel C, Swaminathan S, Marks K, et al. Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific. RNA Biol. 2011;8:1035-46.
    • (2011) RNA Biol. , vol.8 , pp. 1035-1046
    • Suzuki, K.1    Ishida, T.2    Yamagishi, M.3    Ahlenstiel, C.4    Swaminathan, S.5    Marks, K.6
  • 99
    • 84868347414 scopus 로고    scopus 로고
    • Chemically modified oligonucleotides modulate an epigenetically varied and transient form of transcription silencing of HIV-1 in human cells
    • Knowling S, Stapleton K, Turner AM, Uhlmann E, Lehmann T, Vollmer J, et al. Chemically modified oligonucleotides modulate an epigenetically varied and transient form of transcription silencing of HIV-1 in human cells. Mol Ther Nucleic Acids. 2012;1, e16.
    • (2012) Mol Ther Nucleic Acids. , vol.1
    • Knowling, S.1    Stapleton, K.2    Turner, A.M.3    Uhlmann, E.4    Lehmann, T.5    Vollmer, J.6    Morris, K.V.7
  • 100
    • 0027215750 scopus 로고
    • Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots
    • Bebenek K, Abbotts J, Wilson SH, Kunkel TA. Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J Biol Chem. 1993;268:10324-34.
    • (1993) J Biol Chem , vol.268 , pp. 10324-10334
    • Bebenek, K.1    Abbotts, J.2    Wilson, S.H.3    Kunkel, T.A.4
  • 101
    • 0023724652 scopus 로고
    • Low fidelity of cell-free DNA synthesis by reverse transcriptase of human immunodeficiency virus
    • Takeuchi Y, Nagumo T, Hoshino H. Low fidelity of cell-free DNA synthesis by reverse transcriptase of human immunodeficiency virus. J Virol. 1988;62:3900-2.
    • (1988) J Virol. , vol.62 , pp. 3900-3902
    • Takeuchi, Y.1    Nagumo, T.2    Hoshino, H.3
  • 102
    • 80052830258 scopus 로고    scopus 로고
    • Molecular strategies to design an escape-proof antiviral therapy
    • Berkhout B, Sanders RW. Molecular strategies to design an escape-proof antiviral therapy. Antiviral Res. 2011;92:7-14.
    • (2011) Antiviral Res. , vol.92 , pp. 7-14
    • Berkhout, B.1    Sanders, R.W.2
  • 103
    • 84455169971 scopus 로고    scopus 로고
    • Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs
    • Schopman NC, Braun A, Berkhout B. Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs. Antimicrob Agents Chemother. 2012;56:479-86.
    • (2012) Antimicrob Agents Chemother. , vol.56 , pp. 479-486
    • Schopman, N.C.1    Braun, A.2    Berkhout, B.3
  • 104
    • 0142124143 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escape from RNA interference
    • Boden D, Pusch O, Lee F, Tucker L, Ramratnam B. Human immunodeficiency virus type 1 escape from RNA interference. J Virol. 2003;77:11531-5.
    • (2003) J Virol. , vol.77 , pp. 11531-11535
    • Boden, D.1    Pusch, O.2    Lee, F.3    Tucker, L.4    Ramratnam, B.5
  • 106
    • 55249098418 scopus 로고    scopus 로고
    • HIV evades RNA interference directed at TAR by an indirect compensatory mechanism
    • Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host Microbe. 2008;4:484-94.
    • (2008) Cell Host Microbe. , vol.4 , pp. 484-494
    • Leonard, J.N.1    Shah, P.S.2    Burnett, J.C.3    Schaffer, D.V.4
  • 107
    • 84859440756 scopus 로고    scopus 로고
    • HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites
    • Shah PS, Pham NP, Schaffer DV. HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites. Mol Ther. 2012;20:840-8.
    • (2012) Mol Ther. , vol.20 , pp. 840-848
    • Shah, P.S.1    Pham, N.P.2    Schaffer, D.V.3
  • 108
    • 84862251469 scopus 로고    scopus 로고
    • Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct
    • Zhang T, Cheng T, Wei L, Cai Y, Yeo AE, Han J, et al. Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct. Virol J. 2012;9:118.
    • (2012) Virol J. , vol.9 , pp. 118
    • Zhang, T.1    Cheng, T.2    Wei, L.3    Cai, Y.4    Yeo, A.E.5    Han, J.6
  • 109
    • 77953124494 scopus 로고    scopus 로고
    • Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs
    • Schopman NC, ter Brake O, Berkhout B. Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs. Retrovirology. 2010;7:52.
    • (2010) Retrovirology. , vol.7 , pp. 52
    • Schopman, N.C.1    Brake, O.2    Berkhout, B.3
  • 110
    • 40149092147 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference
    • von Eije KJ, ter Brake O, Berkhout B. Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference. J Virol. 2008;82:2895-903.
    • (2008) J Virol. , vol.82 , pp. 2895-2903
    • Eije, K.J.1    Brake, O.2    Berkhout, B.3
  • 112
    • 79959760389 scopus 로고    scopus 로고
    • Systematic approaches towards the development of host-directed antiviral therapeutics
    • Prussia A, Thepchatri P, Snyder JP, Plemper RK. Systematic approaches towards the development of host-directed antiviral therapeutics. Int J Mol Sci. 2011;12:4027-52.
    • (2011) Int J Mol Sci. , vol.12 , pp. 4027-4052
    • Prussia, A.1    Thepchatri, P.2    Snyder, J.P.3    Plemper, R.K.4
  • 113
  • 114
    • 79958125260 scopus 로고    scopus 로고
    • Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cells
    • Hutter G, Ganepola S. Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cells. Scientific World Journal. 2011;11:1068-76.
    • (2011) Scientific World Journal. , vol.11 , pp. 1068-1076
    • Hutter, G.1    Ganepola, S.2
  • 118
    • 51649123734 scopus 로고    scopus 로고
    • Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance
    • Tamhane M, Akkina R. Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance. AIDS Res Ther. 2008;5:16.
    • (2008) AIDS Res Ther. , vol.5 , pp. 16
    • Tamhane, M.1    Akkina, R.2
  • 119
    • 34447105555 scopus 로고    scopus 로고
    • Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization
    • Vazquez-Salat N, Yuhki N, Beck T, O'Brien SJ, Murphy WJ. Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization. Genomics. 2007;90:213-24.
    • (2007) Genomics. , vol.90 , pp. 213-224
    • Vazquez-Salat, N.1    Yuhki, N.2    Beck, T.3    O'Brien, S.J.4    Murphy, W.J.5
  • 120
    • 1642564331 scopus 로고    scopus 로고
    • Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance
    • Anderson J, Banerjea A, Akkina R. Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides. 2003;13:303-12.
    • (2003) Oligonucleotides. , vol.13 , pp. 303-312
    • Anderson, J.1    Banerjea, A.2    Akkina, R.3
  • 122
    • 27744605569 scopus 로고    scopus 로고
    • Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy
    • Li MJ, Kim J, Li S, Zaia J, Yee JK, Anderson J, et al. Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Mol Ther. 2005;12:900-9.
    • (2005) Mol Ther. , vol.12 , pp. 900-909
    • Li, M.J.1    Kim, J.2    Li, S.3    Zaia, J.4    Yee, J.K.5    Anderson, J.6
  • 123
    • 49849102544 scopus 로고    scopus 로고
    • Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis
    • Ishaq M, Hu J, Wu X, Fu Q, Yang Y, Liu Q, et al. Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Mol Biotechnol. 2008;39:231-8.
    • (2008) Mol Biotechnol. , vol.39 , pp. 231-238
    • Ishaq, M.1    Hu, J.2    Wu, X.3    Fu, Q.4    Yang, Y.5    Liu, Q.6    Guo, D.7
  • 124
    • 78049483587 scopus 로고    scopus 로고
    • Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA
    • Subramanya S, Armant M, Salkowitz JR, Nyakeriga AM, Haridas V, Hasan M, et al. Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA. Mol Ther. 2010;18:2028-37.
    • (2010) Mol Ther. , vol.18 , pp. 2028-2037
    • Subramanya, S.1    Armant, M.2    Salkowitz, J.R.3    Nyakeriga, A.M.4    Haridas, V.5    Hasan, M.6
  • 125
    • 34248353881 scopus 로고    scopus 로고
    • Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production
    • Christensen HS, Daher A, Soye KJ, Frankel LB, Alexander MR, Laine S, et al. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. J Virol. 2007;81:5121-31.
    • (2007) J Virol. , vol.81 , pp. 5121-5131
    • Christensen, H.S.1    Daher, A.2    Soye, K.J.3    Frankel, L.B.4    Alexander, M.R.5    Laine, S.6
  • 126
    • 81255164734 scopus 로고    scopus 로고
    • The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR
    • Sanghvi VR, Steel LF. The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR. J Virol. 2011;85:12614-21.
    • (2011) J Virol. , vol.85 , pp. 12614-12621
    • Sanghvi, V.R.1    Steel, L.F.2
  • 128
    • 79961102375 scopus 로고    scopus 로고
    • The effects of stem length and core placement on shRNA activity
    • McIntyre GJ, Yu YH, Lomas M, Fanning GC. The effects of stem length and core placement on shRNA activity. BMC Mol Biol. 2011;12:34.
    • (2011) BMC Mol Biol. , vol.12 , pp. 34
    • McIntyre, G.J.1    Yu, Y.H.2    Lomas, M.3    Fanning, G.C.4
  • 130
    • 79954650563 scopus 로고    scopus 로고
    • State-of-the-art gene-based therapies: the road ahead
    • Kay MA. State-of-the-art gene-based therapies: the road ahead. Nat Rev Genet. 2011;12:316-28.
    • (2011) Nat Rev Genet. , vol.12 , pp. 316-328
    • Kay, M.A.1
  • 131
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNA/shRNA therapeutics in clinical trials
    • Burnett JC, Rossi JJ, Tiemann K. Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J. 2011;6:1130-46.
    • (2011) Biotechnol J. , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 132
    • 77956355233 scopus 로고    scopus 로고
    • Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver
    • Grimm D, Wang L, Lee JS, Schurmann N, Gu S, Borner K, et al. Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. JClin Invest. 2010;120:3106-19.
    • (2010) JClin Invest. , vol.120 , pp. 3106-3119
    • Grimm, D.1    Wang, L.2    Lee, J.S.3    Schurmann, N.4    Gu, S.5    Borner, K.6
  • 133
    • 77952001110 scopus 로고    scopus 로고
    • Lentiviral vector gene therapy: effective and safe?
    • Persons DA. Lentiviral vector gene therapy: effective and safe? Mol Ther. 2010;18:861-2.
    • (2010) Mol Ther. , vol.18 , pp. 861-862
    • Persons, D.A.1
  • 134
    • 33646921719 scopus 로고    scopus 로고
    • Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection
    • Morris KV, Rossi JJ. Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection. Hum Gene Ther. 2006;17:479-86.
    • (2006) Hum Gene Ther. , vol.17 , pp. 479-486
    • Morris, K.V.1    Rossi, J.J.2
  • 135
    • 77953642976 scopus 로고    scopus 로고
    • Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies
    • Liu YP, Vink MA, Westerink JT, Ramirez de Arellano E, Konstantinova P, Ter Brake O, et al. Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies. RNA. 2010;16:1328-39.
    • (2010) RNA , vol.16 , pp. 1328-1339
    • Liu, Y.P.1    Vink, M.A.2    Westerink, J.T.3    Ramirez de Arellano, E.4    Konstantinova, P.5    Brake, O.6    Berkhout, B.7
  • 136
    • 84867743427 scopus 로고    scopus 로고
    • Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapy
    • Chung J, Zhang J, Li H, Ouellet DL, DiGiusto DL, Rossi JJ. Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapy. Hum Gene Ther. 2012;23:1200-8.
    • (2012) Hum Gene Ther. , vol.23 , pp. 1200-1208
    • Chung, J.1    Zhang, J.2    Li, H.3    Ouellet, D.L.4    DiGiusto, D.L.5    Rossi, J.J.6
  • 137
    • 76149120462 scopus 로고    scopus 로고
    • RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?
    • Subramanya S, Kim SS, Manjunath N, Shankar P. RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA? Expert Opin Biol Ther. 2010;10:201-13.
    • (2010) Expert Opin Biol Ther. , vol.10 , pp. 201-213
    • Subramanya, S.1    Kim, S.S.2    Manjunath, N.3    Shankar, P.4
  • 138
    • 84873918201 scopus 로고    scopus 로고
    • Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS
    • Chung J, DiGiusto DL, Rossi JJ. Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS. Expert Opin Biol Ther. 2013;13:437-45.
    • (2013) Expert Opin Biol Ther. , vol.13 , pp. 437-445
    • Chung, J.1    DiGiusto, D.L.2    Rossi, J.J.3
  • 139
    • 84938412743 scopus 로고    scopus 로고
    • Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor.
    • Wolstein O, Boyd M, Millington M, Impey H, Boyer J, Howe A, et al. Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor. Mol Ther. 2014;1. doi:10.1038/mtm.2013.11.
    • (2014) Mol Ther , vol.1
    • Wolstein, O.1    Boyd, M.2    Millington, M.3    Impey, H.4    Boyer, J.5    Howe, A.6
  • 140
    • 82955237641 scopus 로고    scopus 로고
    • Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice
    • Zhou J, NeffCP, Liu X, Zhang J, Li H, Smith DD, et al. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther. 2011;19:2228-38.
    • (2011) Mol Ther. , vol.19 , pp. 2228-2238
    • Zhou, J.1    Neff, C.P.2    Liu, X.3    Zhang, J.4    Li, H.5    Smith, D.D.6
  • 141
  • 142
    • 84868365382 scopus 로고    scopus 로고
    • Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation
    • Broderick KE, Chan A, Lin F, Shen X, Kichaev G, Khan AS, et al. Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation. Mol Ther Nucleic Acids. 2012;1, e11.
    • (2012) Mol Ther Nucleic Acids. , vol.1
    • Broderick, K.E.1    Chan, A.2    Lin, F.3    Shen, X.4    Kichaev, G.5    Khan, A.S.6
  • 143
    • 36849044732 scopus 로고    scopus 로고
    • Nonviral delivery of synthetic siRNAs in vivo
    • Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest. 2007;117:3623-32.
    • (2007) J Clin Invest. , vol.117 , pp. 3623-3632
    • Akhtar, S.1    Benter, I.F.2
  • 144
    • 84874232605 scopus 로고    scopus 로고
    • DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge
    • Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, et al. DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge. Proc Natl Acad Sci U S A. 2013;110:2975-80.
    • (2013) Proc Natl Acad Sci U S A. , vol.110 , pp. 2975-2980
    • Patel, V.1    Jalah, R.2    Kulkarni, V.3    Valentin, A.4    Rosati, M.5    Alicea, C.6
  • 145
    • 84875514065 scopus 로고    scopus 로고
    • HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice
    • Kulkarni V, Rosati M, Valentin A, Ganneru B, Singh AK, Yan J, et al. HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice. PLoS One. 2013;8, e60245.
    • (2013) PLoS One. , vol.8
    • Kulkarni, V.1    Rosati, M.2    Valentin, A.3    Ganneru, B.4    Singh, A.K.5    Yan, J.6
  • 146
    • 10644225886 scopus 로고    scopus 로고
    • Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection
    • Kashiwakura Y, Tamayose K, Iwabuchi K, Hirai Y, Shimada T, Matsumoto K, et al. Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection. J Virol. 2005;79:609-14.
    • (2005) J Virol. , vol.79 , pp. 609-614
    • Kashiwakura, Y.1    Tamayose, K.2    Iwabuchi, K.3    Hirai, Y.4    Shimada, T.5    Matsumoto, K.6
  • 147
    • 84903587200 scopus 로고    scopus 로고
    • Engineering adeno-associated viruses for clinical gene therapy
    • Kotterman MA, Schaffer DV. Engineering adeno-associated viruses for clinical gene therapy. Nat Rev Genet. 2014;15:445-51.
    • (2014) Nat Rev Genet. , vol.15 , pp. 445-451
    • Kotterman, M.A.1    Schaffer, D.V.2
  • 148
    • 76349095131 scopus 로고    scopus 로고
    • RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
    • Kim SS, Peer D, Kumar P, Subramanya S, Wu H, Asthana D, et al. RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther. 2010;18:370-6.
    • (2010) Mol Ther. , vol.18 , pp. 370-376
    • Kim, S.S.1    Peer, D.2    Kumar, P.3    Subramanya, S.4    Wu, H.5    Asthana, D.6
  • 149
    • 79952154606 scopus 로고    scopus 로고
    • Localized, targeted, and sustained siRNA delivery
    • Krebs MD, Alsberg E. Localized, targeted, and sustained siRNA delivery. Chemistry. 2011;17:3054-62.
    • (2011) Chemistry. , vol.17 , pp. 3054-3062
    • Krebs, M.D.1    Alsberg, E.2
  • 150
    • 84879691173 scopus 로고    scopus 로고
    • Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras
    • Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, et al. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013;21:1378-89.
    • (2013) Mol Ther. , vol.21 , pp. 1378-1389
    • Wheeler, L.A.1    Vrbanac, V.2    Trifonova, R.3    Brehm, M.A.4    Gilboa-Geffen, A.5    Tanno, S.6
  • 151
    • 84871919249 scopus 로고    scopus 로고
    • Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge
    • Zhou J, NeffCP, Swiderski P, Li H, Smith DD, Aboellail T, et al. Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther. 2013;21:192-200.
    • (2013) Mol Ther. , vol.21 , pp. 192-200
    • Zhou, J.1    Neff, C.P.2    Swiderski, P.3    Li, H.4    Smith, D.D.5    Aboellail, T.6
  • 152
    • 78751667739 scopus 로고    scopus 로고
    • An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.
    • NeffCP, Zhou J, Remling L, Kuruvilla J, Zhang J, Li H, et al. An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice. Sci Transl Med. 2011;3:66ra66.
    • (2011) Sci Transl Med. , vol.3 , pp. 66-66
    • Neff, C.P.1    Zhou, J.2    Remling, L.3    Kuruvilla, J.4    Zhang, J.5    Li, H.6
  • 153
    • 84862785747 scopus 로고    scopus 로고
    • Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles
    • Pan Y, Zhang Y, Jia T, Zhang K, Li J, Wang L. Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles. FEBS J. 2012;279:1198-208.
    • (2012) FEBS J. , vol.279 , pp. 1198-1208
    • Pan, Y.1    Zhang, Y.2    Jia, T.3    Zhang, K.4    Li, J.5    Wang, L.6
  • 154
    • 79958716788 scopus 로고    scopus 로고
    • Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition
    • Zhou J, Shu Y, Guo P, Smith DD, Rossi JJ. Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition. Methods. 2011;54:284-94.
    • (2011) Methods. , vol.54 , pp. 284-294
    • Zhou, J.1    Shu, Y.2    Guo, P.3    Smith, D.D.4    Rossi, J.J.5
  • 155
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005;23:709-17.
    • (2005) Nat Biotechnol. , vol.23 , pp. 709-717
    • Song, E.1    Zhu, P.2    Lee, S.K.3    Chowdhury, D.4    Kussman, S.5    Dykxhoorn, D.M.6
  • 156
    • 49549117077 scopus 로고    scopus 로고
    • T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    • Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, et al. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008;134:577-86.
    • (2008) Cell. , vol.134 , pp. 577-586
    • Kumar, P.1    Ban, H.S.2    Kim, S.S.3    Wu, H.4    Pearson, T.5    Greiner, D.L.6
  • 157
    • 84873700433 scopus 로고    scopus 로고
    • Advancements in the field of intravaginal siRNA delivery
    • Yang S, Chen Y, Ahmadie R, Ho EA. Advancements in the field of intravaginal siRNA delivery. J Control Release. 2013;167:29-39.
    • (2013) J Control Release. , vol.167 , pp. 29-39
    • Yang, S.1    Chen, Y.2    Ahmadie, R.3    Ho, E.A.4
  • 158
    • 77950826873 scopus 로고    scopus 로고
    • siRNA-based topical microbicides targeting sexually transmitted infections.
    • Katakowski JA, Palliser D. siRNA-based topical microbicides targeting sexually transmitted infections. Curr Opin Mol Ther. 2010;12:192-202.
    • (2010) Curr Opin Mol Ther. , vol.12 , pp. 192-202
    • Katakowski, J.A.1    Palliser, D.2
  • 160
    • 77956481715 scopus 로고    scopus 로고
    • Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV
    • Vaccari M, Poonam P, Franchini G. Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV. Expert Rev Vaccines. 2010;9:997-1005.
    • (2010) Expert Rev Vaccines. , vol.9 , pp. 997-1005
    • Vaccari, M.1    Poonam, P.2    Franchini, G.3
  • 161
    • 84861173075 scopus 로고    scopus 로고
    • The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope
    • de Souza MS, Ratto-Kim S, Chuenarom W, Schuetz A, Chantakulkij S, Nuntapinit B, et al. The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope. J Immunol. 2012;188:5166-76.
    • (2012) J Immunol. , vol.188 , pp. 5166-5176
    • Souza, M.S.1    Ratto-Kim, S.2    Chuenarom, W.3    Schuetz, A.4    Chantakulkij, S.5    Nuntapinit, B.6
  • 163
    • 34247208235 scopus 로고    scopus 로고
    • Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus
    • van Lunzen J, Glaunsinger T, Stahmer I, von Baehr V, Baum C, Schilz A, et al. Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther. 2007;15:1024-33.
    • (2007) Mol Ther. , vol.15 , pp. 1024-1033
    • Lunzen, J.1    Glaunsinger, T.2    Stahmer, I.3    Baehr, V.4    Baum, C.5    Schilz, A.6
  • 164
    • 0034739591 scopus 로고    scopus 로고
    • Ribozyme therapy for HIV infection
    • Rossi JJ. Ribozyme therapy for HIV infection. Adv Drug Deliv Rev. 2000;44:71-8.
    • (2000) Adv Drug Deliv Rev. , vol.44 , pp. 71-78
    • Rossi, J.J.1
  • 166
    • 0031001927 scopus 로고    scopus 로고
    • Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4+ monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA
    • Liu D, Donegan J, Nuovo G, Mitra D, Laurence J. Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4+ monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA. J Virol. 1997;71:4079-85.
    • (1997) J Virol. , vol.71 , pp. 4079-4085
    • Liu, D.1    Donegan, J.2    Nuovo, G.3    Mitra, D.4    Laurence, J.5
  • 167
    • 0033168686 scopus 로고    scopus 로고
    • A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children
    • Kohn DB, Bauer G, Rice CR, Rothschild JC, Carbonaro DA, Valdez P, et al. A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood. 1999;94:368-71.
    • (1999) Blood. , vol.94 , pp. 368-371
    • Kohn, D.B.1    Bauer, G.2    Rice, C.R.3    Rothschild, J.C.4    Carbonaro, D.A.5    Valdez, P.6
  • 169
    • 0242440877 scopus 로고    scopus 로고
    • Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells
    • Park WS, Hayafune M, Miyano-Kurosaki N, Takaku H. Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells. Gene Ther. 2003;10:2046-50.
    • (2003) Gene Ther. , vol.10 , pp. 2046-2050
    • Park, W.S.1    Hayafune, M.2    Miyano-Kurosaki, N.3    Takaku, H.4
  • 170
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn NM, Forthal DN, Harro CD, Judson FN, Mayer KH, Para MF. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis. 2005;191:654-65.
    • (2005) J Infect Dis. , vol.191 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3    Judson, F.N.4    Mayer, K.H.5    Para, M.F.6
  • 172
    • 33751001588 scopus 로고    scopus 로고
    • Silencing of HIV-1 with RNA interference: a multiple shRNA approach
    • ter Brake O, Konstantinova P, Ceylan M, Berkhout B. Silencing of HIV-1 with RNA interference: a multiple shRNA approach. Mol Ther. 2006;14:883-92.
    • (2006) Mol Ther. , vol.14 , pp. 883-892
    • Brake, O.1    Konstantinova, P.2    Ceylan, M.3    Berkhout, B.4
  • 173
    • 33751193683 scopus 로고    scopus 로고
    • Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages
    • Yamamoto T, Miyoshi H, Yamamoto N, Yamamoto N, Inoue J, Tsunetsugu-Yokota Y. Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages. Blood. 2006;108:3305-12.
    • (2006) Blood. , vol.108 , pp. 3305-3312
    • Yamamoto, T.1    Miyoshi, H.2    Yamamoto, N.3    Yamamoto, N.4    Inoue, J.5    Tsunetsugu-Yokota, Y.6
  • 174
    • 58149458865 scopus 로고    scopus 로고
    • Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model
    • ter Brake O, Legrand N, von Eije KJ, Centlivre M, Spits H, Weijer K, et al. Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model. Gene Ther. 2009;16:148-53.
    • (2009) Gene Ther. , vol.16 , pp. 148-153
    • Brake, O.1    Legrand, N.2    Eije, K.J.3    Centlivre, M.4    Spits, H.5    Weijer, K.6
  • 175
    • 33746210111 scopus 로고    scopus 로고
    • Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration
    • Nishitsuji H, Kohara M, Kannagi M, Masuda T. Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol. 2006;80:7658-66.
    • (2006) J Virol. , vol.80 , pp. 7658-7666
    • Nishitsuji, H.1    Kohara, M.2    Kannagi, M.3    Masuda, T.4
  • 176
    • 0037173610 scopus 로고    scopus 로고
    • Modulation of HIV-1 replication by RNA interference
    • Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature. 2002;418:435-8.
    • (2002) Nature. , vol.418 , pp. 435-438
    • Jacque, J.M.1    Triques, K.2    Stevenson, M.3
  • 177
    • 0037032933 scopus 로고    scopus 로고
    • Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication
    • Martinez MA, Gutierrez A, Armand-Ugon M, Blanco J, Parera M, Gomez J, et al. Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. AIDS. 2002;16:2385-90.
    • (2002) AIDS. , vol.16 , pp. 2385-2390
    • Martinez, M.A.1    Gutierrez, A.2    Armand-Ugon, M.3    Blanco, J.4    Parera, M.5    Gomez, J.6
  • 178
    • 84876783559 scopus 로고    scopus 로고
    • Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes
    • Xu WW, Han MJ, Chen D, Chen L, Guo Y, Willden A, et al. Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes. BMC Med Genomics. 2013;6:15.
    • (2013) BMC Med Genomics. , vol.6 , pp. 15
    • Xu, W.W.1    Han, M.J.2    Chen, D.3    Chen, L.4    Guo, Y.5    Willden, A.6
  • 179
    • 84870670336 scopus 로고    scopus 로고
    • The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
    • Christ F, Debyser Z. The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy. Virology. 2013;435:102-9.
    • (2013) Virology. , vol.435 , pp. 102-109
    • Christ, F.1    Debyser, Z.2
  • 181
    • 34748852513 scopus 로고    scopus 로고
    • Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy
    • Al-Mawsawi LQ, Neamati N. Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy. Trends Pharmacol Sci. 2007;28:526-35.
    • (2007) Trends Pharmacol Sci. , vol.28 , pp. 526-535
    • Al-Mawsawi, L.Q.1    Neamati, N.2
  • 182
    • 1242342082 scopus 로고    scopus 로고
    • Inhibition of Human Immunodeficiency Virus Type 1 replication by RNA interference directed against Human Transcription Elongation Factor P-TEFb (CDK9/CyclinT1)
    • Chiu YL, Cao H, Jacque JM, Stevenson M, Rana TM. Inhibition of Human Immunodeficiency Virus Type 1 replication by RNA interference directed against Human Transcription Elongation Factor P-TEFb (CDK9/CyclinT1). J Virol. 2004;78:2517-29.
    • (2004) J Virol. , vol.78 , pp. 2517-2529
    • Chiu, Y.L.1    Cao, H.2    Jacque, J.M.3    Stevenson, M.4    Rana, T.M.5
  • 183
    • 18144372773 scopus 로고    scopus 로고
    • Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5
    • Ping YH, Chu CY, Cao H, Jacque JM, Stevenson M, Rana TM. Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology. 2004;1:46.
    • (2004) Retrovirology. , vol.1 , pp. 46
    • Ping, Y.H.1    Chu, C.Y.2    Cao, H.3    Jacque, J.M.4    Stevenson, M.5    Rana, T.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.