-
1
-
-
0001707601
-
3'-Azido-3"-deoxythymidine (BW A509U). an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro
-
Mitsuya H, Weinhold KJ, Furman PA, St Clair MH, Lehrman SN, Gallo RC, et al. 3'-Azido-3"-deoxythymidine (BW A509U). an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A. 1985;82:7096-100.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 7096-7100
-
-
Mitsuya, H.1
Weinhold, K.J.2
Furman, P.A.3
St Clair, M.H.4
Lehrman, S.N.5
Gallo, R.C.6
-
3
-
-
79551614790
-
HIV infection, inflammation, immunosenescence, and aging
-
Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62:141-55.
-
(2011)
Annu Rev Med.
, vol.62
, pp. 141-155
-
-
Deeks, S.G.1
-
4
-
-
80055078962
-
Deep molecular characterization of HIV-1 dynamics under suppressive HAART
-
Buzon MJ, Codoner FM, Frost SD, Pou C, Puertas MC, Massanella M, et al. Deep molecular characterization of HIV-1 dynamics under suppressive HAART. PLoS Pathog. 2011;7, e1002314.
-
(2011)
PLoS Pathog.
, vol.7
-
-
Buzon, M.J.1
Codoner, F.M.2
Frost, S.D.3
Pou, C.4
Puertas, M.C.5
Massanella, M.6
-
5
-
-
0030712305
-
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
-
Wong JK, Hezareh M, Gunthard HF, Havlir DV, Ignacio CC, Spina CA, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 1997;278:1291-5.
-
(1997)
Science.
, vol.278
, pp. 1291-1295
-
-
Wong, J.K.1
Hezareh, M.2
Gunthard, H.F.3
Havlir, D.V.4
Ignacio, C.C.5
Spina, C.A.6
Richman, D.D.7
-
6
-
-
14444273439
-
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
-
Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science. 1997;278:1295-300.
-
(1997)
Science.
, vol.278
, pp. 1295-1300
-
-
Finzi, D.1
Hermankova, M.2
Pierson, T.3
Carruth, L.M.4
Buck, C.5
Chaisson, R.E.6
-
7
-
-
78549245806
-
Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
-
Yukl SA, Shergill AK, McQuaid K, Gianella S, Lampiris H, Hare CB, et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS. 2010;24:2451-60.
-
(2010)
AIDS.
, vol.24
, pp. 2451-2460
-
-
Yukl, S.A.1
Shergill, A.K.2
McQuaid, K.3
Gianella, S.4
Lampiris, H.5
Hare, C.B.6
-
8
-
-
84901804676
-
Global Report: UNAIDS report on the global AIDS epidemic
-
UNAIDS. Global Report: UNAIDS report on the global AIDS epidemic 2013. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf. Accessed 15 Apr 2015.
-
(2013)
-
-
-
9
-
-
79952699891
-
Coreceptors and HIV-1 pathogenesis
-
Gorry PR, Ancuta P. Coreceptors and HIV-1 pathogenesis. Curr HIV/AIDS Rep. 2011;8:45-53.
-
(2011)
Curr HIV/AIDS Rep.
, vol.8
, pp. 45-53
-
-
Gorry, P.R.1
Ancuta, P.2
-
10
-
-
0027494083
-
Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity
-
Purcell DF, Martin MA. Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. J Virol. 1993;67:6365-78.
-
(1993)
J Virol.
, vol.67
, pp. 6365-6378
-
-
Purcell, D.F.1
Martin, M.A.2
-
11
-
-
80053962808
-
Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane
-
Hogue IB, Grover JR, Soheilian F, Nagashima K, Ono A. Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane. J Virol. 2011;85:9749-66.
-
(2011)
J Virol.
, vol.85
, pp. 9749-9766
-
-
Hogue, I.B.1
Grover, J.R.2
Soheilian, F.3
Nagashima, K.4
Ono, A.5
-
12
-
-
0035923525
-
Plasma membrane rafts play a critical role in HIV-1 assembly and release
-
Ono A, Freed EO. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc Natl Acad Sci U S A. 2001;98:13925-30.
-
(2001)
Proc Natl Acad Sci U S A.
, vol.98
, pp. 13925-13930
-
-
Ono, A.1
Freed, E.O.2
-
14
-
-
84875420616
-
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
-
Maier DA, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, et al. Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Hum Gene Ther. 2013;24:245-58.
-
(2013)
Hum Gene Ther.
, vol.24
, pp. 245-258
-
-
Maier, D.A.1
Brennan, A.L.2
Jiang, S.3
Binder-Scholl, G.K.4
Lee, G.5
Plesa, G.6
-
15
-
-
84862777608
-
Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment
-
Yuan J, Wang J, Crain K, Fearns C, Kim KA, Hua KL, et al. Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment. Mol Ther. 2012;20:849-59.
-
(2012)
Mol Ther.
, vol.20
, pp. 849-859
-
-
Yuan, J.1
Wang, J.2
Crain, K.3
Fearns, C.4
Kim, K.A.5
Hua, K.L.6
-
16
-
-
84891772031
-
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
-
Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, et al. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood. 2014;123:61-9.
-
(2014)
Blood.
, vol.123
, pp. 61-69
-
-
Didigu, C.A.1
Wilen, C.B.2
Wang, J.3
Duong, J.4
Secreto, A.J.5
Danet-Desnoyers, G.A.6
-
17
-
-
79955785236
-
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases
-
Wilen CB, Wang J, Tilton JC, Miller JC, Kim KA, Rebar EJ, et al. Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases. PLoS Pathog. 2011;7, e1002020.
-
(2011)
PLoS Pathog.
, vol.7
-
-
Wilen, C.B.1
Wang, J.2
Tilton, J.C.3
Miller, J.C.4
Kim, K.A.5
Rebar, E.J.6
-
18
-
-
78650735673
-
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
-
Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28:839-47.
-
(2010)
Nat Biotechnol.
, vol.28
, pp. 839-847
-
-
Holt, N.1
Wang, J.2
Kim, K.3
Friedman, G.4
Wang, X.5
Taupin, V.6
-
19
-
-
84878528467
-
Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
-
Li L, Krymskaya L, Wang J, Henley J, Rao A, Cao LF, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013;21:1259-69.
-
(2013)
Mol Ther.
, vol.21
, pp. 1259-1269
-
-
Li, L.1
Krymskaya, L.2
Wang, J.3
Henley, J.4
Rao, A.5
Cao, L.F.6
-
20
-
-
84895487305
-
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
-
Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014;370:901-10.
-
(2014)
N Engl J Med.
, vol.370
, pp. 901-910
-
-
Tebas, P.1
Stein, D.2
Tang, W.W.3
Frank, I.4
Wang, S.Q.5
Lee, G.6
-
21
-
-
46949095221
-
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
-
Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol. 2008;26:808-16.
-
(2008)
Nat Biotechnol.
, vol.26
, pp. 808-816
-
-
Perez, E.E.1
Wang, J.2
Miller, J.C.3
Jouvenot, Y.4
Kim, K.A.5
Liu, O.6
-
22
-
-
84903729497
-
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Delta32 mutation confers resistance to HIV infection
-
Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, et al. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Delta32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014;111:9591-6.
-
(2014)
Proc Natl Acad Sci U S A.
, vol.111
, pp. 9591-9596
-
-
Ye, L.1
Wang, J.2
Beyer, A.I.3
Teque, F.4
Cradick, T.J.5
Qi, Z.6
-
23
-
-
84867061435
-
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption
-
Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, et al. Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nat Methods. 2012;9:973-5.
-
(2012)
Nat Methods.
, vol.9
, pp. 973-975
-
-
Certo, M.T.1
Gwiazda, K.S.2
Kuhar, R.3
Sather, B.4
Curinga, G.5
Mandt, T.6
-
24
-
-
80053145141
-
Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids
-
Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, et al. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chem Biol. 2011;18:1189-98.
-
(2011)
Chem Biol.
, vol.18
, pp. 1189-1198
-
-
Schleifman, E.B.1
Bindra, R.2
Leif, J.3
Campo, J.4
Rogers, F.A.5
Uchil, P.6
-
25
-
-
84884950106
-
CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity
-
Cradick TJ, Fine EJ, Antico CJ, Bao G. CRISPR/Cas9 systems targeting beta-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res. 2013;41:9584-92.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 9584-9592
-
-
Cradick, T.J.1
Fine, E.J.2
Antico, C.J.3
Bao, G.4
-
26
-
-
84874624936
-
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
-
Cho SW, Kim S, Kim JM, Kim JS. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol. 2013;31:230-2.
-
(2013)
Nat Biotechnol.
, vol.31
, pp. 230-232
-
-
Cho, S.W.1
Kim, S.2
Kim, J.M.3
Kim, J.S.4
-
27
-
-
84905643812
-
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
-
Hu W, Kaminski R, Yang F, Zhang Y, Cosentino L, Li F, et al. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A. 2014;111:11461-6.
-
(2014)
Proc Natl Acad Sci U S A.
, vol.111
, pp. 11461-11466
-
-
Hu, W.1
Kaminski, R.2
Yang, F.3
Zhang, Y.4
Cosentino, L.5
Li, F.6
-
28
-
-
84883305437
-
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus
-
Ebina H, Misawa N, Kanemura Y, Koyanagi Y. Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep. 2013;3:2510.
-
(2013)
Sci Rep.
, vol.3
, pp. 2510
-
-
Ebina, H.1
Misawa, N.2
Kanemura, Y.3
Koyanagi, Y.4
-
29
-
-
79951783813
-
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI
-
Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR. Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. PLoS One. 2011;6, e16825.
-
(2011)
PLoS One.
, vol.6
-
-
Aubert, M.1
Ryu, B.Y.2
Banks, L.3
Rawlings, D.J.4
Scharenberg, A.M.5
Jerome, K.R.6
-
30
-
-
84856895124
-
Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase
-
Mariyanna L, Priyadarshini P, Hofmann-Sieber H, Krepstakies M, Walz N, GrundhoffA, et al. Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase. PLoS One. 2012;7, e31576.
-
(2012)
PLoS One.
, vol.7
-
-
Mariyanna, L.1
Priyadarshini, P.2
Hofmann-Sieber, H.3
Krepstakies, M.4
Walz, N.5
Grundhoff, A.6
-
31
-
-
34347398120
-
HIV-1 proviral DNA excision using an evolved recombinase
-
Sarkar I, Hauber I, Hauber J, Buchholz F. HIV-1 proviral DNA excision using an evolved recombinase. Science. 2007;316:1912-5.
-
(2007)
Science.
, vol.316
, pp. 1912-1915
-
-
Sarkar, I.1
Hauber, I.2
Hauber, J.3
Buchholz, F.4
-
32
-
-
78651503825
-
In vitro evolution and analysis of HIV-1 LTR-specific recombinases
-
Buchholz F, Hauber J. In vitro evolution and analysis of HIV-1 LTR-specific recombinases. Methods. 2011;53:102-9.
-
(2011)
Methods.
, vol.53
, pp. 102-109
-
-
Buchholz, F.1
Hauber, J.2
-
33
-
-
85019237824
-
Long-term transgene expression and inhibition of HIV-1 replication by a Cre/loxP-EBNA-1/oriP HIV-1-dependent ribozyme vector: applications for HIV-1 gene therapy
-
Nagawa T, Habu Y, Matsumoto N, Miyano-Kurosaki N, Takaku H. Long-term transgene expression and inhibition of HIV-1 replication by a Cre/loxP-EBNA-1/oriP HIV-1-dependent ribozyme vector: applications for HIV-1 gene therapy. J RNAi Gene Silencing. 2006;2:146-53.
-
(2006)
J RNAi Gene Silencing.
, vol.2
, pp. 146-153
-
-
Nagawa, T.1
Habu, Y.2
Matsumoto, N.3
Miyano-Kurosaki, N.4
Takaku, H.5
-
34
-
-
0029655644
-
RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo
-
Symensma TL, Giver L, Zapp M, Takle GB, Ellington AD. RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo. J Virol. 1996;70:179-87.
-
(1996)
J Virol.
, vol.70
, pp. 179-187
-
-
Symensma, T.L.1
Giver, L.2
Zapp, M.3
Takle, G.B.4
Ellington, A.D.5
-
35
-
-
0034687063
-
Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication
-
Konopka K, Lee NS, Rossi J, Duzgunes N. Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication. Gene. 2000;255:235-44.
-
(2000)
Gene.
, vol.255
, pp. 235-244
-
-
Konopka, K.1
Lee, N.S.2
Rossi, J.3
Duzgunes, N.4
-
37
-
-
77949418266
-
A dual function TAR decoy serves as an anti-HIV siRNA delivery vehicle
-
Unwalla HJ, Rossi JJ. A dual function TAR decoy serves as an anti-HIV siRNA delivery vehicle. Virol J. 2010;7:33.
-
(2010)
Virol J.
, vol.7
, pp. 33
-
-
Unwalla, H.J.1
Rossi, J.J.2
-
38
-
-
77955608799
-
RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma.
-
DiGiusto DL, Krishnan A, Li L, Li H, Li S, Rao A, et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med. 2010;2:36ra43.
-
(2010)
Sci Transl Med.
, vol.2
, pp. 36-43
-
-
DiGiusto, D.L.1
Krishnan, A.2
Li, L.3
Li, H.4
Li, S.5
Rao, A.6
-
39
-
-
84888150047
-
Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice
-
DiGiusto DL, Stan R, Krishnan A, Li H, Rossi JJ, Zaia JA. Development of hematopoietic stem cell based gene therapy for HIV-1 infection: considerations for proof of concept studies and translation to standard medical practice. Viruses. 2013;5:2898-919.
-
(2013)
Viruses.
, vol.5
, pp. 2898-2919
-
-
DiGiusto, D.L.1
Stan, R.2
Krishnan, A.3
Li, H.4
Rossi, J.J.5
Zaia, J.A.6
-
40
-
-
80052777732
-
Phase I/II clinical trials using gene-modified adult hematopoietic stem cells for HIV: lessons learnt
-
Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP. Phase I/II clinical trials using gene-modified adult hematopoietic stem cells for HIV: lessons learnt. Stem Cells Int. 2011;2011:393698.
-
(2011)
Stem Cells Int.
, vol.2011
, pp. 393698
-
-
Mitsuyasu, R.T.1
Zack, J.A.2
Macpherson, J.L.3
Symonds, G.P.4
-
41
-
-
62049083710
-
Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells
-
Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, et al. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells. Nat Med. 2009;15:285-92.
-
(2009)
Nat Med.
, vol.15
, pp. 285-292
-
-
Mitsuyasu, R.T.1
Merigan, T.C.2
Carr, A.3
Zack, J.A.4
Winters, M.A.5
Workman, C.6
-
42
-
-
0032211255
-
A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
-
Wong-Staal F, Poeschla EM, Looney DJ. A controlled, phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther. 1998;9:2407-25.
-
(1998)
Hum Gene Ther.
, vol.9
, pp. 2407-2425
-
-
Wong-Staal, F.1
Poeschla, E.M.2
Looney, D.J.3
-
43
-
-
21144470101
-
Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients
-
Macpherson JL, Boyd MP, Arndt AJ, Todd AV, Fanning GC, Ely JA, et al. Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients. J Gene Med. 2005;7:552-64.
-
(2005)
J Gene Med.
, vol.7
, pp. 552-564
-
-
Macpherson, J.L.1
Boyd, M.P.2
Arndt, A.J.3
Todd, A.V.4
Fanning, G.C.5
Ely, J.A.6
-
44
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-11.
-
(1998)
Nature.
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
45
-
-
84892544892
-
RNAi factors are present and active in human cell nuclei
-
Gagnon KT, Li L, Chu Y, Janowski BA, Corey DR. RNAi factors are present and active in human cell nuclei. Cell Rep. 2014;6:211-21.
-
(2014)
Cell Rep.
, vol.6
, pp. 211-221
-
-
Gagnon, K.T.1
Li, L.2
Chu, Y.3
Janowski, B.A.4
Corey, D.R.5
-
46
-
-
84911471417
-
The role of antisense long noncoding RNA in small RNA-triggered gene activation
-
Zhang X, Li H, Burnett JC, Rossi JJ. The role of antisense long noncoding RNA in small RNA-triggered gene activation. RNA. 2014;20:1916-28.
-
(2014)
RNA.
, vol.20
, pp. 1916-1928
-
-
Zhang, X.1
Li, H.2
Burnett, J.C.3
Rossi, J.J.4
-
47
-
-
31044433795
-
The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
-
Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, Chen ZX, et al. The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA. 2006;12:256-62.
-
(2006)
RNA.
, vol.12
, pp. 256-262
-
-
Weinberg, M.S.1
Villeneuve, L.M.2
Ehsani, A.3
Amarzguioui, M.4
Aagaard, L.5
Chen, Z.X.6
-
48
-
-
77951964981
-
Posttranscriptional regulation of microRNA biogenesis in animals
-
Siomi H, Siomi MC. Posttranscriptional regulation of microRNA biogenesis in animals. Mol Cell. 2010;38:323-32.
-
(2010)
Mol Cell.
, vol.38
, pp. 323-332
-
-
Siomi, H.1
Siomi, M.C.2
-
49
-
-
66149125689
-
The role of RNAi and microRNAs in animal virus replication and antiviral immunity
-
Umbach JL, Cullen BR. The role of RNAi and microRNAs in animal virus replication and antiviral immunity. Genes Dev. 2009;23:1151-64.
-
(2009)
Genes Dev.
, vol.23
, pp. 1151-1164
-
-
Umbach, J.L.1
Cullen, B.R.2
-
50
-
-
77649239548
-
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
-
Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, et al. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010;6, e1000764.
-
(2010)
PLoS Pathog.
, vol.6
-
-
Parameswaran, P.1
Sklan, E.2
Wilkins, C.3
Burgon, T.4
Samuel, M.A.5
Lu, R.6
-
51
-
-
78650575533
-
Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system
-
Bivalkar-Mehla S, Vakharia J, Mehla R, Abreha M, Kanwar JR, Tikoo A, et al. Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system. Virus Res. 2011;155:1-9.
-
(2011)
Virus Res.
, vol.155
, pp. 1-9
-
-
Bivalkar-Mehla, S.1
Vakharia, J.2
Mehla, R.3
Abreha, M.4
Kanwar, J.R.5
Tikoo, A.6
Chauhan, A.7
-
52
-
-
84865123875
-
Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism
-
Backes S, Shapiro JS, Sabin LR, Pham AM, Reyes I, Moss B, et al. Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism. Cell Host Microbe. 2012;12:200-10.
-
(2012)
Cell Host Microbe.
, vol.12
, pp. 200-210
-
-
Backes, S.1
Shapiro, J.S.2
Sabin, L.R.3
Pham, A.M.4
Reyes, I.5
Moss, B.6
-
53
-
-
84885583303
-
Antiviral RNA interference in mammalian cells
-
Maillard PV, Ciaudo C, Marchais A, Li Y, Jay F, Ding SW, et al. Antiviral RNA interference in mammalian cells. Science. 2013;342:235-8.
-
(2013)
Science.
, vol.342
, pp. 235-238
-
-
Maillard, P.V.1
Ciaudo, C.2
Marchais, A.3
Li, Y.4
Jay, F.5
Ding, S.W.6
Voinnet, O.7
-
54
-
-
84885635441
-
RNA interference functions as an antiviral immunity mechanism in mammals
-
Li Y, Lu J, Han Y, Fan X, Ding SW. RNA interference functions as an antiviral immunity mechanism in mammals. Science. 2013;342:231-4.
-
(2013)
Science.
, vol.342
, pp. 231-234
-
-
Li, Y.1
Lu, J.2
Han, Y.3
Fan, X.4
Ding, S.W.5
-
55
-
-
84904038337
-
The mammalian response to virus infection is independent of small RNA silencing
-
Backes S, Langlois RA, Schmid S, Varble A, Shim JV, Sachs D, et al. The mammalian response to virus infection is independent of small RNA silencing. Cell Rep. 2014;8:114-25.
-
(2014)
Cell Rep
, vol.8
, pp. 114-125
-
-
Backes, S.1
Langlois, R.A.2
Schmid, S.3
Varble, A.4
Shim, J.V.5
Sachs, D.6
tenOever, B.R.7
-
56
-
-
84904600856
-
Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs
-
Bogerd HP, Skalsky RL, Kennedy EM, Furuse Y, Whisnant AW, Flores O, et al. Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs. J Virol. 2014;88:8065-76.
-
(2014)
J Virol.
, vol.88
, pp. 8065-8076
-
-
Bogerd, H.P.1
Skalsky, R.L.2
Kennedy, E.M.3
Furuse, Y.4
Whisnant, A.W.5
Flores, O.6
-
57
-
-
84857784900
-
Progress toward in vivo use of siRNAs-II
-
Rettig GR, Behlke MA. Progress toward in vivo use of siRNAs-II. Mol Ther. 2012;20:483-512.
-
(2012)
Mol Ther.
, vol.20
, pp. 483-512
-
-
Rettig, G.R.1
Behlke, M.A.2
-
59
-
-
0142165224
-
Functional siRNAs and miRNAs exhibit strand bias
-
Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell. 2003;115:209-16.
-
(2003)
Cell.
, vol.115
, pp. 209-216
-
-
Khvorova, A.1
Reynolds, A.2
Jayasena, S.D.3
-
60
-
-
10744225153
-
Asymmetry in the assembly of the RNAi enzyme complex
-
Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell. 2003;115:199-208.
-
(2003)
Cell.
, vol.115
, pp. 199-208
-
-
Schwarz, D.S.1
Hutvagner, G.2
Du, T.3
Xu, Z.4
Aronin, N.5
Zamore, P.D.6
-
62
-
-
36148933344
-
Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect
-
Kubo T, Zhelev Z, Ohba H, Bakalova R. Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect. Biochem Biophys Res Commun. 2008;365:54-61.
-
(2008)
Biochem Biophys Res Commun.
, vol.365
, pp. 54-61
-
-
Kubo, T.1
Zhelev, Z.2
Ohba, H.3
Bakalova, R.4
-
63
-
-
54549084606
-
Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
-
Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S. Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res. 2008;36:5812-21.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 5812-5821
-
-
Sano, M.1
Sierant, M.2
Miyagishi, M.3
Nakanishi, M.4
Takagi, Y.5
Sutou, S.6
-
64
-
-
22844448088
-
Functional polarity is introduced by Dicer processing of short substrate RNAs
-
Rose SD, Kim DH, Amarzguioui M, Heidel JD, Collingwood MA, Davis ME, et al. Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res. 2005;33:4140-56.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 4140-4156
-
-
Rose, S.D.1
Kim, D.H.2
Amarzguioui, M.3
Heidel, J.D.4
Collingwood, M.A.5
Davis, M.E.6
-
65
-
-
13844281898
-
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
-
Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, Rossi JJ. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol. 2005;23:222-6.
-
(2005)
Nat Biotechnol.
, vol.23
, pp. 222-226
-
-
Kim, D.H.1
Behlke, M.A.2
Rose, S.D.3
Chang, M.S.4
Choi, S.5
Rossi, J.J.6
-
66
-
-
13844280638
-
Synthetic shRNAs as potent RNAi triggers
-
Siolas D, Lerner C, Burchard J, Ge W, Linsley PS, Paddison PJ, et al. Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol. 2005;23:227-31.
-
(2005)
Nat Biotechnol.
, vol.23
, pp. 227-231
-
-
Siolas, D.1
Lerner, C.2
Burchard, J.3
Ge, W.4
Linsley, P.S.5
Paddison, P.J.6
-
67
-
-
84880213957
-
Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared to other siRNA variants
-
Snead NM, Wu X, Li A, Cui Q, Sakurai K, Burnett JC, et al. Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared to other siRNA variants. Nucleic Acids Res. 2013. doi:10.1093/nar/gkt200.
-
(2013)
Nucleic Acids Res
-
-
Snead, N.M.1
Wu, X.2
Li, A.3
Cui, Q.4
Sakurai, K.5
Burnett, J.C.6
Rossi, J.J.7
-
68
-
-
84868350874
-
Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on Dicing polarity, strand selectivity, and RNA editing of siRNAs
-
Zhou J, Song MS, Jacobi AM, Behlke MA, Wu X, Rossi JJ. Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on Dicing polarity, strand selectivity, and RNA editing of siRNAs. Mol Ther Nucleic Acids. 2012;1, e17.
-
(2012)
Mol Ther Nucleic Acids.
, vol.1
-
-
Zhou, J.1
Song, M.S.2
Jacobi, A.M.3
Behlke, M.A.4
Wu, X.5
Rossi, J.J.6
-
69
-
-
84863418151
-
Action and reaction: the biological response to siRNA and its delivery vehicles
-
Kanasty RL, Whitehead KA, Vegas AJ, Anderson DG. Action and reaction: the biological response to siRNA and its delivery vehicles. Mol Ther. 2012;20:513-24.
-
(2012)
Mol Ther.
, vol.20
, pp. 513-524
-
-
Kanasty, R.L.1
Whitehead, K.A.2
Vegas, A.J.3
Anderson, D.G.4
-
70
-
-
64549120295
-
Targeted delivery of antisense oligonucleotides and siRNAs into mammalian cells
-
Sioud M. Targeted delivery of antisense oligonucleotides and siRNAs into mammalian cells. Methods Mol Biol. 2009;487:61-82.
-
(2009)
Methods Mol Biol.
, vol.487
, pp. 61-82
-
-
Sioud, M.1
-
71
-
-
84878601356
-
Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I
-
Karlsen TA, Brinchmann JE. Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I. Mol Ther. 2013;21:1169-81.
-
(2013)
Mol Ther.
, vol.21
, pp. 1169-1181
-
-
Karlsen, T.A.1
Brinchmann, J.E.2
-
72
-
-
84891784472
-
siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway.
-
Sui H, Zhou M, Chen Q, Lane HC, Imamichi T. siRNA enhances DNA-mediated interferon lambda-1 response through crosstalk between RIG-I and IFI16 signalling pathway. Nucleic Acids Res. 2014;42:583-98.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 583-598
-
-
Sui, H.1
Zhou, M.2
Chen, Q.3
Lane, H.C.4
Imamichi, T.5
-
73
-
-
84555187756
-
Control of the interferon response in RNAi experiments
-
Nejepinska J, Flemr M, Svoboda P. Control of the interferon response in RNAi experiments. Methods Mol Biol. 2012;820:133-61.
-
(2012)
Methods Mol Biol.
, vol.820
, pp. 133-161
-
-
Nejepinska, J.1
Flemr, M.2
Svoboda, P.3
-
74
-
-
79951849229
-
RNA interference therapy in lung transplant patients infected with respiratory syncytial virus
-
Zamora MR, Budev M, Rolfe M, Gottlieb J, Humar A, Devincenzo J, et al. RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. Am J Respir Crit Care Med. 2011;183:531-8.
-
(2011)
Am J Respir Crit Care Med.
, vol.183
, pp. 531-538
-
-
Zamora, M.R.1
Budev, M.2
Rolfe, M.3
Gottlieb, J.4
Humar, A.5
Devincenzo, J.6
-
75
-
-
78650904206
-
Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors
-
Eekels JJ, Geerts D, Jeeninga RE, Berkhout B. Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors. Antiviral Res. 2011;89:43-53.
-
(2011)
Antiviral Res.
, vol.89
, pp. 43-53
-
-
Eekels, J.J.1
Geerts, D.2
Jeeninga, R.E.3
Berkhout, B.4
-
76
-
-
84892472993
-
Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA
-
Singh A, Palanichamy JK, Ramalingam P, Kassab MA, Bhagat M, Andrabi R, et al. Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA. J Antimicrob Chemother. 2014;69:404-15.
-
(2014)
J Antimicrob Chemother.
, vol.69
, pp. 404-415
-
-
Singh, A.1
Palanichamy, J.K.2
Ramalingam, P.3
Kassab, M.A.4
Bhagat, M.5
Andrabi, R.6
-
77
-
-
68149158913
-
Long-term RNA interference and its application to hepatitis B virus
-
Pan JS, Wang XZ, Ren JL. Long-term RNA interference and its application to hepatitis B virus. J Dig Dis. 2009;10:165-71.
-
(2009)
J Dig Dis.
, vol.10
, pp. 165-171
-
-
Pan, J.S.1
Wang, X.Z.2
Ren, J.L.3
-
78
-
-
84875311939
-
Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors
-
Boutimah F, Eekels JJ, Liu YP, Berkhout B. Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors. Antiviral Res. 2013;98:121-9.
-
(2013)
Antiviral Res.
, vol.98
, pp. 121-129
-
-
Boutimah, F.1
Eekels, J.J.2
Liu, Y.P.3
Berkhout, B.4
-
80
-
-
84878076945
-
Antiviral stratagems against HIV-1 using RNA interference (RNAi) technology
-
Vlachakis D, Tsiliki G, Pavlopoulou A, Roubelakis MG, Tsaniras SC, Kossida S. Antiviral stratagems against HIV-1 using RNA interference (RNAi) technology. Evol Bioinform Online. 2013;9:203-13.
-
(2013)
Evol Bioinform Online.
, vol.9
, pp. 203-213
-
-
Vlachakis, D.1
Tsiliki, G.2
Pavlopoulou, A.3
Roubelakis, M.G.4
Tsaniras, S.C.5
Kossida, S.6
-
81
-
-
70349302043
-
Progress towards therapeutic application of RNA interference for HIV infection
-
Singh SK, Gaur RK. Progress towards therapeutic application of RNA interference for HIV infection. BioDrugs. 2009;23:269-76.
-
(2009)
BioDrugs.
, vol.23
, pp. 269-276
-
-
Singh, S.K.1
Gaur, R.K.2
-
82
-
-
77957268423
-
The therapeutic potential of RNA interference in controlling HIV-1 replication
-
Soejitno A, Wihandani DM, Kuswardhani T. The therapeutic potential of RNA interference in controlling HIV-1 replication. Acta Med Indones. 2009;41:215-21.
-
(2009)
Acta Med Indones.
, vol.41
, pp. 215-221
-
-
Soejitno, A.1
Wihandani, D.M.2
Kuswardhani, T.3
-
83
-
-
70349887777
-
Combinatorial RNAi against HIV-1 using extended short hairpin RNAs
-
Liu YP, von Eije KJ, Schopman NC, Westerink JT, ter Brake O, Haasnoot J, et al. Combinatorial RNAi against HIV-1 using extended short hairpin RNAs. Mol Ther. 2009;17:1712-3.
-
(2009)
Mol Ther.
, vol.17
, pp. 1712-1713
-
-
Liu, Y.P.1
Eije, K.J.2
Schopman, N.C.3
Westerink, J.T.4
Brake, O.5
Haasnoot, J.6
Berkhout, B.7
-
84
-
-
53149132028
-
Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region
-
Suzuki K, Juelich T, Lim H, Ishida T, Watanebe T, Cooper DA, et al. Closed chromatin architecture is induced by an RNA duplex targeting the HIV-1 promoter region. J Biol Chem. 2008;283:23353-63.
-
(2008)
J Biol Chem.
, vol.283
, pp. 23353-23363
-
-
Suzuki, K.1
Juelich, T.2
Lim, H.3
Ishida, T.4
Watanebe, T.5
Cooper, D.A.6
-
85
-
-
85015372182
-
Promoter targeting shRNA suppresses HIV-1 infection in vivo through transcriptional gene silencing
-
Suzuki K, Hattori S, Marks K, Ahlenstiel C, Maeda Y, Ishida T, et al. Promoter targeting shRNA suppresses HIV-1 infection in vivo through transcriptional gene silencing. Mol Ther Nucleic Acids. 2013;2, e137.
-
(2013)
Mol Ther Nucleic Acids.
, vol.2
-
-
Suzuki, K.1
Hattori, S.2
Marks, K.3
Ahlenstiel, C.4
Maeda, Y.5
Ishida, T.6
-
86
-
-
79959931148
-
siRNA off-target effects can be reduced at concentrations that match their individual potency.
-
Caffrey DR, Zhao J, Song Z, Schaffer ME, Haney SA, Subramanian RR, et al. siRNA off-target effects can be reduced at concentrations that match their individual potency. PLoS One. 2011;6:e21503.
-
(2011)
PLoS One
, vol.6
-
-
Caffrey, D.R.1
Zhao, J.2
Song, Z.3
Schaffer, M.E.4
Haney, S.A.5
Subramanian, R.R.6
-
87
-
-
84868672935
-
Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells
-
Green VA, Arbuthnot P, Weinberg MS. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Virol J. 2012;9:272.
-
(2012)
Virol J.
, vol.9
, pp. 272
-
-
Green, V.A.1
Arbuthnot, P.2
Weinberg, M.S.3
-
88
-
-
33845668311
-
RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapy
-
Li M, Li H, Rossi JJ. RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapy. Ann N Y Acad Sci. 2006;1082:172-9.
-
(2006)
Ann N Y Acad Sci.
, vol.1082
, pp. 172-179
-
-
Li, M.1
Li, H.2
Rossi, J.J.3
-
89
-
-
80051882660
-
Toward a durable treatment of HIV-1 infection using RNA interference
-
Eekels JJ, Berkhout B. Toward a durable treatment of HIV-1 infection using RNA interference. Prog Mol Biol Transl Sci. 2011;102:141-63.
-
(2011)
Prog Mol Biol Transl Sci.
, vol.102
, pp. 141-163
-
-
Eekels, J.J.1
Berkhout, B.2
-
90
-
-
84939261536
-
Los Alamos National Laboratory
-
Accessed 15 Apr
-
HIV Databases. Los Alamos National Laboratory. http://www.hiv.lanl.gov. Accessed 15 Apr 2015.
-
(2015)
-
-
-
91
-
-
34250821095
-
Suppression of HIV replication using RNA interference against HIV-1 integrase
-
Lau TS, Li Y, Kameoka M, Ng TB, Wan DC. Suppression of HIV replication using RNA interference against HIV-1 integrase. FEBS Lett. 2007;581:3253-9.
-
(2007)
FEBS Lett.
, vol.581
, pp. 3253-3259
-
-
Lau, T.S.1
Li, Y.2
Kameoka, M.3
Ng, T.B.4
Wan, D.C.5
-
92
-
-
13844320402
-
HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome
-
Westerhout EM, Ooms M, Vink M, Das AT, Berkhout B. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res. 2005;33:796-804.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 796-804
-
-
Westerhout, E.M.1
Ooms, M.2
Vink, M.3
Das, A.T.4
Berkhout, B.5
-
93
-
-
20644442897
-
Inhibition of HIV-1 replication by RNA targeted against the LTR region
-
Puerta-Fernandez E, Barroso-del Jesus A, Romero-Lopez C, Tapia N, Martinez MA, Berzal-Herranz A. Inhibition of HIV-1 replication by RNA targeted against the LTR region. AIDS. 2005;19:863-70.
-
(2005)
AIDS.
, vol.19
, pp. 863-870
-
-
Puerta-Fernandez, E.1
Barroso-del Jesus, A.2
Romero-Lopez, C.3
Tapia, N.4
Martinez, M.A.5
Berzal-Herranz, A.6
-
94
-
-
33646862794
-
Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag
-
Cave E, Weinberg MS, Cilliers T, Carmona S, Morris L, Arbuthnot P. Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag. AIDS Res Hum Retroviruses. 2006;22:401-10.
-
(2006)
AIDS Res Hum Retroviruses.
, vol.22
, pp. 401-410
-
-
Cave, E.1
Weinberg, M.S.2
Cilliers, T.3
Carmona, S.4
Morris, L.5
Arbuthnot, P.6
-
95
-
-
27744453385
-
Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol
-
Morris KV, Chung CH, Witke W, Looney DJ. Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol. RNA Biol. 2005;2:17-20.
-
(2005)
RNA Biol.
, vol.2
, pp. 17-20
-
-
Morris, K.V.1
Chung, C.H.2
Witke, W.3
Looney, D.J.4
-
96
-
-
23044517213
-
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV
-
Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, et al. Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood. 2005;106:818-26.
-
(2005)
Blood.
, vol.106
, pp. 818-826
-
-
Lee, S.K.1
Dykxhoorn, D.M.2
Kumar, P.3
Ranjbar, S.4
Song, E.5
Maliszewski, L.E.6
-
97
-
-
78651321339
-
Multiple shRNA combinations for near-complete coverage of all HIV-1 strains
-
McIntyre GJ, Groneman JL, Yu YH, Tran A, Applegate TL. Multiple shRNA combinations for near-complete coverage of all HIV-1 strains. AIDS Res Ther. 2011;8:1.
-
(2011)
AIDS Res Ther.
, vol.8
, pp. 1
-
-
McIntyre, G.J.1
Groneman, J.L.2
Yu, Y.H.3
Tran, A.4
Applegate, T.L.5
-
98
-
-
81255176941
-
Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific
-
Suzuki K, Ishida T, Yamagishi M, Ahlenstiel C, Swaminathan S, Marks K, et al. Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific. RNA Biol. 2011;8:1035-46.
-
(2011)
RNA Biol.
, vol.8
, pp. 1035-1046
-
-
Suzuki, K.1
Ishida, T.2
Yamagishi, M.3
Ahlenstiel, C.4
Swaminathan, S.5
Marks, K.6
-
99
-
-
84868347414
-
Chemically modified oligonucleotides modulate an epigenetically varied and transient form of transcription silencing of HIV-1 in human cells
-
Knowling S, Stapleton K, Turner AM, Uhlmann E, Lehmann T, Vollmer J, et al. Chemically modified oligonucleotides modulate an epigenetically varied and transient form of transcription silencing of HIV-1 in human cells. Mol Ther Nucleic Acids. 2012;1, e16.
-
(2012)
Mol Ther Nucleic Acids.
, vol.1
-
-
Knowling, S.1
Stapleton, K.2
Turner, A.M.3
Uhlmann, E.4
Lehmann, T.5
Vollmer, J.6
Morris, K.V.7
-
100
-
-
0027215750
-
Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots
-
Bebenek K, Abbotts J, Wilson SH, Kunkel TA. Error-prone polymerization by HIV-1 reverse transcriptase. Contribution of template-primer misalignment, miscoding, and termination probability to mutational hot spots. J Biol Chem. 1993;268:10324-34.
-
(1993)
J Biol Chem
, vol.268
, pp. 10324-10334
-
-
Bebenek, K.1
Abbotts, J.2
Wilson, S.H.3
Kunkel, T.A.4
-
101
-
-
0023724652
-
Low fidelity of cell-free DNA synthesis by reverse transcriptase of human immunodeficiency virus
-
Takeuchi Y, Nagumo T, Hoshino H. Low fidelity of cell-free DNA synthesis by reverse transcriptase of human immunodeficiency virus. J Virol. 1988;62:3900-2.
-
(1988)
J Virol.
, vol.62
, pp. 3900-3902
-
-
Takeuchi, Y.1
Nagumo, T.2
Hoshino, H.3
-
102
-
-
80052830258
-
Molecular strategies to design an escape-proof antiviral therapy
-
Berkhout B, Sanders RW. Molecular strategies to design an escape-proof antiviral therapy. Antiviral Res. 2011;92:7-14.
-
(2011)
Antiviral Res.
, vol.92
, pp. 7-14
-
-
Berkhout, B.1
Sanders, R.W.2
-
103
-
-
84455169971
-
Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs
-
Schopman NC, Braun A, Berkhout B. Directed HIV-1 evolution of protease inhibitor resistance by second-generation short hairpin RNAs. Antimicrob Agents Chemother. 2012;56:479-86.
-
(2012)
Antimicrob Agents Chemother.
, vol.56
, pp. 479-486
-
-
Schopman, N.C.1
Braun, A.2
Berkhout, B.3
-
104
-
-
0142124143
-
Human immunodeficiency virus type 1 escape from RNA interference
-
Boden D, Pusch O, Lee F, Tucker L, Ramratnam B. Human immunodeficiency virus type 1 escape from RNA interference. J Virol. 2003;77:11531-5.
-
(2003)
J Virol.
, vol.77
, pp. 11531-11535
-
-
Boden, D.1
Pusch, O.2
Lee, F.3
Tucker, L.4
Ramratnam, B.5
-
105
-
-
1242319384
-
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition
-
Das AT, Brummelkamp TR, Westerhout EM, Vink M, Madiredjo M, Bernards R, et al. Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. J Virol. 2004;78:2601-5.
-
(2004)
J Virol.
, vol.78
, pp. 2601-2605
-
-
Das, A.T.1
Brummelkamp, T.R.2
Westerhout, E.M.3
Vink, M.4
Madiredjo, M.5
Bernards, R.6
Berkhout, B.7
-
106
-
-
55249098418
-
HIV evades RNA interference directed at TAR by an indirect compensatory mechanism
-
Leonard JN, Shah PS, Burnett JC, Schaffer DV. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host Microbe. 2008;4:484-94.
-
(2008)
Cell Host Microbe.
, vol.4
, pp. 484-494
-
-
Leonard, J.N.1
Shah, P.S.2
Burnett, J.C.3
Schaffer, D.V.4
-
107
-
-
84859440756
-
HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites
-
Shah PS, Pham NP, Schaffer DV. HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites. Mol Ther. 2012;20:840-8.
-
(2012)
Mol Ther.
, vol.20
, pp. 840-848
-
-
Shah, P.S.1
Pham, N.P.2
Schaffer, D.V.3
-
108
-
-
84862251469
-
Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct
-
Zhang T, Cheng T, Wei L, Cai Y, Yeo AE, Han J, et al. Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct. Virol J. 2012;9:118.
-
(2012)
Virol J.
, vol.9
, pp. 118
-
-
Zhang, T.1
Cheng, T.2
Wei, L.3
Cai, Y.4
Yeo, A.E.5
Han, J.6
-
109
-
-
77953124494
-
Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs
-
Schopman NC, ter Brake O, Berkhout B. Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs. Retrovirology. 2010;7:52.
-
(2010)
Retrovirology.
, vol.7
, pp. 52
-
-
Schopman, N.C.1
Brake, O.2
Berkhout, B.3
-
110
-
-
40149092147
-
Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference
-
von Eije KJ, ter Brake O, Berkhout B. Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference. J Virol. 2008;82:2895-903.
-
(2008)
J Virol.
, vol.82
, pp. 2895-2903
-
-
Eije, K.J.1
Brake, O.2
Berkhout, B.3
-
111
-
-
84890379963
-
Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1.
-
Centlivre M, Legrand N, Klamer S, Liu YP, Jasmijn von Eije K, Bohne M, et al. Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1. Mol Ther Nucleic Acids. 2013;2:e120.
-
(2013)
Mol Ther Nucleic Acids.
, vol.2
-
-
Centlivre, M.1
Legrand, N.2
Klamer, S.3
Liu, Y.P.4
Jasmijn von Eije, K.5
Bohne, M.6
-
112
-
-
79959760389
-
Systematic approaches towards the development of host-directed antiviral therapeutics
-
Prussia A, Thepchatri P, Snyder JP, Plemper RK. Systematic approaches towards the development of host-directed antiviral therapeutics. Int J Mol Sci. 2011;12:4027-52.
-
(2011)
Int J Mol Sci.
, vol.12
, pp. 4027-4052
-
-
Prussia, A.1
Thepchatri, P.2
Snyder, J.P.3
Plemper, R.K.4
-
113
-
-
60549090253
-
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
-
Hutter G, Nowak D, Mossner M, Ganepola S, Mussig A, Allers K, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360:692-8.
-
(2009)
N Engl J Med.
, vol.360
, pp. 692-698
-
-
Hutter, G.1
Nowak, D.2
Mossner, M.3
Ganepola, S.4
Mussig, A.5
Allers, K.6
-
114
-
-
79958125260
-
Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cells
-
Hutter G, Ganepola S. Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cells. Scientific World Journal. 2011;11:1068-76.
-
(2011)
Scientific World Journal.
, vol.11
, pp. 1068-1076
-
-
Hutter, G.1
Ganepola, S.2
-
115
-
-
79953117041
-
Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
-
Allers K, Hutter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood. 2011;117:2791-9.
-
(2011)
Blood.
, vol.117
, pp. 2791-2799
-
-
Allers, K.1
Hutter, G.2
Hofmann, J.3
Loddenkemper, C.4
Rieger, K.5
Thiel, E.6
Schneider, T.7
-
116
-
-
84907367370
-
Shift of HIV tropism in stem-cell transplantation with CCR5 Delta32 mutation
-
Kordelas L, Verheyen J, Beelen DW, Horn PA, Heinold A, Kaiser R, et al. Shift of HIV tropism in stem-cell transplantation with CCR5 Delta32 mutation. N Engl J Med. 2014;371:880-2.
-
(2014)
N Engl J Med.
, vol.371
, pp. 880-882
-
-
Kordelas, L.1
Verheyen, J.2
Beelen, D.W.3
Horn, P.A.4
Heinold, A.5
Kaiser, R.6
-
117
-
-
67649842588
-
Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5
-
Shimizu S, Kamata M, Kittipongdaja P, Chen KN, Kim S, Pang S, et al. Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5. Genet Vaccines Ther. 2009;7:8.
-
(2009)
Genet Vaccines Ther.
, vol.7
, pp. 8
-
-
Shimizu, S.1
Kamata, M.2
Kittipongdaja, P.3
Chen, K.N.4
Kim, S.5
Pang, S.6
-
118
-
-
51649123734
-
Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance
-
Tamhane M, Akkina R. Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance. AIDS Res Ther. 2008;5:16.
-
(2008)
AIDS Res Ther.
, vol.5
, pp. 16
-
-
Tamhane, M.1
Akkina, R.2
-
119
-
-
34447105555
-
Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization
-
Vazquez-Salat N, Yuhki N, Beck T, O'Brien SJ, Murphy WJ. Gene conversion between mammalian CCR2 and CCR5 chemokine receptor genes: a potential mechanism for receptor dimerization. Genomics. 2007;90:213-24.
-
(2007)
Genomics.
, vol.90
, pp. 213-224
-
-
Vazquez-Salat, N.1
Yuhki, N.2
Beck, T.3
O'Brien, S.J.4
Murphy, W.J.5
-
120
-
-
1642564331
-
Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance
-
Anderson J, Banerjea A, Akkina R. Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance. Oligonucleotides. 2003;13:303-12.
-
(2003)
Oligonucleotides.
, vol.13
, pp. 303-312
-
-
Anderson, J.1
Banerjea, A.2
Akkina, R.3
-
121
-
-
84858211760
-
Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors
-
Eekels JJ, Sagnier S, Geerts D, Jeeninga RE, Biard-Piechaczyk M, Berkhout B. Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors. Virol J. 2012;9:69.
-
(2012)
Virol J.
, vol.9
, pp. 69
-
-
Eekels, J.J.1
Sagnier, S.2
Geerts, D.3
Jeeninga, R.E.4
Biard-Piechaczyk, M.5
Berkhout, B.6
-
122
-
-
27744605569
-
Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy
-
Li MJ, Kim J, Li S, Zaia J, Yee JK, Anderson J, et al. Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Mol Ther. 2005;12:900-9.
-
(2005)
Mol Ther.
, vol.12
, pp. 900-909
-
-
Li, M.J.1
Kim, J.2
Li, S.3
Zaia, J.4
Yee, J.K.5
Anderson, J.6
-
123
-
-
49849102544
-
Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis
-
Ishaq M, Hu J, Wu X, Fu Q, Yang Y, Liu Q, et al. Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Mol Biotechnol. 2008;39:231-8.
-
(2008)
Mol Biotechnol.
, vol.39
, pp. 231-238
-
-
Ishaq, M.1
Hu, J.2
Wu, X.3
Fu, Q.4
Yang, Y.5
Liu, Q.6
Guo, D.7
-
124
-
-
78049483587
-
Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA
-
Subramanya S, Armant M, Salkowitz JR, Nyakeriga AM, Haridas V, Hasan M, et al. Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA. Mol Ther. 2010;18:2028-37.
-
(2010)
Mol Ther.
, vol.18
, pp. 2028-2037
-
-
Subramanya, S.1
Armant, M.2
Salkowitz, J.R.3
Nyakeriga, A.M.4
Haridas, V.5
Hasan, M.6
-
125
-
-
34248353881
-
Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production
-
Christensen HS, Daher A, Soye KJ, Frankel LB, Alexander MR, Laine S, et al. Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production. J Virol. 2007;81:5121-31.
-
(2007)
J Virol.
, vol.81
, pp. 5121-5131
-
-
Christensen, H.S.1
Daher, A.2
Soye, K.J.3
Frankel, L.B.4
Alexander, M.R.5
Laine, S.6
-
126
-
-
81255164734
-
The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR
-
Sanghvi VR, Steel LF. The cellular TAR RNA binding protein, TRBP, promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR. J Virol. 2011;85:12614-21.
-
(2011)
J Virol.
, vol.85
, pp. 12614-12621
-
-
Sanghvi, V.R.1
Steel, L.F.2
-
127
-
-
23644433363
-
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
-
Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005;436:740-4.
-
(2005)
Nature.
, vol.436
, pp. 740-744
-
-
Chendrimada, T.P.1
Gregory, R.I.2
Kumaraswamy, E.3
Norman, J.4
Cooch, N.5
Nishikura, K.6
Shiekhattar, R.7
-
129
-
-
84891589340
-
CCR5 as a natural and modulated target for inhibition of HIV
-
Burke BP, Boyd MP, Impey H, Breton LR, Bartlett JS, Symonds GP, et al. CCR5 as a natural and modulated target for inhibition of HIV. Viruses. 2014;6:54-68.
-
(2014)
Viruses.
, vol.6
, pp. 54-68
-
-
Burke, B.P.1
Boyd, M.P.2
Impey, H.3
Breton, L.R.4
Bartlett, J.S.5
Symonds, G.P.6
Hutter, G.7
-
130
-
-
79954650563
-
State-of-the-art gene-based therapies: the road ahead
-
Kay MA. State-of-the-art gene-based therapies: the road ahead. Nat Rev Genet. 2011;12:316-28.
-
(2011)
Nat Rev Genet.
, vol.12
, pp. 316-328
-
-
Kay, M.A.1
-
131
-
-
80052627990
-
Current progress of siRNA/shRNA therapeutics in clinical trials
-
Burnett JC, Rossi JJ, Tiemann K. Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J. 2011;6:1130-46.
-
(2011)
Biotechnol J.
, vol.6
, pp. 1130-1146
-
-
Burnett, J.C.1
Rossi, J.J.2
Tiemann, K.3
-
132
-
-
77956355233
-
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver
-
Grimm D, Wang L, Lee JS, Schurmann N, Gu S, Borner K, et al. Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. JClin Invest. 2010;120:3106-19.
-
(2010)
JClin Invest.
, vol.120
, pp. 3106-3119
-
-
Grimm, D.1
Wang, L.2
Lee, J.S.3
Schurmann, N.4
Gu, S.5
Borner, K.6
-
133
-
-
77952001110
-
Lentiviral vector gene therapy: effective and safe?
-
Persons DA. Lentiviral vector gene therapy: effective and safe? Mol Ther. 2010;18:861-2.
-
(2010)
Mol Ther.
, vol.18
, pp. 861-862
-
-
Persons, D.A.1
-
134
-
-
33646921719
-
Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection
-
Morris KV, Rossi JJ. Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection. Hum Gene Ther. 2006;17:479-86.
-
(2006)
Hum Gene Ther.
, vol.17
, pp. 479-486
-
-
Morris, K.V.1
Rossi, J.J.2
-
135
-
-
77953642976
-
Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies
-
Liu YP, Vink MA, Westerink JT, Ramirez de Arellano E, Konstantinova P, Ter Brake O, et al. Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies. RNA. 2010;16:1328-39.
-
(2010)
RNA
, vol.16
, pp. 1328-1339
-
-
Liu, Y.P.1
Vink, M.A.2
Westerink, J.T.3
Ramirez de Arellano, E.4
Konstantinova, P.5
Brake, O.6
Berkhout, B.7
-
136
-
-
84867743427
-
Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapy
-
Chung J, Zhang J, Li H, Ouellet DL, DiGiusto DL, Rossi JJ. Endogenous MCM7 microRNA cluster as a novel platform to multiplex small interfering and nucleolar RNAs for combinational HIV-1 gene therapy. Hum Gene Ther. 2012;23:1200-8.
-
(2012)
Hum Gene Ther.
, vol.23
, pp. 1200-1208
-
-
Chung, J.1
Zhang, J.2
Li, H.3
Ouellet, D.L.4
DiGiusto, D.L.5
Rossi, J.J.6
-
137
-
-
76149120462
-
RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?
-
Subramanya S, Kim SS, Manjunath N, Shankar P. RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA? Expert Opin Biol Ther. 2010;10:201-13.
-
(2010)
Expert Opin Biol Ther.
, vol.10
, pp. 201-213
-
-
Subramanya, S.1
Kim, S.S.2
Manjunath, N.3
Shankar, P.4
-
138
-
-
84873918201
-
Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS
-
Chung J, DiGiusto DL, Rossi JJ. Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS. Expert Opin Biol Ther. 2013;13:437-45.
-
(2013)
Expert Opin Biol Ther.
, vol.13
, pp. 437-445
-
-
Chung, J.1
DiGiusto, D.L.2
Rossi, J.J.3
-
139
-
-
84938412743
-
Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor.
-
Wolstein O, Boyd M, Millington M, Impey H, Boyer J, Howe A, et al. Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor. Mol Ther. 2014;1. doi:10.1038/mtm.2013.11.
-
(2014)
Mol Ther
, vol.1
-
-
Wolstein, O.1
Boyd, M.2
Millington, M.3
Impey, H.4
Boyer, J.5
Howe, A.6
-
140
-
-
82955237641
-
Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice
-
Zhou J, NeffCP, Liu X, Zhang J, Li H, Smith DD, et al. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther. 2011;19:2228-38.
-
(2011)
Mol Ther.
, vol.19
, pp. 2228-2238
-
-
Zhou, J.1
Neff, C.P.2
Liu, X.3
Zhang, J.4
Li, H.5
Smith, D.D.6
-
141
-
-
84865416817
-
Single siRNA nanocapsules for enhanced RNAi delivery
-
Yan M, Liang M, Wen J, Liu Y, Lu Y, Chen IS. Single siRNA nanocapsules for enhanced RNAi delivery. J Am Chem Soc. 2012;134:13542-5.
-
(2012)
J Am Chem Soc.
, vol.134
, pp. 13542-13545
-
-
Yan, M.1
Liang, M.2
Wen, J.3
Liu, Y.4
Lu, Y.5
Chen, I.S.6
-
142
-
-
84868365382
-
Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation
-
Broderick KE, Chan A, Lin F, Shen X, Kichaev G, Khan AS, et al. Optimized in vivo transfer of small interfering RNA targeting dermal tissue using in vivo surface electroporation. Mol Ther Nucleic Acids. 2012;1, e11.
-
(2012)
Mol Ther Nucleic Acids.
, vol.1
-
-
Broderick, K.E.1
Chan, A.2
Lin, F.3
Shen, X.4
Kichaev, G.5
Khan, A.S.6
-
143
-
-
36849044732
-
Nonviral delivery of synthetic siRNAs in vivo
-
Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest. 2007;117:3623-32.
-
(2007)
J Clin Invest.
, vol.117
, pp. 3623-3632
-
-
Akhtar, S.1
Benter, I.F.2
-
144
-
-
84874232605
-
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge
-
Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, et al. DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge. Proc Natl Acad Sci U S A. 2013;110:2975-80.
-
(2013)
Proc Natl Acad Sci U S A.
, vol.110
, pp. 2975-2980
-
-
Patel, V.1
Jalah, R.2
Kulkarni, V.3
Valentin, A.4
Rosati, M.5
Alicea, C.6
-
145
-
-
84875514065
-
HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice
-
Kulkarni V, Rosati M, Valentin A, Ganneru B, Singh AK, Yan J, et al. HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice. PLoS One. 2013;8, e60245.
-
(2013)
PLoS One.
, vol.8
-
-
Kulkarni, V.1
Rosati, M.2
Valentin, A.3
Ganneru, B.4
Singh, A.K.5
Yan, J.6
-
146
-
-
10644225886
-
Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection
-
Kashiwakura Y, Tamayose K, Iwabuchi K, Hirai Y, Shimada T, Matsumoto K, et al. Hepatocyte growth factor receptor is a coreceptor for adeno-associated virus type 2 infection. J Virol. 2005;79:609-14.
-
(2005)
J Virol.
, vol.79
, pp. 609-614
-
-
Kashiwakura, Y.1
Tamayose, K.2
Iwabuchi, K.3
Hirai, Y.4
Shimada, T.5
Matsumoto, K.6
-
147
-
-
84903587200
-
Engineering adeno-associated viruses for clinical gene therapy
-
Kotterman MA, Schaffer DV. Engineering adeno-associated viruses for clinical gene therapy. Nat Rev Genet. 2014;15:445-51.
-
(2014)
Nat Rev Genet.
, vol.15
, pp. 445-451
-
-
Kotterman, M.A.1
Schaffer, D.V.2
-
148
-
-
76349095131
-
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
-
Kim SS, Peer D, Kumar P, Subramanya S, Wu H, Asthana D, et al. RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. Mol Ther. 2010;18:370-6.
-
(2010)
Mol Ther.
, vol.18
, pp. 370-376
-
-
Kim, S.S.1
Peer, D.2
Kumar, P.3
Subramanya, S.4
Wu, H.5
Asthana, D.6
-
149
-
-
79952154606
-
Localized, targeted, and sustained siRNA delivery
-
Krebs MD, Alsberg E. Localized, targeted, and sustained siRNA delivery. Chemistry. 2011;17:3054-62.
-
(2011)
Chemistry.
, vol.17
, pp. 3054-3062
-
-
Krebs, M.D.1
Alsberg, E.2
-
150
-
-
84879691173
-
Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras
-
Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, et al. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013;21:1378-89.
-
(2013)
Mol Ther.
, vol.21
, pp. 1378-1389
-
-
Wheeler, L.A.1
Vrbanac, V.2
Trifonova, R.3
Brehm, M.A.4
Gilboa-Geffen, A.5
Tanno, S.6
-
151
-
-
84871919249
-
Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge
-
Zhou J, NeffCP, Swiderski P, Li H, Smith DD, Aboellail T, et al. Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge. Mol Ther. 2013;21:192-200.
-
(2013)
Mol Ther.
, vol.21
, pp. 192-200
-
-
Zhou, J.1
Neff, C.P.2
Swiderski, P.3
Li, H.4
Smith, D.D.5
Aboellail, T.6
-
152
-
-
78751667739
-
An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice.
-
NeffCP, Zhou J, Remling L, Kuruvilla J, Zhang J, Li H, et al. An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice. Sci Transl Med. 2011;3:66ra66.
-
(2011)
Sci Transl Med.
, vol.3
, pp. 66-66
-
-
Neff, C.P.1
Zhou, J.2
Remling, L.3
Kuruvilla, J.4
Zhang, J.5
Li, H.6
-
153
-
-
84862785747
-
Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles
-
Pan Y, Zhang Y, Jia T, Zhang K, Li J, Wang L. Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles. FEBS J. 2012;279:1198-208.
-
(2012)
FEBS J.
, vol.279
, pp. 1198-1208
-
-
Pan, Y.1
Zhang, Y.2
Jia, T.3
Zhang, K.4
Li, J.5
Wang, L.6
-
154
-
-
79958716788
-
Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition
-
Zhou J, Shu Y, Guo P, Smith DD, Rossi JJ. Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition. Methods. 2011;54:284-94.
-
(2011)
Methods.
, vol.54
, pp. 284-294
-
-
Zhou, J.1
Shu, Y.2
Guo, P.3
Smith, D.D.4
Rossi, J.J.5
-
155
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005;23:709-17.
-
(2005)
Nat Biotechnol.
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
Chowdhury, D.4
Kussman, S.5
Dykxhoorn, D.M.6
-
156
-
-
49549117077
-
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
-
Kumar P, Ban HS, Kim SS, Wu H, Pearson T, Greiner DL, et al. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell. 2008;134:577-86.
-
(2008)
Cell.
, vol.134
, pp. 577-586
-
-
Kumar, P.1
Ban, H.S.2
Kim, S.S.3
Wu, H.4
Pearson, T.5
Greiner, D.L.6
-
157
-
-
84873700433
-
Advancements in the field of intravaginal siRNA delivery
-
Yang S, Chen Y, Ahmadie R, Ho EA. Advancements in the field of intravaginal siRNA delivery. J Control Release. 2013;167:29-39.
-
(2013)
J Control Release.
, vol.167
, pp. 29-39
-
-
Yang, S.1
Chen, Y.2
Ahmadie, R.3
Ho, E.A.4
-
158
-
-
77950826873
-
siRNA-based topical microbicides targeting sexually transmitted infections.
-
Katakowski JA, Palliser D. siRNA-based topical microbicides targeting sexually transmitted infections. Curr Opin Mol Ther. 2010;12:192-202.
-
(2010)
Curr Opin Mol Ther.
, vol.12
, pp. 192-202
-
-
Katakowski, J.A.1
Palliser, D.2
-
160
-
-
77956481715
-
Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV
-
Vaccari M, Poonam P, Franchini G. Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV. Expert Rev Vaccines. 2010;9:997-1005.
-
(2010)
Expert Rev Vaccines.
, vol.9
, pp. 997-1005
-
-
Vaccari, M.1
Poonam, P.2
Franchini, G.3
-
161
-
-
84861173075
-
The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope
-
de Souza MS, Ratto-Kim S, Chuenarom W, Schuetz A, Chantakulkij S, Nuntapinit B, et al. The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope. J Immunol. 2012;188:5166-76.
-
(2012)
J Immunol.
, vol.188
, pp. 5166-5176
-
-
Souza, M.S.1
Ratto-Kim, S.2
Chuenarom, W.3
Schuetz, A.4
Chantakulkij, S.5
Nuntapinit, B.6
-
162
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, Chiu J, Paris R, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med. 2009;361:2209-20.
-
(2009)
N Engl J Med.
, vol.361
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
Pitisuttithum, P.2
Nitayaphan, S.3
Kaewkungwal, J.4
Chiu, J.5
Paris, R.6
-
163
-
-
34247208235
-
Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus
-
van Lunzen J, Glaunsinger T, Stahmer I, von Baehr V, Baum C, Schilz A, et al. Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther. 2007;15:1024-33.
-
(2007)
Mol Ther.
, vol.15
, pp. 1024-1033
-
-
Lunzen, J.1
Glaunsinger, T.2
Stahmer, I.3
Baehr, V.4
Baum, C.5
Schilz, A.6
-
164
-
-
0034739591
-
Ribozyme therapy for HIV infection
-
Rossi JJ. Ribozyme therapy for HIV infection. Adv Drug Deliv Rev. 2000;44:71-8.
-
(2000)
Adv Drug Deliv Rev.
, vol.44
, pp. 71-78
-
-
Rossi, J.J.1
-
165
-
-
33751251058
-
Gene transfer in humans using a conditionally replicating lentiviral vector
-
Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, et al. Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci U S A. 2006;103:17372-7.
-
(2006)
Proc Natl Acad Sci U S A.
, vol.103
, pp. 17372-17377
-
-
Levine, B.L.1
Humeau, L.M.2
Boyer, J.3
MacGregor, R.R.4
Rebello, T.5
Lu, X.6
-
166
-
-
0031001927
-
Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4+ monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA
-
Liu D, Donegan J, Nuovo G, Mitra D, Laurence J. Stable human immunodeficiency virus type 1 (HIV-1) resistance in transformed CD4+ monocytic cells treated with multitargeting HIV-1 antisense sequences incorporated into U1 snRNA. J Virol. 1997;71:4079-85.
-
(1997)
J Virol.
, vol.71
, pp. 4079-4085
-
-
Liu, D.1
Donegan, J.2
Nuovo, G.3
Mitra, D.4
Laurence, J.5
-
167
-
-
0033168686
-
A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children
-
Kohn DB, Bauer G, Rice CR, Rothschild JC, Carbonaro DA, Valdez P, et al. A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood. 1999;94:368-71.
-
(1999)
Blood.
, vol.94
, pp. 368-371
-
-
Kohn, D.B.1
Bauer, G.2
Rice, C.R.3
Rothschild, J.C.4
Carbonaro, D.A.5
Valdez, P.6
-
168
-
-
84905284525
-
A conserved target site in HIV-1 Gag RNA is accessible to inhibition by both an HDV ribozyme and a short hairpin RNA
-
Scarborough RJ, Levesque MV, Boudrias-Dalle E, Chute IC, Daniels SM, Ouellette RJ, et al. A conserved target site in HIV-1 Gag RNA is accessible to inhibition by both an HDV ribozyme and a short hairpin RNA. Mol Ther Nucleic Acids. 2014;3, e178.
-
(2014)
Mol Ther Nucleic Acids.
, vol.3
-
-
Scarborough, R.J.1
Levesque, M.V.2
Boudrias-Dalle, E.3
Chute, I.C.4
Daniels, S.M.5
Ouellette, R.J.6
-
169
-
-
0242440877
-
Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells
-
Park WS, Hayafune M, Miyano-Kurosaki N, Takaku H. Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells. Gene Ther. 2003;10:2046-50.
-
(2003)
Gene Ther.
, vol.10
, pp. 2046-2050
-
-
Park, W.S.1
Hayafune, M.2
Miyano-Kurosaki, N.3
Takaku, H.4
-
170
-
-
13944254982
-
Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
-
Flynn NM, Forthal DN, Harro CD, Judson FN, Mayer KH, Para MF. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis. 2005;191:654-65.
-
(2005)
J Infect Dis.
, vol.191
, pp. 654-665
-
-
Flynn, N.M.1
Forthal, D.N.2
Harro, C.D.3
Judson, F.N.4
Mayer, K.H.5
Para, M.F.6
-
171
-
-
14744284227
-
HIV-1 nef suppression by virally encoded microRNA
-
Omoto S, Ito M, Tsutsumi Y, Ichikawa Y, Okuyama H, Brisibe EA, et al. HIV-1 nef suppression by virally encoded microRNA. Retrovirology. 2004;1:44.
-
(2004)
Retrovirology.
, vol.1
, pp. 44
-
-
Omoto, S.1
Ito, M.2
Tsutsumi, Y.3
Ichikawa, Y.4
Okuyama, H.5
Brisibe, E.A.6
-
172
-
-
33751001588
-
Silencing of HIV-1 with RNA interference: a multiple shRNA approach
-
ter Brake O, Konstantinova P, Ceylan M, Berkhout B. Silencing of HIV-1 with RNA interference: a multiple shRNA approach. Mol Ther. 2006;14:883-92.
-
(2006)
Mol Ther.
, vol.14
, pp. 883-892
-
-
Brake, O.1
Konstantinova, P.2
Ceylan, M.3
Berkhout, B.4
-
173
-
-
33751193683
-
Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages
-
Yamamoto T, Miyoshi H, Yamamoto N, Yamamoto N, Inoue J, Tsunetsugu-Yokota Y. Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages. Blood. 2006;108:3305-12.
-
(2006)
Blood.
, vol.108
, pp. 3305-3312
-
-
Yamamoto, T.1
Miyoshi, H.2
Yamamoto, N.3
Yamamoto, N.4
Inoue, J.5
Tsunetsugu-Yokota, Y.6
-
174
-
-
58149458865
-
Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model
-
ter Brake O, Legrand N, von Eije KJ, Centlivre M, Spits H, Weijer K, et al. Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model. Gene Ther. 2009;16:148-53.
-
(2009)
Gene Ther.
, vol.16
, pp. 148-153
-
-
Brake, O.1
Legrand, N.2
Eije, K.J.3
Centlivre, M.4
Spits, H.5
Weijer, K.6
-
175
-
-
33746210111
-
Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration
-
Nishitsuji H, Kohara M, Kannagi M, Masuda T. Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol. 2006;80:7658-66.
-
(2006)
J Virol.
, vol.80
, pp. 7658-7666
-
-
Nishitsuji, H.1
Kohara, M.2
Kannagi, M.3
Masuda, T.4
-
176
-
-
0037173610
-
Modulation of HIV-1 replication by RNA interference
-
Jacque JM, Triques K, Stevenson M. Modulation of HIV-1 replication by RNA interference. Nature. 2002;418:435-8.
-
(2002)
Nature.
, vol.418
, pp. 435-438
-
-
Jacque, J.M.1
Triques, K.2
Stevenson, M.3
-
177
-
-
0037032933
-
Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication
-
Martinez MA, Gutierrez A, Armand-Ugon M, Blanco J, Parera M, Gomez J, et al. Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. AIDS. 2002;16:2385-90.
-
(2002)
AIDS.
, vol.16
, pp. 2385-2390
-
-
Martinez, M.A.1
Gutierrez, A.2
Armand-Ugon, M.3
Blanco, J.4
Parera, M.5
Gomez, J.6
-
178
-
-
84876783559
-
Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes
-
Xu WW, Han MJ, Chen D, Chen L, Guo Y, Willden A, et al. Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes. BMC Med Genomics. 2013;6:15.
-
(2013)
BMC Med Genomics.
, vol.6
, pp. 15
-
-
Xu, W.W.1
Han, M.J.2
Chen, D.3
Chen, L.4
Guo, Y.5
Willden, A.6
-
179
-
-
84870670336
-
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
-
Christ F, Debyser Z. The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy. Virology. 2013;435:102-9.
-
(2013)
Virology.
, vol.435
, pp. 102-109
-
-
Christ, F.1
Debyser, Z.2
-
180
-
-
63549131996
-
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome
-
Zaitseva L, Cherepanov P, Leyens L, Wilson SJ, Rasaiyaah J, Fassati A. HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology. 2009;6:11.
-
(2009)
Retrovirology.
, vol.6
, pp. 11
-
-
Zaitseva, L.1
Cherepanov, P.2
Leyens, L.3
Wilson, S.J.4
Rasaiyaah, J.5
Fassati, A.6
-
181
-
-
34748852513
-
Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy
-
Al-Mawsawi LQ, Neamati N. Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy. Trends Pharmacol Sci. 2007;28:526-35.
-
(2007)
Trends Pharmacol Sci.
, vol.28
, pp. 526-535
-
-
Al-Mawsawi, L.Q.1
Neamati, N.2
-
182
-
-
1242342082
-
Inhibition of Human Immunodeficiency Virus Type 1 replication by RNA interference directed against Human Transcription Elongation Factor P-TEFb (CDK9/CyclinT1)
-
Chiu YL, Cao H, Jacque JM, Stevenson M, Rana TM. Inhibition of Human Immunodeficiency Virus Type 1 replication by RNA interference directed against Human Transcription Elongation Factor P-TEFb (CDK9/CyclinT1). J Virol. 2004;78:2517-29.
-
(2004)
J Virol.
, vol.78
, pp. 2517-2529
-
-
Chiu, Y.L.1
Cao, H.2
Jacque, J.M.3
Stevenson, M.4
Rana, T.M.5
-
183
-
-
18144372773
-
Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5
-
Ping YH, Chu CY, Cao H, Jacque JM, Stevenson M, Rana TM. Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology. 2004;1:46.
-
(2004)
Retrovirology.
, vol.1
, pp. 46
-
-
Ping, Y.H.1
Chu, C.Y.2
Cao, H.3
Jacque, J.M.4
Stevenson, M.5
Rana, T.M.6
|