A dual function TAR Decoy serves as an anti-HIV siRNA delivery vehicle

Virology Journal

Volumn 7, Issue , 2010, Pages

  Unwalla, Hoshang J ^a   Rossi, John J ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; VIRUS DNA; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOLOGICAL PRODUCT;

ARTICLE; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PROTEIN BINDING; REPORTER GENE; RNA INTERFERENCE; CELL LINE; CONFORMATION; DRUG EFFECT; GENE SILENCING; GENETICS; HUMAN; LONG TERMINAL REPEAT; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ANTI-HIV AGENTS; BASE SEQUENCE; BIOLOGICAL PRODUCTS; CELL LINE; GENE KNOCKDOWN TECHNIQUES; HIV; HIV LONG TERMINAL REPEAT; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA, SMALL INTERFERING;

EID: 77949418266     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-7-33     Document Type: Article

References (28)

1. Transduction of human CD34+ hematopoietic progenitor cells by a retroviral vector expressing an RRE decoy inhibits human immunodeficiency virus type 1 replication in myelomonocytic cells produced in long-term culture. I Bahner K Kearns QL Hao EM Smogorzewska DB Kohn, J Virol 1996 70 4352 4360 8676458
2. Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages. A Banerjea MJ Li L Remling J Rossi R Akkina, AIDS Res Ther 2004 1 2 10.1186/1742-6405-1-2 15813986
3. A nucleolar TAR decoy inhibitor of HIV-1 replication. A Michienzi S Li JA Zaia JJ Rossi, Proc Natl Acad Sci USA 2002 99 14047 14052 10.1073/pnas. 212229599 12376617
4. RevM10-mediated inhibition of HIV-1 replication in chronically infected T cells. S Escaich C Kalfoglou I Plavec S Kaushal JD Mosca E Bohnlein, Hum Gene Ther 1995 6 625 634 10.1089/hum.1995.6.5-625 7578399
5. High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS. I Plavec M Agarwal KE Ho M Pineda J Auten J Baker H Matsuzaki S Escaich M Bonyhadi E Bohnlein, Gene Ther 1997 4 128 139 10.1038/sj.gt.3300369 9081703
6. Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein. HJ Unwalla HT Li I Bahner MJ Li D Kohn JJ Rossi, J Virol 2006 80 1863 1873 10.1128/JVI.80.4.1863- 1873.2006 16439542
7. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. NJ Caplen S Parrish F Imani A Fire RA Morgan, Proc Natl Acad Sci USA 2001 98 9742 9747 10.1073/pnas.171251798 11481446
8. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. SM Elbashir J Harborth W Lendeckel A Yalcin K Weber T Tuschl, Nature 2001 411 494 498 10.1038/35078107 11373684
9. A system for stable expression of short interfering RNAs in mammalian cells. TR Brummelkamp R Bernards R Agami, Science 2002 296 550 553 10.1126/science.1068999 11910072
10. Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. NS Lee T Dohjima G Bauer H Li MJ Li A Ehsani P Salvaterra J Rossi, Nat Biotechnol 2002 20 500 505 11981565
11. microRNA-guided posttranscriptional gene regulation. PY Chen G Meister, Biol Chem 2005 386 1205 1218 10.1515/BC.2005.139 16336116
12. The developmental role of microRNA in plants. CA Kidner RA Martienssen, Curr Opin Plant Biol 2005 8 38 44 10.1016/j.pbi.2004.11.008 15653398
13. The microRNA: overview of the RNA gene that modulates gene functions. SY Ying DC Chang JD Miller SL Lin, Methods Mol Biol 2006 342 1 18 16957363
14. Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. LA Aagaard J Zhang KJ von Eije H Li P Saetrom M Amarzguioui JJ Rossi, Gene Ther 2008 15 1536 1549 10.1038/gt.2008.147 18800151
15. Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5. S Barth T Pfuhl A Mamiani C Ehses K Roemer E Kremmer C Jaker J Hock G Meister FA Grasser, Nucleic Acids Res 2008 36 666 675 10.1093/nar/gkm1080 18073197
16. A viral microRNA functions as an orthologue of cellular miR-155. E Gottwein N Mukherjee C Sachse C Frenzel WH Majoros JT Chi R Braich M Manoharan J Soutschek U Ohler BR Cullen, Nature 2007 450 1096 1099 10.1038/nature05992 18075594
17. A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication. F Grey H Meyers EA White DH Spector J Nelson, PLoS Pathog 2007 3 163 10.1371/journal.ppat.0030163 17983268
18. Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element. DL Ouellet I Plante P Landry C Barat ME Janelle L Flamand MJ Tremblay P Provost, Nucleic Acids Res 2008 36 2353 2365 10.1093/nar/gkn076 18299284
19. Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. TM Rana KT Jeang, Arch Biochem Biophys 1999 365 175 185 10.1006/abbi.1999.1206 10328810
20. Discoveries of Tat-TAR interaction inhibitors for HIV-1. M Yang, Curr Drug Targets Infect Disord 2005 5 433 444 10.2174/156800505774912901 16535863
21. High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region. MJ Churcher C Lamont F Hamy C Dingwall SM Green AD Lowe JG Butler MJ Gait J Karn, J Mol Biol 1993 230 90 110 10.1006/jmbi.1993.1128 8450553
22. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. DH Kim M Longo Y Han P Lundberg E Cantin JJ Rossi, Nat Biotechnol 2004 22 321 325 10.1038/nbt940 14990954
23. Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition. BJ Calnan S Biancalana D Hudson AD Frankel, Genes Dev 1991 5 201 210 10.1101/gad.5.2.201 1899841
24. Functional siRNA expression from transfected PCR products. D Castanotto H Li JJ Rossi, RNA 2002 8 1454 1460 10.1017/S1355838202021362 12458798
25. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. P Kumar HS Ban SS Kim H Wu T Pearson DL Greiner A Laouar J Yao V Haridas K Habiro, et al. Cell 2008 134 577 586 10.1016/j.cell.2008.06.034 18691745
26. Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. J Zhou H Li S Li J Zaia JJ Rossi, Mol Ther 2008 16 1481 1489 10.1038/mt.2008.92 18461053
27. Molecular cloning: A Laboratory Manual. J Sambrook EF Fritsch T Maniatis, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA 1989
28. Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA. HJ Unwalla MJ Li JD Kim HT Li A Ehsani J Alluin JJ Rossi, Nat Biotechnol 2004 22 1573 1578 10.1038/nbt1040 15568018