Recent progress in gene therapy to deliver nucleic acids with multivalent cationic vectors

Advances in Colloid and Interface Science

Volumn 233, Issue , 2016, Pages 161-175

  Junquera, Elena ^a   Aicart, Emilio ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Cationic polyrotaxanes; DNA; Gemini or multivalent cationic lipids; Gene therapy; Polycations; siRNA

Indexed keywords

BIOACTIVITY; BIOCOMPATIBILITY; BIOMOLECULES; DNA; GENES; LIPIDS; MEDICAL NANOTECHNOLOGY; NUCLEIC ACIDS; VECTORS;

BIOPHYSICAL CHARACTERIZATION; CATIONIC LIPIDS; CATIONIC POLYMERS; EXPERIMENTAL METHODS; OPTIMUM FORMULATION; POLYCATIONS; POLYROTAXANES; SIRNA;

GENE THERAPY;

LIPID; NUCLEIC ACID; POLYAMINE; POLYCATIONS; QUATERNARY AMMONIUM DERIVATIVE; ROTAXANE;

ANIMAL; CHEMISTRY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETIC DISORDER; GENETICS; HUMAN; NEOPLASM; PATHOLOGY; PHARMACOKINETICS; PROCEDURES;

ANIMALS; GENE TRANSFER TECHNIQUES; GENETIC DISEASES, INBORN; GENETIC THERAPY; GENETIC VECTORS; HUMANS; LIPIDS; NEOPLASMS; NUCLEIC ACIDS; POLYAMINES; QUATERNARY AMMONIUM COMPOUNDS; ROTAXANES;

EID: 84938705153     PISSN: 00018686     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cis.2015.07.003     Document Type: Review

References (214)

1. W.F. Anderson Human gene therapy Nature 392 1998 25 30
2. Y. Yang, F.A. Nunes, K. Berencsi, E. Goenczoel, J.F. Engelhardt, and J.M. Wilson Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis Nat Genet 7 1994 362 369
3. D.D. Lasic Liposomes in gene delivery 1997 CRC Press Boca Raton, FL
4. T. Montier, T. Benvegnu, P.A. Jaffres, J.J. Yaouanc, and P. Lehn Progress in cationic lipid-mediated gene transfection: a series of bio-inspired lipids as an example Curr Gene Ther 8 2008 296 312
5. I.M. Verma, and M.D. Weitzman Gene therapy: twenty-first century medicine Annu Rev Biochem 74 2005 711 738
6. R.S. Dias, and B. Lindman DNA interaction with polymers and surfactants 2008 Wiley & Sons Hoboken
7. M. Donkuru, I. Badea, S. Wettig, R. Verrall, M. Elsabahy, and M. Foldvari Advancing nonviral gene delivery: lipid- and surfactant-based nanoparticle design strategies Nanomedicine 5 2010 1103 1127
8. P.P. Karmali, and A. Chaudhuri Cationic liposomes as non-viral carriers of gene medicines: resolved issues, open questions, and future promises Med Res Rev 27 2007 696 722
9. A.J. Kirby, P. Camilleri, J. Engberts, M.C. Feiters, R.J.M. Nolte, O. Soderman, and et al. Gemini surfactants: new synthetic vectors for gene transfection Angew Chem Int Ed 42 2003 1448 1457
10. C. Nicolazzi, M. Garinot, N. Mignet, D. Scherman, and M. Bessodes Cationic lipids for transfection Curr Med Chem 10 2003 1263 1277
11. D.F. Zhi, S.B. Zhang, B. Wang, Y.N. Zhao, B.L. Yang, and S.J. Yu Transfection efficiency of cationic lipids with different hydrophobic domains in gene delivery Bioconjug Chem 21 2010 563 577
12. K. Ewert, N.L. Slack, A. Ahmad, H.M. Evans, A.J. Lin, C.E. Samuel, and et al. Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level Curr Med Chem 11 2004 133 149
13. E. Junquera, and E. Aicart Cationic lipids as transfecting agents of DNA in gene therapy Curr Top Med Chem 14 2014 649 663
14. M.A. Islam, T.E. Park, B. Singh, S. Maharjan, J. Firdous, M.H. Cho, and et al. Major degradable polycations as carriers for DNA and siRNA J Control Release 193 2014 74 89
15. D. Zhi, S. Zhang, S. Cui, Y. Zhao, Y. Wang, and D. Zhao The headgroup evolution of cationic lipids for gene delivery Bioconjug Chem 24 2013 487 519
16. P. Kesharwani, V. Gajbhiye, and N.K. Jain A review of nanocarriers for the delivery of small interfering RNA Biomaterials 33 2012 7138 7150
17. B. Khurana, A.K. Goyal, A. Budhiraja, D. Arora, and S.P. Vyas siRNA delivery using nanocarriers - an efficient tool for gene silencing Curr Gene Ther 10 2010 139 155
18. J.H. Felgner, T.R. Gadek, M. Holm, R. Roman, H.W. Chan, M. Wenz, and et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc Natl Acad Sci U S A 84 1987 7413 7417
19. L. Huang, M.C. Hung, and E. Wagner Nonviral vectors for gene therapy 1999 Academic Press San Diego
20. S. Bhattacharya, and A. Bajaj Advances in gene delivery through molecular design of cationic lipids Chem Commun 2009 4632 4656
21. A. Estevez-Torres, and D. Baigl DNA compaction: fundamentals and applications Soft Matter 7 2011 6746 6756
22. A. Bilalov, U. Olsson, and B. Lindman Complexation between DNA and surfactants and lipids: phase behavior and molecular organization Soft Matter 8 2012 11022 11033
23. Y.S. Tarahovsky Cell transfection by DNA-lipid complexes - lipoplexes Biochemistry (Mosc) 74 2009 1293 1304
24. S. Chesnoy, and L. Huang Structure and function of lipid-DNA complexes for gene delivery Annu Rev Biophys Biomol Struct 29 2000 27 47
25. N. Dan, and D. Danino Structure and kinetics of lipid-nucleic acid complexes Adv Colloid Interface Sci 205 2014 230 239
26. M.B. Bally, P. Harvie, F.M.P. Wong, S. Kong, E.K. Wasan, and D.L. Reimer Biological barriers to cellular delivery of lipid-based DNA carriers Adv Drug Deliv Rev 38 1999 291 315
27. P.R. Clark, and E.M. Hersh Cationic lipid-mediated gene transfer: current concepts Curr Opin Mol Ther 1 1999 158 176
28. M.C. Pedroso de Lima, S. Simoes, P. Pires, H. Faneca, and N. Duzgunes Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications Adv Drug Deliv Rev 47 2001 277 294
29. C. Lonez, M. Vandenbranden, and J.M. Ruysschaert Cationic lipids activate intracellular signaling pathways Adv Drug Deliv Rev 64 2012 1749 1758
30. I.S. Zuhorn, J. Engberts, and D. Hoekstra Gene delivery by cationic lipid vectors: overcoming cellular barriers Eur Biophys J 36 2007 349 362
31. C. Tros de Ilarduya, L. Garcia, and N. Düzgünes Liposomes and lipopolymeric carriers for gene delivery J Microencapsul 27 2010 602 608
32. R. Koynova, and B. Tenchov Cationic phospholipids: structure-transfection activity relationships Soft Matter 5 2009 3187 3200
33. G. Caracciolo, and H. Amenitsch Cationic liposome/DNA complexes: from structure to interactions with cellular membranes Eur Biophys J 41 2012 815 829
34. B.C. Ma, S.B. Zhang, H.M. Jiang, B.D. Zhao, and H.T. Lv Lipoplex morphologies and their influences on transfection efficiency in gene delivery J Control Release 123 2007 184 194
35. C.R. Safinya, K. Ewert, A. Ahmad, H.M. Evans, U. Raviv, D.J. Needleman, and et al. Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications Philos Trans R Soc A 364 2006 2573 2596
36. C.R. Safinya, K.K. Ewert, R.N. Majzoub, and C. Leal Cationic liposome-nucleic acid complexes for gene delivery and gene silencing New J Chem 38 2014 5164 5172
37. V.D. Sharma, and M.A. Ilies Heterocyclic cationic gemini surfactants: a comparative overview of their synthesis, self-assembling, physicochemical, and biological properties Med Res Rev 34 2014 1 44
38. G. Lin, H. Zhang, and L. Huang Smart polymeric nanoparticles for cancer gene delivery Mol Pharm 12 2015
39. Y.N. Yue, and C. Wu Progress and perspectives in developing polymeric vectors for in vitro gene delivery Biomater Sci 1 2013 152 170
40. R.V. Rodik, A.S. Klymchenko, Y. Mely, and V.I. Kalchenko Calixarenes and related macrocycles as gene delivery vehicles J Incl Phenom Macrocycl Chem 80 2014 189 200
41. J. Li, and X.J. Loh Cyclodextrin-based supramolecular architectures: syntheses, structures, and applications for drug and gene delivery Adv Drug Deliv Rev 60 2008 1000 1017
42. W.F. Lai Cyclodextrins in non-viral gene delivery Biomaterials 35 2014 401 411
43. J.X. Zhang, and P.X. Ma Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective Adv Drug Deliv Rev 65 2013 1215 1233
44. M.L. Ainalem, and T. Nylander DNA condensation using cationic dendrimers-morphology and supramolecular structure of formed aggregates Soft Matter 7 2011 4577 4594
45. S.K. Misra, M. Muñoz-Ubeda, S. Data, A.L. Barran-Berdon, C. Aicart-Ramos, P. Castro-Hartmann, and et al. Effects of a delocalizable cation on the headgroup of gemini lipids on the lipoplex-type nano-aggregates directly formed from plasmid DNA Biomacromolecules 14 2013 3951 3963
46. A. Bajaj, P. Kondaiah, and S. Bhattacharya Gene transfection efficacies of novel cationic gemini lipids possessing aromatic backbone and oxyethylene spacers Biomacromolecules 9 2008 991 999
47. L. Ciani, A. Casini, C. Gabbiani, S. Ristori, L. Messori, and G. Martini DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques Biophys Chem 127 2007 213 220
48. L. Ciani, S. Ristori, C. Bonechi, C. Rossi, and G. Martin Effect of the preparation procedure on the structural properties of oligonucleotide/cationic liposome complexes (lipoplexes) studied by electron spin resonance and zeta potential Biophys Chem 131 2007 80 87
49. R. Marty, C.N. N'Soukpoe-Kossi, D. Charbonneau, C.M. Weinert, L. Kreplak, and H.A. Tajmir-Riahi Structural analysis of DNA complexation with cationic lipids Nucleic Acid Res 37 2009 849 857
50. C. Srinivasan, and D.J. Burgess Optimization and characterization of anionic lipoplexes for gene delivery J Control Release 136 2009 62 70
51. L. Wasungu, and D. Hoekstra Cationic lipids, lipoplexes and intracellular delivery of genes J Control Release 116 2006 255 264
52. A. Rodriguez-Pulido, E. Aicart, O. Llorca, and E. Junquera Compaction process of calf thymus DNA by mixed cationic-zwitterionic liposomes: a physicochemical study J Phys Chem B 112 2008 2187 2197
53. X.F. Zhao, Y.H. Shang, J. Hu, H.L. Liu, and Y. Hu Biophysical characterization of complexation of DNA with oppositely charged gemini surfactant 12-3-12 Biophys Chem 138 2008 144 149
54. M. Muñoz-Ubeda, S.K. Misra, A.L. Barran-Berdon, S. Data, C. Aicart-Ramos, P. Castro-Hartmann, and et al. How does the spacer length of cationic gemini lipids influence the lipoplex formation with plasmid DNA? Physicochemical and biochemical characterizations and their relevance in gene therapy Biomacromolecules 13 2012 3926 3937
55. M.Q. Ao, P.P. Huang, G.Y. Xu, X.D. Yang, and Y.J. Wang Aggregation and thermodynamic properties of ionic liquid-type gemini imidazolium surfactants with different spacer length Colloid Polym Sci 287 2009 395 402
56. Q.D. Huang, W.J. Ou, H. Chen, Z.H. Feng, J.Y. Wang, J.Z.W. Zhu, and et al. Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery Eur J Pharm Biopharm 78 2011 326 335
57. A. Bhadani, and S. Singh Novel gemini pyridinium surfactants: synthesis and study of their surface activity, DNA binding, and cytotoxicity Langmuir 25 2009 11703 11712
58. V. Chauhan, S. Singh, R. Kamboj, R. Mishra, and G. Kaur Self-assembly, DNA binding and cytotoxicity trends of ether functionalized gemini pyridinium amphiphiles J Colloid Interface Sci 417 2014 385 395
59. E. Fisicaro, C. Compari, F. Bacciottini, L. Contardi, N. Barbero, G. Viscardi, and et al. Nonviral gene delivery: gemini bispyridinium surfactant-based DNA nanoparticles J Phys Chem B 118 2014 13183 13191
60. A.L. Barran-Berdon, M. Muñoz-Ubeda, C. Aicart-Ramos, L. Perez, M.R. Infante, P. Castro-Hartmann, and et al. Ribbon-type and cluster-type lipoplexes constituted by a chiral lysine based cationic gemini lipid and plasmid DNA Soft Matter 8 2012 7368 7380
61. M.R. Infante, L. Perez, M.C. Moran, R. Pons, M. Mitjans, M.P. Vinardell, and et al. Biocompatible surfactants from renewable hydrophiles Eur J Lipid Sci Technol 112 2010 110 121
62. M. Damen, E. Cristobal-Lecina, G.C. Sanmarti, S.F.M. van Dongen, C.L. Garcia Rodriguez, I.P. Dolbnya, and et al. Structure-delivery relationships of lysine-based gemini surfactants and their lipoplexes Soft Matter 10 2014 5702 5714
63. A. Zidovska, H.M. Evans, K.K. Ewert, J. Quispe, B. Carragher, C.S. Potter, and et al. Liquid crystalline phases of dendritic lipid-DNA self-assemblies: lamellar, hexagonal, and DNA bundles J Phys Chem B 113 2009 3694 3703
64. Y. Obata, S. Saito, N. Takeda, and S. Takeoka Plasmid DNA-encapsulating liposomes: effect of a spacer between the cationic head group and hydrophobic moieties of the lipids on gene expression efficiency Biochim Biophys Acta 2009 1788 1148 1158
65. T. Dewa, T. Asai, Y. Tsunoda, K. Kato, D. Baba, M. Uchida, and et al. Liposomal polyamine-dialkyl phosphate conjugates as effective gene carriers: chemical structure, morphology, and gene transfer activity Bioconjug Chem 21 2010 844 852
66. G. Candiani, D. Pezzoli, L. Ciani, R. Chiesa, and S. Ristori Bioreducible liposomes for gene delivery: from the formulation to the mechanism of action PLoS One 5 2010 e13430
67. R.S. Shirazi, K.K. Ewert, C. Leal, R.N. Majzoub, N.F. Bouxsein, and C.R. Safinya Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery Biochim Biophys Acta 2011 1808 2156 2166
68. I.S. Zuhorn, U. Bakowsky, E. Polushkin, W.H. Visser, M.C.A. Stuart, J.B.F.N. Engberts, and et al. Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency Mol Ther 11 2005 801 810
69. D. Hirsch-Lerner, M. Zhang, H. Eliyahu, M.E. Ferrari, C.J. Wheeler, and Y. Barenholz Effect of "helper lipid" on lipoplex electrostatics Biochim Biophys Acta 2005 1714 71 84
70. A. Salvati, L. Ciani, S. Ristori, G. Martini, A. Masi, and A. Arcangeli Physico-chemical characterization and transfection efficacy of cationic liposomes containing the pEGFP plasmid Biophys Chem 121 2006 21 29
71. M. Muñoz-Ubeda, S.K. Misra, A.L. Barran-Berdon, C. Aicart-Ramos, M.B. Sierra, J. Biswas, and et al. Why is less cationic lipid required to prepare lipoplexes from plasmid DNA than linear DNA in gene therapy? J Am Chem Soc 133 2011 18014 18017
72. C. Leal, K.K. Ewert, R.S. Shirazi, N.F. Bouxsein, and C.R. Safinya Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing Langmuir 27 2011 7691 7697
73. C. Leal, N.F. Bouxsein, K.K. Ewert, and C.R. Safinya Highly efficient gene silencing activity of siRNA embedded in a nanostructured gyroid cubic lipid matrix J Am Chem Soc 132 2010 16841 16847
74. R. Zana, and J. Xia Gemini surfactants 2004 Marcel Dekker, Inc. New York
75. K. Kumar, A.L. Barran-Berdon, S. Datta, M. Munoz-Ubeda, C. Aicart-Ramos, P. Kondaiah, and et al. A delocalizable cationic headgroup together with an oligo-oxyethylene spacer in gemini cationic lipids improves their biological activity as vectors of plasmid DNA J Mater Chem B 3 2015 1495 1506
76. J.P. Behr, B. Demeemeix, J.P. Loeffler, and J. Perez-Mutul Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA Proc Natl Acad Sci U S A 86 1989 6982 6986
77. A. Ahmad, H.M. Evans, K. Ewert, C.X. George, C.E. Samuel, and C.R. Safinya New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery J Gene Med 7 2005 739 748
78. K.K. Ewert, H.M. Evans, N.F. Bouxsein, and C.R. Safinya Dendritic cationic lipids with highly charged headgroups for efficient gene delivery Bioconjug Chem 17 2006 877 888
79. O. Boussif, F. Lezoualch, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in-vivo - polyethylenimine Proc Natl Acad Sci U S A 92 1995 7297 7301
80. M.L. Orberg, K. Schillen, and T. Nylander Dynamic light scattering and fluorescence study of the interaction between double-stranded DNA and poly(amido amine) dendrimers Biomacromolecules 8 2007 1557 1563
81. Y. Aoyama Macrocyclic glycoclusters: from amphiphiles through nanoparticles to glycoviruses Chem Eur J 10 2004 588 593
82. M. Dudic, A. Colombo, F. Sansone, A. Casnati, G. Donofrio, and R. Ungaro A general synthesis of water soluble upper rim calix[n]arene guanidinium derivatives which bind to plasmid DNA Tetrahedron 60 2004 11613 11618
83. C. Ortiz-Mellet, J.M. Garcia-Fernandez, and J.M. Benito Glycotransporters for gene delivery A.P. Rauter, T.K. Lindhorst, Carbohydrate Chemistry: Chemical and Biological Approaches vol. 38 2012 338 375
84. C. Ortiz Mellet, J.M. Benito, and J.M. García-Fernandez Preorganized, macromolecular, gene-delivery systems Chem Eur J 16 2010 6728 6742
85. L. Brito, S. Little, R. Langer, and M. Amiji Poly(beta-amino ester) and cationic phospholipid-based lipopolyplexes for gene delivery and transfection in human aortic endothelial and smooth muscle cells Biomacromolecules 9 2008 1179 1187
86. N. Penacho, M. Rosa, B. Lindman, M.G. Miguel, S. Simoes, and M.C.P. de Lima Physicochemical properties of transferrin-associated lipopolyplexes and their role in biological activity Colloids Surf B 76 2010 207 214
87. L. Garcia-Rio, F.J. Otero-Espinar, A. Luzardo-Alvarez, and J. Blanco-Mendez Cyclodextrin based rotaxanes, polyrotaxanes and polypseudorotaxanes and their biomedical applications Curr Top Med Chem 14 2014 478 493
88. A. Kulkarni, K. DeFrees, R.A. Schuldt, A. Vlahu, R. VerHeul, S.-H. Hyun, and et al. Multi-armed cationic cyclodextrin:poly(ethylene glycol) polyrotaxanes as efficient gene silencing vectors Integr Biol 5 2013 115 121
89. C. Yang, X. Wang, H.Z. Li, E. Tan, C.T. Lim, and J. Li Cationic polyrotaxanes as gene carriers: physicochemical properties and real-time observation of DNA complexation, and gene transfection in cancer cells J Phys Chem B 113 2009 7903 7911
90. R.C. Jiang, X.M. Lu, M.H. Yang, W.X. Deng, Q.L. Fan, and W. Huang Monodispersed brush-like conjugated polyelectrolyte nanoparticles with efficient and visualized siRNA delivery for gene silencing Biomacromolecules 14 2013 3643 3652
91. Y.F. He, Y.Z. Shang, S. Shao, H.L. Liu, and Y. Hu Micellization of cationic gemini surfactant and its interaction with DNA in dilute brine J Colloid Interface Sci 358 2011 513 520
92. J. Sparks, and C. Scholz Evaluation of a cationic poly(beta-hydroxyalkanoate) as a plasmid DNA delivery system Biomacromolecules 10 2009 1715 1719
93. A.L. Barran-Berdon, S.K. Misra, S. Datta, M. Muñoz-Ubeda, P. Kondaiah, E. Junquera, and et al. Cationic gemini lipids containing polyoxyethylene spacers as improved transfecting agents of plasmid DNA in cancer cells J Mater Chem B 2 2014 4640 4652
94. A.H. Casé, I.P.D. Picola, M.E.D. Zaniquelli, J.C. Fernandes, S.R. Taboga, F.M. Winnik, and et al. Physicochemical characterization of nanoparticles formed between DNA and phosphorylcholine substituted chitosans J Colloid Interface Sci 336 2009 125 133
95. L.E. Prevette, M.L. Lynch, and T.M. Reineke Amide spacing influences pDNA binding of poly(amidoamine)s Biomacromolecules 11 2010 326 332
96. Z. Pietralik, R. Krzyszton, W. Kida, W. Andrzejewska, and M. Kozak Structure and conformational dynamics of DMPC/Dicationic surfactant and DMPC/Dicationic surfactant/DNA systems Int J Mol Sci 14 2013 7642 7659
97. S. Sajeesh, J.Y. Choe, T.Y. Lee, and D.K. Lee Guanidine modified polyethyleneimine-g-polyethylene glycol nanocarriers for long interfering RNA (liRNA) based advanced anticancer therapy J Mater Chem B 3 2015 207 216
98. S.K. Filippov, C. Konak, P. Kopeckova, L. Starovoytova, M. Spirkova, and P. Stepanek Effect of hydrophobic interactions on properties and stability of DNA-polyelectrolyte complexes Langmuir 26 2010 4999 5006
99. R. Kamboj, S. Singh, A. Bhadani, H. Kataria, and G. Kaur Gemini imidazolium surfactants: synthesis and their biophysiochemical study Langmuir 28 2012 11969 11978
100. Y. Hu, K.Y. Cai, Z. Luo, and R. Hu Construction of polyethyleneimine-beta-cyclodextrin/pDNA multilayer structure for improved in situ gene transfection Adv Eng Mater 12 2010 B18 B25
101. M.Y. Arteta, D. Berti, C. Montis, R.A. Campbell, L.A. Clifton, M.W.A. Skoda, and et al. Molecular recognition of nucleic acids by nucleolipid/dendrimer surface complexes Soft Matter 10 2014 8401 8405
102. E. Froehlich, J.S. Mandeville, C.M. Weinert, L. Kreplak, and H.A. Tajmir-Riahi Bundling and aggregation of DNA by cationic dendrimers Biomacromolecules 12 2011 511 517
103. L.J. van der Aa, P. Vader, G. Storm, R.M. Schiffelers, and J.F.J. Engbersen Optimization of poly(amido amine)s as vectors for siRNA delivery J Control Release 150 2011 177 186
104. Y. Zhang, J. Chen, C.S. Xiao, M.Q. Li, H.Y. Tian, and X.S. Chen Cationic dendron-bearing lipids: investigating structure-activity relationships for small interfering RNA delivery Biomacromolecules 14 2013 4289 4300
105. A.M. Cardoso, M.T. Calejo, C.M. Morais, A.L. Cardoso, R. Cruz, K.Z. Zhu, and et al. Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery Mol Pharm 11 2014 819 827
106. A. Diaz-Moscoso, D. Vercauteren, J. Rejman, J.M. Benito, C. Ortiz-Mellet, S.C. De Smedt, and et al. Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes) J Control Release 143 2010 318 325
107. Q.F. Zhang, Q.Y. Yu, Y.Y. Geng, J. Zhang, W.X. Wu, G. Wang, and et al. Ring-opening polymerization for hyperbranched polycationic gene delivery vectors with excellent serum tolerance ACS Appl Mater Interfaces 6 2014 15733 15742
108. L. Xue, N.P. Ingle, and T.M. Reineke Highlighting the role of polymer length, carbohydrate size, and nucleic acid type in potency of glycopolycation agents for pDNA and siRNA delivery Biomacromolecules 14 2013 3903 3915
109. P. Luciani, C. Bombelli, M. Colone, L. Giansanti, S.J. Ryhanen, V.M.J. Saily, and et al. Influence of the spacer of cationic gemini amphiphiles on the hydration of lipoplexes Biomacromolecules 8 2007 1999 2003
110. I. Badea, S. Wettig, R. Verrall, and M. Foldvari Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice Eur J Pharm Biopharm 65 2007 414 422
111. P. Yang, J. Singh, S. Wettig, M. Foldvari, R.E. Verrall, and I. Badea Enhanced gene expression in epithelial cells transfected with amino acid-substituted gemini nanoparticles Eur J Pharm Biopharm 75 2010 311 320
112. X.F. Zhao, Y.Z. Shang, H.L. Liu, and Y. Hu Complexation of DNA with cationic gemini surfactant in aqueous solution J Colloid Interface Sci 314 2007 478 483
113. P. Pullmannova, M. Bastos, G.Y. Bai, S.S. Funari, I. Lacko, F. Devinsky, and et al. The ionic strength effect on the DNA complexation by DOPC - gemini surfactants liposomes Biophys Chem 160 2012 35 45
114. S. Ristori, L. Ciani, G. Candiani, C. Battistini, A. Frati, I. Grillo, and et al. Complexing a small interfering RNA with divalent cationic surfactants Soft Matter 8 2012 749 756
115. F. Bordi, G. Cerichelli, N. de Berardinis, M. Diociaiuti, L. Giansanti, G. Mancini, and et al. Synthesis and physicochemical characterization of new twin-tailed N-oxide based gemini surfactants Langmuir 26 2010 6177 6183
116. S.G. Silva, I.S. Oliveira, M.L.C. do Vale, and E.F. Marques Serine-based gemini surfactants with different spacer linkages: from self-assembly to DNA compaction Soft Matter 10 2014 9352 9361
117. J. Biswas, A. Bajaj, and S. Bhattacharya Membranes of cationic gemini lipids based on cholesterol with hydroxyl headgroups and their Interactions with DNA and phospholipid J Phys Chem B 115 2011 478 486
118. S.K. Misra, J. Biswas, P. Kondaiah, and S. Bhattacharya Gene transfection in high serum levels: case studies with new cholesterol based cationic gemini lipids PLoS One 8 2013 e68305
119. S.K. Misra, S. Naz, P. Kondaiah, and S. Bhattacharya A cationic cholesterol based nanocarrier for the delivery of p53-EGFP-C3 plasmid to cancer cells Biomaterials 35 2014 1334 1346
120. H.J. Wang, Y.H. Liu, J. Zhang, Y. Zhang, Y. Xia, and X.Q. Yu Cyclen-based cationic lipids with double hydrophobic tails for efficient gene delivery Biomater Sci 2 2014 1460 1470
121. S.K. Misra, P. Kondaiah, S. Bhattacharya, D. Boturyn, and P. Dumy Co-liposomes comprising a lipidated multivalent RGD-peptide and a cationic gemini cholesterol induce selective gene transfection in alpha v beta 3 and alpha v beta 5 integrin receptor-rich cancer cells J Mater Chem B 2 2014 5758 5767
122. Y.N. Zhao, S.B. Zhang, Y. Zhang, S.H. Cui, H.Y. Chen, D.F. Zhi, and et al. Tri-peptide cationic lipids for gene delivery J Mater Chem B 3 2015 119 126
123. E.J. Adolph, C.E. Nelson, T.A. Werfel, R.J. Guo, J.M. Davidson, S.A. Guelcher, and et al. Enhanced performance of plasmid DNA polyplexes stabilized by a combination of core hydrophobicity and surface PEGylation J Mater Chem B 2 2014 8154 8164
124. S. Joubran, M. Zigler, N. Pessah, S. Klein, A. Shir, N. Edinger, and et al. Optimization of liganded polyethylenimine polyethylene glycol vector for nucleic acid delivery Bioconjug Chem 25 2014 1644 1654
125. S. Hou, N. Ziebacz, S.A. Wieczorek, E. Kalwarczyk, V. Sashuk, T. Kalwarczyk, and et al. Formation and structure of PEI/DNA complexes: quantitative analysis Soft Matter 7 2011 6967 6972
126. T. Memanishvili, N. Zavradashvili, N. Kupatadze, D. Tugushi, M. Gverdtsiteli, V.P. Torchilin, and et al. Arginine-based biodegradable ether-ester polymers with low cytotoxicity as potential gene carriers Biomacromolecules 15 2014 2839 2848
127. S. Lu, V.B. Morris, and V. Labhasetwar Codelivery of DNA and siRNA via arginine-rich PEI-based polyplexes Mol Pharm 12 2015 621 629
128. K. Naicker, M. Ariatti, and M. Singh PEGylated galactosylated cationic liposomes for hepatocytic gene delivery Colloids Surf B 122 2014 482 490
129. A. Kulkarni, V. Badwaik, K. DeFrees, R.A. Schuldt, D.S. Gunasekera, C. Powers, and et al. Effect of pendant group on pDNA delivery by cationic-beta-cyclodextrin:alkyl-PVA-PEG pendant polymer complexes Biomacromolecules 15 2014 12 19
130. A. Kulkarni, W. Deng, S.-H. Hyun, and D.H. Thompson Development of a low toxicity, effective pDNA vector based on noncovalent assembly of bioresponsive amino-beta-cyclodextrin:adamantane-poly(vinyl alcohol)-poly(ethylene glycol) transfection complexes Bioconjug Chem 23 2012 933 940
131. R. Bansal, M. Singh, K.C. Gupta, and P. Kumar Oligoamine-tethered low generation polyamidoamine dendrimers as potential nucleic acid carriers Biomater Sci 2 2014 1275 1286
132. P.T. Wong, K. Tang, A. Coulter, S. Tang, J.R. Baker, and S.K. Choi Multivalent dendrimer vectors with DNA intercalation motifs for gene delivery Biomacromolecules 15 2014 4134 4145
133. Y.H. Song, T.B. Zhang, X.Y. Song, L. Zhang, C.Q. Zhang, J.F. Xing, and et al. Polycations with excellent gene transfection ability based on PVP-g-PDMAEMA with random coil and micelle structures as non-viral gene vectors J Mater Chem B 3 2015 911 918
134. C. Aranda, K. Urbiola, A.M. Ardoy, J.M. García-Fernandez, C. Ortiz-Mellet, and C. Tros de Ilarduya Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo Eur J Pharm Biopharm 85 2013 390 397
135. A. Mendez-Ardoy, N. Guilloteau, C. Di Giorgio, P. Vierling, F. Santoyo-Gonzalez, C. Ortiz-Mellet, and et al. Beta-cyclodextrin-based polycationic amphiphilic "click" clusters: effect of structural modifications in their DNA complexing and delivery properties J Org Chem 76 2011 5882 5894
136. L. Gallego-Yerga, M. Lomazzi, V. Franceschi, F. Sansone, C. Ortiz-Mellet, G. Donofrio, and et al. Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study Org Biomol Chem 13 2015 1708 1723
137. S.D. Wettig, R. Deubry, J. Akbar, T. Kaur, H.T. Wang, T. Sheinin, and et al. Thermodynamic investigation of the binding of dissymmetric pyrenyl-gemini surfactants to DNA Phys Chem Chem Phys 12 2010 4821 4826
138. T. Le Gall, J. Barbeau, S. Barrier, M. Berchel, L. Lemiegre, J. Jeftic, and et al. Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles Mol Pharm 11 2014 2973 2988
139. S. Malhotra, H. Bauer, A. Tschiche, A.M. Staedtler, A. Mohr, M. Calderon, and et al. Glycine-terminated dendritic amphiphiles for nonviral gene delivery Biomacromolecules 13 2012 3087 3098
140. R. Cavalli, A. Bisazza, R. Sessa, L. Primo, F. Fenili, A. Manfredi, and et al. Amphoteric agmatine containing polyamidoamines as carriers for plasmid DNA in vitro and in vivo delivery Biomacromolecules 11 2010 2667 2674
141. V. Villari, A. Mazzaglia, R. Darcy, C.M. O'Driscoll, and N. Micali Nanostructures of cationic amphiphilic cyclodextrin complexes with DNA Biomacromolecules 14 2013 811 817
142. M.J. O' Neill, J.F. Guo, C. Byrne, R. Darcy, and C.M. O' Driscoll Mechanistic studies on the uptake and intracellular trafficking of novel cyclodextrin transfection complexes by intestinal epithelial cells Int J Pharm 413 2011 174 183
143. M. Spelios, M. Kearns, and M. Savva From gene delivery to gene silencing: Plasmid DNA-transfecting cationic lipid 1,3-dimyristoylamidopropane-2-[bis(2-dimethylaminoethane)] carbamate efficiently promotes small Interfering RNA-induced RNA interference Biochemistry 49 2010 5753 5759
144. C. Dhomen, D. Edinger, T. Fröhlich, L. Schreiner, U. Lächelt, C. Troiber, and et al. Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery ACS Nano 6 2012 5198 5208
145. S.Y. Wu, H.-I. Chang, M. Burgess, and N.A.J. McMillan Vaginal delivery of siRNA using a novel PEGylated lipoplex-entrapped alginate scaffold system J Control Release 155 2011 418 426
146. S. Sennato, F. Bordi, and C. Cametti On the phase diagram of reentrant condensation in polyelectrolyte-liposome complexation J Chem Phys 121 2004 4936 4940
147. R.S. Shirazi, K.K. Ewert, B.F.B. Silva, C. Leal, Y.L. Li, and C.R. Safinya Structural evolution of environmentally responsive cationic liposome-DNA complexes with a reducible lipid linker Langmuir 28 2012 10495 10503
148. C.Y. Chen, C.J. Su, S.F. Peng, H.L. Chen, and H.W. Sung Dendrimer-induced DNA bending Soft Matter 7 2011 61 63
149. C.J. Su, H.L. Chen, M.C. Wei, S.F. Peng, H.W. Sung, and V.A. Ivanov Columnar mesophases of the complexes of in DNA with low-generation poly(amido amine) dendrimers Biomacromolecules 10 2009 773 783
150. M. Damen, J. Aarbiou, S.F.M. van Dongen, R.M. Buijs-Offerman, P.P. Spijkers, M. van den Heuvel, and et al. Delivery of DNA and siRNA by novel gemini-like amphiphilic peptides J Control Release 145 2010 33 39
151. S. Falsini, S. Ristori, L. Ciani, E. Di Cola, C.T. Supuran, A. Arcangeli, and et al. Time resolved SAXS to study the complexation of siRNA with cationic micelles of divalent surfactants Soft Matter 10 2014 2226 2233
152. C. Leal, K.K. Ewert, N.F. Bouxsein, R.S. Shirazi, Y.L. Li, and C.R. Safinya Stacking of short DNA induces the gyroid cubic-to-inverted hexagonal phase transition in lipid-DNA complexes Soft Matter 9 2013 795 804
153. L.B. Jensen, K. Mortensen, G.M. Pavan, M.R. Kasimova, D.K. Jensen, V. Gadzhyeva, and et al. Molecular characterization of the interaction between siRNA and PAMAM G7 dendrimers by SAXS, ITC, and molecular dynamics simulations Biomacromolecules 11 2010 3571 3577
154. M. Muñoz-Ubeda, A. Rodriguez-Pulido, A. Nogales, O. Llorca, M. Quesada-Perez, A. Martin-Molina, and et al. Gene vectors based on DOEPC/DOPE mixed cationic liposomes: a physicochemical study Soft Matter 7 2011 5991 6004
155. C. Marchini, D. Pozzi, M. Montani, C. Alfonsi, A. Amici, H. Amenitsch, and et al. Tailoring lipoplex composition to the lipid composition of plasma membrane: a trojan horse for cell entry? Langmuir 26 2010 13867 13873
156. W.L. Hsu, Y.C. Li, H.L. Chen, W. Liou, U.S. Jeng, H.K. Lin, and et al. Thermally-induced order-order transition of DNA-cationic surfactant complexes Langmuir 22 2006 7521 7527
157. R. Koynova, and R.C. MacDonald Natural lipid extracts and biomembrane-mimicking lipid compositions are disposed to form nonlamellar phases, and they release DNA from lipoplexes most efficiently Biochim Biophys Acta 2007 1768 2373 2382
158. R. Koynova, Y.S. Tarahovsky, L. Wang, and R.C. MacDonald Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA Biochim Biophys Acta 2007 1768 375 386
159. C.Z. Wang, X.F. Li, S.D. Wettig, I. Badea, M. Foldvari, and R.E. Verrall Investigation of complexes formed by interaction of cationic gemini surfactants with deoxyribonucleic acid Phys Chem Chem Phys 9 2007 1616 1628
160. X.L. Wang, X.H. Zhang, M.W. Cao, H.Z. Zheng, B. Xiao, Y.L. Wang, and et al. Gemini surfactant-induced DNA condensation into a beadlike structure J Phys Chem B 113 2009 2328 2332
161. E. Froehlich, J.S. Mandeville, D. Arnold, L. Kreplak, and H.A. Tajmir-Riahi PEG and mPEG-anthracene induce DNA condensation and particle formation J Phys Chem B 115 2011 9873 9879
162. M. Alatorre-Meda, P. Taboada, F. Hardl, T. Wagner, M. Freis, and J.R. Rodriguez The influence of chitosan valence on the complexation and transfection of DNA: the weaker the DNA-chitosan binding the higher the transfection efficiency Colloids Surf B 82 2011 54 62
163. A. Kulkarni, R. VerHeul, K. DeFrees, C.J. Collins, R.A. Schuldt, A. Vlahu, and et al. Microfluidic assembly of cationic-beta-cyclodextrin: hyaluronic acid-adamantane host:guest pDNA nanoparticles Biomater Sci 1 2013 1029 1033
164. J.-J. Nie, X.-B. Dou, H. Hu, B. Yu, D.-F. Chen, R.-X. Wang, and et al. Poly(aspartic acid)-based degradable assemblies for highly efficient gene delivery ACS Appl Mater Interfaces 7 2015 553 562
165. V. Bagnacani, V. Franceschi, M. Bassi, M. Lomazzi, G. Donofrio, F. Sansone, and et al. Arginine clustering on calix 4 arene macrocycles for improved cell penetration and DNA delivery Nat Commun 4 2013
166. F. Sansone, M. Dudic, G. Donofrio, C. Rivetti, L. Baldini, A. Casnati, and et al. DNA condensation and cell transfection properties of guanidinium calixarenes: dependence on macrocycle lipophilicity, size, and conformation J Am Chem Soc 128 2006 14528 14536
167. A. Kulkarni, K. DeFrees, S.-H. Hyun, and D.H. Thompson Pendant polymer:amino-β-cyclodextrin:siRNA guest:host nanoparticles as efficient vectors for gene silencing J Am Chem Soc 134 2012 7596 7599
168. A. Kulkarni, K. DeFrees, R.A. Schuldt, S.-H. Hyun, K.J. Wright, C.K. Yerneni, and et al. Cationic alpha-cyclodextrin:poly(ethylene glycol) polyrotaxanes for siRNA delivery Mol Pharm 10 2013 1299 1305
169. A.M. Carnerup, M.L. Ainalem, V. Alfredsson, and T. Nylander Watching DNA condensation induced by poly(amido amine) dendrimers with time-resolved cryo-TEM Langmuir 25 2009 12466 12470
170. M.F.M. Mustapa, S.M. Grosse, L. Kudsiova, M. Elbs, E.A. Raiber, J.B. Wong, and et al. Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell Bioconjug Chem 20 2009 518 532
171. H.K. Kim, D.H. Thompson, H.S. Jang, Y.J. Chung, and J. Van den Bossche pH-responsive biodegradable assemblies containing tunable phenyl-substituted vinyl ethers for use as efficient gene delivery vehicles ACS Appl Mater Interfaces 5 2013 5648 5658
172. A. Zidovska, K.K. Ewert, J. Quispe, B. Carragher, C.S. Potter, and C.R. Safinya The effect of salt and pH on block liposomes studied by cryogenic transmission electron microscopy Biochim Biophys Acta 2009 1788 1869 1876
173. A. Aljaberi, M. Spelios, M. Kearns, B. Selvi, and M. Savva Physicochemical properties affecting lipofection potency of a new series of 1,2-dialkoylamidopropane-based cationic lipids Colloids Surf B 57 2007 108 117
174. A.J. Lin, N.L. Slack, A. Ahmad, C.X. George, C.E. Samuel, and C.R. Safinya Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes Biophys J 84 2003 3307 3316
175. P. Pullmannova, S.S. Funari, F. Devinsky, and D. Uhrikova The DNA-DNA spacing in gemini surfactants-DOPE-DNA complexes Biochim Biophys Acta 2012 1818 2725 2731
176. P.L. Ma, M. Lavertu, F.M. Winnik, and M.D. Buschmann New insights into chitosan-DNA interactions using isothermal titration microcalorimetry Biomacromolecules 10 2009 1490 1499
177. O. Farago, and N. Gronbech-Jensen Molecular simulation analysis of structural variations in lipoplexes Soft Matter 7 2011 4302 4306
178. O. Farago, K. Ewert, A. Ahmad, H.M. Evans, N. Gronbech-Jensen, and C.R. Safinya Transitions between distinct compaction regimes in complexes of multivalent cationic lipids and DNA Biophys J 95 2008 836 846
179. C. Bombelli, F. Faggioli, P. Luciani, G. Mancini, and M.G. Sacco PEGylated lipoplexes: preparation protocols affecting DNA condensation and cell transfection efficiency J Med Chem 50 2007 6274 6278
180. Y.M. Zhang, Y.H. Liu, J. Zhang, Q. Liu, Z. Huang, and X.Q. Yu Cationic gemini lipids with cyclen headgroups: interaction with DNA and gene delivery abilities RSC Adv 4 2014 44261 44268
181. C.L. Chan, K.K. Ewert, R.N. Majzoub, Y.K. Hwu, K.S. Liang, C. Leal, and et al. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content J Gene Med 16 2014 84 96
182. M.N. Antipina, I. Schulze, M. Heinze, B. Dobner, A. Langner, and G. Brezesinski Physical-chemical properties and transfection activity of cationic lipid/DNA complexes ChemPhysChem 10 2009 2471 2479
183. G. Grandinetti, and T.M. Reineke Exploring the mechanism of plasmid DNA nuclear internalization with polymer-based vehicles Mol Pharm 9 2012 2256 2267
184. L. Rose, P. Mahdipoor, C. Kucharski, and H. Uludag Pharmacokinetics and transgene expression of implanted polyethylenimine-based pDNA complexes Biomater Sci 2 2014 833 842
185. A.J. Convertine, C. Diab, M. Prieve, A. Paschal, A.S. Hoffman, P.H. Johnson, and et al. pH-responsive polymeric micelle carriers for siRNA drugs Biomacromolecules 11 2010 2904 2911
186. Y.C. Chung, W.Y. Hsieh, and T.H. Young Polycation/DNA complexes coated with oligonucleotides for gene delivery Biomaterials 31 2010 4194 4203
187. J.G. Piao, J.J. Yan, M.Z. Wang, D.C. Wu, and Y.Z. You A new method to cross-link a polyplex for enhancing in vivo stability and transfection efficiency Biomater Sci 2 2014 390 398
188. Q.K. Lin, K.F. Ren, and J. Ji Hyaluronic acid and chitosan-DNA complex multilayered thin film as surface-mediated nonviral gene delivery system Colloids Surf B 74 2009 298 303
189. Y. Ren, X.A. Jiang, D. Pan, and H.Q. Mao Charge density and molecular weight of polyphosphoramidate gene carrier are key parameters influencing its DNA compaction ability and transfection efficiency Biomacromolecules 11 2010 3432 3439
190. H.S. Hwang, J. Hu, K. Na, and Y.H. Bae Role of polymeric endosomolytic agents in gene transfection: a comparative study of poly(L-lysine) grafted with monomeric L-histidine analogue and poly(L-histidine) Biomacromolecules 15 2014 3577 3586
191. M. Gillard, Z.F. Jia, J. Jia, C. Hou, M. Song, P.P. Gray, and et al. Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers Biomacromolecules 15 2014 3569 3576
192. R.V. Rodik, A.S. Klymchenko, N. Jain, S.I. Miroshnichenko, L. Richert, V.I. Kalchenko, and et al. Virus-sized DNA nanoparticles for gene delivery based on micelles of cationic calixarenes Chem Eur J 17 2011 5526 5538
193. A. Mendez-Ardoy, K. Urbiola, C. Aranda, C. Ortiz-Mellet, J.M. Garcia-Fernandez, and C. Tros de Ilarduya Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery Nanomedicine 6 2011 1697 1707
194. H.W. Yang, J.W. Yi, E.K. Bang, E.M. Jeon, and B.H. Kim Cationic nucleolipids as efficient siRNA carriers Org Biomol Chem 9 2011 291 296
195. C.L. Walsh, J. Nguyen, M.R. Tiffany, and F.C. Szoka Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery Bioconjug Chem 24 2013 36 43
196. A.H. Wu, X.H. Shen, and Y.K. He Investigation on gamma-cyclodextrin nanotube induced by N,N′-diphenylbenzidine molecule J Colloid Interface Sci 297 2006 525 533
197. W.E. Rudzinski, and T.M. Aminabhavi Chitosan as a carrier for targeted delivery of small interfering RNA Int J Pharm 399 2010 1 11
198. C. Buerkli, S.H. Lee, E. Moroz, M.C. Stuparu, J.C. Leroux, and A. Khan Amphipathic homopolymers for siRNA delivery: probing impact of bifunctional polymer composition on transfection Biomacromolecules 15 2014 1707 1715
199. S.K. Hamilton, A.L. Sims, J. Donavan, and E. Harth Non-viral siRNA delivery vectors: dendritic molecular transporter and molecular transporter nanovectors for target gene silencing Polym Chem 2 2011 441 446
200. P. Posocco, X.X. Liu, E. Laurini, D. Marson, C. Chen, C. Liu, and et al. Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing Mol Pharm 10 2013 3262 3273
201. M.D. Giron-Gonzalez, A. Morales-Portillo, A. Salinas-Castillo, F.J. Lopez-Jaramillo, F. Hernandez-Mateo, F. Santoyo-Gonzalez, and et al. Engineered glycated amino dendritic polymers as specific nonviral gene delivery vectors targeting the receptor for advanced glycation end products Bioconjug Chem 25 2014 1151 1161
202. T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, and et al. Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery Bioconjug Chem 22 2011 429 435
203. M. Ahmed, N. Bhuchar, K. Ishihara, and R. Narain Well-controlled cationic water-soluble phospholipid polymer-DNA nanocomplexes for gene delivery Bioconjug Chem 22 2011 1228 1238
204. C.H. Liu, and S.Y. Yu Cationic nanoemulsions as non-viral vectors for plasmid DNA delivery Colloids Surf B 79 2010 509 515
205. R.V. Rodik, A.S. Anthony, V.I. Kalchenko, Y. Mely, and A.S. Klymchenko Cationic amphiphilic calixarenes to compact DNA into small nanoparticles for gene delivery New J Chem 39 2015 1654 1664
206. A. Bajaj, P. Kondiah, and S. Bhattacharya Design, synthesis, and in vitro gene delivery efficacies of novel cholesterol-based gemini cationic lipids and their serum compatibility: a structure-activity investigation J Med Chem 50 2007 2432 2442
207. A. Bajaj, P. Kondaiah, and S. Bhattacharya Synthesis and gene transfer activities of novel serum compatible cholesterol-based gemini lipids possessing oxyethylene-type spacers Bioconjug Chem 18 2007 1537 1546
208. Y. Obata, D. Suzuki, and S. Takeoka Evaluation of cationic assemblies constructed with amino acid based lipids for plasmid DNA delivery Bioconjug Chem 19 2008 1055 1063
209. U.P. Thankappan, S.N. Madhusudana, A. Desai, G. Jayamurugan, Y. Rajesh, and N. Jayaraman Dendritic poly(ether imine) based gene delivery vector Bioconjug Chem 22 2011 115 119
210. R. Koynova, L. Wang, and R.C. MacDonald Cationic phospholipids forming cubic phases: lipoplex structure and transfection efficiency Mol Pharm 5 2008 739 744
211. M. Foldvari, I. Badea, S. Wettig, R. Verrall, and M. Bagonluri Structural characterization of novel gemini non-viral DNA delivery systems for cutaneous gene therapy J Exp Nanosci 1 2006 165 176
212. A.L. Barran-Berdon, D. Pozzi, G. Caracciolo, A.L. Capriotti, G. Caruso, C. Cavaliere, and et al. Time evolution of nanoparticle-protein corona in human plasma: relevance for targeted drug delivery Langmuir 29 2013 6485 6494
213. G. Caracciolo, L. Callipo, S.C. De Sanctis, C. Cavaliere, D. Pozzi, and A. Lagana Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol-DOPE/DNA lipoplexes in serum Biochim Biophys Acta 2010 1798 536 543
214. G. Caracciolo, D. Pozzi, S.C. De Sanctis, A.L. Capriotti, G. Caruso, R. Samperi, and et al. Effect of membrane charge density on the protein corona of cationic liposomes: interplay between cationic charge and surface area Appl Phys Lett 99 2011