From gene delivery to gene silencing: Plasmid DNA-transfecting cationic lipid 1,3-dimyristoylamidopropane-2-[bis(2-dimethylaminoethane)] carbamate efficiently promotes small interfering RNA-induced RNA interference

Biochemistry

Volumn 49, Issue 27, 2010, Pages 5753-5759

  Spelios, Michael ^a   Kearns, Molinda ^a   Savva, Michalakis ^a  

^a LONG ISLAND UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AVERAGE DIAMETER; BINDING CONSTANT; BIOLOGICAL ACTIVITIES; CATIONIC LIPIDS; DELIVERY SYSTEMS; GENE DELIVERY; GENE SILENCING; HILL COEFFICIENT; HUMAN PROSTATE; IN-VITRO; LIPOPLEXES; LONG LASTING; MONODISPERSE; OPTIMAL FORMULATION; PHOSPHOROTHIOATES; PLASMID DNA; RNA INTERFERENCE; SMALL INTERFERING RNA; SMALL INTERFERING RNA (SIRNA); VASCULAR ENDOTHELIAL GROWTH FACTOR;

BIOACTIVITY; BODY FLUIDS; CELL CULTURE; GENE THERAPY; GENE TRANSFER; NUCLEIC ACIDS;

RNA;

1,3 DIMYRISTOYLAMIDOPROPANE 2 [BIS(2 DIMETHYLAMINOETHANE)]CARBAMATE; DRUG CARRIER; LIPID; LIPOPLEX; NITROGEN; NUCLEIC ACID; PHOSPHOROTHIOIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; CARBAMIC ACID DERIVATIVE; CATION; DNA; VASCULOTROPIN A;

ARTICLE; AVERAGE; BINDING AFFINITY; CARCINOMA CELL; CONTROLLED STUDY; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROSTATE CARCINOMA; RNA INTERFERENCE; ZETA POTENTIAL; CELL LINE; CHEMISTRY; GENE; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; MALE; METABOLISM; PLASMID;

CARBAMATES; CATIONS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DNA; GENE SILENCING; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES; HUMANS; LIPIDS; MALE; NUCLEIC ACIDS; PLASMIDS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77954696773     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1002376     Document Type: Article

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