A cationic cholesterol based nanocarrier for the delivery of p53-EGFP-C3 plasmid to cancer cells

Biomaterials

Volumn 35, Issue 4, 2014, Pages 1334-1346

  Misra, Santosh K ^a   Naz, Sarwat ^a   Kondaiah, Paturu ^a   Bhattacharya, Santanu ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Cationic cholesterol; Gene therapy; Gene transfer; Nanocomposite; Serum; Xenograft tumor regression

Indexed keywords

ANTI-TUMOR ACTIVITIES; APOPTOSIS INDUCTION; CELL CYCLE ANALYSIS; COMMERCIAL REAGENTS; GREEN FLUORESCENCE PROTEINS; SERUM; TRANSFECTED CELLS; TUMOR REGRESSION;

ASSAYS; BODY FLUIDS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CHOLESTEROL; GENE THERAPY; GENE TRANSFER; NANOCOMPOSITES; POLYMERASE CHAIN REACTION; PROTEINS; TUMORS;

MOLECULAR BIOLOGY;

CHOLESTEROL; EFFECTENE; ENHANCED GREEN FLUORESCENT PROTEIN; GLYCEROPHOSPHOETHANOLAMINE; HYBRID PROTEIN; LIPOFECTAMINE; LIPOPLEX; LIPOSOME; NANOCARRIER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; REAGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER CELL; CANCER GENE THERAPY; CELL CYCLE; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG FORMULATION; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; HYDRODYNAMICS; LIPOSOMAL GENE DELIVERY SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCREENING; TRANSIENT TRANSFECTION; TUMOR REGRESSION; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING;

MUS MUSCULUS;

CATIONIC CHOLESTEROL; GENE THERAPY; GENE TRANSFER; NANOCOMPOSITE; SERUM; XENOGRAFT TUMOR REGRESSION;

ANIMALS; APOPTOSIS; CATIONS; CELL LINE, TUMOR; CHOLESTEROL; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MICE, NUDE; NANOSTRUCTURES; NEOPLASMS; PLASMIDS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84888436829     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.10.062     Document Type: Article

References (59)

1. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A., Butel J.S., et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 1992, 356:215-221.
2. Attardi L.D., Jacks T. The role of p53 in tumor suppression: lessons from mouse models. Cell Mol Life Sci 1999, 55:48-63.
3. Donehower L.A., Bradley A. The tumor suppressor p53. Biochim Biophys Acta 1993, 1155:181-205.
4. Oren M. p53: the ultimate tumor suppressor gene?. FASEB J 1992, 6:3169-3176.
5. Cho Y., Gorina S., Jefrey P.D., Pavletich N.P. Crystal structure of p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 1994, 265:346-355.
6. Prives C. How loops, β sheets, and α helices help us to understand p53. Cell 1994, 78:543-546.
7. Baker S.J., Markowitz S.R., Fearon E.R., Willson J.K., Volgelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 1990, 249:912-915.
8. Ramqvist T., Magnusson K.P., Wang Y., Szekely L., Klein G., Wilman K.G. Wild-type p53 induces apoptosis in a burkitt lymphoma (BL) line that carries mutant p53. Oncogene 1993, 8:1495-1500.
9. Swisher S.G., Roth J.A., Nemunaitis J., Lawrence D.D., Kemp B.L., Carrasco C.H., et al. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. JNatl Cancer Inst 1999, 91:763-771.
10. Wolff J.A., Maloone R.W., Williams P., Chong W., Ascadi G., Jani A., et al. Direct gene transfer into mouse muscle invivo. Science 1990, 247:1465-1468.
11. San H., Yang Z., Pompili V.J., Jaffe M.L., Plautz G.E., Xu L., et al. Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy. Hum Gene Ther 1993, 4:981-988.
12. Aliabadi H.M., Landry B., Sun C., Tang T., Uluda H. Supramolecular assemblies infunctional siRNA delivery: where do we stand?. Biomaterials 2012, 33:2546-2569.
13. Dileep P.V., Antony A., Bhattacharya S. Incorporation of oxyethylene units between hydrocarbon chain and pseudoglyceryl backbone in cationic lipid potentiates gene transfection efficiency in the presence of serum. FEBS Lett 2001, 509:327-331.
14. Bhattacharya S., Dileep P.V. Cationic oxyethylene lipids. synthesis, aggregation, and transfection properties. Bioconjug Chem 2004, 15:508-519.
15. LaManna C.M., Lusic H., Camplo M., McIntosh T.J., Barthelemy P., Grinstaff M.W. Charge-reversal lipids, peptide-based lipids, and nucleoside-based lipids for gene delivery. Acc Chem Res 2012, 45:1026-1038.
16. Teo P.Y., Yang C., Hedrick J.L., Engler A.C., Coady D.J., Ghaem-Maghami S., et al. Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfection. Biomaterials 2013, 34:7971-7979.
17. Ahmad A., Evans H.M., Ewert K., George C.X., Samuel C.E., Safinya C.R. New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery. JGene Med 2005, 7:739-748.
18. Ewert K.K., Evans H.M., Bouxsein N.F., Safinya C.R. Dendritic cationic lipids with highly charged headgroups for efficient gene delivery. Bioconjug Chem 2006, 17:877-888.
19. Koiwai K., Tokuhisa K., Karinaga R., Kudo Y., Kusuki S., Takeda Y., et al. Transition from a normal to inverted cylinder for an amidine-bearing Lipid/pDNA complex and its excellent transfection. Bioconjug Chem 2005, 16:1349-1351.
20. Ilies M.A., Johnson B.H., Makori F., Miller A., Seitz W.A., Thompson E.B., et al. Pyridinium cationic lipids in gene delivery: an invitro and invivo comparison of transfection efficiency versus a tetraalkylammonium congener. Arch Biochem Biophys 2005, 435:217-226.
21. Chan C.-L., Majzoub R.N., Shirazi R.S., Ewert K.K., Chen Y.-J., Liang K.S., et al. Endosomal escape and transfection efficiency of PEGylated cationic liposomeeDNA complexes prepared with an acid-labile PEG-lipid. Biomaterials 2012, 33:4928-4935.
22. Van der Woude I., Wagenaar A., Meekel A.A.P., Ter Beest M.B.A., Ruiters M.H.J., Engberts J.B.F.N., et al. Novel pyridinium surfactants for efficient, nontoxic invitro gene delivery. Proc Natl Acad Sci U S A 1997, 94:1160-1165.
23. Hyvonen Z., Ruponen M., Ronkko S., Suhonen P., Urtti A. Extracellular and intracellular factors influencing gene transfection mediated by 1,4-dihydropyridine amphiphiles. Eur J Pharm Sci 2002, 15:449-460.
24. Ghosh Y.K., Visweswariah S.S., Bhattacharya S. Nature of linkage between the cationic headgroup and cholesteryl skeleton controls gene transfection efficiency. FEBS Lett 2000, 473:341-344.
25. Boomer J.A., Qualls M.M., Inerowicz H.D., Haynes R., Patri G.V., Kim J.M., et al. Cytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugate. Bioconjug Chem 2009, 20:47-59.
26. Bajaj A., Mishra S.K., Kondaiah P., Bhattacharya S. Effect of the headgroups on gene transfection efficiencies of cholesterol based cationic lipids. Biochim Biophys Acta Biomem 2008, 1778:1222-1236.
27. Singh R.S., Alves C.G., Sandrin P., Pichon C.P., Midoux P., Chaudhuri A. On the gene delivery efficacies of pH-Sensitive cationic lipids via endosomal protonation: a chemical biology investigation. Chem Biol 2004, 11:713-723.
28. Bajaj A., Paul B., Kondaiah P., Bhattacharya S. Structure-activity investigation on the gene transfection properties of cardiolipin mimicking gemini lipid analogues. Bioconjug Chem 2008, 19:1283-1300.
29. Ilies M.A., Seitz W.A., Johnson B.H., Ezell E.L., Miller A.L., Thompson E.B., et al. Lipophilic pyrylium salts in the synthesis of efficient pyridinium-based cationic lipids, gemini surfactants, and lipophilic oligomers for gene delivery. JMed Chem 2006, 49:3872-3887.
30. Gardner R.A., Belting M., Svensson K., Phanstiel O. Synthesis and transfection efficiencies of new lipophilic polyamines. JMed Chem 2007, 50:308-318.
31. Bajaj A., Paul B., Indi S.S., Kondaiah P., Bhattacharya S. Effect of the hydrocarbon chain lengths and spacer lengths on gene transfection efficacies of gemini lipids based on aromatic backbone. Bioconjug Chem 2007, 18:2144-2158.
32. Bajaj A., Kondaiah P., Bhattacharya S. Gene transfection efficacies of novel cationic gemini lipid possessing aromatic backbone and oxyethylene spacers. Biomacromolecules 2008, 9:991-999.
33. Bajaj A., Kondaiah P., Bhattacharya S. Synthesis and gene transfection properties of novel serum compatible cholesterol based gemini lipids possessing oxyethylene spacers. Bioconjug Chem 2007, 18:1537-1546.
34. Bajaj A., Kondaiah P., Bhattacharya S. Effect of the nature of the spacer on gene transfer efficacies of novel thiocholesterol derived gemini lipids in different cell lines: a structure-activity investigation. JMed Chem 2008, 51:2533-2540.
35. Bajaj A., Kondaiah P., Bhattacharya S. Deisgn, synthesis and invitro gene transfection properties of novel cholesterol based gemini lipids and their serum compatibility: a structure-activity investigation. JMed Chem 2007, 50:2432-2444.
36. Choi S.H., Jin S.E., Lee M.K., Lim S.J., Park J.S., Kim B.G., et al. Novel cationic solid lipid nanoparticles enhanced p53 gene transfer to lung cancer cells. Eur J Pharm Biopharm 2008, 68:545-554.
37. Norris P.S., Haas M. Afluorescent p53GFP fusion protein facilitates its detection in mammalian cells while retaining the properties of wild-type p53. Oncogene 1997, 15:2241-2247.
38. 2 is involved in its antitumor effect invitro and invivo. Biochem Biophys Res Commun 2008, 377:567-572.
39. Naz S., Ranganathan P., Bodapati P., Shastry A.H., Mishra L.N., Kondaiah P. Regulation of S100A2 expression by TGF-β-induced MEK/ERK signalling and its role in cell migration/invasion. Biochem J 2012, 447:81-91.
40. Somasundaram K., El-Deiry W.S. Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region. Oncogene 1997, 14:1047-1057.
41. Oberle V., Bakowsky U., Hoekstra D. Lipoplex assembly visualized by atomic force microscopy. Meth Enzymol 2003, 373:281-297.
42. Wang C., Li X., Wettig S.D., Badea I., Foldvari M., Verrall R.E. Investigation of complexes formed by interaction of cationic gemini surfactants with deoxyribonucleic acid. Phys Chem Chem Phys:PCCP 2007, 9:1616-1628.
43. Ranganathan P., Agrawal A., Bhushan R., Chavalmane A.K., Kalathur R.K., Takahashi T., et al. Expression profiling of genes regulated by TGF-β: differential regulation in normal and tumor cells. BMC Genomics 2007, 8:98.
44. Reddy S.P., Britto R., Vinnakota K., Aparna H., Sreepathi H.K., Thota B., et al. Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis. Clin Cancer Res 2008, 14:2978-2987.
45. Misra S.K., Kondaiah P., Bhattacharya S., Rao C.N.R. Graphene as a nanocarrier for tamoxifen induces apoptosis in transformed cancer cell lines of different origins. Small 2012, 8:131-143.
46. Tomayko M.M., Reynolds C.P. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 1989, 24:148-154.
47. Weber W.A., Wieder H. Monitoring chemotherapy and radiotherapy of solid tumors. Eur J Nucl Med Mol Imaging 2006, 33:27-37.
48. Yue J., Liu S., Wang R., Hu X., Xie Z., Huang Y., et al. Transferrin-conjugated micelles: enhanced accumulation and antitumor effect for transferrin-receptor-overexpressing cancer models. Mol Pharmacol 2012, 9:1919-1931.
49. Felgner P.L., Gadek T.R., Holm M., Roman R., Chan H.W., Wenz M., et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci U S A 1987, 84:7413-7417.
50. Wang J., Guo X., Xu Y., Barron L., Szoka F.C. Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery. JMed Chem 1998, 41:2207-2215.
51. Felgner J.H., Kumar R., Sridhar C.J., Wheeler Y.J., Tsai R., Border P., et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. JBiol Chem 1994, 269:2550-2561.
52. Walker W.E., Porteous D.J., Boyd A.C. The effects of plasmid copy number and sequence context upon transfection efficiency. JControl Release 2004, 94:245-252.
53. Linnik M.D., Zobrist R.H., Hatfield M.D. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993, 24:2002-2009.
54. Couldwell W.T., Hinton D.R., He S. Protein kinase c inhibitors induce apoptosis in human malignant glioma cell lines. FEBS Lett 1994, 345:43-46.
55. Malika L., Lise D., Nathalie V., Catherine A., Zahia S.-O., Annie-France B., et al. Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor. FEBS Lett 2006, 580:2547-2552.
56. Zhang W., Shi Y., Chen Y., Yu S., Hao J., Luo J., et al. Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance. Eur J Pharm Biopharm 2010, 75:341-353.
57. Ullal A.V., Reiner T., Yang K.S., Gorbatov R., Min C., Issadore D., et al. Nanoparticle-mediated measurement of target drug binding in cancer cells. ACS Nano 2011, 5:9216-9224.
58. Dubrez L., Coll J.L., Hurbin A., Fraipont Fde, Lantejoul S., Favrot M.-C. Cell cycle arrest is sufficient for p53-mediated tumor regression. Gene Ther 2001, 8:1705-1712.
59. JSde Jong, Diest P.J., Baak J.P.A. Number of apoptotic cells as a prognostic marker in invasive breast cancer. Br J Cancer 2000, 82:368-373.