How does the spacer length of cationic gemini lipids influence the lipoplex formation with plasmid DNA? physicochemical and biochemical characterizations and their relevance in gene therapy

Biomacromolecules

Volumn 13, Issue 12, 2012, Pages 3926-3937

  Muñoz Úbeda, Mónica ^a   Misra, Santosh K ^b   Barrán Berdón, Ana L ^a   Datta, Sougata ^b   Aicart Ramos, Clara ^a   Castro Hartmann, Pablo ^c   Kondaiah, Paturu ^b   Junquera, Elena ^a   Bhattacharya, Santanu ^a   Aicart, Emilio ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INDIAN INSTITUTE OF SCIENCE   (India)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL CHARACTERIZATION; BIOLOGICAL STANDPOINT; BIOLOGICAL STUDIES; CATIONIC GEMINI; CATIONIC GEMINI SURFACTANT; CATIONIC LIPIDS; CELL VIABILITY; CONFOCAL FLUORESCENCE MICROSCOPY; COUNTERIONS; CRYO-TEM; EFFECTIVE CHARGE; EXPERIMENTAL METHODS; GEL ELECTROPHORESIS; GENE TRANSFECTION; GENE VECTORS; LIPID MIXTURES; LIPOPLEXES; MOLAR COMPOSITIONS; NEGATIVE CHARGE; PLASMID DNA; PLASMID DNA (PDNA); SHORT SPACERS; SMALL ANGLE X-RAY SCATTERING; SPACER LENGTHS; SUPERCOILED; TRANSFECTION EFFICIENCY;

AMERICIUM; AMMONIUM COMPOUNDS; BIOMOLECULES; BODY FLUIDS; CELLS; CYTOLOGY; DIGITAL STORAGE; ELECTROPHORESIS; FLUORESCENCE MICROSCOPY; GENES; LAMELLAR STRUCTURES; LIPID BILAYERS; LIPOSOMES; MONOLAYERS; PARAFFINS; ZETA POTENTIAL;

MIXTURES;

1,2 DIOLEOYL SN GLYCERO 3 PHOSPHATIDYLETHANOLAMINE; ALKANE; AMPHOLYTE; ENHANCED GREEN FLUORESCENT PROTEIN; LIPID; LIPOFECTAMINE; LIPOPLEX; PHOSPHATIDYLETHANOLAMINE; PLASMID DNA; SODIUM ION; SURFACTANT; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL STRAIN HEK293; CELL VIABILITY; CHEMICAL COMPOSITION; CHO CELL; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DNA CONFORMATION; DNA SUPERCOILING; FLUORESCENCE MICROSCOPY; GEL ELECTROPHORESIS; GENE THERAPY; GENETIC TRANSFECTION; HELA CELL; LIPID BILAYER; LIPOSOMAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY; ZETA POTENTIAL;

ANIMALS; CATIONS; CELL SURVIVAL; CHO CELLS; CRICETINAE; DNA; ELECTROPHORESIS, AGAR GEL; GENETIC THERAPY; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HELA CELLS; HUMANS; LIPIDS; LIPOSOMES; MICROSCOPY, CONFOCAL; PHOSPHATIDYLETHANOLAMINES; PHYSICOCHEMICAL PHENOMENA; PLASMIDS; SCATTERING, SMALL ANGLE; SURFACE-ACTIVE AGENTS; TRANSFECTION; VISCOSITY; X-RAY DIFFRACTION;

EID: 84870873789     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm301066w     Document Type: Article

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