CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases

Molecular Neurodegeneration

Volumn 10, Issue 1, 2015, Pages

  Tu, Zhuchi ^a   Yang, Weili ^a   Yan, Sen ^a   Guo, Xiangyu ^a   Li, Xiao Jiang ^a,b  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; CRISPR Cas9; Neurodegenerative diseases; Non human primates

Indexed keywords

TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; BACTERIAL PROTEIN; CRISPR ASSOCIATED PROTEIN; ENDONUCLEASE; GUIDE RNA; HYBRID PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; DEGENERATIVE DISEASE; DISEASE MODEL; DNA MODIFICATION; GENETIC ENGINEERING; GENETIC MODEL; HUMAN; HUNTINGTON CHOREA; NONHUMAN; RNA EDITING; RODENT MODEL; TRANSGENICS; ANIMAL; DNA END JOINING REPAIR; EMBRYO TRANSFER; ENZYMOLOGY; FEMALE; GENE VECTOR; GENETICS; INTRACYTOPLASMIC SPERM INJECTION; MALE; METABOLISM; MOSAICISM; MUTAGENESIS; PIG; PRIMATE; PROCEDURES; SHEEP; SPECIES DIFFERENCE; STREPTOCOCCUS PYOGENES; TRANSGENIC ANIMAL;

ANIMALIA; PRIMATES; RODENTIA;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BACTERIAL PROTEINS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; DNA END-JOINING REPAIR; EMBRYO TRANSFER; ENDONUCLEASES; FEMALE; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; MALE; MOSAICISM; MUTAGENESIS; NEURODEGENERATIVE DISEASES; PRIMATES; RECOMBINANT FUSION PROTEINS; RNA, GUIDE; SHEEP; SPECIES SPECIFICITY; SPERM INJECTIONS, INTRACYTOPLASMIC; STREPTOCOCCUS PYOGENES; SUS SCROFA;

EID: 84938537178     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0031-x     Document Type: Article

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