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Volumn 2, Issue 10, 2012, Pages

Animal models of Parkinson's disease: Vertebrate genetics

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; LEUCINE RICH REPEAT KINASE 2; PARKIN; PLATELET DERIVED GROWTH FACTOR B; TAMOXIFEN; LRRK2 PROTEIN, HUMAN; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PTEN INDUCED PUTATIVE KINASE; PTEN-INDUCED PUTATIVE KINASE; SIGNAL PEPTIDE; UBIQUITIN PROTEIN LIGASE;

EID: 84886652249     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a009324     Document Type: Article
Times cited : (97)

References (76)
  • 4
    • 0024564718 scopus 로고
    • The new mouse genetics: Altering the genome by gene targeting
    • Capecchi MR. 1989. The new mouse genetics: Altering the genome by gene targeting. Trends Genet 5: 70-76.
    • (1989) Trends Genet , vol.5 , pp. 70-76
    • Capecchi, M.R.1
  • 7
    • 0031454241 scopus 로고    scopus 로고
    • The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease
    • Churchyard A, Lees AJ. 1997. The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease. Neurology 49: 1570-1576.
    • (1997) Neurology , vol.49 , pp. 1570-1576
    • Churchyard, A.1    Lees, A.J.2
  • 9
    • 77950805294 scopus 로고    scopus 로고
    • The control systems structures of energy metabolism
    • Cloutier M, Wellstead P. 2010. The control systems structures of energy metabolism. J R Soc Interface 7: 651-665.
    • (2010) J R Soc Interface , vol.7 , pp. 651-665
    • Cloutier, M.1    Wellstead, P.2
  • 10
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W, Przedborski S. 2003. Parkinson's disease: Mechanisms and models. Neuron 39: 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 12
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson TM, Ko HS, Dawson VL. 2010. Genetic animal models of Parkinson's disease. Neuron 66: 646-661.
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 13
    • 0038460184 scopus 로고    scopus 로고
    • Part II: α-Synuclein and its molecular pathophysiological role in neurodegenerative disease
    • Dev KK, Hofele K, Barbieri S, Buchman VL, van der Putten H. 2003. Part II: α-Synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology 45: 14-44.
    • (2003) Neuropharmacology , vol.45 , pp. 14-44
    • Dev, K.K.1    Hofele, K.2    Barbieri, S.3    Buchman, V.L.4    van der Putten, H.5
  • 14
    • 5144234034 scopus 로고    scopus 로고
    • α-Synuclein and transgenic mouse models
    • Fernagut PO, Chesselet MF. 2004. α-Synuclein and transgenic mouse models. Neurobiol Dis 17: 123-130.
    • (2004) Neurobiol Dis , vol.17 , pp. 123-130
    • Fernagut, P.O.1    Chesselet, M.F.2
  • 15
    • 0023255221 scopus 로고
    • The Lewy body in Parkinson's disease
    • Forno LS. 1987. The Lewy body in Parkinson's disease. Adv Neurol 45: 35-43.
    • (1987) Adv Neurol , vol.45 , pp. 35-43
    • Forno, L.S.1
  • 16
    • 0345293158 scopus 로고    scopus 로고
    • Why are some human disease-associated mutations fixed in mice?
    • Gao L, Zhang J. 2003. Why are some human disease-associated mutations fixed in mice? Trends Genet 19: 678-681.
    • (2003) Trends Genet , vol.19 , pp. 678-681
    • Gao, L.1    Zhang, J.2
  • 17
    • 49649097747 scopus 로고    scopus 로고
    • Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
    • Gautier CA, Kitada T, Shen J. 2008. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci 105: 11364-11369.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 11364-11369
    • Gautier, C.A.1    Kitada, T.2    Shen, J.3
  • 18
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein
    • Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. 2002. Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 34: 521-533.
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 24
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci 89: 5547-5551.
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 28
    • 0345269757 scopus 로고    scopus 로고
    • Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease
    • Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Bjorklund A. 2003. Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease. Proc Natl Acad Sci 100: 2884-2889.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 2884-2889
    • Kirik, D.1    Annett, L.E.2    Burger, C.3    Muzyczka, N.4    Mandel, R.J.5    Bjorklund, A.6
  • 31
    • 70349923087 scopus 로고    scopus 로고
    • Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice
    • Kitada T, Tong Y, Gautier CA, Shen J. 2009. Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem 111: 696-702.
    • (2009) J Neurochem , vol.111 , pp. 696-702
    • Kitada, T.1    Tong, Y.2    Gautier, C.A.3    Shen, J.4
  • 33
    • 33745220302 scopus 로고    scopus 로고
    • Identification of far upstream element-binding protein-1 as an authentic Parkin substrate
    • Ko HS, Kim SW, Sriram SR, Dawson VL, Dawson TM. 2006. Identification of far upstream element-binding protein-1 as an authentic Parkin substrate. J Biol Chem 281: 16193-16196.
    • (2006) J Biol Chem , vol.281 , pp. 16193-16196
    • Ko, H.S.1    Kim, S.W.2    Sriram, S.R.3    Dawson, V.L.4    Dawson, T.M.5
  • 34
    • 19444374556 scopus 로고    scopus 로고
    • Mediation of cell death by poly(ADP-ribose) polymerase-1
    • Koh DW, Dawson TM, Dawson VL. 2005. Mediation of cell death by poly(ADP-ribose) polymerase-1. Pharmacol Res 52: 5-14.
    • (2005) Pharmacol Res , vol.52 , pp. 5-14
    • Koh, D.W.1    Dawson, T.M.2    Dawson, V.L.3
  • 36
    • 0037173006 scopus 로고    scopus 로고
    • Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
    • Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL. 2002. Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice. Proc Natl Acad Sci 99: 8968-8973.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3    Xu, X.4    Qui, D.5    Mandir, A.S.6    Dawson, T.M.7    Copeland, N.G.8    Jenkins, N.A.9    Price, D.L.10
  • 39
    • 72149087091 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein
    • Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, DingJ, et al. 2009. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein. Neuron 64: 807-827.
    • (2009) Neuron , vol.64 , pp. 807-827
    • Lin, X.1    Parisiadou, L.2    Gu, X.L.3    Wang, L.4    Shim, H.5    Sun, L.6    Xie, C.7    Long, C.X.8    Yang, W.J.9    Ding, J.10
  • 40
    • 0036679197 scopus 로고    scopus 로고
    • α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P. 2002. α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci 99: 10813-10818.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.L.2    Schneider, B.L.3    Deglon, N.4    Aebischer, P.5
  • 46
    • 0041835899 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease: What do mutations in DJ-1 tell us?
    • Moore DJ, Dawson VL, Dawson TM. 2003. Genetics of Parkinson's disease: What do mutations in DJ-1 tell us? Ann Neurol 54: 281-282.
    • (2003) Ann Neurol , vol.54 , pp. 281-282
    • Moore, D.J.1    Dawson, V.L.2    Dawson, T.M.3
  • 48
    • 0036855635 scopus 로고    scopus 로고
    • Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies
    • Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, OdoyS, Fujiwara H, Hasegawa M, et al. 2002. Misfolded proteinase K-resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies. J Clin Invest 110: 1429-1439.
    • (2002) J Clin Invest , vol.110 , pp. 1429-1439
    • Neumann, M.1    Kahle, P.J.2    Giasson, B.I.3    Ozmen, L.4    Borroni, E.5    Spooren, W.6    Muller, V.7    Odoy, S.8    Fujiwara, H.9    Hasegawa, M.10
  • 52
    • 33947282153 scopus 로고    scopus 로고
    • DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice
    • Paterna JC, Leng A, Weber E, Feldon J, Bueler H. 2007. DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice. Mol Ther 15: 698-704.
    • (2007) Mol Ther , vol.15 , pp. 698-704
    • Paterna, J.C.1    Leng, A.2    Weber, E.3    Feldon, J.4    Bueler, H.5
  • 53
    • 30344450813 scopus 로고    scopus 로고
    • Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity
    • Perez FA, Curtis WR, Palmiter RD. 2005. Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity. BMC Neurosci 6: 71.
    • (2005) BMC Neurosci , vol.6 , pp. 71
    • Perez, F.A.1    Curtis, W.R.2    Palmiter, R.D.3
  • 57
    • 35348932113 scopus 로고    scopus 로고
    • Transgenic animal models of neurodegenerative diseases and their application to treatment development
    • Rockenstein E, Crews L, Masliah E. 2007. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev 59: 1093-1102.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 1093-1102
    • Rockenstein, E.1    Crews, L.2    Masliah, E.3
  • 58
    • 34548348780 scopus 로고    scopus 로고
    • The mouse ascending: Perspectives for human-disease models
    • Rosenthal N, Brown S. 2007. The mouse ascending: Perspectives for human-disease models. Nat Cell Biol 9: 993-999.
    • (2007) Nat Cell Biol , vol.9 , pp. 993-999
    • Rosenthal, N.1    Brown, S.2
  • 59
    • 34547575539 scopus 로고    scopus 로고
    • FELASA guidelines for the production and nomenclature of transgenic rodents
    • Rulicke T, Montagutelli X, Pintado B, Thon R, Hedrich HJ. 2007. FELASA guidelines for the production and nomenclature of transgenic rodents. Lab Anim 41: 301-311.
    • (2007) Lab Anim , vol.41 , pp. 301-311
    • Rulicke, T.1    Montagutelli, X.2    Pintado, B.3    Thon, R.4    Hedrich, H.J.5
  • 60
    • 33745847479 scopus 로고    scopus 로고
    • Diagnosis and treatment of Parkinson disease: Molecules to medicine
    • Savitt JM, Dawson VL, Dawson TM. 2006. Diagnosis and treatment of Parkinson disease: Molecules to medicine. J Clin Invest 116: 1744-1754.
    • (2006) J Clin Invest , vol.116 , pp. 1744-1754
    • Savitt, J.M.1    Dawson, V.L.2    Dawson, T.M.3
  • 64
    • 1542617769 scopus 로고    scopus 로고
    • Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP
    • Song DD, Shults CW, Sisk A, Rockenstein E, Masliah E. 2004. Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP. Exp Neurol 186: 158-172.
    • (2004) Exp Neurol , vol.186 , pp. 158-172
    • Song, D.D.1    Shults, C.W.2    Sisk, A.3    Rockenstein, E.4    Masliah, E.5
  • 66
    • 33846913712 scopus 로고    scopus 로고
    • Tetracycline-controlled genetic switches
    • Sprengel R, Hasan MT. 2007. Tetracycline-controlled genetic switches. Handb Exp Pharmacol 2007: 49-72.
    • (2007) Handb Exp Pharmacol , vol.2007 , pp. 49-72
    • Sprengel, R.1    Hasan, M.T.2
  • 68
    • 79551619339 scopus 로고    scopus 로고
    • Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation
    • Thomas B, Mandir AS, West N, Liu Y, Andrabi SA, Stirling W, Dawson VL, Dawson TM, Lee MK. 2011. Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. PloS ONE 6: e16706.
    • (2011) PloS ONE , vol.6
    • Thomas, B.1    Mandir, A.S.2    West, N.3    Liu, Y.4    Andrabi, S.A.5    Stirling, W.6    Dawson, V.L.7    Dawson, T.M.8    Lee, M.K.9
  • 69
    • 72149109520 scopus 로고    scopus 로고
    • α-Synuclein and LRRK2: Partners in crime
    • Tong Y, Shen J. 2009. α-Synuclein and LRRK2: Partners in crime. Neuron 64: 771-773.
    • (2009) Neuron , vol.64 , pp. 771-773
    • Tong, Y.1    Shen, J.2
  • 71
    • 41549144503 scopus 로고    scopus 로고
    • The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
    • Wang L, Xie C, Greggio E, Parisiadou L, Shim H, Sun L, Chandran J, Lin X, Lai C, Yang WJ, et al. 2008. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci 28: 3384-3391.
    • (2008) J Neurosci , vol.28 , pp. 3384-3391
    • Wang, L.1    Xie, C.2    Greggio, E.3    Parisiadou, L.4    Shim, H.5    Sun, L.6    Chandran, J.7    Lin, X.8    Lai, C.9    Yang, W.J.10
  • 75
    • 75949104449 scopus 로고    scopus 로고
    • Mitochondria get a Parkin' ticket
    • Wild P, Dikic I. 2010. Mitochondria get a Parkin' ticket. Nat Cell Biol 12: 104-106.
    • (2010) Nat Cell Biol , vol.12 , pp. 104-106
    • Wild, P.1    Dikic, I.2
  • 76
    • 33947228781 scopus 로고    scopus 로고
    • Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice
    • Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z, Xia XG. 2007. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci 3: 242-250.
    • (2007) Int J Biol Sci , vol.3 , pp. 242-250
    • Zhou, H.1    Falkenburger, B.H.2    Schulz, J.B.3    Tieu, K.4    Xu, Z.5    Xia, X.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.