-
1
-
-
77949335521
-
The worldwide societal costs of dementia: Estimates for 2009
-
Wimo A, Winblad B, Jonsson L. The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement. 2010;6:98-103.
-
(2010)
Alzheimers Dement
, vol.6
, pp. 98-103
-
-
Wimo, A.1
Winblad, B.2
Jonsson, L.3
-
2
-
-
79952747862
-
Alzheimer's disease
-
Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E. Alzheimer's disease. Lancet. 2011;377:1019-31.
-
(2011)
Lancet
, vol.377
, pp. 1019-1031
-
-
Ballard, C.1
Gauthier, S.2
Corbett, A.3
Brayne, C.4
Aarsland, D.5
Jones, E.6
-
3
-
-
36949016215
-
Alzheimer disease models and human neuropathology: Similarities and differences
-
Duyckaerts C, Potier MC, Delatour B. Alzheimer disease models and human neuropathology: similarities and differences. Acta Neuropathol. 2008;115:5-38.
-
(2008)
Acta Neuropathol
, vol.115
, pp. 5-38
-
-
Duyckaerts, C.1
Potier, M.C.2
Delatour, B.3
-
6
-
-
33846047004
-
Pathways by which Abeta facilitates tau pathology
-
Blurton-Jones M, Laferla FM. Pathways by which Abeta facilitates tau pathology. Cur Alzheimer Res. 2006;3:437-48.
-
(2006)
Cur Alzheimer Res
, vol.3
, pp. 437-448
-
-
Blurton-Jones, M.1
Laferla, F.M.2
-
7
-
-
0025295039
-
Cleavage of amyloid beta peptide during constitutive processing of its precursor
-
Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, et al. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science. 1990;248:1122-4.
-
(1990)
Science
, vol.248
, pp. 1122-1124
-
-
Esch, F.S.1
Keim, P.S.2
Beattie, E.C.3
Blacher, R.W.4
Culwell, A.R.5
Oltersdorf, T.6
-
9
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
-
Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010;9:119-28.
-
(2010)
Lancet Neurol
, vol.9
, pp. 119-128
-
-
Jack Jr., C.R.1
Knopman, D.S.2
Jagust, W.J.3
Shaw, L.M.4
Aisen, P.S.5
Weiner, M.W.6
-
10
-
-
80051569682
-
Amyloid-dependent and amyloid-independent stages of Alzheimer disease
-
Hyman BT. Amyloid-dependent and amyloid-independent stages of Alzheimer disease. Arch Neurol. 2011;68:1062-4.
-
(2011)
Arch Neurol
, vol.68
, pp. 1062-1064
-
-
Hyman, B.T.1
-
11
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991;30:572-80.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
Deteresa, R.5
Hill, R.6
-
12
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ. Alzheimer's disease is a synaptic failure. Science. 2002;298:789-91.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
13
-
-
0029934027
-
Rodent models of Alzheimer's disease: Rat A beta infusion approaches to amyloid deposits
-
Frautschy SA, Yang F, Calderon L, Cole GM. Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging. 1996;17:311-21.
-
(1996)
Neurobiol Aging
, vol.17
, pp. 311-321
-
-
Frautschy, S.A.1
Yang, F.2
Calderon, L.3
Cole, G.M.4
-
14
-
-
80051544073
-
Animal models in the drug discovery pipeline for Alzheimer's disease
-
Van Dam D, De Deyn PP. Animal models in the drug discovery pipeline for Alzheimer's disease. Br J Pharmacol. 2011;164:1285-300.
-
(2011)
Br J Pharmacol
, vol.164
, pp. 1285-1300
-
-
van Dam, D.1
de Deyn, P.P.2
-
15
-
-
0038755949
-
Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE
-
Savonenko AV, Xu GM, Price DL, Borchelt DR, Markowska AL. Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. Neurobiol Dis. 2003;12:194-211.
-
(2003)
Neurobiol Dis
, vol.12
, pp. 194-211
-
-
Savonenko, A.V.1
Xu, G.M.2
Price, D.L.3
Borchelt, D.R.4
Markowska, A.L.5
-
16
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A. 1986;83:4044-8.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
17
-
-
1842685948
-
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)
-
Wood JG, Mirra SS, Pollock NJ, Binder LI. Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau). Proc Natl Acad Sci U S A. 1986;83:4040-3.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4040-4043
-
-
Wood, J.G.1
Mirra, S.S.2
Pollock, N.J.3
Binder, L.I.4
-
18
-
-
33847199377
-
A decade of tau transgenic animal models and beyond
-
Gotz J, Deters N, Doldissen A, Bokhari L, Ke Y, Wiesner A, et al. A decade of tau transgenic animal models and beyond. Brain Pathol. 2007;17:91-103.
-
(2007)
Brain Pathol
, vol.17
, pp. 91-103
-
-
Gotz, J.1
Deters, N.2
Doldissen, A.3
Bokhari, L.4
Ke, Y.5
Wiesner, A.6
-
19
-
-
4043167747
-
Abeta immunotherapy leads to clearance of early, but not late, hyperpho-sphorylated tau aggregates via the proteasome
-
Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. Abeta immunotherapy leads to clearance of early, but not late, hyperpho-sphorylated tau aggregates via the proteasome. Neuron. 2004;43:321-32.
-
(2004)
Neuron
, vol.43
, pp. 321-332
-
-
Oddo, S.1
Billings, L.2
Kesslak, J.P.3
Cribbs, D.H.4
Laferla, F.M.5
-
20
-
-
51449096696
-
Abeta inhibits the proteasome and enhances amyloid and tau accumulation
-
Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging. 2008;29:1607-18.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1607-1608
-
-
Tseng, B.P.1
Green, K.N.2
Chan, J.L.3
Blurton-Jones, M.4
Laferla, F.M.5
-
21
-
-
0034131044
-
Impaired proteasome function in Alzheimer's disease
-
Keller JN, Hanni KB, Markesbery WR. Impaired proteasome function in Alzheimer's disease. J Neurochem. 2000;75:436-9.
-
(2000)
J Neurochem
, vol.75
, pp. 436-439
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
22
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001;293:1487-91.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
-
23
-
-
0035943436
-
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
-
Gotz J, Chen F, van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001;293:1491-5.
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Gotz, J.1
Chen, F.2
van Dorpe, J.3
Nitsch, R.M.4
-
24
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007;316:750-4.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
-
25
-
-
78650251838
-
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
-
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, et al. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010;68:1067-81.
-
(2010)
Neuron
, vol.68
, pp. 1067-1081
-
-
Hoover, B.R.1
Reed, M.N.2
Su, J.3
Penrod, R.D.4
Kotilinek, L.A.5
Grant, M.K.6
-
26
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010;142:387-97.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
van Eersel, J.6
-
27
-
-
23044445669
-
Regulation of NMDA receptor trafficking by amyloid-beta
-
Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci. 2005;8:1051-8.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1051-1058
-
-
Snyder, E.M.1
Nong, Y.2
Almeida, C.G.3
Paul, S.4
Moran, T.5
Choi, E.Y.6
-
28
-
-
0030779784
-
Skeletal and CNS defects in Presenilin-1-deficient mice
-
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 1997;89:629-39.
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
Bronson, R.T.2
Chen, D.F.3
Xia, W.4
Selkoe, D.J.5
Tonegawa, S.6
-
29
-
-
13044278313
-
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
-
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A. 1999;96:11872-7.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 11872-11877
-
-
Herreman, A.1
Hartmann, D.2
Annaert, W.3
Saftig, P.4
Craessaerts, K.5
Serneels, L.6
-
30
-
-
0035116273
-
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation
-
Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci. 2001;4:231-2.
-
(2001)
Nat Neurosci
, vol.4
, pp. 231-232
-
-
Luo, Y.1
Bolon, B.2
Kahn, S.3
Bennett, B.D.4
Babu-Khan, S.5
Denis, P.6
-
31
-
-
0346055155
-
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease
-
Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, et al. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 2004;41:27-33.
-
(2004)
Neuron
, vol.41
, pp. 27-33
-
-
Ohno, M.1
Sametsky, E.A.2
Younkin, L.H.3
Oakley, H.4
Younkin, S.G.5
Citron, M.6
-
32
-
-
0036314949
-
Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice
-
Wen PH, Shao X, Shao Z, Hof PR, Wisniewski T, Kelley K, et al. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol Dis. 2002;10:8-19.
-
(2002)
Neurobiol Dis
, vol.10
, pp. 8-19
-
-
Wen, P.H.1
Shao, X.2
Shao, Z.3
Hof, P.R.4
Wisniewski, T.5
Kelley, K.6
-
33
-
-
16044366039
-
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
-
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996;383:710-3.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.M.5
Perez-Tur, J.6
-
34
-
-
18544411933
-
Mutant presenilin 2 transgenic mouse: Effect on an age-dependent increase of amyloid beta-protein 42 in the brain
-
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. J Neurochem. 1998;71:313-22.
-
(1998)
J Neurochem
, vol.71
, pp. 313-322
-
-
Oyama, F.1
Sawamura, N.2
Kobayashi, K.3
Morishima-Kawashima, M.4
Kuramochi, T.5
Ito, M.6
-
35
-
-
3042651851
-
APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1
-
Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging. 2004;25:885-92.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 885-892
-
-
Jankowsky, J.L.1
Slunt, H.H.2
Gonzales, V.3
Jenkins, N.A.4
Copeland, N.G.5
Borchelt, D.R.6
-
36
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 2003;39:409-21.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
-
37
-
-
84980053710
-
Can zebrafish be used as animal model to study Alzheimer's disease?
-
Santana S, Rico EP, Burgos JS. Can zebrafish be used as animal model to study Alzheimer's disease? Am J Neurodegener Dis. 2012;1:32-48.
-
(2012)
Am J Neurodegener Dis
, vol.1
, pp. 32-48
-
-
Santana, S.1
Rico, E.P.2
Burgos, J.S.3
-
38
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
-
Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 2001;293:711-4.
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
Salvaterra, P.M.4
Lewis, J.5
Hutton, M.6
-
39
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
Jackson GR, Wiedau-Pazos M, Sang TK, Wagle N, Brown CA, Massachi S, et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron. 2002;34:509-19.
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
Wiedau-Pazos, M.2
Sang, T.K.3
Wagle, N.4
Brown, C.A.5
Massachi, S.6
-
40
-
-
0032506013
-
Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype
-
Fossgreen A, Bruckner B, Czech C, Masters CL, Beyreuther K, Paro R. Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype. Proc Natl Acad Sci U S A. 1998;95:13703-8.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13703-13708
-
-
Fossgreen, A.1
Bruckner, B.2
Czech, C.3
Masters, C.L.4
Beyreuther, K.5
Paro, R.6
-
41
-
-
2342473791
-
Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: A potential model for Alzheimer's disease
-
Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M, Zhong Y. Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc Natl Acad Sci U S A. 2004;101:6623-8.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 6623-6628
-
-
Iijima, K.1
Liu, H.P.2
Chiang, A.S.3
Hearn, S.A.4
Konsolaki, M.5
Zhong, Y.6
-
42
-
-
2142645114
-
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila
-
Greeve I, Kretzschmar D, Tschape JA, Beyn A, Brellinger C, Schweizer M, et al. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J Neurosci. 2004;24:3899-906.
-
(2004)
J Neurosci
, vol.24
, pp. 3899-3906
-
-
Greeve, I.1
Kretzschmar, D.2
Tschape, J.A.3
Beyn, A.4
Brellinger, C.5
Schweizer, M.6
-
43
-
-
0031468610
-
Analysis of protein domain families in Caenorhabditis elegans
-
Sonnhammer EL, Durbin R. Analysis of protein domain families in Caenorhabditis elegans. Genomics. 1997;46:200-16.
-
(1997)
Genomics
, vol.46
, pp. 200-216
-
-
Sonnhammer, E.L.1
Durbin, R.2
-
44
-
-
0028981288
-
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
-
Link CD. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1995;92:9368-72.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9368-9372
-
-
Link, C.D.1
-
45
-
-
33751397131
-
C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer's disease
-
Link CD. C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp Gerontol. 2006;41:1007-13.
-
(2006)
Exp Gerontol
, vol.41
, pp. 1007-1013
-
-
Link, C.D.1
-
46
-
-
0042889049
-
Neurodegeneration and defective neurotrans-mission in a Caenorhabditis elegans model of tauopathy
-
Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, Schellenberg GD. Neurodegeneration and defective neurotrans-mission in a Caenorhabditis elegans model of tauopathy. Proc Natl Acad Sci U S A. 2003;100:9980-5.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9980-9985
-
-
Kraemer, B.C.1
Zhang, B.2
Leverenz, J.B.3
Thomas, J.H.4
Trojanowski, J.Q.5
Schellenberg, G.D.6
-
47
-
-
26944463072
-
Progressive neurodegeneration in C. elegans model of tauopathy
-
Miyasaka T, Ding Z, Gengyo-Ando K, Oue M, Yamaguchi H, Mitani S, et al. Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis. 2005;20:372-83.
-
(2005)
Neurobiol Dis
, vol.20
, pp. 372-383
-
-
Miyasaka, T.1
Ding, Z.2
Gengyo-Ando, K.3
Oue, M.4
Yamaguchi, H.5
Mitani, S.6
-
48
-
-
74249120382
-
Geographic and ethnic variation in Parkinson disease: A population-based study of US medicare beneficiaries
-
Willis AL, Evanoff BA, Lian M, Criswell SR, Racette BA. Geographic and ethnic variation in Parkinson disease: a population-based study of US medicare beneficiaries. Neuroepidemiology. 2010;34:143-51.
-
(2010)
Neuroepidemiology
, vol.34
, pp. 143-151
-
-
Willis, A.L.1
Evanoff, B.A.2
Lian, M.3
Criswell, S.R.4
Racette, B.A.5
-
49
-
-
0031013848
-
Prevalence of parkinsonism and Parkinson's disease in Europe: The EUROPARKINSON collaborative study. European Community Concerted Action on the Epidemiology of Parkinson's disease
-
De Rijk MC, Tzourio C, Breteler MM, Dartigues JF, Amaducci L, Lopez-Pousa S, et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the Europarkinson collaborative study. European Community Concerted Action on the Epidemiology of Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997;62:10-5.
-
(1997)
J Neurol Neurosurg Psychiatry
, vol.62
, pp. 10-15
-
-
de Rijk, M.C.1
Tzourio, C.2
Breteler, M.M.3
Dartigues, J.F.4
Amaducci, L.5
Lopez-Pousa, S.6
-
50
-
-
41149163183
-
Parkinson's disease: Clinical features and diagnosis
-
Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79:368-76.
-
(2008)
J Neurol Neurosurg Psychiatry
, vol.79
, pp. 368-376
-
-
Jankovic, J.1
-
52
-
-
5444255434
-
Stages in the development of Parkinson's disease-related pathology
-
Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 2004;318:121-134.
-
(2004)
Cell Tissue Res
, vol.318
, pp. 121-134
-
-
Braak, H.1
Ghebremedhin, E.2
Rub, U.3
Bratzke, H.4
Del Tredici, K.5
-
53
-
-
77953229747
-
Missing pieces in the Parkinson's disease puzzle
-
Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordowr JH, Rodriguez M, et al. Missing pieces in the Parkinson's disease puzzle. Nat Med. 2010;16:653-661.
-
(2010)
Nat Med
, vol.16
, pp. 653-661
-
-
Obeso, J.A.1
Rodriguez-Oroz, M.C.2
Goetz, C.G.3
Marin, C.4
Kordowr, J.H.5
Rodriguez, M.6
-
54
-
-
84884907135
-
A guide to neurotoxic animal models of Parkinson's disease
-
Tieu K. A guide to neurotoxic animal models of Parkinson's disease. Cold Spring Harb Perspect Med. 2011;1:a009316.
-
(2011)
Cold Spring Harb Perspect Med
, vol.1
-
-
Tieu, K.1
-
55
-
-
0030724621
-
Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease
-
Pearce RK, Owen A, Daniel S, Jenner P, Marsden CD. Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease. J Neural Transm. 1997;104:661-677.
-
(1997)
J Neural Transm
, vol.104
, pp. 661-677
-
-
Pearce, R.K.1
Owen, A.2
Daniel, S.3
Jenner, P.4
Marsden, C.D.5
-
56
-
-
0031962268
-
Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhy-drazine assay
-
Floor E, Wetzel MG. Increased protein oxidation in human substantia nigra pars compacta in comparison with basal ganglia and prefrontal cortex measured with an improved dinitrophenylhy-drazine assay. J Neurochem. 1998;70:268-275.
-
(1998)
J Neurochem
, vol.70
, pp. 268-275
-
-
Floor, E.1
Wetzel, M.G.2
-
57
-
-
79957608284
-
A tale on animal models of Parkinson's disease
-
Bezard E, Przedborski S. A tale on animal models of Parkinson's disease. Mov Disord. 2011;26:993-1002.
-
(2011)
Mov Disord
, vol.26
, pp. 993-1002
-
-
Bezard, E.1
Przedborski, S.2
-
58
-
-
0032977408
-
Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter
-
Bezard E, Gross CE, Fournier MC, Dovero S, Bloch B, Jaber M. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Exp Neurol. 1999;155:268-273.
-
(1999)
Exp Neurol
, vol.155
, pp. 268-273
-
-
Bezard, E.1
Gross, C.E.2
Fournier, M.C.3
Dovero, S.4
Bloch, B.5
Jaber, M.6
-
59
-
-
0030831158
-
Manganese decreases glutamate uptake in cultured astrocytes
-
Hazell AS, Norenberg MD. Manganese decreases glutamate uptake in cultured astrocytes. Neurochem Res. 1997;22:1443-1447.
-
(1997)
Neurochem Res
, vol.22
, pp. 1443-1447
-
-
Hazell, A.S.1
Norenberg, M.D.2
-
62
-
-
72649092503
-
From the MPTP-treated primate to the treatment of motor complications in Parkinson's disease
-
Jenner P. From the MPTP-treated primate to the treatment of motor complications in Parkinson's disease. Parkinsonism Relat Disord. 2009;15:S18-23.
-
(2009)
Parkinsonism Relat Disord
, vol.15
-
-
Jenner, P.1
-
63
-
-
27744450270
-
Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates
-
Purisai MG, McCormack AL, Langston WJ, Johnston LC, Di Monte DA. Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates. Neurobiol Dis. 2005;20:898-906.
-
(2005)
Neurobiol Dis
, vol.20
, pp. 898-906
-
-
Purisai, M.G.1
McCormack, A.L.2
Langston, W.J.3
Johnston, L.C.4
Di Monte, D.A.5
-
64
-
-
79959977446
-
IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease
-
Barcia C, Ros CM, Annese V, Gómez A, Ros-Bernal F, Aguado-Year D, et al. IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell Death Dis. 2011;2:e142.
-
(2011)
Cell Death Dis
, vol.2
-
-
Barcia, C.1
Ros, C.M.2
Annese, V.3
Gómez, A.4
Ros-Bernal, F.5
Aguado-Year, D.6
-
65
-
-
79953318386
-
The Intranasal Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): A New Rodent Model to Test Palliative and Neuroprotective Agents for Parkinson's disease
-
Prediger RD, Aguiar AS Jr, Moreira EL, Matheus FC, Castro AA, Walz R, et al. The Intranasal Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): A New Rodent Model to Test Palliative and Neuroprotective Agents for Parkinson's disease. Curr Pharm Des. 2001;17:489-507.
-
(2001)
Curr Pharm Des
, vol.17
, pp. 489-507
-
-
Prediger, R.D.1
Aguiar Jr., A.S.2
Moreira, E.L.3
Matheus, F.C.4
Castro, A.A.5
Walz, R.6
-
66
-
-
84856282425
-
Intranasal administration of neurotoxicants in animals: Support for the olfactory vector hypothesis of Parkinson's disease
-
Prediger RD, Aguiar AS Jr, Matheus FC, Walz R, Antoury L, Raisman-Vozari R, et al. Intranasal administration of neurotoxicants in animals: support for the olfactory vector hypothesis of Parkinson's disease. Neurotox Res. 2012;21:90-116.
-
(2012)
Neurotox Res
, vol.21
, pp. 90-116
-
-
Prediger, R.D.1
Aguiar Jr., A.S.2
Matheus, F.C.3
Walz, R.4
Antoury, L.5
Raisman-Vozari, R.6
-
67
-
-
0344198025
-
Mechanism of toxicity in rotenone models of Parkinson's disease
-
Sherer TB, Betarbet R, Testa CM, Seo BB, Richardson JR, Kim JH, et al. Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci. 2003;23:10756-10764.
-
(2003)
J Neurosci
, vol.23
, pp. 10756-10764
-
-
Sherer, T.B.1
Betarbet, R.2
Testa, C.M.3
Seo, B.B.4
Richardson, J.R.5
Kim, J.H.6
-
68
-
-
1642317769
-
The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro
-
Mazzio EA, Reams RR, Soliman KF. The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro. Brain Res. 2004;1004:29-44.
-
(2004)
Brain Res
, vol.1004
, pp. 29-44
-
-
Mazzio, E.A.1
Reams, R.R.2
Soliman, K.F.3
-
69
-
-
80052533576
-
Animal models of Parkinson's disease: A source of novel treatments and clues to the cause of the disease
-
Duty S, Jenner P. Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease. Br J Pharmacol. 2011;164:1357-1391.
-
(2011)
Br J Pharmacol
, vol.164
, pp. 1357-1391
-
-
Duty, S.1
Jenner, P.2
-
70
-
-
0038335842
-
Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity
-
Saura J, Parés M, Bové J, Pezzi S, Alberch J, Marin C, et al. Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity. J Neurochem. 2003;85:651-661.
-
(2003)
J Neurochem
, vol.85
, pp. 651-661
-
-
Saura, J.1
Parés, M.2
Bové, J.3
Pezzi, S.4
Alberch, J.5
Marin, C.6
-
72
-
-
84879091554
-
Genomics and Bioinformatics of Parkinson's Disease
-
Scholz SW, Mhyre T, Ressom H, Shah S, Federoff HJ. Genomics and Bioinformatics of Parkinson's Disease. Cold Spring Harb Perspect Med. 2012;2:a009449.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Scholz, S.W.1
Mhyre, T.2
Ressom, H.3
Shah, S.4
Federoff, H.J.5
-
73
-
-
79960587095
-
Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications
-
Yue Z, Lachenmayer ML. Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications. Mov Disord. 2011;26:1386-1397.
-
(2011)
Mov Disord
, vol.26
, pp. 1386-1397
-
-
Yue, Z.1
Lachenmayer, M.L.2
-
74
-
-
0028178281
-
Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
-
Mogi M, Harada M, Riederer P, Narabayashi H, Fujita K, Nagatsu T. Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett. 1994;165:208-210.
-
(1994)
Neurosci Lett
, vol.165
, pp. 208-210
-
-
Mogi, M.1
Harada, M.2
Riederer, P.3
Narabayashi, H.4
Fujita, K.5
Nagatsu, T.6
-
75
-
-
71749083139
-
Increased serum levels of soluble tumor necrosis factor-alpha receptor-1 in patients with Parkinson's disease
-
Scalzo P, Kümmer A, Cardoso F, Teixeira AL. Increased serum levels of soluble tumor necrosis factor-alpha receptor-1 in patients with Parkinson's disease. J Neuroimmunol. 2009;216:122-125.
-
(2009)
J Neuroimmunol
, vol.216
, pp. 122-125
-
-
Scalzo, P.1
Kümmer, A.2
Cardoso, F.3
Teixeira, A.L.4
-
76
-
-
52449115580
-
The Lipopolysaccharide Parkinson's disease animal model: Mechanistic studies and drug discovery
-
Dutta G, Zhang P, Liu B. The Lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery. Fundam Clin Pharmacol. 2008;22:453-464.
-
(2008)
Fundam Clin Pharmacol
, vol.22
, pp. 453-464
-
-
Dutta, G.1
Zhang, P.2
Liu, B.3
-
77
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark IE, Dodson MW, Jiang C, Cao JH, Huth JR, Seol JH, et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 2006;441:1162-1166.
-
(2006)
Nature
, vol.441
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huth, J.R.5
Seol, J.H.6
-
78
-
-
77949478474
-
Phosphorylation of Parkin by Parkinson disease-linked kinase PINK1 activates Parkin E3 ligase function and NF-kB signaling
-
Sha D, Chin LS, Li L. Phosphorylation of Parkin by Parkinson disease-linked kinase PINK1 activates Parkin E3 ligase function and NF-kB signaling. Hum Mol Genet. 2010;19:352-363.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 352-363
-
-
Sha, D.1
Chin, L.S.2
Li, L.3
-
79
-
-
84886715175
-
Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease
-
Guo M. Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease. Cold Spring Harb Perspect Med. 2012;2:a009944.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Guo, M.1
-
80
-
-
84867269951
-
AMP kinase activation mitigates dopaminergic dysfunction and mitochon-drial abnormalities in Drosophila models of Parkinson's disease
-
Ng CH, Guan MS, Koh C, Ouyang X, Yu F, Tan EK, et al. AMP kinase activation mitigates dopaminergic dysfunction and mitochon-drial abnormalities in Drosophila models of Parkinson's disease. J Neurosci. 2012;32:14311-14317.
-
(2012)
J Neurosci
, vol.32
, pp. 14311-14317
-
-
Ng, C.H.1
Guan, M.S.2
Koh, C.3
Ouyang, X.4
Yu, F.5
Tan, E.K.6
-
81
-
-
1242338856
-
Huntingtin-protein interactions and the pathogenesis of Huntington's disease
-
Li SH, Li XJ. Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet. 2004;20:146-154.
-
(2004)
Trends Genet
, vol.20
, pp. 146-154
-
-
Li, S.H.1
Li, X.J.2
-
82
-
-
0037316787
-
Huntingtin in health and disease
-
Young AB. Huntingtin in health and disease. J Clin Invest. 2003;111:299-302.
-
(2003)
J Clin Invest
, vol.111
, pp. 299-302
-
-
Young, A.B.1
-
83
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
The Huntington's Disease Collaborative Research Group
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell. 1993;72:971-983.
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
84
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004;431:805-810.
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
85
-
-
0037461730
-
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
-
Sanchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 2003;421:373-379.
-
(2003)
Nature
, vol.421
, pp. 373-379
-
-
Sanchez, I.1
Mahlke, C.2
Yuan, J.3
-
86
-
-
0023865274
-
Clinical and neuropathologic assessment of severity in Huntington's disease
-
Myers RH, Vonsattel JP, Stevens TJ, Cupples LA, Richardson EP, Martin JB, et al. Clinical and neuropathologic assessment of severity in Huntington's disease. Neurology. 1988;38:341-347.
-
(1988)
Neurology
, vol.38
, pp. 341-347
-
-
Myers, R.H.1
Vonsattel, J.P.2
Stevens, T.J.3
Cupples, L.A.4
Richardson, E.P.5
Martin, J.B.6
-
87
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell. 1997;90:537-548.
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
Difiglia, M.4
Sharp, A.H.5
Ross, C.A.6
-
88
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, et al. Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet. 1999;8:397-407.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
-
89
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell. 1996;87:493-506.
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
-
90
-
-
10744227174
-
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
-
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, et al. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum Mol Genet. 2003;12: 1555-1567.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 1555-1567
-
-
Slow, E.J.1
van Raamsdonk, J.2
Rogers, D.3
Coleman, S.H.4
Graham, R.K.5
Deng, Y.6
-
91
-
-
46749157501
-
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
-
Gray M, Shirasaki DI, Cepeda C, Andre VM, Wilburn B, Lu XH, et al. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci. 2008;28:6182-6195.
-
(2008)
J Neurosci
, vol.28
, pp. 6182-6195
-
-
Gray, M.1
Shirasaki, D.I.2
Cepeda, C.3
Andre, V.M.4
Wilburn, B.5
Lu, X.H.6
-
92
-
-
0034163497
-
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice
-
Wheeler VC, White JK, Gutekunst CA, Vrbanac V, Weaver M, Li XJ, et al. Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice. Hum Mol Genet. 2000;9:503-513.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 503-513
-
-
Wheeler, V.C.1
White, J.K.2
Gutekunst, C.A.3
Vrbanac, V.4
Weaver, M.5
Li, X.J.6
-
93
-
-
0035862896
-
Neurological abnormalities in a knock-in mouse model of Huntington's disease
-
Lin CH, Tallaksen-Greene S, Chien WM, Cearley JA, Jackson WS, Crouse AB, et al. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum Mol Genet. 2001;10: 137-144.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 137-144
-
-
Lin, C.H.1
Tallaksen-Greene, S.2
Chien, W.M.3
Cearley, J.A.4
Jackson, W.S.5
Crouse, A.B.6
-
94
-
-
0037107191
-
Early motor dysfunction and striosomal distribution of huntingtin micro-aggregates in Huntington's disease knock-in mice
-
Menalled LB, Sison JD, Wu Y, Olivieri M, Li XJ, Li H, et al. Early motor dysfunction and striosomal distribution of huntingtin micro-aggregates in Huntington's disease knock-in mice. J Neurosci. 2002;22:8266-8276.
-
(2002)
J Neurosci
, vol.22
, pp. 8266-8276
-
-
Menalled, L.B.1
Sison, J.D.2
Wu, Y.3
Olivieri, M.4
Li, X.J.5
Li, H.6
-
95
-
-
0033560924
-
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
-
Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, et al. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci. 1999;19:3248-57.
-
(1999)
J Neurosci
, vol.19
, pp. 3248-3257
-
-
Carter, R.J.1
Lione, L.A.2
Humby, T.3
Mangiarini, L.4
Mahal, A.5
Bates, G.P.6
-
96
-
-
0033500593
-
Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation
-
Lione LA, Carter RJ, Hunt MJ, Bates GP, Morton AJ, Dunnett SB. Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation. J Neurosci. 1999;19:10428-10437.
-
(1999)
J Neurosci
, vol.19
, pp. 10428-10437
-
-
Lione, L.A.1
Carter, R.J.2
Hunt, M.J.3
Bates, G.P.4
Morton, A.J.5
Dunnett, S.B.6
-
97
-
-
0032811511
-
Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice
-
Li H, Li SH, Cheng AL, Mangiarini L, Bates GP, Li XJ. Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice. Hum Mol Genet. 1999;8:1227-1236.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1227-1236
-
-
Li, H.1
Li, S.H.2
Cheng, A.L.3
Mangiarini, L.4
Bates, G.P.5
Li, X.J.6
-
98
-
-
0034660457
-
Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease
-
Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, et al. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci. 2000;20:4389-4397.
-
(2000)
J Neurosci
, vol.20
, pp. 4389-4397
-
-
Ferrante, R.J.1
Andreassen, O.A.2
Jenkins, B.G.3
Dedeoglu, A.4
Kuemmerle, S.5
Kubilus, J.K.6
-
99
-
-
0033587128
-
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
-
Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, et al. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature. 1999;399:263-267.
-
(1999)
Nature
, vol.399
, pp. 263-267
-
-
Ona, V.O.1
Li, M.2
Vonsattel, J.P.3
Andrews, L.J.4
Khan, S.Q.5
Chung, W.M.6
-
101
-
-
68249155312
-
Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models
-
Menalled L, El-Khodor BF, Patry M, Suarez-Farinas M, Orenstein SJ, Zahasky B, et al. Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models. Neurobiol Dis. 2009;35:319-336.
-
(2009)
Neurobiol Dis
, vol.35
, pp. 319-336
-
-
Menalled, L.1
El-Khodor, B.F.2
Patry, M.3
Suarez-Farinas, M.4
Orenstein, S.J.5
Zahasky, B.6
-
102
-
-
33847684865
-
The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes
-
Woodman B, Butler R, Landles C, Lupton MK, Tse J, Hockly E, et al. The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes. Brain Res Bull. 2007;72:83-97.
-
(2007)
Brain Res Bull
, vol.72
, pp. 83-97
-
-
Woodman, B.1
Butler, R.2
Landles, C.3
Lupton, M.K.4
Tse, J.5
Hockly, E.6
-
103
-
-
23844472610
-
Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
-
Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, et al. Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proc Natl Acad Sci U S A. 2005;102:11402-11407.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 11402-11407
-
-
Slow, E.J.1
Graham, R.K.2
Osmand, A.P.3
Devon, R.S.4
Lu, G.5
Deng, Y.6
-
104
-
-
49649117786
-
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
-
Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, et al. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Hum Mol Genet. 2008;17:2738-2751.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2738-2751
-
-
Wang, C.E.1
Tydlacka, S.2
Orr, A.L.3
Yang, S.H.4
Graham, R.K.5
Hayden, M.R.6
-
105
-
-
0034641936
-
Apoptosis in the nervous system
-
Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000;407:802-809.
-
(2000)
Nature
, vol.407
, pp. 802-809
-
-
Yuan, J.1
Yankner, B.A.2
-
106
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol. 2000;1:120-129.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
107
-
-
84863100006
-
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models
-
Li XJ, Li S. Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. J Genet Genomics. 2012;39:239-245.
-
(2012)
J Genet Genomics
, vol.39
, pp. 239-245
-
-
Li, X.J.1
Li, S.2
-
108
-
-
0032855148
-
A putative Drosophila homolog of the Huntington's disease gene
-
Li Z, Karlovich CA, Fish MP, Scott MP, Myers RM. A putative Drosophila homolog of the Huntington's disease gene. Hum Mol Genet. 1999;8:1807-1815.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1807-1815
-
-
Li, Z.1
Karlovich, C.A.2
Fish, M.P.3
Scott, M.P.4
Myers, R.M.5
-
109
-
-
0032168160
-
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
-
Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, et al. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 1998;21:633-642.
-
(1998)
Neuron
, vol.21
, pp. 633-642
-
-
Jackson, G.R.1
Salecker, I.2
Dong, X.3
Yao, X.4
Arnheim, N.5
Faber, P.W.6
-
110
-
-
0034110465
-
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
-
Marsh JL, Walker H, Theisen H, Zhu YZ, Fielder T, Purcell J, et al. Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila. Hum Mol Genet. 2000;9:13-25.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 13-25
-
-
Marsh, J.L.1
Walker, H.2
Theisen, H.3
Zhu, Y.Z.4
Fielder, T.5
Purcell, J.6
-
111
-
-
80052464728
-
Learning and memory in Drosophila: Behavior, genetics, and neural systems
-
Kahsai L, Zars T. Learning and memory in Drosophila: behavior, genetics, and neural systems. Int Rev Neurobiol. 2011;99:139-167.
-
(2011)
Int Rev Neurobiol
, vol.99
, pp. 139-167
-
-
Kahsai, L.1
Zars, T.2
-
112
-
-
14844341251
-
Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila
-
Agrawal N, Pallos J, Slepko N, Apostol BL, Bodai L, Chang LW, et al. Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc Natl Acad Sci U S A. 2005;102:3777-37781.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3777-37781
-
-
Agrawal, N.1
Pallos, J.2
Slepko, N.3
Apostol, B.L.4
Bodai, L.5
Chang, L.W.6
-
113
-
-
0034705224
-
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
-
Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, et al. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2000;97:5750-5755.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5750-5755
-
-
Satyal, S.H.1
Schmidt, E.2
Kitagawa, K.3
Sondheimer, N.4
Lindquist, S.5
Kramer, J.M.6
-
114
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley JF, Brignull HR, Weyers JJ, Morimoto RI. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2002;99:10417-10422.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
115
-
-
0033524413
-
Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron
-
Faber PW, Alter JR, MacDonald ME, Hart AC. Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron. Proc Natl Acad Sci U S A. 1999;96:179-184.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 179-184
-
-
Faber, P.W.1
Alter, J.R.2
Macdonald, M.E.3
Hart, A.C.4
-
116
-
-
0035818590
-
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosen-sory neurons without cell death
-
Parker JA, Connolly JB, Wellington C, Hayden M, Dausset J, Neri C. Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosen-sory neurons without cell death. Proc Natl Acad Sci U S A. 2001;98:13318-13323.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13318-13323
-
-
Parker, J.A.1
Connolly, J.B.2
Wellington, C.3
Hayden, M.4
Dausset, J.5
Neri, C.6
-
117
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science. 2003;300:1142-1145.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
118
-
-
0037168585
-
Glutamine/ proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity
-
Faber PW, Voisine C, King DC, Bates EA, Hart AC. Glutamine/ proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Proc Natl Acad Sci U S A. 2002;99:17131-17136.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 17131-17136
-
-
Faber, P.W.1
Voisine, C.2
King, D.C.3
Bates, E.A.4
Hart, A.C.5
-
119
-
-
79956311279
-
The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans
-
Haldimann P, Muriset M, Vigh L, Goloubinoff P. The novel hydroxylamine derivative NG-094 suppresses polyglutamine protein toxicity in Caenorhabditis elegans. J Biol Chem. 2011;286:18784-18794.
-
(2011)
J Biol Chem
, vol.286
, pp. 18784-18794
-
-
Haldimann, P.1
Muriset, M.2
Vigh, L.3
Goloubinoff, P.4
-
120
-
-
35548950179
-
Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans
-
Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. PloS One. 2007;2:e504.
-
(2007)
PloS One
, vol.2
-
-
Voisine, C.1
Varma, H.2
Walker, N.3
Bates, E.A.4
Stockwell, B.R.5
Hart, A.C.6
|