Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models

Journal of Pathology

Volumn 219, Issue 2, 2009, Pages 173-181

  Pereson, Sandra ^a,b   Wils, Hans ^a,b   Kleinberger, Gernot ^a,b   McGowan, Eileen ^c   Vandewoestyne, Mado ^d   Van Broeck, Bianca ^a,b,e   Joris, Geert ^a,b   Cuijt, Ivy ^a,b   Deforce, Dieter ^d   Hutton, Michael ^c   Van Broeckhoven, Christine ^a,b   Kumar Singh, Samir ^a,b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c MAYO CLINIC   (United States)

^d GHENT UNIVERSITY   (Belgium)

^e JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Alzheimer disease; Dense core plaques; Image analysis; Immunohistochemistry; Neuroinflammation; Progranulin; Transcriptional profiling; Transgenic mice

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; BIOLOGICAL MARKER; PROGRANULIN;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN TISSUE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GROUPS BY AGE; IMMUNE RESPONSE; INFLAMMATION; LASER MICRODISSECTION; MICROGLIA; MOLECULE; MOUSE; NERVE CELL; NEURITE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; RISK FACTOR;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; NEURITES; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENILE PLAQUES; UP-REGULATION;

EID: 70349091081     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2580     Document Type: Article

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