Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils

Molecular Biology of the Cell

Volumn 18, Issue 4, 2007, Pages 1490-1496

  Majumdar, Amitabha ^a   Cruz, Dana ^a   Asamoah, Nikiya ^a   Buxbaum, Adina ^a   Sohar, Istvan ^b   Lobel, Peter ^b   Maxfield, Frederick R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; AMYLOID; AMYLOID BETA PROTEIN; ANION TRANSPORT PROTEIN; COLONY STIMULATING FACTOR 1; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; INTERLEUKIN 6; LYSOSOME ENZYME; PROTEINASE;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CELL PH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; LYSOSOME; MACROPHAGE; MICROGLIA; MOUSE; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM;

ALZHEIMER DISEASE; AMMONIUM CHLORIDE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-6; LYSOSOMES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICROGLIA; PEPTIDE HYDROLASES;

EID: 34247264399     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E06-10-0975     Document Type: Article

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