Regulated in Development and DNA Damage Responses -1 (REDD1) Protein Contributes to Insulin Signaling Pathway in Adipocytes

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Regazzetti, Claire ^a,b   Dumas, Karine ^a,b   Le Marchand Brustel, Yannick ^a,b   Peraldi, Pascal ^b,c   Tanti, Jean François ^a,b   Giorgetti Peraldi, Sophie ^a,b  

^a CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CUL4A DDB1 UBIQUITIN PROTEIN LIGASE COMPLEX; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; MULTIENZYME COMPLEX; PROTEASOME; RAPAMYCIN; REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSES 1 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME DEGRADATION; HORMONAL REGULATION; HUMAN; HUMAN CELL; INSULIN RESPONSE; INSULIN SIGNALING; LIPOGENESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; INSULIN; MAP KINASE SIGNALING SYSTEM; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MURINAE;

EID: 84871313202     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052154     Document Type: Article

References (40)

1. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, et al. (2002) REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10: 995-1005.
2. Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, et al. (2002) Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22: 2283-2293.
3. Jin HO, An S, Lee HC, Woo SH, Seo SK, et al. (2007) Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway. Cell Signal 19: 1393-1403.
4. Kimball SR, Jefferson LS, (2012) Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2alpha phosphorylation, ATF4-dependent cascade. Biochem Biophys Res Commun 427: 485-489.
5. Jin HO, Seo SK, Woo SH, Kim ES, Lee HC, et al. (2009) Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic Biol Med 46: 1158-1167.
6. Catania C, Binder E, Cota D, (2011) mTORC1 signaling in energy balance and metabolic disease. Int J Obes (Lond) 35: 751-761.
7. Zoncu R, Efeyan A, Sabatini DM, (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35.
8. DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW, (2008) Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22: 239-251.
9. Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J, et al. (2010) Structural analysis and functional implications of the negative mTORC1 regulator REDD1. Biochemistry 49: 2491-2501.
10. Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS, (2008) Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 283: 3465-3475.
11. Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, et al. (2009) REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep 10: 866-872.
12. Taniguchi CM, Emanuelli B, Kahn CR, (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7: 85-96.
13. Siddle K, (2012) Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne) 3: 34.
14. Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, et al. (2001) SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 276: 47944-47949.
15. Goenaga D, Hampe C, Carre N, Cailliau K, Browaeys-Poly E, et al. (2009) Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol 23: 1043-1051.
16. Gual P, Le Marchand-Brustel Y, Tanti JF, (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87: 99-109.
17. Tanti JF, Jager J, (2009) Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr Opin Pharmacol 9: 753-762.
18. Frost RA, Huber D, Pruznak A, Lang CH, (2009) Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes. J Cell Biochem 108: 1192-1202.
19. Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S, (2010) Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. J Biol Chem 285: 5157-5164.
20. Tanti JF, Gremeaux T, Grillo S, Calleja V, Klippel A, et al. (1996) Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes. J Biol Chem 271: 25227-25232.
21. Murdaca J, Treins C, Monthouel-Kartmann MN, Pontier-Bres R, Kumar S, et al. (2004) Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem 279: 26754-26761.
22. Regazzetti C, Peraldi P, Gremeaux T, Najem-Lendom R, Ben-Sahra I, et al. (2009) Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 58: 95-103.
23. Plaisant M, Giorgetti-Peraldi S, Gabrielson M, Loubat A, Dani C, et al. (2011) Inhibition of Hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells. Plos One 6: e16798.
24. Kilroy G, Burk DH, Floyd ZE, (2009) High efficiency lipid-based siRNA transfection of adipocytes in suspension. PLoS One 4: e6940.
25. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632.
26. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, et al. (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18: 2893-2904.
27. Ahmed M, Kundu GC, (2010) Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappaB dependent AP-1-mediated ICAM-1 expression in breast cancer cells. Mol Cancer 9: 101.
28. Samuel VT, Shulman GI, (2012) Mechanisms for insulin resistance: common threads and missing links. Cell 148: 852-871.
29. McGhee NK, Jefferson LS, Kimball SR, (2009) Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. J Nutr 139: 828-834.
30. Sofer A, Lei K, Johannessen CM, Ellisen LW, (2005) Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25: 5834-5845.
31. Schneider A, Younis RH, Gutkind JS, (2008) Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 10: 1295-1302.
32. Ren S, Xu C, Cui Z, Yu Y, Xu W, et al. (2012) Oncogenic CUL4A determines the response to thalidomide treatment in prostate cancer. J Mol Med (Berl) 90: 1121-1132.
33. Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.
34. Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, et al. (2012) DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metab 16: 202-212.
35. Hotamisligil G, Peraldi P, Budavari A, Ellis R, White M, et al. (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271: 665-668.
36. Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332: 1317-1322.
37. Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332: 1322-1326.
38. Favier FB, Costes F, Defour A, Bonnefoy R, Lefai E, et al. (2010) Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia. Am J Physiol Regul Integr Comp Physiol 298: R1659-1666.
39. Hulmi JJ, Silvennoinen M, Lehti M, Kivela R, Kainulainen H, (2012) Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy. Am J Physiol Endocrinol Metab 302: E307-315.
40. Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, et al. (2011) Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metab 13: 170-182.