Rapamycin inhibits the growth of glioblastoma

Brain Research

Volumn 1495, Issue , 2013, Pages 37-51

  Arcella, Antonietta ^a   Biagioni, Francesca ^a   Antonietta Oliva, Maria ^a   Bucci, Domenico ^a   Frati, Alessandro ^a,b   Esposito, Vincenzo ^a,b   Cantore, Giampaolo ^a   Giangaspero, Felice ^a,b   Fornai, Francesco ^a,c  

^a IRCCS Neuromed Pozzilli   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

GBM brain xenografts; Glioblastoma; Human GBM primary cultures; mTOR; Rapamycin

Indexed keywords

BROXURIDINE; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CANCER INHIBITION; CELL COUNT; CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DETERMINATION; DOWN REGULATION; ELECTRON MICROSCOPY; FLUORESCENCE ACTIVATED CELL SORTING; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; MALE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GLIOBLASTOMA; HUMANS; MICE; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; SIROLIMUS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS; MUS MUSCULUS;

EID: 84872383987     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.11.044     Document Type: Article

References (24)

1. J.E. Chang, D. Khuntia, H.I. Robins, and M.P. Mehta Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme Clin. Adv. Hematol. Oncol. 5 2007 907 915
2. T.F. Cloughesy, K. Yoshimoto, and P. Nghiemphu Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma PLoS Med. 22 2008 e8
3. J.S. Eshleman, B.L. Carlson, A.C. Mladek, B.D. Kastner, K.L. Shide, and J.N. Sarkaria Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy Cancer Res. 62 2002 7291 7297
4. Q.W. Fan, and W.A. Weiss Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors Methods Mol. Biol. 821 2012 349 359
5. K.B.J. Franklin, and G. Paxinos The Mouse Brain in Stereotaxic Coordinates 1997 Academic Press San Diego, Calif
6. E.M. Galan-Moya, A. Le Guelte, and E. Lima Fernandes Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion mTOR through the pathway EMBO Rep. 12 2011 470 476
7. N. Gaspar, S.Y. Sharp, and S.A. Eccles Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma Mol. Cancer Ther. 9 2010 1219 1233
8. X. Hu, P.P. Pandolfi, Y. Li, J.A. Koutcher, M. Rosenblum, and E.C. Holland mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma Neoplasia 7 2005 356 368
9. H. Jiang, E.J. White, C. Conrad, C. Gomez-Manzano, and J. Fueyo Autophagy pathways in glioblastoma Method Enzymol. 453 2009 273 286
10. B.L. Kasiske, B. Nashan, and M.C. Rial A prospective, multinational pharmacoepidemiological study of clinical conversion to sirolimus immunosuppression after renal transplantation J. Transplant. 2012 2012 1 16
11. F. Lefranc, and R. Kiss Autophagy, the Trojan horse to combat glioblastomas Neurosurg. Focus. 20 2006 E7
12. F. Lefranc, V. Facchini, and R. Kiss Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas Oncologist 12 2007 1395 1403
13. W.T. Liu, C.H. Lin, M. Hsiao, and P.W. Gean Minocycline inhibits the growth of glioma by inducing autophagy Autophagy 7 2011 166 175
14. K.A. Osborne, T. Shigeno, and A.M. Balarsky Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia J. Neurol. Neurosurg. Psychiatry 50 1987 402 410
15. T. Pan, S. Kondo, W. Zhu, W. Xie, J. Jankovic, and W. Le Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement Neurobiol. Dis. 32 2008 16 25
16. A. Panner, C.D. James, M.S. Berger, and R.O. Pieper mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells Mol. Cell Biol. 25 2005 8809 8823
17. M.A. Park, R. Reinehr, and D. Häussinger Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells Mol. Cancer Ther. 9 2010 2220 2231
18. I.V. Pop, L.M. Pop, M.A. Ghetie, and ES Vitetta Targeting mammalian target of rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines Leuk. Lymphoma 50 2009 1155 1162
19. S. Puli, A. Jain, J.C. Lai, and A. Bhushan Effect of combination treatment of rapamycin and isoflavones on mTOR pathway in human glioblastoma (U87) cells Neurochem Res. 35 2010 986 993
20. R. Stupp, M.E. Hegi, and W.P. Mason Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Lancet Oncol. 10 2009 459 466
21. A. Zanotto-Filho, E. Braganhol, and R. Schröder NFκB inhibitors induce cell death in glioblastomas Biochem. Pharmacol. 81 2011 412 424
22. Y. Zhao, Q. Huang, and J. Yang Autophagy impairment inhibits differentiation of glioma stem/progenitor cells Brain Res. 1313 2010 250 258
23. W. Zhuang, Z. Qin, and Z. Liang The role of autophagy in sensitizing malignant glioma cells to radiation therapy Acta Biochim. Biophys. Sin. (Shanghai) 41 2009 341 351
24. W. Zhuang, B. Li, L. Long, L. Chen, Q. Huang, and Z. Liang Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity Int. J. Cancer 129 2011 2720 2731