-
1
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
DOI 10.1038/362059a0
-
DR Rosen T Siddique D Patterson DA Figlewicz P Sapp A Hentati D Donaldson J Goto JP O'Regan HX Deng Z Rahmani A Krizus D McKenna-Yasek A Cayabyab SM Gaston R Berger RE Tanzi JJ Halperin B Herzfeldt R Van den Bergh WY Hung T Bird G Deng DW Mulder C Smyth NG Laing E Soriano MA Pericak-Vance J Haines GA Rouleau JS Gusella HR Horvitz RH Brown Jr 1993 Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 59 62 doi:10.1038/362059a0 10.1038/362059a0 1993Natur.362...59R (Pubitemid 23087289)
-
(1993)
Nature
, vol.362
, Issue.6415
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.-X.10
Rahmani, Z.11
Krizus, A.12
McKenna-Yasek, D.13
Cayabyab, A.14
Gaston, S.M.15
Berger, R.16
Tanzi, R.E.17
Halperin, J.J.18
Herzfeldt, B.19
-
2
-
-
15844393658
-
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
-
DOI 10.1038/ng0596-43
-
AG Reaume JL Elliott EK Hoffman NW Kowall RJ Ferrante DF Siwek HM Wilcox DG Flood MF Beal RH Brown RW Scott Jr. WD Snider 1996 Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury Nat. Genet. 13 43 47 doi:10.1038/ng0596-43 10.1038/ng0596-43 (Pubitemid 26139292)
-
(1996)
Nature Genetics
, vol.13
, Issue.1
, pp. 43-47
-
-
Reaume, A.G.1
Elliott, J.L.2
Hoffman, E.K.3
Kowall, N.W.4
Ferrante, R.J.5
Siwek, D.F.6
Wilcox, H.M.7
Flood, D.G.8
Beal, M.F.9
Brown Jr., R.H.10
Scott, R.W.11
Snider, W.D.12
-
3
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
-
ME Gurney H Pu AY Chiu MC Dal Canto CY Polchow DD Alexander J Caliendo A Hentati YW Kwon HX Deng W Chen P Zhai RL Sufit T Siddique 1994 Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation Science 264 1772 1775 doi:10.1126/science.8209258 10.1126/science.8209258 1994Sci...264.1772G (Pubitemid 24227760)
-
(1994)
Science
, vol.264
, Issue.5166
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
Caliendo, J.7
Hentati, A.8
Kwon, Y.W.9
Deng, H.-X.10
Chen, W.11
Zhai, P.12
Sufit, R.L.13
Siddique, T.14
-
4
-
-
0037096354
-
Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease
-
MM Lino C Schneider P Caroni 2002 Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease J. Neurosci. 22 4825 4832
-
(2002)
J. Neurosci
, vol.22
, pp. 4825-4832
-
-
Lino, M.M.1
Schneider, C.2
Caroni, P.3
-
5
-
-
0035873076
-
Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
-
A Pramatarova J Laganiere J Roussel K Brisebois G Rouleau 2001 Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J. Neurosci. 21 3369 3374
-
(2001)
J. Neurosci
, vol.21
, pp. 3369-3374
-
-
Pramatarova, A.1
Laganiere, J.2
Roussel, J.3
Brisebois, K.4
Rouleau, G.5
-
6
-
-
0034651102
-
Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
-
YH Gong AS Parsadanian A Andreeva WD Snider JL Elliott 2000 Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration J. Neurosci. 20 660 665
-
(2000)
J. Neurosci
, vol.20
, pp. 660-665
-
-
Gong, Y.H.1
Parsadanian, A.S.2
Andreeva, A.3
Snider, W.D.4
Elliott, J.L.5
-
7
-
-
39849103473
-
Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
-
DOI 10.1523/JNEUROSCI.5258-07.2008
-
D Jaarsma E Teuling ED Haasdijk CI De Zeeuw CC Hoogenraad 2008 Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice J. Neurosci. 28 2075 2088 doi:10.1523/JNEUROSCI.5258-07.2008 10.1523/JNEUROSCI.5258-07.2008 (Pubitemid 351317636)
-
(2008)
Journal of Neuroscience
, vol.28
, Issue.9
, pp. 2075-2088
-
-
Jaarsma, D.1
Teuling, E.2
Haasdijk, E.D.3
De Zeeuw, C.I.4
Hoogenraad, C.C.5
-
8
-
-
0141642203
-
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
-
DOI 10.1126/science.1086071
-
AM Clement MD Nguyen EA Roberts ML Garcia S Boillée M Rule AP McMahon W Doucette D Siwek RJ Ferrante RH Brown JP Julien Jr. LS Goldstein DW Cleveland 2003 Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science 302 113 117 doi:10.1126/science.1086071 10.1126/science.1086071 2003Sci...302..113C (Pubitemid 37210700)
-
(2003)
Science
, vol.302
, Issue.5642
, pp. 113-117
-
-
Clement, A.M.1
Nguyen, M.D.2
Roberts, E.A.3
Garcia, M.L.4
Boillee, S.5
Rule, M.6
McMahon, A.P.7
Doucette, W.8
Siwek, D.9
Ferrante, R.J.10
Brown Jr., R.H.11
Julien, J.-P.12
Goldstein, L.S.B.13
Cleveland, D.W.14
-
9
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
DOI 10.1126/science.1123511
-
S Boillée K Yamanaka CS Lobsiger NG Copeland NA Jenkins G Kassiotis G Kollias DW Cleveland 2006 Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 1389 1392 doi:10.1126/science.1123511 10.1126/science.1123511 2006Sci...312.1389B (Pubitemid 43839552)
-
(2006)
Science
, vol.312
, Issue.5778
, pp. 1389-1392
-
-
Boillee, S.1
Yamanaka, K.2
Lobsiger, C.S.3
Copeland, N.G.4
Jenkins, N.A.5
Kassiotis, G.6
Kollias, G.7
Cleveland, D.W.8
-
10
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
DOI 10.1038/nn2047, PII NN2047
-
K Yamanaka SJ Chun S Boillée N Fujimori-Tonou H Yamashita DH Gutmann R Takahashi H Misawa DW Cleveland 2008 Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis Nat. Neurosci. 11 251 253 doi:10.1038/nn2047 10.1038/nn2047 (Pubitemid 351311795)
-
(2008)
Nature Neuroscience
, vol.11
, Issue.3
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
Fujimori-Tonou, N.4
Yamashita, H.5
Gutmann, D.H.6
Takahashi, R.7
Misawa, H.8
Cleveland, D.W.9
-
11
-
-
0032125587
-
Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
-
DOI 10.1002/(SICI)1098-1136(199807)23:3<249::AID-GLIA7>3.0.CO;2-#
-
ED Hall JA Oostveen ME Gurney 1998 Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS Glia 23 249 256 doi:10.1002/(SICI)1098-1136(199807)23:3<249:: AID-GLIA7>3.0.CO;2-# 10.1002/(SICI)1098-1136(199807)23:3<249::AID- GLIA7>3.0.CO;2-# (Pubitemid 28259722)
-
(1998)
GLIA
, vol.23
, Issue.3
, pp. 249-256
-
-
Hall, E.D.1
Oostveen, J.A.2
Gurney, M.E.3
-
12
-
-
0025868659
-
Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain
-
doi:10.1097/00005072-199105000-00008 10.1097/00005072-199105000-00008
-
PD Kushner DT Stephenson S Wright 1991 Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain J. Neuropathol. Exp. Neurol. 50 263 277 doi:10.1097/00005072-199105000- 00008 10.1097/00005072-199105000-00008
-
(1991)
J. Neuropathol. Exp. Neurol
, vol.50
, pp. 263-277
-
-
Kushner, P.D.1
Stephenson, D.T.2
Wright, S.3
-
14
-
-
0026597010
-
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
-
JD Rothstein LJ Martin RW Kuncl 1992 Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis N. Engl. J. Med. 326 1464 1468
-
(1992)
N. Engl. J. Med
, vol.326
, pp. 1464-1468
-
-
Rothstein, J.D.1
Martin, L.J.2
Kuncl, R.W.3
-
15
-
-
0028168346
-
3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: A quantitative autoradiographic study
-
DOI 10.1016/0006-8993(94)91614-4
-
3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study Brain Res. 655 195 201 doi:10.1016/0006- 8993(94)91614-4 10.1016/0006-8993(94)91614-4 (Pubitemid 24263009)
-
(1994)
Brain Research
, vol.655
, Issue.1-2
, pp. 195-201
-
-
Shaw, P.J.1
Chimnery, R.M.2
Ince, P.G.3
-
16
-
-
0029030610
-
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
-
doi:10.1002/ana.410380114 10.1002/ana.410380114
-
JD Rothstein M Van Kammen AI Levey LJ Martin RW Kuncl 1995 Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann. Neurol. 38 73 84 doi:10.1002/ana.410380114 10.1002/ana.410380114
-
(1995)
Ann. Neurol
, vol.38
, pp. 73-84
-
-
Rothstein, J.D.1
Van Kammen, M.2
Levey, A.I.3
Martin, L.J.4
Kuncl, R.W.5
-
17
-
-
0033938202
-
Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis
-
doi:10.1007/s004019900159 10.1007/s004019900159
-
S Sasaki T Komori M Iwata 2000 Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis Acta Neuropathol. 100 138 144 doi:10.1007/s004019900159 10.1007/s004019900159
-
(2000)
Acta Neuropathol
, vol.100
, pp. 138-144
-
-
Sasaki, S.1
Komori, T.2
Iwata, M.3
-
18
-
-
0031879593
-
The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: An immunohistochemical study
-
DOI 10.1046/j.1460-9568.1998.00273.x
-
AE Fray PG Ince SJ Banner ID Milton PA Usher MR Cookson PJ Shaw 1998 The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study Eur. J. Neurosci. 10 2481 2489 doi:10.1046/j.1460-9568.1998.00273.x 10.1046/j.1460-9568.1998.00273.x (Pubitemid 28362556)
-
(1998)
European Journal of Neuroscience
, vol.10
, Issue.8
, pp. 2481-2489
-
-
Fray, A.E.1
Ince, P.G.2
Banner, S.J.3
Milton, I.D.4
Usher, P.A.5
Cookson, M.R.6
Shaw, P.J.7
-
19
-
-
0035189072
-
Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels
-
DOI 10.1046/j.1471-4159.2001.00572.x
-
C Bendotti M Tortarolo SK Suchak N Calvaresi L Carvelli A Bastone M Rizzi M Rattray T Mennini 2001 Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels J. Neurochem. 79 737 746 doi:10.1046/j.1471-4159.2001.00572.x 10.1046/j.1471-4159. 2001.00572.x (Pubitemid 33086511)
-
(2001)
Journal of Neurochemistry
, vol.79
, Issue.4
, pp. 737-746
-
-
Bendotti, C.1
Tortarolo, M.2
Suchak, S.K.3
Calvaresi, N.4
Carvelli, L.5
Bastone, A.6
Rizzi, M.7
Rattray, M.8
Mennini, T.9
-
20
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
DOI 10.1016/S0896-6273(00)80272-X
-
LI Bruijn MW Becher MK Lee KL Anderson NA Jenkins NG Copeland SS Sisodia JD Rothstein DR Borchelt DL Price DW Cleveland 1997 ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions Neuron 18 327 338 doi:10.1016/S0896-6273(00)80272-X 10.1016/S0896-6273(00)80272-X (Pubitemid 27111114)
-
(1997)
Neuron
, vol.18
, Issue.2
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
Sisodia, S.S.7
Rothstein, J.D.8
Borchelt, D.R.9
Price, D.L.10
Cleveland, D.W.11
-
21
-
-
0037022339
-
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
-
DOI 10.1073/pnas.032539299
-
DS Howland J Liu Y She B Goad NJ Maragakis B Kim J Erickson J Kulik L DeVito G Psaltis LJ DeGennaro DW Cleveland JD Rothstein 2002 Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) Proc. Natl. Acad. Sci. U. S. A. 99 1604 1609 doi:10.1073/pnas.032539299 10.1073/pnas.032539299 2002PNAS...99.1604H (Pubitemid 34136539)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.3
, pp. 1604-1609
-
-
Howland, D.S.1
Liu, J.2
She, Y.3
Goad, B.4
Maragakis, N.J.5
Kim, B.6
Erickson, J.7
Kulik, J.8
DeVito, L.9
Psaltis, G.10
DeGennaro, L.J.11
Cleveland, D.W.12
Rothstein, J.D.13
-
22
-
-
13344286293
-
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
-
DOI 10.1016/S0896-6273(00)80086-0
-
JD Rothstein M Dykes-Hoberg CA Pardo LA Bristol L Jin RW Kuncl Y Kanai MA Hediger Y Wang JP Schielke DF Welty 1996 Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate Neuron 16 675 686 doi:10.1016/S0896-6273(00)80086-0 10.1016/S0896-6273(00)80086-0 (Pubitemid 26103145)
-
(1996)
Neuron
, vol.16
, Issue.3
, pp. 675-686
-
-
Rothstein, J.D.1
Dykes-Hoberg, M.2
Pardo, C.A.3
Bristol, L.A.4
Jin, L.5
Kuncl, R.W.6
Kanai, Y.7
Hediger, M.A.8
Wang, Y.9
Schielke, J.P.10
Welty, D.F.11
-
23
-
-
0033366461
-
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
-
DOI 10.1038/8091
-
D Trotti A Rolfs NC Danbolt RH Brown Hediger MA Jr. 1999 SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nat. Neurosci. 2 427 433 doi:10.1038/8091 10.1038/8091 (Pubitemid 30491252)
-
(1999)
Nature Neuroscience
, vol.2
, Issue.5
, pp. 427-433
-
-
Trotti, D.1
Rolfs, A.2
Danbolt, N.C.3
Brown Jr., R.H.4
Hediger, M.A.5
-
25
-
-
0345269737
-
Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons
-
SD Rao HZ Yin JH Weiss 2003 Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons J. Neurosci. 23 2627 2633
-
(2003)
J. Neurosci
, vol.23
, pp. 2627-2633
-
-
Rao, S.D.1
Yin, H.Z.2
Weiss, J.H.3
-
26
-
-
0033569575
-
Calcium dynamics and lowering in motoneurones of the mouse spinal cord
-
DOI 10.1111/j.1469-7793.1999.00485.x
-
J Palecek MB Lips BU Keller 1999 Calcium dynamics and buffering in motoneurons of the mouse spinal cord J. Physiol. 520 Pt 2 485 502 doi:10.1111/j.1469-7793.1999.00485.x 10.1111/j.1469-7793.1999.00485.x (Pubitemid 29511912)
-
(1999)
Journal of Physiology
, vol.520
, Issue.2
, pp. 485-502
-
-
Palecek, J.1
Lips, M.B.2
Keller, B.U.3
-
27
-
-
34248592075
-
2+ transients in cultured spinal motor neurons
-
DOI 10.1016/j.ceca.2006.11.010, PII S0143416006002156
-
2+ transients in cultured spinal motor neurons Cell Calcium 42 59 69 doi:10.1016/j.ceca.2006.11.010 10.1016/j.ceca.2006.11.010 (Pubitemid 46760454)
-
(2007)
Cell Calcium
, vol.42
, Issue.1
, pp. 59-69
-
-
Grosskreutz, J.1
Haastert, K.2
Dewil, M.3
Van Damme, P.4
Callewaert, G.5
Robberecht, W.6
Dengler, R.7
Van Den Bosch, L.8
-
28
-
-
5644229846
-
Neurotrophic factors and amyotrophic lateral sclerosis
-
DOI 10.1159/000080049
-
E Ekestern 2004 Neurotrophic factors and amyotrophic lateral sclerosis Neurodegener. Dis. 1 88 100 doi:10.1159/000080049 10.1159/000080049 (Pubitemid 39369422)
-
(2004)
Neurodegenerative Diseases
, vol.1
, Issue.2-3
, pp. 88-100
-
-
Ekestern, E.1
-
29
-
-
4444377607
-
Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
-
DOI 10.1016/j.nbd.2004.06.004, PII S0969996104001330
-
L Van Den Bosch E Storkebaum V Vleminckx L Moons L Vanopdenbosch W Scheveneels P Carmeliet W Robberecht 2004 Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration Neurobiol. Dis. 17 21 28 doi:10.1016/j.nbd.2004.06.004 10.1016/j.nbd.2004.06.004 (Pubitemid 39209309)
-
(2004)
Neurobiology of Disease
, vol.17
, Issue.1
, pp. 21-28
-
-
Van Den Bosch, L.1
Storkebaum, E.2
Vleminckx, V.3
Moons, L.4
Vanopdenbosch, L.5
Scheveneels, W.6
Carmeliet, P.7
Robberecht, W.8
-
30
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
DOI 10.1038/88842
-
B Oosthuyse L Moons E Storkebaum H Beck D Nuyens K Brusselmans J Van Dorpe P Hellings M Gorselink S Heymans G Theilmeier M Dewerchin V Laudenbach P Vermylen H Raat T Acker V Vleminckx L Van Den Bosch N Cashman H Fujisawa MR Drost R Sciot F Bruyninckx DJ Hicklin C Ince P Gressens F Lupu KH Plate W Robberecht JM Herbert D Collen P Carmeliet 2001 Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration Nat. Genet. 28 131 138 doi:10.1038/88842 10.1038/88842 (Pubitemid 32538057)
-
(2001)
Nature Genetics
, vol.28
, Issue.2
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Storkebaum, E.3
Beck, H.4
Nuyens, D.5
Brusselmans, K.6
Dorpe, J.V.7
Hellings, P.8
Gorselink, M.9
Heymans, S.10
Theilmeier, G.11
Dewerchin, M.12
Laudenbach, V.13
Vermylen, P.14
Raat, H.15
Acker, T.16
Vleminckx, V.17
Bosch, L.V.D.18
Cashman, N.19
Fujisawa, H.20
Drost, M.R.21
Sciot, R.22
Bruyninckx, F.23
Hicklin, D.J.24
Ince, C.25
Gressens, P.26
Lupu, F.27
Plate, K.H.28
Robberecht, W.29
Herbert, J.-M.30
Collen, D.31
Carmeliet, P.32
more..
-
32
-
-
22844452812
-
Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis
-
DOI 10.1016/j.jns.2005.04.011, PII S0022510X05001541
-
I Nagano H Ilieva M Shiote T Murakami M Yokoyama M Shoji K Abe 2005 Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis J. Neurol. Sci. 235 61 68 doi:10.1016/j.jns.2005.04.011 10.1016/j.jns.2005.04.011 (Pubitemid 41039094)
-
(2005)
Journal of the Neurological Sciences
, vol.235
, Issue.1-2
, pp. 61-68
-
-
Nagano, I.1
Ilieva, H.2
Shiote, M.3
Murakami, T.4
Yokoyama, M.5
Shoji, M.6
Abe, K.7
-
33
-
-
1942423576
-
Astrocytic production of nerve growth factor in motor neuron apoptosis: Implications for amyotrophic lateral sclerosis
-
DOI 10.1111/j.1471-4159.2004.02357.x
-
M Pehar P Cassina MR Vargas R Castellanos L Viera JS Beckman AG Estevez L Barbeito 2004 Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis J. Neurochem. 89 464 473 doi:10.1111/j.1471-4159.2004.02357.x 10.1111/j.1471-4159.2004.02357.x (Pubitemid 38495994)
-
(2004)
Journal of Neurochemistry
, vol.89
, Issue.2
, pp. 464-473
-
-
Pehar, M.1
Cassina, P.2
Vargas, M.R.3
Castellanos, R.4
Viera, L.5
Beckman, J.S.6
Estevez, A.G.7
Barbeito, L.8
-
34
-
-
34247473080
-
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
-
DOI 10.1038/nn1885, PII NN1885
-
FP Di Giorgio MA Carrasco MC Siao T Maniatis K Eggan 2007 Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat. Neurosci. 10 608 614 doi:10.1038/nn1885 10.1038/nn1885 (Pubitemid 46652442)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.5
, pp. 608-614
-
-
Di Giorgio, F.P.1
Carrasco, M.A.2
Siao, M.C.3
Maniatis, T.4
Eggan, K.5
-
35
-
-
34247475338
-
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
-
DOI 10.1038/nn1876, PII NN1876
-
M Nagai DB Re T Nagata A Chalazonitis TM Jessell H Wichterle S Przedborski 2007 Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Nat. Neurosci. 10 615 622 doi:10.1038/nn1876 10.1038/nn1876 (Pubitemid 46652435)
-
(2007)
Nature Neuroscience
, vol.10
, Issue.5
, pp. 615-622
-
-
Nagai, M.1
Re, D.B.2
Nagata, T.3
Chalazonitis, A.4
Jessell, T.M.5
Wichterle, H.6
Przedborski, S.7
-
36
-
-
29444443348
-
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
-
DOI 10.1038/nn1603
-
M Urushitani A Sik T Sakurai N Nukina R Takahashi JP Julien 2006 Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat. Neurosci. 9 108 118 doi:10.1038/nn1603 10.1038/nn1603 (Pubitemid 43011916)
-
(2006)
Nature Neuroscience
, vol.9
, Issue.1
, pp. 108-118
-
-
Urushitani, M.1
Sik, A.2
Sakurai, T.3
Nukina, N.4
Takahashi, R.5
Julien, J.-P.6
-
37
-
-
0037067009
-
Minocycline delays disease onset and mortality in a transgenic model of ALS
-
doi:10.1097/00001756-200206120-00018 10.1097/00001756-200206120-00018
-
L Van Den Bosch P Tilkin G Lemmens W Robberecht 2002 Minocycline delays disease onset and mortality in a transgenic model of ALS NeuroReport 13 1067 1070 doi:10.1097/00001756-200206120-00018 10.1097/00001756-200206120-00018
-
(2002)
NeuroReport
, vol.13
, pp. 1067-1070
-
-
Van Den Bosch, L.1
Tilkin, P.2
Lemmens, G.3
Robberecht, W.4
-
38
-
-
0036406903
-
Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
-
DOI 10.1006/nbdi.2002.0487
-
J Kriz MD Nguyen JP Julien 2002 Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis Neurobiol. Dis. 10 268 278 doi:10.1006/nbdi.2002.0487 10.1006/nbdi.2002.0487 (Pubitemid 35217580)
-
(2002)
Neurobiology of Disease
, vol.10
, Issue.3
, pp. 268-278
-
-
Kriz, J.1
Nguyen, M.D.2
Julien, J.-P.3
-
39
-
-
0032487656
-
Glial cells potentiate kainate-induced neuronal death in a motoneuron- enriched spinal coculture system
-
DOI 10.1016/S0006-8993(98)00569-1, PII S0006899398005691
-
W Vandenberghe L Van Den Bosch W Robberecht 1998 Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system Brain Res. 807 1 10 doi:10.1016/S0006-8993(98)00569-1 10.1016/S0006-8993(98) 00569-1 (Pubitemid 29005230)
-
(1998)
Brain Research
, vol.807
, Issue.1-2
, pp. 1-10
-
-
Vandenberghe, W.1
Van Den Bosch, L.2
Robberecht, W.3
-
40
-
-
0030015076
-
Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
-
SG Carriedo HZ Yin JH Weiss 1996 Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro J. Neurosci. 16 4069 4079
-
(1996)
J. Neurosci
, vol.16
, pp. 4069-4079
-
-
Carriedo, S.G.1
Yin, H.Z.2
Weiss, J.H.3
-
42
-
-
5444222849
-
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model
-
DOI 10.1093/hmg/ddh246
-
M Tateno H Sadakata M Tanaka S Itohara RM Shin M Miura M Masuda T Aosaki M Urushitani H Misawa R Takahashi 2004 Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model Hum. Mol. Genet. 13 2183 2196 doi:10.1093/hmg/ddh246 10.1093/hmg/ddh246 (Pubitemid 39359919)
-
(2004)
Human Molecular Genetics
, vol.13
, Issue.19
, pp. 2183-2196
-
-
Tateno, M.1
Sadakata, H.2
Tanaka, M.3
Itohara, S.4
Shin, R.-M.5
Miura, M.6
Masuda, M.7
Aosaki, T.8
Urushitani, M.9
Misawa, H.10
Takahashi, R.11
-
44
-
-
35548983991
-
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
-
DOI 10.1073/pnas.0705046104
-
P Van Damme E Bogaert M Dewil N Hersmus D Kiraly W Scheveneels I Bockx D Braeken N Verpoorten K Verhoeven V Timmerman P Herijgers G Callewaert P Carmeliet L Van Den Bosch W Robberecht 2007 Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity Proc. Natl. Acad. Sci. U. S. A. 104 14825 14830 doi:10.1073/pnas.0705046104 10.1073/pnas. 0705046104 2007PNAS..10414825V (Pubitemid 350003227)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.37
, pp. 14825-14830
-
-
Van Damme, P.1
Bogaert, E.2
Dewil, M.3
Hersmus, N.4
Kiraly, D.5
Scheveneels, W.6
Bockx, I.7
Braeken, D.8
Verpoorten, N.9
Verhoeven, K.10
Timmerman, V.11
Herijgers, P.12
Callewaert, G.13
Carmeliet, P.14
Van Bosch, L.D.15
Robberecht, W.16
-
45
-
-
77953732352
-
VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
-
doi:10.1016/j.neurobiolaging.2008.12.007
-
Bogaert, E., Van Damme, P., Poesen, K., Dhondt, J., Hersmus, N., Kiraly, D., Scheveneels, W., Robberecht, W., Van Den Bosch, L.: VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. Neurobiol. Aging (2009). doi: 10.1016/j.neurobiolaging.2008.12.007
-
(2009)
Neurobiol. Aging
-
-
Bogaert, E.1
Van Damme, P.2
Poesen, K.3
Dhondt, J.4
Hersmus, N.5
Kiraly, D.6
Scheveneels, W.7
Robberecht, W.8
Van Den Bosch, L.9
-
46
-
-
42549127816
-
Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase
-
DOI 10.1111/j.1471-4159.2007.05206.x
-
L Tolosa M Mir VJ Asensio G Olmos J Llado 2008 Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase J. Neurochem. 105 1080 1090 doi:10.1111/j.1471-4159.2007.05206.x 10.1111/j.1471-4159.2007.05206.x (Pubitemid 351590778)
-
(2008)
Journal of Neurochemistry
, vol.105
, Issue.4
, pp. 1080-1090
-
-
Tolosa, L.1
Mir, M.2
Asensio, V.J.3
Olmos, G.4
Llado, J.5
-
47
-
-
55849091446
-
Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria
-
doi:10.1111/j.1471-4159.2008.05699.x 10.1111/j.1471-4159.2008.05699.x
-
LG Bilsland N Nirmalananthan J Yip L Greensmith MR Duchen 2008 Expression of mutant SOD1 in astrocytes induces functional deficits in motoneuron mitochondria J. Neurochem. 107 1271 1283 doi:10.1111/j.1471-4159.2008.05699.x 10.1111/j.1471-4159.2008.05699.x
-
(2008)
J. Neurochem
, vol.107
, pp. 1271-1283
-
-
Bilsland, L.G.1
Nirmalananthan, N.2
Yip, J.3
Greensmith, L.4
Duchen, M.R.5
-
48
-
-
38149129457
-
A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function
-
doi:10.1523/JNEUROSCI.4178-07.2008 10.1523/JNEUROSCI.4178-07.2008
-
JD Cahoy B Emery A Kaushal LC Foo JL Zamanian KS Christopherson Y Xing JL Lubischer PA Krieg SA Krupenko WJ Thompson BA Barres 2008 A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function J. Neurosci. 28 264 278 doi:10.1523/JNEUROSCI.4178-07.2008 10.1523/JNEUROSCI.4178-07.2008
-
(2008)
J. Neurosci
, vol.28
, pp. 264-278
-
-
Cahoy, J.D.1
Emery, B.2
Kaushal, A.3
Foo, L.C.4
Zamanian, J.L.5
Christopherson, K.S.6
Xing, Y.7
Lubischer, J.L.8
Krieg, P.A.9
Krupenko, S.A.10
Thompson, W.J.11
Barres, B.A.12
-
49
-
-
43449086380
-
Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
-
doi:10.1016/j.expneurol.2008.02.020 10.1016/j.expneurol.2008.02.020
-
AC Lepore C Dejea J Carmen B Rauck DA Kerr MV Sofroniew NJ Maragakis 2008 Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration Exp. Neurol. 211 423 432 doi:10.1016/j.expneurol.2008.02.020 10.1016/j.expneurol.2008.02.020
-
(2008)
Exp. Neurol
, vol.211
, pp. 423-432
-
-
Lepore, A.C.1
Dejea, C.2
Carmen, J.3
Rauck, B.4
Kerr, D.A.5
Sofroniew, M.V.6
Maragakis, N.J.7
-
50
-
-
19944428649
-
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
-
DOI 10.1038/nature03180
-
JD Rothstein S Patel MR Regan C Haenggeli YH Huang DE Bergles L Jin M Dykes Hoberg S Vidensky DS Chung SV Toan LI Bruijn ZZ Su P Gupta PB Fisher 2005 Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature 433 73 77 doi:10.1038/nature03180 10.1038/nature03180 2005Natur.433...73R (Pubitemid 40101145)
-
(2005)
Nature
, vol.433
, Issue.7021
, pp. 73-77
-
-
Rothstein, J.D.1
Patel, S.2
Regan, M.R.3
Haenggeli, C.4
Huang, Y.H.5
Bergles, D.E.6
Jin, L.7
Hoberg, M.D.8
Vidensky, S.9
Chung, D.S.10
Shuy, V.T.11
Bruijn, L.I.12
Su, Z.-Z.13
Gupta, P.14
Fisher, P.B.15
-
51
-
-
33749056809
-
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
-
DOI 10.1016/j.neuron.2006.09.018, PII S0896627306007252
-
S Boillée C Vande Velde DW Cleveland 2006 ALS: a disease of motor neurons and their nonneuronal neighbors Neuron 52 39 59 doi:10.1016/j.neuron. 2006.09.018 10.1016/j.neuron.2006.09.018 (Pubitemid 44466358)
-
(2006)
Neuron
, vol.52
, Issue.1
, pp. 39-59
-
-
Boillee, S.1
Vande Velde, C.2
Cleveland, DonW.3
-
52
-
-
16644382257
-
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
-
DOI 10.1038/nn1360
-
E Storkebaum D Lambrechts M Dewerchin MP Moreno-Murciano S Appelmans H Oh P Van Damme B Rutten WY Man M De Mol S Wyns D Manka K Vermeulen L Van Den Bosch N Mertens C Schmitz W Robberecht EM Conway D Collen L Moons P Carmeliet 2005 Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS Nat. Neurosci. 8 85 92 doi:10.1038/nn1360 10.1038/nn1360 (Pubitemid 41236736)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.1
, pp. 85-92
-
-
Storkebaum, E.1
Lambrechts, D.2
Dewerchin, M.3
Moreno-Murciano, M.-P.4
Appelmans, S.5
Oh, H.6
Van Damme, P.7
Rutten, B.8
Man, W.9
De Mol, M.10
Wyns, S.11
Manka, D.12
Vermeulen, K.13
Van Den Bosch, L.14
Mertens, N.15
Schmitz, C.16
Robberecht, W.17
Conway, E.M.18
Collen, D.19
Moons, L.20
Carmeliet, P.21
more..
-
53
-
-
0030050727
-
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
-
DOI 10.1002/ana.410390203
-
ME Gurney FB Cutting P Zhai A Doble CP Taylor PK Andrus ED Hall 1996 Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis Ann. Neurol. 39 147 157 doi:10.1002/ana.410390203 10.1002/ana.410390203 (Pubitemid 26071564)
-
(1996)
Annals of Neurology
, vol.39
, Issue.2
, pp. 147-157
-
-
Gurney, M.E.1
Cutting, F.B.2
Zhai, P.3
Doble, A.4
Taylor, C.P.5
Andrus, P.K.6
Hall, E.D.7
-
54
-
-
0028097839
-
A controlled trial of riluzole in amyotrophic lateral sclerosis
-
DOI 10.1056/NEJM199403033300901
-
G Bensimon L Lacomblez V Meininger 1994 A controlled trial of riluzole in amyotrophic lateral sclerosis N. Engl. J. Med. 330 585 591 doi:10.1056/ NEJM199403033300901 10.1056/NEJM199403033300901 (Pubitemid 24065791)
-
(1994)
New England Journal of Medicine
, vol.330
, Issue.9
, pp. 585-591
-
-
Bensimon, G.1
Lacomblez, L.2
Meininger, V.3
-
55
-
-
0029977337
-
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/Riluzole study group II
-
L Lacomblez G Bensimon PN Leigh P Guillet V Meininger 1996 Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/Riluzole study group II Lancet 347 1425 1431
-
(1996)
Lancet
, vol.347
, pp. 1425-1431
-
-
Lacomblez, L.1
Bensimon, G.2
Leigh, P.N.3
Guillet, P.4
Meininger, V.5
-
56
-
-
0037986558
-
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
-
DOI 10.1016/S0304-3940(03)00314-8
-
P Van Damme M Leyssen G Callewaert W Robberecht L Van Den Bosch 2003 The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis Neurosci. Lett. 343 81 84 doi:10.1016/S0304- 3940(03)00314-8 10.1016/S0304-3940(03)00314-8 (Pubitemid 36577521)
-
(2003)
Neuroscience Letters
, vol.343
, Issue.2
, pp. 81-84
-
-
Van Damme, P.1
Leyssen, M.2
Callewaert, G.3
Robberecht, W.4
Van Den Bosch, L.5
-
57
-
-
0034802145
-
RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: Synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis
-
T Canton GA Bohme A Boireau F Bordier S Mignani P Jimonet G Jahn M Alavijeh J Stygall S Roberts C Brealey M Vuilhorgne MW Debono S Le Guern M Laville D Briet M Roux JM Stutzmann J Pratt 2001 RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis J. Pharmacol. Exp. Ther. 299 314 322
-
(2001)
J. Pharmacol. Exp. Ther
, vol.299
, pp. 314-322
-
-
Canton, T.1
Bohme, G.A.2
Boireau, A.3
Bordier, F.4
Mignani, S.5
Jimonet, P.6
Jahn, G.7
Alavijeh, M.8
Stygall, J.9
Roberts, S.10
Brealey, C.11
Vuilhorgne, M.12
Debono, M.W.13
Le Guern, S.14
Laville, M.15
Briet, D.16
Roux, M.17
Stutzmann, J.M.18
Pratt, J.19
-
58
-
-
30344437262
-
G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease
-
DOI 10.1002/jnr.20715
-
M Tortarolo G Grignaschi N Calvaresi E Zennaro G Spaltro M Colovic C Fracasso G Guiso B Elger H Schneider B Seilheimer S Caccia C Bendotti 2006 Glutamate AMPA receptors change in motor neurons of SOD1(G93A) transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amyotrophic lateral sclerosis-like disease J. Neurosci. Res. 83 134 146 doi:10.1002/jnr.20715 10.1002/jnr.20715 (Pubitemid 43062017)
-
(2006)
Journal of Neuroscience Research
, vol.83
, Issue.1
, pp. 134-146
-
-
Tortarolo, M.1
Grignaschi, G.2
Calvaresi, N.3
Zennaro, E.4
Spaltro, G.5
Colovic, M.6
Fracasso, C.7
Guiso, G.8
Elger, B.9
Schneider, H.10
Seilheimer, B.11
Caccia, S.12
Bendotti, C.13
-
59
-
-
0041421277
-
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models
-
DOI 10.1073/pnas.1530168100
-
GD Ghadge BS Slusher A Bodner MD Canto K Wozniak AG Thomas C Rojas T Tsukamoto P Majer RJ Miller AL Monti RP Roos 2003 Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models Proc. Natl. Acad. Sci. U. S. A. 100 9554 9559 doi:10.1073/pnas.1530168100 10.1073/pnas.1530168100 2003PNAS..100.9554G (Pubitemid 37033966)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.16
, pp. 9554-9559
-
-
Ghadge, G.D.1
Slusher, B.S.2
Bodner, A.3
Dal Canto, M.4
Wozniak, K.5
Thomas, A.G.6
Rojas, C.7
Tsukamoto, T.8
Majer, P.9
Miller, R.J.10
Monti, A.L.11
Roos, R.P.12
-
60
-
-
70349463585
-
An assessment of the efficacy and safety of LY300164 in patients with ALS/MND
-
Jones, T.: An assessment of the efficacy and safety of LY300164 in patients with ALS/MND. Abstract ALS/MND (1999)
-
(1999)
Abstract ALS/MND
-
-
Jones, T.1
-
61
-
-
33746849034
-
Neuroprotective agents for clinical trials in ALS: A systematic assessment
-
DOI 10.1212/01.wnl.0000223353.34006.54, PII 0000611420060711000010
-
BJ Traynor L Bruijn R Conwit F Beal G O'Neill SC Fagan ME Cudkowicz 2006 Neuroprotective agents for clinical trials in ALS: a systematic assessment Neurology 67 20 27 doi:10.1212/01.wnl.0000223353.34006.54 10.1212/01.wnl. 0000223353.34006.54 (Pubitemid 44305456)
-
(2006)
Neurology
, vol.67
, Issue.1
, pp. 20-27
-
-
Traynor, B.J.1
Bruijn, L.2
Conwit, R.3
Beal, F.4
O'Neill, G.5
Fagan, S.C.6
Cudkowicz, M.E.7
|