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Volumn 10, Issue 8, 2009, Pages 866-872

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CULLIN; CULLIN 4A; DNA DAMAGE BINDING PROTEIN 1; GENE PRODUCT; GLYCOGEN SYNTHASE KINASE; GLYCOGEN SYNTHASE KINASE 3 BETA; MAMMALIAN TARGET OF RAPAMYCIN; REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSE 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 68249104457     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.93     Document Type: Article
Times cited : (120)

References (23)
  • 1
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • Arsham AM, Howell JJ, Simon MC (2003) A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278: 29655-29660
    • (2003) J Biol Chem , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 4
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • Chiang GG, Abraham RT (2005) Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 280: 25485-25490
    • (2005) J Biol Chem , vol.280 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 5
    • 35348820823 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network in cancer
    • Chiang GG, Abraham RT (2007) Targeting the mTOR signaling network in cancer. Trends Mol Med 13: 433-442
    • (2007) Trends Mol Med , vol.13 , pp. 433-442
    • Chiang, G.G.1    Abraham, R.T.2
  • 7
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW (2008) Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22: 239-251
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • DeYoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 9
    • 0033602475 scopus 로고    scopus 로고
    • HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin
    • Fuchs SY, Chen A, Xiong Y, Pan ZQ, Ronai Z (1999) HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Oncogene 18: 2039-2046
    • (1999) Oncogene , vol.18 , pp. 2039-2046
    • Fuchs, S.Y.1    Chen, A.2    Xiong, Y.3    Pan, Z.Q.4    Ronai, Z.5
  • 10
    • 40549123676 scopus 로고    scopus 로고
    • mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase
    • Ghosh P, Wu M, Zhang H, Sun H (2008) mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase. Cell Cycle 7: 373-381
    • (2008) Cell Cycle , vol.7 , pp. 373-381
    • Ghosh, P.1    Wu, M.2    Zhang, H.3    Sun, H.4
  • 11
    • 41649117158 scopus 로고    scopus 로고
    • WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase
    • Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y (2008) WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. Genes Dev 22: 866-871
    • (2008) Genes Dev , vol.22 , pp. 866-871
    • Hu, J.1    Zacharek, S.2    He, Y.J.3    Lee, H.4    Shumway, S.5    Duronio, R.J.6    Xiong, Y.7
  • 12
    • 41249094257 scopus 로고    scopus 로고
    • Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis
    • Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS (2008) Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 283: 3465-3475
    • (2008) J Biol Chem , vol.283 , pp. 3465-3475
    • Kimball, S.R.1    Do, A.N.2    Kutzler, L.3    Cavener, D.R.4    Jefferson, L.S.5
  • 14
    • 28044463802 scopus 로고    scopus 로고
    • Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein
    • Lin L, Stringfield TM, Shi X, Chen Y (2005) Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein. Biochem J 392: 93-102
    • (2005) Biochem J , vol.392 , pp. 93-102
    • Lin, L.1    Stringfield, T.M.2    Shi, X.3    Chen, Y.4
  • 15
    • 51749095471 scopus 로고    scopus 로고
    • FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
    • Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A (2008) FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 321: 1499-1502
    • (2008) Science , vol.321 , pp. 1499-1502
    • Mao, J.H.1    Kim, I.J.2    Wu, D.3    Climent, J.4    Kang, H.C.5    DelRosario, R.6    Balmain, A.7
  • 16
    • 13944252061 scopus 로고    scopus 로고
    • Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells
    • Muerkoster S, Arlt A, Sipos B, Witt M, Grossmann M, Kloppel G, Kalthoff H, Folsch UR, Schafer H (2005) Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res 65: 1316-1324
    • (2005) Cancer Res , vol.65 , pp. 1316-1324
    • Muerkoster, S.1    Arlt, A.2    Sipos, B.3    Witt, M.4    Grossmann, M.5    Kloppel, G.6    Kalthoff, H.7    Folsch, U.R.8    Schafer, H.9
  • 17
    • 3543078617 scopus 로고    scopus 로고
    • Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer
    • Ougolkov A, Zhang B, Yamashita K, Bilim V, Mai M, Fuchs SY, Minamoto T (2004) Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin, and NF-kappaB in colorectal cancer. J Natl Cancer Inst 96: 1161-1170
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1161-1170
    • Ougolkov, A.1    Zhang, B.2    Yamashita, K.3    Bilim, V.4    Mai, M.5    Fuchs, S.Y.6    Minamoto, T.7
  • 18
    • 10044276784 scopus 로고    scopus 로고
    • The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    • Reiling JH, Hafen E (2004) The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 18: 2879-2892
    • (2004) Genes Dev , vol.18 , pp. 2879-2892
    • Reiling, J.H.1    Hafen, E.2
  • 19
    • 0036118562 scopus 로고    scopus 로고
    • Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
    • Shoshani T et al (2002) Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 22: 2283-2293
    • (2002) Mol Cell Biol , vol.22 , pp. 2283-2293
    • Shoshani, T.1
  • 20
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • Sofer A, Lei K, Johannessen CM, Ellisen LW (2005) Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25: 5834-5845
    • (2005) Mol Cell Biol , vol.25 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 21
    • 0026451188 scopus 로고
    • Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells
    • Ting AT, Karnitz LM, Schoon RA, Abraham RT, Leibson PJ (1992) Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells. J Exp Med 176: 1751-1755
    • (1992) J Exp Med , vol.176 , pp. 1751-1755
    • Ting, A.T.1    Karnitz, L.M.2    Schoon, R.A.3    Abraham, R.T.4    Leibson, P.J.5
  • 22
    • 33749496131 scopus 로고    scopus 로고
    • Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells
    • Tsuji T, Ficarro SB, Jiang W (2006) Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. Mol Biol Cell 17: 4459-4472
    • (2006) Mol Biol Cell , vol.17 , pp. 4459-4472
    • Tsuji, T.1    Ficarro, S.B.2    Jiang, W.3
  • 23
    • 0036614698 scopus 로고    scopus 로고
    • TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas
    • Yasui K, Arii S, Zhao C, Imoto I, Ueda M, Nagai H, Emi M, Inazawa J (2002) TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology 35: 1476-1484
    • (2002) Hepatology , vol.35 , pp. 1476-1484
    • Yasui, K.1    Arii, S.2    Zhao, C.3    Imoto, I.4    Ueda, M.5    Nagai, H.6    Emi, M.7    Inazawa, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.