Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure

Metabolic Brain Disease

Volumn 25, Issue 1, 2010, Pages 17-21

  Chastre, Anne ^a   Jiang, Wenlei ^a   Desjardins, Paul ^a   Butterworth, Roger F ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Acute liver failure; Ammonia; Brain edema; Hepatic encephalopathy; Neuroinflammation; Oxidative stress; Proinflammatory cytokines

Indexed keywords

AMMONIA; AQUAPORIN 4; GLIAL FIBRILLARY ACIDIC PROTEIN; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 1BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ASTROCYTE; BRAIN CORTEX; BRAIN EDEMA; CELL CULTURE; CELL VOLUME; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE EXACERBATION; GENE EXPRESSION; GENETIC CODE; LIPID PEROXIDATION; LIVER FAILURE; MEDIATOR; NONHUMAN; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AMMONIA; ANIMALS; AQUAPORIN 4; ASTROCYTES; BRAIN; BRAIN EDEMA; CELLS, CULTURED; CYTOKINES; ENCEPHALITIS; GLIAL FIBRILLARY ACIDIC PROTEIN; HEME OXYGENASE-1; HEPATIC ENCEPHALOPATHY; INTERLEUKIN-1BETA; LIVER FAILURE, ACUTE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RATS; UP-REGULATION;

EID: 77954145923     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-010-9185-y     Document Type: Conference Paper

References (27)

1. M Bélanger P Desjardins N Chatauret RF Butterworth 2002 Loss of expression of glial fibrillary acidic protein in acute hyperammonemia Neurochem Int 41 155 160 10.1016/S0197-0186(02)00037-2 12020615 (Pubitemid 34521688)
2. AT Blei 2004 Infection, inflammation and hepatic encephalopathy, synergism redefined J Hepatol 40 327 330 10.1016/j.jhep.2003.12.007 14739106 (Pubitemid 38115840)
3. H Chan RF Butterworth AS Hazell 2004 Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels Neurosci Lett 366 231 234 10.1016/j.neulet.2004.04.095 1:CAS:528:DC%2BD2cXmt1Wkurw%3D 15288424 (Pubitemid 39024271)
4. JO Clemmesen FS Larsen J Kondrup BA Hansen P Ott 1999 Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration Hepatology 29 648 653 10.1002/hep.510290309 1:STN:280: DyaK1M7mt1emsA%3D%3D 10051463
5. M Eefsen C Bisgaard P Jelnes LE Scmidt B Vainer FS Larsen 2009 The role of aquaporin-4 and -1 in development of brain edema in experimental liver failure Hepatology 50 398A [abstract]
6. R Jalan SW Olde Damink PC Hayes NE Deutz A Lee 2004 Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow J Hepatol 41 613 620 10.1016/j.jhep.2004.06.011 1:CAS:528:DC%2BD2cXotF2isLg%3D 15464242 (Pubitemid 39297797)
7. W Jiang P Desjardins RF Butterworth 2009 Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia J Cereb Blood Flow Metab 29 944 952 10.1038/jcbfm.2009.18 1:CAS:528:DC%2BD1MXlt1Sks7s%3D 19259110
8. W Jiang P Desjardins RF Butterworth 2009 Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats Neurochem Int 55 601 605 10.1016/j.neuint.2009.06.001 1:CAS:528:DC%2BD1MXhtV2ru7bE 19524003
9. E Kosenko Y Kaminski O Lopata N Muravyov V Felipo 1999 Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication Free Radic Biol Med 26 1369 1374 10.1016/S0891-5849(98)00339-6 1:STN:280:DyaK1MzivFynsA%3D%3D 10401599 (Pubitemid 29302268)
10. AM Mans SJ Saunders RE Kirsch JF Biebuyck 1979 Correlation of plasma and brain amino acid and putative neurotransmitter alterations during acute hepatic coma in the rat J Neurochem 32 285 292 10.1111/j.1471-4159.1979.tb00350.x 1:CAS:528:DyaE1MXlt1Wlu7s%3D 33231
11. JE Margulies RC Thompson AA Demetriou 1999 Aquaporin-4 water channel is up-regulated in the brain in fulminant hepatic failure Hepatology 30 395a 10.1002/hep.510300210 [abstract] (Pubitemid 29357503)
12. CRK Murthy G Bai RS Dombro MD Norenberg 2000 Ammonia-induced swelling in primary cultures of rat astrocytes: role of free radicals Soc Neurosci Abstr 26 1893 [abstract]
13. M Nagaki H Iwai T Naiki H Ohnishi Y Muto H Moriwaki 2000 High levels of serum interleukin-10 and tumor necrosis factor-alpha are associated with fatality in fulminant hepatitis J Infect Dis 182 1103 1108 10.1086/315826 1:CAS:528:DC%2BD3cXntlygsr8%3D 10979906
14. JT Neary SR Whittemore Q Zhu MD Norenberg 1994 Destabilization of glial fibrillary acidic protein mRNA in astrocytes by ammonia and protection by extracellular ATP J Neurochem 63 2021 2027 1:CAS:528:DyaK2MXit12ktLc%3D 7964719
15. MD Norenberg JT Neary LO Norenberg M McCarthy 1990 Ammonia induced decrease in glial fibrillary acidic protein in cultured astrocytes J Neuropathol Exp Neurol 49 399 405 10.1097/00005072-199007000-00004 1:CAS:528: DyaK3MXhvVeiurk%3D 2163437
16. MD Norenberg KV Rao AR Jayakumar 2005 Mechanisms of ammonia-induced astrocyte swelling Metab Brain Dis 20 303 318 10.1007/s11011-005-7911-7 1:CAS:528:DC%2BD2MXhtlGhu77N 16382341 (Pubitemid 43029804)
17. JE O'Connor M Costell 1990 New roles of carnitine metabolism in ammonia cytotoxicity Adv Exp Med Biol 272 183 195 2103686
18. KV Rama Rao MD Norenberg 2007 Aquaporin-4 in hepatic encephalopathy Metab Brain Dis 22 265 275 10.1007/s11011-007-9063-4 1:STN:280:DC%2BD2snisVWktA%3D%3D 17879149 (Pubitemid 47624315)
19. KV Rama Rao M Chen JM Simard MD Norenberg 2003 Increased aquaporin-4 expression in ammonia-treated cultured astrocytes NeuroReport 14 2379 2382 10.1097/00001756-200312190-00018 1:STN:280:DC%2BD3srot1Kntw%3D%3D 14663195
20. N Rolando J Wade M Davalos J Wendon J Philpott-Howard R Williams 2000 The systemic inflammatory response syndrome in acute liver failure Hepatology 32 734 739 10.1053/jhep.2000.17687 1:STN:280:DC%2BD3cvpsFKnuw%3D%3D 11003617
21. S Rozen H Skaletsky 2000 Primer3 on the WWW for general users and for biologist programmers Methods Mol Biol 132 365 386 1:CAS:528:DyaK1MXmslKqsbo%3D 10547847
22. F Schliess B Görg R Fischer P Desjardins HJ Bidmon A Herrmann RF Butterworth K Zilles D Häussinger 2002 Ammonia induces MK-801 sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes FASEB J 16 739 741 1:CAS:528:DC%2BD38XjsVeqt74%3D 11923223
23. M Swain RF Butterworth AT Blei 1992 Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats Hepatology 15 449 453 10.1002/hep.1840150316 1:CAS:528:DyaK38XhslWnsL0%3D 1544626
24. M Swain M Bergeron R Audet AT Blei RF Butterworth 1992 Monitoring of neurotransmitter amino acids by means an indwelling cisterna magna catheter: a comparison of two rodent models of fulminant hepatic failure Hepatology 16 1028 1035 10.1002/hep.1840160428 1:CAS:528:DyaK3sXjs12rug%3D%3D 1356903
25. J Vaquero C Chung AT Blei 2003 Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy Ann Hepatol 2 12 22 15094701
26. G Wright D Shawcross SW Olde Damink R Jalan 2007 Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension Metab Brain Dis 22 375 388 10.1007/s11011-007-9071-4 1:CAS:528:DC%2BD2sXht1amur%2FI 17899343 (Pubitemid 47624323)
27. M Zielińska RO Law J Albrecht 2003 Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia Neurochem Int 43 299 303 10.1016/S0197-0186(03)00015-9 12742072 (Pubitemid 36561281)