Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex

Neurobiology of Aging

Volumn 36, Issue 8, 2015, Pages 2443.e9-2443.e20

  Wehrspaun, Claudia C ^a,b   Haerty, Wilfried ^a,c   Ponting, Chris P ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Aging; Hematopoiesis; Immune system; Master regulator; Microglia; Transcriptional network

Indexed keywords

INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; KRUPPEL LIKE FACTOR 6; PROTEIN FOS; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR TAL1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL SURFACE RECEPTOR; INTERFERON REGULATORY FACTOR; ONCOPROTEIN; PROTO-ONCOGENE PROTEIN SPI-1; RUNX1 PROTEIN, HUMAN; TAL1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

ADULT; AGED; AGING; ARTICLE; AUTOPSY; BNC2 GENE; C1QA GENE; CELL FATE; CONTROLLED STUDY; ELK3 GENE; FLI1 GENE; FOS GENE; FRONTAL CORTEX; GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC MARKER; GPR34 GENE; HEMATOPOIESIS; HHEX GENE; HOMEOSTASIS; HUMAN; HUMAN TISSUE; IFI16 GENE; IRF8 GENE; KLF6 GENE; LIFESPAN; LYL1 GENE; MAF GENE; MICROGLIA; NERVE CELL NETWORK; NFATC2 GENE; P2RY12 GENE; PARP12 GENE; PHENOTYPE; PLEK GENE; PRDM4 GENE; PRIORITY JOURNAL; PROS1 GENE; PROTEIN PROTEIN INTERACTION; PU 1 GENE; RUNX1 GENE; TAL1 GENE; TRANSCRIPTION REGULATION; ZFP36L2 GENE; ANIMAL; FRONTAL LOBE; GENETICS; INFORMATION PROCESSING; NERVE CELL; PHYSIOLOGY;

AGING; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DATASETS AS TOPIC; FRONTAL LOBE; HEMATOPOIESIS; HOMEOSTASIS; HUMANS; INTERFERON REGULATORY FACTORS; MICROGLIA; NEURONS; PROTEIN INTERACTION MAPS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84936151811     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.04.008     Document Type: Article

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