-
1
-
-
84864401215
-
Pathway-selective sensitization of Mycobacterium tuber-culosis for target-based whole-cell screening
-
Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE III, Sherman DR, Boshoff HI, Mizrahi V. 2012a. Pathway-selective sensitization of Mycobacterium tuber-culosis for target-based whole-cell screening. Chem Biol 19: 844-854.
-
(2012)
Chem Biol
, vol.19
, pp. 844-854
-
-
Abrahams, G.L.1
Kumar, A.2
Savvi, S.3
Hung, A.W.4
Wen, S.5
Abell, C.6
Barry, C.7
Sherman, D.R.8
Boshoff, H.I.9
Mizrahi, V.10
-
2
-
-
84871764621
-
Identification of novel im-idazo[1,2-a]pyridine inhibitors targeting M. Tuberculosis QcrB
-
Abrahams KA, Cox JA, Spivey VL, Loman NJ, Pallen MJ, Constantinidou C, Fernandez R, Alemparte C, Remuinan MJ, Barros D, et al. 2012b. Identification of novel im-idazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB. PloS ONE 7: e52951.
-
(2012)
Plos ONE
, vol.7
-
-
Abrahams, K.A.1
Cox, J.A.2
Spivey, V.L.3
Loman, N.J.4
Pallen, M.J.5
Constantinidou, C.6
Fernandez, R.7
Alemparte, C.8
Remuinan, M.J.9
Barros, D.10
-
3
-
-
33645675960
-
Estimating the cost of new drug development: Is it really 802 million dollars?
-
Adams CP, Brantner VV. 2006. Estimating the cost of new drug development: Is it really 802 million dollars? Health Aff (Millwood) 25: 420-428.
-
(2006)
Health Aff (Millwood)
, vol.25
, pp. 420-428
-
-
Adams, C.P.1
Brantner, V.V.2
-
4
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
Andries K, Verhasselt P, Guillemont J, Gohlmann HW, Neefs JM, Winkler H, Van Gestel J, Timmerman P, Zhu M, Lee E, et al. 2005. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307: 223-227.
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
Verhasselt, P.2
Guillemont, J.3
Gohlmann, H.W.4
Neefs, J.M.5
Winkler, H.6
Van Gestel, J.7
Timmerman, P.8
Zhu, M.9
Lee, E.10
-
5
-
-
84860731440
-
Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis
-
Arnvig K, Young D. 2012. Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis. RNA Biol 9: 427-436.
-
(2012)
RNA Biol
, vol.9
, pp. 427-436
-
-
Arnvig, K.1
Young, D.2
-
6
-
-
79961000327
-
Ligand specificity, privileged sub-structures and protein druggability from fragment-based screening
-
Barelier S, Krimm I. 2011. Ligand specificity, privileged sub-structures and protein druggability from fragment-based screening. Curr Opin Chem Biol 15: 469-474.
-
(2011)
Curr Opin Chem Biol
, vol.15
, pp. 469-474
-
-
Barelier, S.1
Krimm, I.2
-
7
-
-
70449705831
-
The spec-trum of latent tuberculosis: Rethinking the biology and intervention strategies
-
Barry CE III, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. 2009. The spec-trum of latent tuberculosis: Rethinking the biology and intervention strategies. Nat Rev Microbiol 7: 845-855.
-
(2009)
Nat Rev Microbiol
, vol.7
, pp. 845-855
-
-
Barry, C.1
Boshoff, H.I.2
Dartois, V.3
Dick, T.4
Ehrt, S.5
Flynn, J.6
Schnappinger, D.7
Wilkinson, R.J.8
Young, D.9
-
8
-
-
84855829699
-
Drug discovery in the next decade: In-novation needed ASAP
-
Bennani YL. 2012. Drug discovery in the next decade: In-novation needed ASAP. Drug Discov Today 17: S31-S44.
-
(2012)
Drug Discov Today
, vol.17
, pp. S31-S44
-
-
Bennani, Y.L.1
-
9
-
-
19744382790
-
Tetracy-cline-inducible gene regulation in mycobacteria
-
Blokpoel MC, Murphy HN, O’Toole R, Wiles S, Runn ES, Stewart GR, Young DB, Robertson BD. 2005. Tetracy-cline-inducible gene regulation in mycobacteria. Nucleic Acids Res 33: e22.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Blokpoel, M.C.1
Murphy, H.N.2
O’Toole, R.3
Wiles, S.4
Runn, E.S.5
Stewart, G.R.6
Young, D.B.7
Robertson, B.D.8
-
10
-
-
77955074030
-
Development of a repressible mycobacterial promoter system based on two transcriptional repressors
-
Boldrin F, Casonato S, Dainese E, Sala C, Dhar N, Palu G, Riccardi G, Cole ST, Manganelli R. 2010. Development of a repressible mycobacterial promoter system based on two transcriptional repressors. Nucleic Acids Res 38: e134.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Boldrin, F.1
Casonato, S.2
Dainese, E.3
Sala, C.4
Dhar, N.5
Palu, G.6
Riccardi, G.7
Cole, S.T.8
Manganelli, R.9
-
11
-
-
4544312369
-
The transcriptional responses of My-cobacterium tuberculosis to inhibitors of metabolism: Novel insights into drug mechanisms of action
-
Boshoff HI, Myers TG, Copp BR, McNeil MR, Wilson MA, Barry CE III. 2004. The transcriptional responses of My-cobacterium tuberculosis to inhibitors of metabolism: Novel insights into drug mechanisms of action. J Biol Chem 279: 40174-40184.
-
(2004)
J Biol Chem
, vol.279
, pp. 40174-40184
-
-
Boshoff, H.I.1
Myers, T.G.2
Copp, B.R.3
McNeil, M.R.4
Wilson, M.A.5
Barry, C.6
-
12
-
-
50349099789
-
Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli
-
Boshoff HI, Xu X, Tahlan K, Dowd CS, Pethe K, Camacho LR, Park TH, Yun CS, Schnappinger D, Ehrt S, et al. 2008. Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem 283: 19329-19341.
-
(2008)
J Biol Chem
, vol.283
, pp. 19329-19341
-
-
Boshoff, H.I.1
Xu, X.2
Tahlan, K.3
Dowd, C.S.4
Pethe, K.5
Camacho, L.R.6
Park, T.H.7
Yun, C.S.8
Schnappinger, D.9
Ehrt, S.10
-
13
-
-
26244440553
-
Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance
-
Brazas MD, Hancock RE. 2005. Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance. Drug Discov Today 10: 1245-1252.
-
(2005)
Drug Discov Today
, vol.10
, pp. 1245-1252
-
-
Brazas, M.D.1
Hancock, R.E.2
-
14
-
-
78449244856
-
Postgenomic strategies in antibacterial drug discovery
-
Brotz-Oesterhelt H, Sass P. 2010. Postgenomic strategies in antibacterial drug discovery. Future Microbiol 5: 1553-1579.
-
(2010)
Future Microbiol
, vol.5
-
-
Brotz-Oesterhelt, H.1
Sass, P.2
-
15
-
-
67650930400
-
Platensimycin activity against mycobacterial b-ketoacyl-ACP synthases
-
Brown AK, Taylor RC, Bhatt A, Futterer K, Besra GS. 2009. Platensimycin activity against mycobacterial b-ketoacyl-ACP synthases. PloS ONE 4: e6306.
-
(2009)
Plos ONE
, vol.4
-
-
Brown, A.K.1
Taylor, R.C.2
Bhatt, A.3
Futterer, K.4
Besra, G.S.5
-
16
-
-
0030872573
-
Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacteri-um smegmatis
-
Caceres NE, Harris NB, Wellehan JF, Feng Z, Kapur V, Bar-letta RG. 1997. Overexpression of the D-alanine racemase gene confers resistance to D-cycloserine in Mycobacteri-um smegmatis. J Bacteriol 179: 5046-5055.
-
(1997)
J Bacteriol
, vol.179
, pp. 5046-5055
-
-
Caceres, N.E.1
Harris, N.B.2
Wellehan, J.F.3
Feng, Z.4
Kapur, V.5
Bar-Letta, R.G.6
-
17
-
-
20444377222
-
Use of a tetra-cycline-inducible system for conditional expression in Mycobacterium tuberculosis and Mycobacterium smegma-tis
-
Carroll P, Muttucumaru DG, Parish T. 2005. Use of a tetra-cycline-inducible system for conditional expression in Mycobacterium tuberculosis and Mycobacterium smegma-tis. Appl Environ Microbiol 71: 3077-3084.
-
(2005)
Appl Environ Microbiol
, vol.71
, pp. 3077-3084
-
-
Carroll, P.1
Muttucumaru, D.G.2
Parish, T.3
-
18
-
-
84871927537
-
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
-
Chakraborty S, Gruber T, Barry CE III, Boshoff HI, Rhee KY. 2013. Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis. Science 339: 88-91.
-
(2013)
Science
, vol.339
, pp. 88-91
-
-
Chakraborty, S.1
Gruber, T.2
Barry, C.3
Boshoff, H.I.4
Rhee, K.Y.5
-
19
-
-
73649143180
-
High content screening identifies decaprenyl-phosphoribose 20 epimerase as a target for intracellular antimycobacterial inhibitors
-
Christophe T, Jackson M, Jeon HK, Fenistein D, Contreras-Dominguez M, Kim J, Genovesio A, Carralot JP, Ewann F, Kim EH, et al. 2009. High content screening identifies decaprenyl-phosphoribose 20 epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog 5: e1000645.
-
(2009)
Plos Pathog
, vol.5
-
-
Christophe, T.1
Jackson, M.2
Jeon, H.K.3
Fenistein, D.4
Contreras-Dominguez, M.5
Kim, J.6
Genovesio, A.7
Carralot, J.P.8
Ewann, F.9
Kim, E.H.10
-
20
-
-
75649111192
-
The genetic landscape of a cell
-
Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, et al. 2010. The genetic landscape of a cell. Science 327: 425-431.
-
(2010)
Science
, vol.327
, pp. 425-431
-
-
Costanzo, M.1
Baryshnikova, A.2
Bellay, J.3
Kim, Y.4
Spear, E.D.5
Sevier, C.S.6
Ding, H.7
Koh, J.L.8
Toufighi, K.9
Mostafavi, S.10
-
21
-
-
84881367368
-
A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis
-
Dartois V, Barry CE III. 2013. A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis. Bioorg Med Chem Lett 23: 4741-4750.
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 4741-4750
-
-
Dartois, V.1
Barry, C.2
-
22
-
-
33845388057
-
Where have all the antibiotics gone?
-
Davies J. 2006. Where have all the antibiotics gone? Can J Infect Dis Med Microbiol 17: 287-290.
-
(2006)
Can J Infect Dis Med Microbiol
, vol.17
, pp. 287-290
-
-
Davies, J.1
-
23
-
-
0036256037
-
An array of target-specific screening strains for antibacterial discovery
-
DeVito JA, Mills JA, Liu VG, Agarwal A, Sizemore CF, Yao Z, Stoughton DM, Cappiello MG, Barbosa MD, Foster LA, et al. 2002. An array of target-specific screening strains for antibacterial discovery. Nat Biotechnol 20: 478-483.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 478-483
-
-
Devito, J.A.1
Mills, J.A.2
Liu, V.G.3
Agarwal, A.4
Sizemore, C.F.5
Yao, Z.6
Stoughton, D.M.7
Cappiello, M.G.8
Barbosa, M.D.9
Foster, L.A.10
-
24
-
-
62949112206
-
Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence
-
Dhiman RK, Mahapatra S, Slayden RA, Boyne ME, Lenaerts A, Hinshaw JC, Angala SK, Chatterjee D, Biswas K, Nar-ayanasamy P, et al. 2009. Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence. Mol Microbiol 72: 85-97.
-
(2009)
Mol Microbiol
, vol.72
, pp. 85-97
-
-
Dhiman, R.K.1
Mahapatra, S.2
Slayden, R.A.3
Boyne, M.E.4
Lenaerts, A.5
Hinshaw, J.C.6
Angala, S.K.7
Chatterjee, D.8
Biswas, K.9
Nar-Ayanasamy, P.10
-
25
-
-
73349095048
-
Systematic mapping of genetic interaction networks
-
Dixon SJ, Costanzo M, Baryshnikova A, Andrews B, Boone C. 2009. Systematic mapping of genetic interaction networks. Annu Rev Genet 43: 601-625.
-
(2009)
Annu Rev Genet
, vol.43
, pp. 601-625
-
-
Dixon, S.J.1
Costanzo, M.2
Baryshnikova, A.3
Rews, B.4
Boone, C.5
-
26
-
-
69049093794
-
A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds
-
Donald RG, Skwish S, Forsyth RA, Anderson JW, Zhong T, Burns C, Lee S, Meng X, LoCastro L, Jarantow LW, et al. 2009. A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds. Chem Biol 16: 826-836.
-
(2009)
Chem Biol
, vol.16
, pp. 826-836
-
-
Donald, R.G.1
Skwish, S.2
Forsyth, R.A.3
Erson, J.W.4
Zhong, T.5
Burns, C.6
Lee, S.7
Meng, X.8
Locastro, L.9
Jarantow, L.W.10
-
27
-
-
82255186665
-
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis
-
Duckworth BP, Geders TW, Tiwari D, Boshoff HI, Sibbald PA, Barry CE III, Schnappinger D, Finzel BC, Aldrich CC. 2011. Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis. Chem Biol 18: 1432-1441.
-
(2011)
Chem Biol
, vol.18
, pp. 1432-1441
-
-
Duckworth, B.P.1
Geders, T.W.2
Tiwari, D.3
Boshoff, H.I.4
Sibbald, P.A.5
Barry, C.6
Schnappinger, D.7
Finzel, B.C.8
Aldrich, C.C.9
-
28
-
-
19744383611
-
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repres-sor
-
Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D. 2005. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repres-sor. Nucleic Acids Res 33: e21.
-
(2005)
Nucleic Acids Res
, vol.33
-
-
Ehrt, S.1
Guo, X.V.2
Hickey, C.M.3
Ryou, M.4
Monteleone, M.5
Riley, L.W.6
Schnappinger, D.7
-
29
-
-
10044286102
-
5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs
-
Fang F, Hoskins J, Butler JS. 2004. 5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs. Mol Cell Biol 24: 10766-10776.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10766-10776
-
-
Fang, F.1
Hoskins, J.2
Butler, J.S.3
-
30
-
-
79960985571
-
Structure-baseddruggability assessment—Identifying suitable targets for small molecule therapeutics
-
Fauman EB, Rai BK, Huang ES. 2011. Structure-based druggability assessment—Identifying suitable targets for small molecule therapeutics. Curr Opin Chem Biol 15: 463-468.
-
(2011)
Curr Opin Chem Biol
, vol.15
, pp. 463-468
-
-
Fauman, E.B.1
Rai, B.K.2
Huang, E.S.3
-
31
-
-
0037228454
-
Roles of Mycobacterium smegma-tis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine
-
Feng Z, Barletta RG. 2003. Roles of Mycobacterium smegma-tis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine. Antimicrob Agents Chemother 47: 283-291.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 283-291
-
-
Feng, Z.1
Barletta, R.G.2
-
32
-
-
69549111337
-
Antibiotics for emerging pathogens
-
Fischbach MA, Walsh CT. 2009. Antibiotics for emerging pathogens. Science 325: 1089-1093.
-
(2009)
Science
, vol.325
, pp. 1089-1093
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
33
-
-
12944327876
-
Discoveringthe mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants
-
Freiberg C, Fischer HP, Brunner NA. 2005. Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants. Antimicrob Agents Chemother 49: 749-759.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 749-759
-
-
Freiberg, C.1
Fischer, H.P.2
Brunner, N.A.3
-
34
-
-
33846934758
-
Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide Gene-Chips
-
Fu LM, Shinnick TM. 2007. Genome-wide exploration of the drug action of capreomycin on Mycobacterium tuberculosis using Affymetrix oligonucleotide Gene-Chips. J Infect 54: 277-284.
-
(2007)
J Infect
, vol.54
, pp. 277-284
-
-
Fu, L.M.1
Shinnick, T.M.2
-
35
-
-
0033048778
-
Genomic profiling of drug sensitivities via induced haploinsufficiency
-
Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, Astromoff A, Davis RW. 1999. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat Genet 21: 278-283.
-
(1999)
Nat Genet
, vol.21
, pp. 278-283
-
-
Giaever, G.1
Shoemaker, D.D.2
Jones, T.W.3
Liang, H.4
Winzeler, E.A.5
Astromoff, A.6
Davis, R.W.7
-
36
-
-
9144268287
-
Chemogenomic profiling: Identifying the func-tional interactions of small molecules in yeast
-
Giaever G, Flaherty P, Kumm J, Proctor M, Nislow C, Jar-amillo DF, Chu AM, Jordan MI, Arkin AP, Davis RW. 2004. Chemogenomic profiling: Identifying the func-tional interactions of small molecules in yeast. Proc Natl Acad Sci 101: 793-798.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 793-798
-
-
Giaever, G.1
Flaherty, P.2
Kumm, J.3
Proctor, M.4
Nislow, C.5
Jar-Amillo, D.F.6
Chu, A.M.7
Jordan, M.I.8
Arkin, A.P.9
Davis, R.W.10
-
37
-
-
66249098133
-
Genetic architecture of intrinsic antibiotic susceptibility
-
Girgis HS, Hottes AK, Tavazoie S. 2009. Genetic architecture of intrinsic antibiotic susceptibility. PloS ONE 4: e5629.
-
(2009)
Plos ONE
, vol.4
-
-
Girgis, H.S.1
Hottes, A.K.2
Tavazoie, S.3
-
38
-
-
70349342842
-
The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis
-
Goude R, Amin AG, Chatterjee D, Parish T. 2009. The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemo-ther 53: 4138-4146.
-
(2009)
Antimicrob Agents Chemo-Ther
, vol.53
, pp. 4138-4146
-
-
Goude, R.1
Amin, A.G.2
Chatterjee, D.3
Parish, T.4
-
39
-
-
84857619791
-
Cholesterol catabolism by Mycobacterium tuberculosis requires transcrip-tional and metabolic adaptations
-
Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi CR, Sassetti CM. 2012. Cholesterol catabolism by Mycobacterium tuberculosis requires transcrip-tional and metabolic adaptations. Chem Biol 19: 218-227.
-
(2012)
Chem Biol
, vol.19
-
-
Griffin, J.E.1
Pandey, A.K.2
Gilmore, S.A.3
Mizrahi, V.4
McKinney, J.D.5
Bertozzi, C.R.6
Sassetti, C.M.7
-
40
-
-
84858677107
-
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
-
Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Kordulakova J, et al. 2012. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8: 334-341.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 334-341
-
-
Grzegorzewicz, A.E.1
Pham, H.2
Gundi, V.A.3
Scherman, M.S.4
North, E.J.5
Hess, T.6
Jones, V.7
Gruppo, V.8
Born, S.E.9
Kordulakova, J.10
-
41
-
-
84867067622
-
Towards a new tuberculosis drug: Pyridomycin—Na-ture’s isoniazid
-
Hartkoorn RC, Sala C, Neres J, Pojer F, Magnet S, Mukherjee R, Uplekar S, Boy-Rottger S, Altmann KH, Cole ST. 2012. Towards a new tuberculosis drug: Pyridomycin—Na-ture’s isoniazid. EMBO Mol Med 4: 1032-1042.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 1032-1042
-
-
Hartkoorn, R.C.1
Sala, C.2
Neres, J.3
Pojer, F.4
Magnet, S.5
Mukherjee, R.6
Uplekar, S.7
Boy-Rottger, S.8
Altmann, K.H.9
Cole, S.T.10
-
42
-
-
50949097255
-
RNA-based 5-fluorouracil toxic-ity requires the pseudouridylation activity of Cbf5p
-
Hoskins J, Butler JS. 2008. RNA-based 5-fluorouracil toxic-ity requires the pseudouridylation activity of Cbf5p. Genetics 179: 323-330.
-
(2008)
Genetics
, vol.179
, pp. 323-330
-
-
Hoskins, J.1
Butler, J.S.2
-
43
-
-
35348999495
-
Evidence for distinct DNA-and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae
-
Hoskins J, Scott Butler J. 2007. Evidence for distinct DNA-and RNA-based mechanisms of 5-fluorouracil cytotoxicity in Saccharomyces cerevisiae. Yeast 24: 861-870.
-
(2007)
Yeast
, vol.24
, pp. 861-870
-
-
Hoskins, J.1
Scott Butler, J.2
-
44
-
-
69049091879
-
Chemical genetic identification of peptidogly-can inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus
-
Huber J, Donald RG, Lee SH, Jarantow LW, Salvatore MJ, Meng X, Painter R, Onishi RH, Occi J, Dorso K, et al. 2009. Chemical genetic identification of peptidogly-can inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus. Chem Biol 16: 837-848.
-
(2009)
Chem Biol
, vol.16
, pp. 837-848
-
-
Huber, J.1
Donald, R.G.2
Lee, S.H.3
Jarantow, L.W.4
Salvatore, M.J.5
Meng, X.6
Painter, R.7
Onishi, R.H.8
Occi, J.9
Dorso, K.10
-
45
-
-
0034616930
-
Functional discovery via a compendium of expres-sion profiles
-
Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, et al. 2000. Functional discovery via a compendium of expres-sion profiles. Cell 102: 109-126.
-
(2000)
Cell
, vol.102
, pp. 109-126
-
-
Hughes, T.R.1
Marton, M.J.2
Jones, A.R.3
Roberts, C.J.4
Stoughton, R.5
Armour, C.D.6
Bennett, H.A.7
Coffey, E.8
Dai, H.9
He, Y.D.10
-
46
-
-
84884505005
-
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis
-
Ioerger TR, O’Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, et al. 2013. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PloS ONE 8: e75245.
-
(2013)
Plos ONE
, vol.8
-
-
Ioerger, T.R.1
O’Malley, T.2
Liao, R.3
Guinn, K.M.4
Hickey, M.J.5
Mohaideen, N.6
Murphy, K.C.7
Boshoff, H.I.8
Mizrahi, V.9
Rubin, E.J.10
-
47
-
-
34347219762
-
Isolation and structure of platencin: A FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity
-
Jayasuriya H, Herath KB, Zhang C, Zink DL, Basilio A, Genilloud O, Diez MT, Vicente F, Gonzalez I, Salazar O, et al. 2007. Isolation and structure of platencin: A FabH and FabF dual inhibitor with potent broad-spectrum antibiotic activity. Angew Chem Int Ed Engl 46: 4684-4688.
-
(2007)
Angew Chem Int Ed Engl
, vol.46
-
-
Jayasuriya, H.1
Herath, K.B.2
Zhang, C.3
Zink, D.L.4
Basilio, A.5
Genilloud, O.6
Diez, M.T.7
Vicente, F.8
Gonzalez, I.9
Salazar, O.10
-
48
-
-
41949100293
-
PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products
-
Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu W, Rodriguez-Suarez R, Trosok S, et al. 2008. PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products. Chem Biol 15: 363-374.
-
(2008)
Chem Biol
, vol.15
, pp. 363-374
-
-
Jiang, B.1
Xu, D.2
Allocco, J.3
Parish, C.4
Davison, J.5
Veillette, K.6
Sillaots, S.7
Hu, W.8
Rodriguez-Suarez, R.9
Trosok, S.10
-
49
-
-
50349097798
-
The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells
-
Kammler S, Lykke-Andersen S, Jensen TH. 2008. The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells. Mol Cancer Res 6: 990-995.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 990-995
-
-
Kammler, S.1
Lykke-Andersen, S.2
Jensen, T.H.3
-
50
-
-
38349088326
-
Altered ex-pression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis
-
Karakousis PC, Williams EP, Bishai WR. 2008. Altered ex-pression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis. J Antimicrob Che-mother 61: 323-331.
-
(2008)
J Antimicrob Che-Mother
, vol.61
, pp. 323-331
-
-
Karakousis, P.C.1
Williams, E.P.2
Bishai, W.R.3
-
51
-
-
79953701962
-
Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase
-
Kim JH, Wei JR, Wallach JB, Robbins RS, Rubin EJ, Schnappinger D. 2010. Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Res 39: 2210-2220.
-
(2010)
Nucleic Acids Res
, vol.39
, pp. 2210-2220
-
-
Kim, J.H.1
Wei, J.R.2
Wallach, J.B.3
Robbins, R.S.4
Rubin, E.J.5
Schnappinger, D.6
-
52
-
-
84888113573
-
A genetic strategy to identify targets for the development of drugs that prevent bacte-rial persistence
-
Kim JH, O’Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, et al. 2013. A genetic strategy to identify targets for the development of drugs that prevent bacte-rial persistence. Proc Natl Acad Sci 110: 19095-19100.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 19095-19100
-
-
Kim, J.H.1
O’Brien, K.M.2
Sharma, R.3
Boshoff, H.I.4
Rehren, G.5
Chakraborty, S.6
Wallach, J.B.7
Monteleone, M.8
Wilson, D.J.9
Aldrich, C.C.10
-
53
-
-
64549137584
-
Improved tetracycline repressors for gene silencing in mycobacteria
-
Klotzsche M, Ehrt S, Schnappinger D. 2009. Improved tetracycline repressors for gene silencing in mycobacteria. Nucleic Acids Res 37: 1778-1788.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 1778-1788
-
-
Klotzsche, M.1
Ehrt, S.2
Schnappinger, D.3
-
54
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola I, Landis J. 2004. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3: 711-715.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
55
-
-
34248998479
-
Diarylquinolines target subunit c of mycobacterial ATP synthase
-
Koul A, Dendouga N, Vergauwen K, Molenberghs B, Vranckx L, Willebrords R, Ristic Z, Lill H, Dorange I, Guillemont J, et al. 2007. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nat Chem Biol 3: 323-324.
-
(2007)
Nat Chem Biol
, vol.3
-
-
Koul, A.1
Dendouga, N.2
Vergauwen, K.3
Molenberghs, B.4
Vranckx, L.5
Willebrords, R.6
Ristic, Z.7
Lill, H.8
Dorange, I.9
Guillemont, J.10
-
56
-
-
84863088810
-
High-throughput screening and sensitized bacteria identify an M. Tuberculosis dihydrofolate reductase inhibitor with whole cell activity
-
Kumar A, Zhang M, Zhu L, Liao RP, Mutai C, Hafsat S, Sherman DR, Wang MW. 2012. High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity. PloS ONE 7: e39961.
-
(2012)
Plos ONE
, vol.7
-
-
Kumar, A.1
Zhang, M.2
Zhu, L.3
Liao, R.P.4
Mutai, C.5
Hafsat, S.6
Sherman, D.R.7
Wang, M.W.8
-
57
-
-
84455173193
-
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
-
La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, et al. 2012. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother 56: 324-331.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 324-331
-
-
La Rosa, V.1
Poce, G.2
Canseco, J.O.3
Buroni, S.4
Pasca, M.R.5
Biava, M.6
Raju, R.M.7
Porretta, G.C.8
Alfonso, S.9
Battilocchio, C.10
-
58
-
-
0014465373
-
Relationships be-tween bactericidal effect and inhibition of ribonucleic acid nucleotidyltransferase by rifampicin in Escherichia coli K-12
-
Lancini G, Pallanza R, Silvestri LG. 1969. Relationships be-tween bactericidal effect and inhibition of ribonucleic acid nucleotidyltransferase by rifampicin in Escherichia coli K-12. J Bacteriol 97: 761-768.
-
(1969)
J Bacteriol
, vol.97
, pp. 761-768
-
-
Lancini, G.1
Pallanza, R.2
Silvestri, L.G.3
-
59
-
-
18744398724
-
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Myco-bacterium smegmatis
-
Larsen MH, Vilcheze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, et al. 2002. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Myco-bacterium smegmatis, M. bovis BCG and M. tuberculosis. Mol Microbiol 46: 453-466.
-
(2002)
M. Bovis BCG and M. Tuberculosis. Mol Microbiol
, vol.46
, pp. 453-466
-
-
Larsen, M.H.1
Vilcheze, C.2
Kremer, L.3
Besra, G.S.4
Parsons, L.5
Salfinger, M.6
Heifets, L.7
Hazbon, M.H.8
Alland, D.9
Sacchettini, J.C.10
-
60
-
-
0030699475
-
Yeast microarrays for genome wide parallel genetic and gene expres-sion analysis
-
Lashkari DA, DeRisi JL, McCusker JH, Namath AF, Gentile C, Hwang SY, Brown PO, Davis RW. 1997. Yeast microarrays for genome wide parallel genetic and gene expres-sion analysis. Proc Natl Acad Sci 94: 13057-13062.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 13057-13062
-
-
Lashkari, D.A.1
Derisi, J.L.2
McCusker, J.H.3
Namath, A.F.4
Gentile, C.5
Hwang, S.Y.6
Brown, P.O.7
Davis, R.W.8
-
61
-
-
84872033341
-
-
Leblanc C, Prudhomme T, Tabouret G, Ray A, Burbaud S, Cabantous S, Mourey L, Guilhot C, Chalut C. 2012. 40-Phosphopantetheinyl transferase PptT, a new drug tar-get required for Mycobacterium tuberculosis growth and persistence in vivo. PLoS Pathog 8: e1003097.
-
(2012)
Plos Pathog
, vol.8
-
-
Leblanc, C.1
Prudhomme, T.2
Tabouret, G.3
Ray, A.4
Burbaud, S.5
Cabantous, S.6
Mourey, L.7
Guilhot, C.8
Chalut, C.9
-
63
-
-
55449118522
-
Genome-wide requirements for resistance to functionally distinct DNA-damaging agents
-
Lee W, St Onge RP, Proctor M, Flaherty P, Jordan MI, Arkin AP, Davis RW, Nislow C, Giaever G. 2005. Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet 1: e24.
-
(2005)
Plos Genet
, vol.1
-
-
Lee, W.1
St Onge, R.P.2
Proctor, M.3
Flaherty, P.4
Jordan, M.I.5
Arkin, A.P.6
Davis, R.W.7
Nislow, C.8
Giaever, G.9
-
64
-
-
79954418392
-
Microarray analysis of the chelerythrine-induced transcriptome of Mycobacterium tuber-culosis
-
Liang J, Zeng F, Guo A, Liu L, Guo N, Li L, Jin J, Wu X, Liu M, Zhao D, et al. 2011. Microarray analysis of the chelerythrine-induced transcriptome of Mycobacterium tuber-culosis. Curr Microbiol 62: 1200-1208.
-
(2011)
Curr Microbiol
, vol.62
, pp. 1200-1208
-
-
Liang, J.1
Zeng, F.2
Guo, A.3
Liu, L.4
Guo, N.5
Li, L.6
Jin, J.7
Wu, X.8
Liu, M.9
Zhao, D.10
-
65
-
-
77950165418
-
Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: Generating an antibiotic bar code
-
Liu A, Tran L, Becket E, Lee K, Chinn L, Park E, Tran K, Miller JH. 2010. Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: Generating an antibiotic bar code. Antimicrob Agents Chemother 54: 1393-1403.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 1393-1403
-
-
Liu, A.1
Tran, L.2
Becket, E.3
Lee, K.4
Chinn, L.5
Park, E.6
Tran, K.7
Miller, J.H.8
-
66
-
-
10744225364
-
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
-
Lum PY, Armour CD, Stepaniants SB, Cavet G, Wolf MK, Butler JS, Hinshaw JC, Garnier P, Prestwich GD, Leonardson A, et al. 2004. Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell 116: 121-137.
-
(2004)
Cell
, vol.116
, pp. 121-137
-
-
Lum, P.Y.1
Armour, C.D.2
Stepaniants, S.B.3
Cavet, G.4
Wolf, M.K.5
Butler, J.S.6
Hinshaw, J.C.7
Garnier, P.8
Prestwich, G.D.9
Leonardson, A.10
-
67
-
-
78049483746
-
Leads for antitubercular compounds from kinase inhibitor library screens
-
Magnet S, Hartkoorn RC, Szekely R, Pato J, Triccas JA, Schneider P, Szantai-Kis C, Orfi L, Chambon M, Banfi D, et al. 2010. Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis 90: 354-360.
-
(2010)
Tuberculosis
, vol.90
-
-
Magnet, S.1
Hartkoorn, R.C.2
Szekely, R.3
Pato, J.4
Triccas, J.A.5
Schneider, P.6
Szantai-Kis, C.7
Orfi, L.8
Chambon, M.9
Banfi, D.10
-
68
-
-
65649096556
-
Benzothiazinones kill Mycobacterium tu-berculosis by blocking arabinan synthesis
-
Makarov V, Manina G, Mikusova K, Mollmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, et al. 2009. Benzothiazinones kill Mycobacterium tu-berculosis by blocking arabinan synthesis. Science 324: 801-804.
-
(2009)
Science
, vol.324
, pp. 801-804
-
-
Makarov, V.1
Manina, G.2
Mikusova, K.3
Mollmann, U.4
Ryabova, O.5
Saint-Joanis, B.6
Dhar, N.7
Pasca, M.R.8
Buroni, S.9
Lucarelli, A.P.10
-
69
-
-
77951298792
-
The mechanism of action of PA-824: Novel insights from transcriptional profiling
-
Manjunatha U, Boshoff HI, Barry CE. 2009. The mechanism of action of PA-824: Novel insights from transcriptional profiling. Commun Integr Biol 2: 215-218.
-
(2009)
Commun Integr Biol
, vol.2
, pp. 215-218
-
-
Manjunatha, U.1
Boshoff, H.I.2
Barry, C.E.3
-
70
-
-
3142536716
-
Exploration of essential gene functions via titrat-able promoter alleles
-
Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, et al. 2004. Exploration of essential gene functions via titrat-able promoter alleles. Cell 118: 31-44.
-
(2004)
Cell
, vol.118
, pp. 31-44
-
-
Mnaimneh, S.1
Davierwala, A.P.2
Haynes, J.3
Moffat, J.4
Peng, W.T.5
Zhang, W.6
Yang, X.7
Pootoolal, J.8
Chua, G.9
Lopez, A.10
-
71
-
-
33745235266
-
Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
-
Munoz-Elias EJ, Upton AM, Cherian J, McKinney JD. 2006. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol 60: 1109-1122.
-
(2006)
Mol Microbiol
, vol.60
, pp. 1109-1122
-
-
Munoz-Elias, E.J.1
Upton, A.M.2
Cherian, J.3
McKinney, J.D.4
-
72
-
-
45549088326
-
The transcriptional landscape of the yeast genome defined by RNA sequencing
-
Nagalakshmi U, Wang Z, Waern K, Shou C, Raha D, Ger-stein M, Snyder M. 2008. The transcriptional landscape of the yeast genome defined by RNA sequencing. Science 320: 1344-1349.
-
(2008)
Science
, vol.320
, pp. 1344-1349
-
-
Nagalakshmi, U.1
Wang, Z.2
Waern, K.3
Shou, C.4
Raha, D.5
Ger-Stein, M.6
Snyder, M.7
-
73
-
-
75149115775
-
Methionine aminopeptidases from Mycobacterium tuber-culosis as novel antimycobacterial targets
-
Olaleye O, Raghunand TR, Bhat S, He J, Tyagi S, Lamich-hane G, Gu P, Zhou J, Zhang Y, Grosset J, et al. 2010. Methionine aminopeptidases from Mycobacterium tuber-culosis as novel antimycobacterial targets. Chem Biol 17: 86-97.
-
(2010)
Chem Biol
, vol.17
, pp. 86-97
-
-
Olaleye, O.1
Raghunand, T.R.2
Bhat, S.3
He, J.4
Tyagi, S.5
Lamich-Hane, G.6
Gu, P.7
Zhou, J.8
Zhang, Y.9
Grosset, J.10
-
74
-
-
84861380413
-
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions
-
Ollinger J, O’Malley T, Ahn J, Odingo J, Parish T. 2012. Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions. J Bacteriol 194: 2614-2619.
-
(2012)
J Bacteriol
, vol.194
, pp. 2614-2619
-
-
Ollinger, J.1
O’Malley, T.2
Ahn, J.3
Odingo, J.4
Parish, T.5
-
75
-
-
0347473810
-
Inte-gration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways
-
Parsons AB, Brost RL, Ding H, Li Z, Zhang C, Sheikh B, Brown GW, Kane PM, Hughes TR, Boone C. 2004. Inte-gration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways. Nat Biotechnol 22: 62-69.
-
(2004)
Nat Biotechnol
, vol.22
, pp. 62-69
-
-
Parsons, A.B.1
Brost, R.L.2
Ding, H.3
Li, Z.4
Zhang, C.5
Sheikh, B.6
Brown, G.W.7
Kane, P.M.8
Hughes, T.R.9
Boone, C.10
-
76
-
-
33746753342
-
Exploring the mode-of-action of bioactive com-pounds by chemical-genetic profiling in yeast
-
Parsons AB, Lopez A, Givoni IE, Williams DE, Gray CA, Porter J, Chua G, Sopko R, Brost RL, Ho CH, et al. 2006. Exploring the mode-of-action of bioactive com-pounds by chemical-genetic profiling in yeast. Cell 126: 611-625.
-
(2006)
Cell
, vol.126
, pp. 611-625
-
-
Parsons, A.B.1
Lopez, A.2
Givoni, I.E.3
Williams, D.E.4
Gray, C.A.5
Porter, J.6
Chua, G.7
Sopko, R.8
Brost, R.L.9
Ho, C.H.10
-
77
-
-
70350342020
-
Chemical genomics in Escherichia coli identifies an inhib-itor of bacterial lipoprotein targeting
-
Pathania R, Zlitni S, Barker C, Das R, Gerritsma DA, Lebert J, Awuah E, Melacini G, Capretta FA, Brown ED. 2009. Chemical genomics in Escherichia coli identifies an inhib-itor of bacterial lipoprotein targeting. Nat Chem Biol 5: 849-856.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 849-856
-
-
Pathania, R.1
Zlitni, S.2
Barker, C.3
Das, R.4
Gerritsma, D.A.5
Lebert, J.6
Awuah, E.7
Melacini, G.8
Capretta, F.A.9
Brown, E.D.10
-
78
-
-
77649234756
-
How to improve R&D productivity: The pharmaceutical industry’s grand challenge
-
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL. 2010. How to improve R&D productivity: The pharmaceutical industry’s grand challenge. Nat Rev Drug Discov 9: 203-214.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
Schacht, A.L.7
-
80
-
-
77955517509
-
Druggable pockets and binding site cen-tric chemical space: A paradigm shift in drug discovery
-
Perot S, Sperandio O, Miteva MA, Camproux AC, Villoutreix BO. 2010. Druggable pockets and binding site cen-tric chemical space: A paradigm shift in drug discovery. Drug Discov Today 15: 656-667.
-
(2010)
Drug Discov Today
, vol.15
, pp. 656-667
-
-
Perot, S.1
Sperandio, O.2
Miteva, M.A.3
Camproux, A.C.4
Villoutreix, B.O.5
-
81
-
-
84883824094
-
Discovery of Q203, a potent clinical candidate for the treatment of tuberculo-sis
-
Pethe K, Bifani P, Jang J, Kang S, Park S, Ahn S, Jiricek J, Jung J, Jeon HK, Cechetto J, et al. 2013. Discovery of Q203, a potent clinical candidate for the treatment of tuberculo-sis. Nat Med 19: 1157-1160.
-
(2013)
Nat Med
, vol.19
, pp. 1157-1160
-
-
Pethe, K.1
Bifani, P.2
Jang, J.3
Kang, S.4
Park, S.5
Ahn, S.6
Jiricek, J.7
Jung, J.8
Jeon, H.K.9
Cechetto, J.10
-
82
-
-
65649120032
-
Global transcriptional response to vancomycin in Mycobacterium tuberculosis
-
Provvedi R, Boldrin F, Falciani F, Palu G, Manganelli R. 2009. Global transcriptional response to vancomycin in Mycobacterium tuberculosis. Microbiology 155: 1093-1102.
-
(2009)
Microbiology
, vol.155
, pp. 1093-1102
-
-
Provvedi, R.1
Boldrin, F.2
Falciani, F.3
Palu, G.4
Manganelli, R.5
-
83
-
-
84876272210
-
Tetrahydropyrazolo[1,5-a]pyrim-idine-3-carboxamide and N-benzyl-60,70-dihydrospiro [piperidine-4,4’-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
-
Remuinan MJ, Perez-Herran E, Rullas J, Alemparte C, Martinez-Hoyos M, Dow DJ, Afari J, Mehta N, Esquivias J, Jimenez E, et al. 2013. Tetrahydropyrazolo[1,5-a]pyrim-idine-3-carboxamide and N-benzyl-60,70-dihydrospiro [piperidine-4,4’-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PloS One 8: e60933.
-
(2013)
Plos One
, vol.8
-
-
Remuinan, M.J.1
Perez-Herran, E.2
Rullas, J.3
Alemparte, C.4
Martinez-Hoyos, M.5
Dow, D.J.6
Afari, J.7
Mehta, N.8
Esquivias, J.9
Jimenez, E.10
-
84
-
-
20444419421
-
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
-
Rengarajan J, Bloom BR, Rubin EJ. 2005. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci 102: 8327-8332.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 8327-8332
-
-
Rengarajan, J.1
Bloom, B.R.2
Rubin, E.J.3
-
85
-
-
30744441922
-
Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis
-
Rodriguez GM, Smith I. 2006. Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol 188: 424-430.
-
(2006)
J Bacteriol
, vol.188
, pp. 424-430
-
-
Rodriguez, G.M.1
Smith, I.2
-
86
-
-
35348988264
-
Mechanism-of-action determination of GMP syn-thase inhibitors and target validation in Candida albicans and Aspergillus fumigatus
-
Rodriguez-Suarez R, Xu D, Veillette K, Davison J, Sillaots S, Kauffman S, Hu W, Bowman J, Martel N, Trosok S, et al. 2007. Mechanism-of-action determination of GMP syn-thase inhibitors and target validation in Candida albicans and Aspergillus fumigatus. Chem Biol 14: 1163-1175.
-
(2007)
Chem Biol
, vol.14
, pp. 1163-1175
-
-
Rodriguez-Suarez, R.1
Xu, D.2
Veillette, K.3
Davison, J.4
Sillaots, S.5
Kauffman, S.6
Hu, W.7
Bowman, J.8
Martel, N.9
Trosok, S.10
-
87
-
-
84875467898
-
Systems-level antimicrobial drug and drug synergy discovery
-
Roemer T, Boone C. 2013. Systems-level antimicrobial drug and drug synergy discovery. Nat Chem Biol 9: 222-231.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 222-231
-
-
Roemer, T.1
Boone, C.2
-
88
-
-
0242268400
-
Genetic requirements for mycobacterial survival during infection
-
Sassetti CM, Rubin EJ. 2003. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci 100: 12989-12994.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 12989-12994
-
-
Sassetti, C.M.1
Rubin, E.J.2
-
89
-
-
0035940515
-
Comprehensiveidentification of conditionally essential genes in mycobacteria
-
Sassetti CM, Boyd DH, Rubin EJ. 2001. Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci 98: 12712-12717.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 12712-12717
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
90
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagen-esis
-
Sassetti CM, Boyd DH, Rubin EJ. 2003. Genes required for mycobacterial growth defined by high density mutagen-esis. Mol Microbiol 48: 77-84.
-
(2003)
Mol Microbiol
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
91
-
-
0028806048
-
Quantitative monitoring of gene expression patterns with a complementary DNA microarray
-
Schena M, Shalon D, Davis RW, Brown PO. 1995. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270: 467-470.
-
(1995)
Science
, vol.270
, pp. 467-470
-
-
Schena, M.1
Shalon, D.2
Davis, R.W.3
Brown, P.O.4
-
92
-
-
84925240314
-
Regulated expression systems for mycobacteria and their applications
-
Schnappinger D, Ehrt S. 2014. Regulated expression systems for mycobacteria and their applications. Microbiol Spectr 2: doi: 10.1128/microbiolspec.MGM1122-0018-2013.
-
(2014)
Microbiol Spectr
, vol.2
-
-
Schnappinger, D.1
Ehrt, S.2
-
93
-
-
0025361947
-
Dihydrofolatereductase as a therapeutic target
-
Schweitzer BI, Dicker AP, Bertino JR. 1990. Dihydrofolate reductase as a therapeutic target. FASEB J 4: 2441-2452.
-
(1990)
FASEB J
, vol.4
, pp. 2441-2452
-
-
Schweitzer, B.I.1
Dicker, A.P.2
Bertino, J.R.3
-
94
-
-
84862869077
-
Fragment based approaches in drug discovery and chemical biol-ogy
-
Scott DE, Coyne AG, Hudson SA, Abell C. 2012. Fragment based approaches in drug discovery and chemical biol-ogy. Biochemistry 51: 4990-5003.
-
(2012)
Biochemistry
, vol.51
, pp. 4990-5003
-
-
Scott, D.E.1
Coyne, A.G.2
Hudson, S.A.3
Abell, C.4
-
95
-
-
80755126602
-
Mechanism-based inactivation by aro-matization of the transaminase BioA involved in biotin biosynthesis in Mycobacterium tuberculosis
-
Shi C, Geders TW, Park SW, Wilson DJ, Boshoff HI, Abayomi O, Barry CE III, Schnappinger D, Finzel BC, Aldrich CC. 2011. Mechanism-based inactivation by aro-matization of the transaminase BioA involved in biotin biosynthesis in Mycobacterium tuberculosis. J Am Chem Soc 133: 18194-18201.
-
(2011)
J am Chem Soc
, vol.133
, pp. 18194-18201
-
-
Shi, C.1
Geders, T.W.2
Park, S.W.3
Wilson, D.J.4
Boshoff, H.I.5
Abayomi, O.6
Barry, C.7
Schnappinger, D.8
Finzel, B.C.9
Aldrich, C.C.10
-
96
-
-
78751477224
-
Challenges of antibacterial discovery
-
Silver LL. 2011. Challenges of antibacterial discovery. Clin Microbiol Rev 24: 71-109.
-
(2011)
Clin Microbiol Rev
, vol.24
, pp. 71-109
-
-
Silver, L.L.1
-
97
-
-
60649107144
-
Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis
-
Slayden RA, Belisle JT. 2009. Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis. J Antimicrob Chemother 63: 451-457.
-
(2009)
J Antimicrob Chemother
, vol.63
, pp. 451-457
-
-
Slayden, R.A.1
Belisle, J.T.2
-
98
-
-
77954212737
-
A survey of yeast genomic assays for drug and target discovery
-
Smith AM, Ammar R, Nislow C, Giaever G. 2010. A survey of yeast genomic assays for drug and target discovery. Pharmacol Ther 127: 156-164.
-
(2010)
Pharmacol Ther
, vol.127
, pp. 156-164
-
-
Smith, A.M.1
Ammar, R.2
Nislow, C.3
Giaever, G.4
-
99
-
-
84865253965
-
Identification of novel inhibitors of M. Tuberculosis growth using whole cell based high-throughput screen-ing
-
Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, et al. 2012. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screen-ing. ACS Chem Biol 7: 1377-1384.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 1377-1384
-
-
Stanley, S.A.1
Grant, S.S.2
Kawate, T.3
Iwase, N.4
Shimizu, M.5
Wivagg, C.6
Silvis, M.7
Kazyanskaya, E.8
Aquadro, J.9
Golas, A.10
-
100
-
-
84879939125
-
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32
-
Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, et al. 2013. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci 110: 11565-11570.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. 11565-11570
-
-
Stanley, S.A.1
Kawate, T.2
Iwase, N.3
Shimizu, M.4
Clatworthy, A.E.5
Kazyanskaya, E.6
Sacchettini, J.C.7
Ioerger, T.R.8
Siddiqi, N.A.9
Minami, S.10
-
101
-
-
0001534829
-
Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme
-
Sugino A, Peebles CL, Kreuzer KN, Cozzarelli NR. 1977. Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. Proc Natl Acad Sci 74: 4767-4771.
-
(1977)
Proc Natl Acad Sci
, vol.74
, pp. 4767-4771
-
-
Sugino, A.1
Peebles, C.L.2
Kreuzer, K.N.3
Cozzarelli, N.R.4
-
103
-
-
84863404695
-
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
-
Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE III, et al. 2012. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother 56: 1797-1809.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 1797-1809
-
-
Tahlan, K.1
Wilson, R.2
Kastrinsky, D.B.3
Arora, K.4
Nair, V.5
Fischer, E.6
Barnes, S.W.7
Walker, J.R.8
Alland, D.9
Barry, C.10
-
104
-
-
50249172242
-
Determinationof antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli
-
Tamae C, Liu A, Kim K, Sitz D, Hong J, Becket E, Bui A, Solaimani P, Tran KP, Yang H, et al. 2008. Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli. J Bacteriol 190: 5981-5988.
-
(2008)
J Bacteriol
, vol.190
, pp. 5981-5988
-
-
Tamae, C.1
Liu, A.2
Kim, K.3
Sitz, D.4
Hong, J.5
Becket, E.6
Bui, A.7
Solaimani, P.8
Tran, K.P.9
Yang, H.10
-
105
-
-
84877845374
-
Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aure-us USA300
-
Thorsing M, Klitgaard JK, Atilano ML, Skov MN, Kolmos HJ, Filipe SR, Kallipolitis BH. 2013. Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aure-us USA300. PloS ONE 8: e64518.
-
(2013)
Plos ONE
, vol.8
-
-
Thorsing, M.1
Klitgaard, J.K.2
Atilano, M.L.3
Skov, M.N.4
Kolmos, H.J.5
Filipe, S.R.6
Kallipolitis, B.H.7
-
106
-
-
78650744683
-
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against My-cobacterium tuberculosis
-
Usha V, Gurcha SS, Lovering AL, Lloyd AJ, Papaemmanouil A, Reynolds RC, Besra GS. 2011. Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against My-cobacterium tuberculosis. Microbiology 157: 290-299.
-
(2011)
Microbiology
, vol.157
, pp. 290-299
-
-
Usha, V.1
Gurcha, S.S.2
Lovering, A.L.3
Lloyd, A.J.4
Papaemmanouil, A.5
Reynolds, R.C.6
Besra, G.S.7
-
107
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, et al. 2006. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441: 358-361.
-
(2006)
Nature
, vol.441
, pp. 358-361
-
-
Wang, J.1
Soisson, S.M.2
Young, K.3
Shoop, W.4
Kodali, S.5
Galgoci, A.6
Painter, R.7
Parthasarathy, G.8
Tang, Y.S.9
Cummings, R.10
-
108
-
-
34250649348
-
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
-
Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, et al. 2007. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc Natl Acad Sci 104: 7612-7616.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 7612-7616
-
-
Wang, J.1
Kodali, S.2
Lee, S.H.3
Galgoci, A.4
Painter, R.5
Dorso, K.6
Racine, F.7
Motyl, M.8
Hernandez, L.9
Tinney, E.10
-
109
-
-
84879707160
-
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
-
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, et al. 2013. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci 110: E2510-E2517.
-
(2013)
Proc Natl Acad Sci
, vol.110
, pp. E2510-E2517
-
-
Wang, F.1
Sambandan, D.2
Halder, R.3
Wang, J.4
Batt, S.M.5
Weinrick, B.6
Ahmad, I.7
Yang, P.8
Zhang, Y.9
Kim, J.10
-
110
-
-
81855168417
-
Antibiotic research in the age of omics: From expression profiles to interspecies communication
-
Wecke T, Mascher T. 2011. Antibiotic research in the age of omics: From expression profiles to interspecies communication. J Antimicrob Chemother 66: 2689-2704.
-
(2011)
J Antimicrob Chemother
, vol.66
, pp. 2689-2704
-
-
Wecke, T.1
Mascher, T.2
-
111
-
-
79952760675
-
Depletion of antibiotic targets has widely varying effects on growth
-
Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. 2011. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci 108: 4176-4181.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 4176-4181
-
-
Wei, J.R.1
Krishnamoorthy, V.2
Murphy, K.3
Kim, J.H.4
Schnappinger, D.5
Alber, T.6
Sassetti, C.M.7
Rhee, K.Y.8
Rubin, E.J.9
-
112
-
-
46249096804
-
Dynam-ic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
-
Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bahler J. 2008. Dynam-ic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453: 1239-1243.
-
(2008)
Nature
, vol.453
, pp. 1239-1243
-
-
Wilhelm, B.T.1
Marguerat, S.2
Watt, S.3
Schubert, F.4
Wood, V.5
Goodhead, I.6
Penkett, C.J.7
Rogers, J.8
Bahler, J.9
-
113
-
-
0033607188
-
Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
-
Wilson M, DeRisi J, Kristensen HH, Imboden P, Rane S, Brown PO, Schoolnik GK. 1999. Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization. Proc Natl Acad Sci 96: 12833-12838.
-
(1999)
Proc Natl Acad Sci
, vol.96
, pp. 12833-12838
-
-
Wilson, M.1
Derisi, J.2
Kristensen, H.H.3
Imboden, P.4
Rane, S.5
Brown, P.O.6
Schoolnik, G.K.7
-
114
-
-
84880924467
-
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosyn-thesis
-
Wilson R, Kumar P, Parashar V, Vilcheze C, Veyron-Churlet R, Freundlich JS, Barnes SW, Walker JR, Szymonifka MJ, Marchiano E, et al. 2013. Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosyn-thesis. Nat Chem Biol 9: 499-506.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 499-506
-
-
Wilson, R.1
Kumar, P.2
Parashar, V.3
Vilcheze, C.4
Veyron-Churlet, R.5
Freundlich, J.S.6
Barnes, S.W.7
Walker, J.R.8
Szymonifka, M.J.9
Marchiano, E.10
-
115
-
-
80053459537
-
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using reg-ulated gene expression
-
Woong Park S, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee K, Barry CE III, Aldrich CC, et al. 2011. Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using reg-ulated gene expression. PLoS Pathog 7: e1002264.
-
(2011)
Plos Pathog
, vol.7
-
-
Woong Park, S.1
Klotzsche, M.2
Wilson, D.J.3
Boshoff, H.I.4
Eoh, H.5
Manjunatha, U.6
Blumenthal, A.7
Rhee, K.8
Barry, C.9
Aldrich, C.C.10
-
116
-
-
67749122471
-
Chem-ical genetic profiling and characterization of small-mol-ecule compounds that affect the biosynthesis of unsatu-rated fatty acids in Candida albicans
-
Xu D, Sillaots S, Davison J, Hu W, Jiang B, Kauffman S, Martel N, Ocampo P, Oh C, Trosok S, et al. 2009. Chem-ical genetic profiling and characterization of small-mol-ecule compounds that affect the biosynthesis of unsatu-rated fatty acids in Candida albicans. J Biol Chem 284: 19754-19764.
-
(2009)
J Biol Chem
, vol.284
, pp. 19754-19764
-
-
Xu, D.1
Sillaots, S.2
Davison, J.3
Hu, W.4
Jiang, B.5
Kauffman, S.6
Martel, N.7
Ocampo, P.8
Oh, C.9
Trosok, S.10
-
117
-
-
77956118820
-
Staphylococcus aureus TargetArray: Compre-hensive differential essential gene expression as a mech-anistic tool to profile antibacterials
-
Xu HH, Trawick JD, Haselbeck RJ, Forsyth RA, Yamamoto RT, Archer R, Patterson J, Allen M, Froelich JM, Taylor I, et al. 2010. Staphylococcus aureus TargetArray: Compre-hensive differential essential gene expression as a mech-anistic tool to profile antibacterials. Antimicrob Agents Chemother 54: 3659-3670.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 3659-3670
-
-
Xu, H.H.1
Trawick, J.D.2
Haselbeck, R.J.3
Forsyth, R.A.4
Yamamoto, R.T.5
Archer, R.6
Patterson, J.7
Allen, M.8
Froelich, J.M.9
Taylor, I.10
-
118
-
-
0347136011
-
Identification of antimicrobial targets using a comprehensive genomic approach
-
Yin D, Fox B, Lonetto ML, Etherton MR, Payne DJ, Holmes DJ, Rosenberg M, Ji Y. 2004. Identification of antimicrobial targets using a comprehensive genomic approach. Pharmacogenomics 5: 101-113.
-
(2004)
Pharmacogenomics
, vol.5
, pp. 101-113
-
-
Yin, D.1
Fox, B.2
Lonetto, M.L.3
Etherton, M.R.4
Payne, D.J.5
Holmes, D.J.6
Rosenberg, M.7
Ji, Y.8
-
119
-
-
31944450795
-
Discovery of FabH/FabF inhibitors from natural products
-
Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang CW, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, et al. 2006. Discovery of FabH/FabF inhibitors from natural products. Antimicrob Agents Chemother 50: 519-526.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 519-526
-
-
Young, K.1
Jayasuriya, H.2
Ondeyka, J.G.3
Herath, K.4
Zhang, C.W.5
Kodali, S.6
Galgoci, A.7
Painter, R.8
Brown-Driver, V.9
Yamamoto, R.10
-
120
-
-
84866887386
-
Global assessment of genomic regions required for growth in Mycobacteri-um tuberculosis
-
Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. 2012. Global assessment of genomic regions required for growth in Mycobacteri-um tuberculosis. PLoS Pathog 8: e1002946.
-
(2012)
Plos Pathog
, vol.8
-
-
Zhang, Y.J.1
Ioerger, T.R.2
Huttenhower, C.3
Long, J.E.4
Sassetti, C.M.5
Sacchettini, J.C.6
Rubin, E.J.7
-
121
-
-
84890037649
-
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing
-
Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, et al. 2013. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell 155: 1296-1308.
-
(2013)
Cell
, vol.155
, pp. 1296-1308
-
-
Zhang, Y.J.1
Reddy, M.C.2
Ioerger, T.R.3
Rothchild, A.C.4
Dartois, V.5
Schuster, B.M.6
Trauner, A.7
Wallis, D.8
Galaviz, S.9
Huttenhower, C.10
|