Evaluating the sensitivity of mycobacterium tuberculosis to biotin deprivation using regulated gene expression

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Park, Sae ^a   Klotzsche, Marcus ^a   Wilson, Daniel J ^b   Boshoff, Helena I ^c   Eoh, Hyungjin ^a   Manjunatha, Ujjini ^d   Blumenthal, Antje ^a   Rhee, Kyu ^a   Barry, Clifton E ^c   Aldrich, Courtney C ^b   Ehrt, Sabine ^a   Schnappinger, Dirk ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d Novartis Institute for Tropical Diseases   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIAMINOPELARGONIC ACID SYNTHASE; ANHYDROTETRACYCLINE; BIOTIN; BIOTIN DERIVATIVE; DOXYCYCLINE; UNCLASSIFIED DRUG; AMINOTRANSFERASE; BACTERIAL PROTEIN; BIOA PROTEIN, BACTERIA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIABILITY; BIOTINYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TUBERCULOSIS; WILD TYPE; ANIMAL; BIOSYNTHESIS; CHRONIC DISEASE; DISEASE MODEL; DRUG DELIVERY SYSTEM; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; MUTATION;

BACTERIA (MICROORGANISMS); MURINAE; MUS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; BACTERIAL PROTEINS; BIOTIN; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; MICE; MUTATION; MYCOBACTERIUM TUBERCULOSIS; TRANSAMINASES; TUBERCULOSIS;

EID: 80053459537     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002264     Document Type: Article

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