Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis

Microbiology

Volumn 157, Issue 1, 2011, Pages 290-299

  Usha, Veeraraghavan ^a   Gurcha, Sudagar S ^a   Lovering, Andrew L ^a   Lloyd, Adrian J ^b   Papaemmanouil, Athina ^a   Reynolds, Robert C ^c   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; DIPHENYL UREA INHIBITOR; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; PROTEIN GUAB1; PROTEIN GUAB2; PROTEIN GUAB3; UNCLASSIFIED DRUG;

ARTICLE; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE OVEREXPRESSION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; CARBANILIDES; CLONING, MOLECULAR; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; ENZYME STABILITY; ESCHERICHIA COLI; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; IMP DEHYDROGENASE; INOSINE MONOPHOSPHATE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TEMPERATURE;

ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 78650744683     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.042549-0     Document Type: Article

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