The pharmacology of second-generation chimeric antigen receptors

Nature Reviews Drug Discovery

Volumn 14, Issue 7, 2015, Pages 499-509

  Van Der Stegen, Sjoukje J C ^a   Hamieh, Mohamad ^a   Sadelain, Michel ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 1BB RECEPTOR ZETA CHAIN BASED CHIMERIC ANTIGEN RECEPTOR; ANTINEOPLASTIC AGENT; CD134 ANTIGEN; CD137 ANTIGEN; CD19 ANTIGEN; CD19 BASED CHIMERIC ANTIGEN RECEPTOR; CD27 ANTIGEN; CD27 BASED CHIMERIC ANTIGEN RECEPTOR; CD28 ANTIGEN; CD28 ZETA CHAIN BASED CHIMERIC ANTIGEN RECEPTOR; CD3 ANTIGEN; CD3 ZETA CHAIN BASED CHIMERIC ANTIGEN RECEPTOR; CD33 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; IMMUNE CHECKPOINT ANTAGONIST; INDUCIBLE COSTIMULATOR; INDUCIBLE COSTIMULATOR ZETA CHAIN BASED CHIMERIC ANTIGEN RECEPTOR; INTERLEUKIN 2; IPILIMUMAB; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER CELL RECEPTOR NKG2D BASED CHIMERIC ANTIGEN RECEPTOR; OX40 BASED CHIMERIC ANTIGEN RECEPTOR; PEMBROLIZUMAB; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL XL; T LYMPHOCYTE RECEPTOR; TGN 1412; UNCLASSIFIED DRUG; UNINDEXED DRUG; URELUMAB; LYMPHOCYTE ANTIGEN RECEPTOR;

ACUTE KIDNEY FAILURE; ACUTE LUNG INJURY; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIGEN BINDING; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APLASIA; B CELL APLASIA; B CELL LYMPHOMA; BINDING AFFINITY; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; CELL CYCLE PROGRESSION; CELL ENGINEERING; CELL EXPANSION; CELL METABOLISM; CELL THERAPY; CHRONIC LYMPHATIC LEUKEMIA; CIS TRANS ISOMERISM; COLON PERFORATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RELEASE SYNDROME; CYTOKINE STORM; CYTOTOXICITY; DERMATITIS; DIMERIZATION; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG BINDING; DRUG DESIGN; DRUG MEGADOSE; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENTEROCOLITIS; FATIGUE; HEART ARREST; HUMAN; IMMUNOPHARMACOLOGY; IMMUNOSTIMULATION; KIDNEY CARCINOMA; LEUKEMIA REMISSION; LIVER TOXICITY; LOW DRUG DOSE; LUNG INFILTRATE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MELANOMA; MEMBRANE POTENTIAL; METASTATIC MELANOMA; NEPHRITIS; NEUROTOXICITY; NONHODGKIN LYMPHOMA; NONHUMAN; PANCREATITIS; PNEUMONIA; PRIORITY JOURNAL; RASH; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; STRUCTURE ANALYSIS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UVEITIS; ANIMAL; CHIMERA; IMMUNOLOGY; IMMUNOTHERAPY; NEOPLASMS; PROCEDURES; TRENDS;

ANIMALS; ANTIGENS, CD28; CHIMERA; HUMANS; IMMUNOTHERAPY; NEOPLASMS; RECEPTORS, ANTIGEN; T-LYMPHOCYTES;

EID: 84934268032     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4597     Document Type: Review

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