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Volumn 190, Issue 5, 2013, Pages 2455-2463

Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CD3 ANTIGEN; CD3DELTA ANTIGEN; CHIMERIC NATURAL KILLER CELL RECEPTOR NKG2D; CHIMERIC PROTEIN; GAMMA INTERFERON; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER CELL RECEPTOR NKG2D LIGAND RAE1; PERFORIN; UNCLASSIFIED DRUG;

EID: 84874285199     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201314     Document Type: Article
Times cited : (39)

References (55)
  • 1
    • 78650050458 scopus 로고    scopus 로고
    • Endothelial cells as key determinants of the tumor microenvironment: Interaction with tumor cells, extracellular matrix and immune killer cells
    • Chouaib, S., C. Kieda, H. Benlalam, M. Z. Noman, F. Mami-Chouaib, and C. Rüegg. 2010. Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells. Crit. Rev. Immunol. 30: 529-545.
    • (2010) Crit. Rev. Immunol. , vol.30 , pp. 529-545
    • Chouaib, S.1    Kieda, C.2    Benlalam, H.3    Noman, M.Z.4    Mami-Chouaib, F.5    Rüegg, C.6
  • 2
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel, R. S. 2008. Tumor angiogenesis. N. Engl. J. Med. 358: 2039-2049.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 3
    • 78249257291 scopus 로고    scopus 로고
    • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation
    • Rakhra, K., P. Bachireddy, T. Zabuawala, R. Zeiser, L. Xu, A. Kopelman, A. C. Fan, Q. Yang, L. Braunstein, E. Crosby, et al. 2010. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell 18: 485-498.
    • (2010) Cancer Cell , vol.18 , pp. 485-498
    • Rakhra, K.1    Bachireddy, P.2    Zabuawala, T.3    Zeiser, R.4    Xu, L.5    Kopelman, A.6    Fan, A.C.7    Yang, Q.8    Braunstein, L.9    Crosby, E.10
  • 5
    • 34247849335 scopus 로고    scopus 로고
    • Target practice: Lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer
    • Los, M., J. M. Roodhart, and E. E. Voest. 2007. Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer. Oncologist 12: 443-450.
    • (2007) Oncologist , vol.12 , pp. 443-450
    • Los, M.1    Roodhart, J.M.2    Voest, E.E.3
  • 7
    • 53549124398 scopus 로고    scopus 로고
    • NKG2D ligands in tumor immunity
    • Nausch, N., and A. Cerwenka. 2008. NKG2D ligands in tumor immunity. Oncogene 27: 5944-5958.
    • (2008) Oncogene , vol.27 , pp. 5944-5958
    • Nausch, N.1    Cerwenka, A.2
  • 8
    • 58949086448 scopus 로고    scopus 로고
    • Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    • Nausch, N., I. E. Galani, E. Schlecker, and A. Cerwenka. 2008. Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. Blood 112: 4080-4089.
    • (2008) Blood , vol.112 , pp. 4080-4089
    • Nausch, N.1    Galani, I.E.2    Schlecker, E.3    Cerwenka, A.4
  • 9
    • 79952755728 scopus 로고    scopus 로고
    • Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells
    • Zhang, T., and C. L. Sentman. 2011. Cancer immunotherapy using a bispecific NK receptor fusion protein that engages both T cells and tumor cells. Cancer Res. 71: 2066-2076.
    • (2011) Cancer Res. , vol.71 , pp. 2066-2076
    • Zhang, T.1    Sentman, C.L.2
  • 10
    • 73349123470 scopus 로고    scopus 로고
    • Chimeric NKG2D expressing T cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment
    • Barber, A., A. Rynda, and C. L. Sentman. 2009. Chimeric NKG2D expressing T cells eliminate immunosuppression and activate immunity within the ovarian tumor microenvironment. J. Immunol. 183: 6939-6947.
    • (2009) J. Immunol. , vol.183 , pp. 6939-6947
    • Barber, A.1    Rynda, A.2    Sentman, C.L.3
  • 13
    • 33745257896 scopus 로고    scopus 로고
    • Generation of antitumor responses by genetic modification of primary human T cells with a chimeric NKG2D receptor
    • Zhang, T., A. Barber, and C. L. Sentman. 2006. Generation of antitumor responses by genetic modification of primary human T cells with a chimeric NKG2D receptor. Cancer Res. 66: 5927-5933.
    • (2006) Cancer Res. , vol.66 , pp. 5927-5933
    • Zhang, T.1    Barber, A.2    Sentman, C.L.3
  • 14
    • 23944488287 scopus 로고    scopus 로고
    • Chimeric NK-receptorbearing T cells mediate antitumor immunotherapy
    • Zhang, T., B. A. Lemoi, and C. L. Sentman. 2005. Chimeric NK-receptorbearing T cells mediate antitumor immunotherapy. Blood 106: 1544-1551.
    • (2005) Blood , vol.106 , pp. 1544-1551
    • Zhang, T.1    Lemoi, B.A.2    Sentman, C.L.3
  • 15
    • 33646484491 scopus 로고    scopus 로고
    • TLRs mediate IFN-gamma production by human uterine NK cells in endometrium
    • Eriksson, M., S. K. Meadows, S. Basu, T. F. Mselle, C. R. Wira, and C. L. Sentman. 2006. TLRs mediate IFN-gamma production by human uterine NK cells in endometrium. J. Immunol. 176: 6219-6224.
    • (2006) J. Immunol. , vol.176 , pp. 6219-6224
    • Eriksson, M.1    Meadows, S.K.2    Basu, S.3    Mselle, T.F.4    Wira, C.R.5    Sentman, C.L.6
  • 16
    • 36348955143 scopus 로고    scopus 로고
    • Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways
    • Zhang, T., A. Barber, and C. L. Sentman. 2007. Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways. Cancer Res. 67: 11029-11036.
    • (2007) Cancer Res. , vol.67 , pp. 11029-11036
    • Zhang, T.1    Barber, A.2    Sentman, C.L.3
  • 17
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • Gasser, S., S. Orsulic, E. J. Brown, and D. H. Raulet. 2005. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436: 1186-1190.
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 19
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • Hammond, E. M., M. J. Dorie, and A. J. Giaccia. 2003. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278: 12207-12213.
    • (2003) J. Biol. Chem. , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 20
    • 4644318239 scopus 로고    scopus 로고
    • Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
    • Hammond, E. M., M. J. Dorie, and A. J. Giaccia. 2004. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res. 64: 6556-6562.
    • (2004) Cancer Res. , vol.64 , pp. 6556-6562
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 21
    • 0028239057 scopus 로고
    • Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: Implications for the pathogenesis of opportunistic vascular tumors
    • Garlanda, C., C. Parravicini, M. Sironi, M. De Rossi, R.Wainstok de Calmanovici, F. Carozzi, F. Bussolino, F. Colotta, A. Mantovani, and A. Vecchi. 1994. Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors. Proc. Natl. Acad. Sci. USA 91: 7291-7295.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7291-7295
    • Garlanda, C.1    Parravicini, C.2    Sironi, M.3    De Rossi, M.4    Wainstok De Calmanovici, R.5    Carozzi, F.6    Bussolino, F.7    Colotta, F.8    Mantovani, A.9    Vecchi, A.10
  • 22
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: An overview of signals, mechanisms and functions
    • Schroder, K., P. J. Hertzog, T. Ravasi, and D. A. Hume. 2004. Interferon-gamma: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75: 163-189.
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 24
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara, N., and R. S. Kerbel. 2005. Angiogenesis as a therapeutic target. Nature 438: 967-974.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 25
    • 3042772669 scopus 로고    scopus 로고
    • Genetic modification of T lymphocytes for adoptive immunotherapy
    • Rossig, C., and M. K. Brenner. 2004. Genetic modification of T lymphocytes for adoptive immunotherapy. Mol. Ther. 10: 5-18.
    • (2004) Mol. Ther. , vol.10 , pp. 5-18
    • Rossig, C.1    Brenner, M.K.2
  • 26
    • 1542404892 scopus 로고    scopus 로고
    • Adoptive immunotherapy: Engineering T cell responses as biologic weapons for tumor mass destruction
    • Ho, W. Y., J. N. Blattman, M. L. Dossett, C. Yee, and P. D. Greenberg. 2003. Adoptive immunotherapy: engineering T cell responses as biologic weapons for tumor mass destruction. Cancer Cell 3: 431-437.
    • (2003) Cancer Cell , vol.3 , pp. 431-437
    • Ho, W.Y.1    Blattman, J.N.2    Dossett, M.L.3    Yee, C.4    Greenberg, P.D.5
  • 27
    • 0036494443 scopus 로고    scopus 로고
    • Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
    • Ganss, R., E. Ryschich, E. Klar, B. Arnold, and G. J. Hämmerling. 2002. Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62: 1462-1470.
    • (2002) Cancer Res. , vol.62 , pp. 1462-1470
    • Ganss, R.1    Ryschich, E.2    Klar, E.3    Arnold, B.4    Hämmerling, G.J.5
  • 29
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou, W. 2005. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5: 263-274.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 30
    • 51049108540 scopus 로고    scopus 로고
    • Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
    • Quezada, S. A., K. S. Peggs, T. R. Simpson, Y. Shen, D. R. Littman, and J. P. Allison. 2008. Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J. Exp. Med. 205: 2125-2138.
    • (2008) J. Exp. Med. , vol.205 , pp. 2125-2138
    • Quezada, S.A.1    Peggs, K.S.2    Simpson, T.R.3    Shen, Y.4    Littman, D.R.5    Allison, J.P.6
  • 32
    • 77649164899 scopus 로고    scopus 로고
    • Tumor secretion of VEGF induces endothelial cells to suppress T cell functions through the production of PGE2
    • Mulligan, J. K., S. A. Rosenzweig, and M. R. Young. 2010. Tumor secretion of VEGF induces endothelial cells to suppress T cell functions through the production of PGE2. J. Immunother. 33: 126-135.
    • (2010) J. Immunother. , vol.33 , pp. 126-135
    • Mulligan, J.K.1    Rosenzweig, S.A.2    Young, M.R.3
  • 33
    • 80053159303 scopus 로고    scopus 로고
    • The parallel lives of angiogenesis and immunosuppression: Cancer and other tales
    • Motz, G. T., and G. Coukos. 2011. The parallel lives of angiogenesis and immunosuppression: cancer and other tales. Nat. Rev. Immunol. 11: 702-711.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 702-711
    • Motz, G.T.1    Coukos, G.2
  • 34
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali, R. K., Z. Yu, M. R. Theoret, D. Chinnasamy, N. P. Restifo, and S. A. Rosenberg. 2010. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res. 70: 6171-6180.
    • (2010) Cancer Res. , vol.70 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 35
    • 0037124333 scopus 로고    scopus 로고
    • Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis
    • Li, Y., M. N. Wang, H. Li, K. D. King, R. Bassi, H. Sun, A. Santiago, A. T. Hooper, P. Bohlen, and D. J. Hicklin. 2002. Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis. J. Exp. Med. 195: 1575-1584.
    • (2002) J. Exp. Med. , vol.195 , pp. 1575-1584
    • Li, Y.1    Wang, M.N.2    Li, H.3    King, K.D.4    Bassi, R.5    Sun, H.6    Santiago, A.7    Hooper, A.T.8    Bohlen, P.9    Hicklin, D.J.10
  • 36
    • 40749162020 scopus 로고    scopus 로고
    • NK cells lyse T regulatory cells that expand in response to an intracellular pathogen
    • Roy, S., P. F. Barnes, A. Garg, S. Wu, D. Cosman, and R. Vankayalapati. 2008. NK cells lyse T regulatory cells that expand in response to an intracellular pathogen. J. Immunol. 180: 1729-1736.
    • (2008) J. Immunol. , vol.180 , pp. 1729-1736
    • Roy, S.1    Barnes, P.F.2    Garg, A.3    Wu, S.4    Cosman, D.5    Vankayalapati, R.6
  • 37
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch, C., M. Muthana, S. B. Coffelt, and C. E. Lewis. 2008. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8: 618-631.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 39
    • 0344288376 scopus 로고    scopus 로고
    • Antiangiogenic therapy and p53
    • Hammond, E. M., and A. J. Giaccia. 2002. Antiangiogenic therapy and p53. Science 297: 471.
    • (2002) Science , vol.297 , pp. 471
    • Hammond, E.M.1    Giaccia, A.J.2
  • 40
    • 0842278645 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
    • Hamerman, J. A., K. Ogasawara, and L. L. Lanier. 2004. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J. Immunol. 172: 2001-2005.
    • (2004) J. Immunol. , vol.172 , pp. 2001-2005
    • Hamerman, J.A.1    Ogasawara, K.2    Lanier, L.L.3
  • 42
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside, T. L. 2008. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27: 5904-5912.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 43
    • 0033104852 scopus 로고    scopus 로고
    • Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12
    • Yao, L., C. Sgadari, K. Furuke, E. T. Bloom, J. Teruya-Feldstein, and G. Tosato. 1999. Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12. Blood 93: 1612-1621.
    • (1999) Blood , vol.93 , pp. 1612-1621
    • Yao, L.1    Sgadari, C.2    Furuke, K.3    Bloom, E.T.4    Teruya-Feldstein, J.5    Tosato, G.6
  • 44
    • 0035869599 scopus 로고    scopus 로고
    • IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk
    • Strasly, M., F. Cavallo, M. Geuna, S. Mitola, M. P. Colombo, G. Forni, and F. Bussolino. 2001. IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk. J. Immunol. 166: 3890-3899.
    • (2001) J. Immunol. , vol.166 , pp. 3890-3899
    • Strasly, M.1    Cavallo, F.2    Geuna, M.3    Mitola, S.4    Colombo, M.P.5    Forni, G.6    Bussolino, F.7
  • 45
    • 40449117478 scopus 로고    scopus 로고
    • Immunotherapy with chimeric NKG2D receptors leads to long-term tumor-free survival and development of host antitumor immunity in murine ovarian cancer
    • Barber, A., T. Zhang, and C. L. Sentman. 2008. Immunotherapy with chimeric NKG2D receptors leads to long-term tumor-free survival and development of host antitumor immunity in murine ovarian cancer. J. Immunol. 180: 72-78.
    • (2008) J. Immunol. , vol.180 , pp. 72-78
    • Barber, A.1    Zhang, T.2    Sentman, C.L.3
  • 46
    • 0040887215 scopus 로고    scopus 로고
    • Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
    • Rüegg, C., A. Yilmaz, G. Bieler, J. Bamat, P. Chaubert, and F. J. Lejeune. 1998. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nat. Med. 4: 408-414.
    • (1998) Nat. Med. , vol.4 , pp. 408-414
    • Rüegg, C.1    Yilmaz, A.2    Bieler, G.3    Bamat, J.4    Chaubert, P.5    Lejeune, F.J.6
  • 47
    • 34547235967 scopus 로고    scopus 로고
    • A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity
    • Ray, P. S., and P. L. Fox. 2007. A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity. EMBO J. 26: 3360-3372.
    • (2007) EMBO J. , vol.26 , pp. 3360-3372
    • Ray, P.S.1    Fox, P.L.2
  • 49
    • 33646584526 scopus 로고    scopus 로고
    • Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria
    • Potter, S., T. Chan-Ling, H. J. Ball, H. Mansour, A. Mitchell, L. Maluish, and N. H. Hunt. 2006. Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. Int. J. Parasitol. 36: 485-496.
    • (2006) Int. J. Parasitol. , vol.36 , pp. 485-496
    • Potter, S.1    Chan-Ling, T.2    Ball, H.J.3    Mansour, H.4    Mitchell, A.5    Maluish, L.6    Hunt, N.H.7
  • 51
    • 3042639234 scopus 로고    scopus 로고
    • Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allografts
    • Choy, J. C., A. Kerjner, B. W. Wong, B. M. McManus, and D. J. Granville. 2004. Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allografts. Am. J. Pathol. 165: 127-133.
    • (2004) Am. J. Pathol. , vol.165 , pp. 127-133
    • Choy, J.C.1    Kerjner, A.2    Wong, B.W.3    McManus, B.M.4    Granville, D.J.5
  • 52
    • 0028206892 scopus 로고
    • Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis
    • Seko, Y., S. Minota, A. Kawasaki, Y. Shinkai, K. Maeda, H. Yagita, K. Okumura, O. Sato, A. Takagi, Y. Tada, et al. 1994. Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis. J. Clin. Invest. 93: 750-758.
    • (1994) J. Clin. Invest. , vol.93 , pp. 750-758
    • Seko, Y.1    Minota, S.2    Kawasaki, A.3    Shinkai, Y.4    Maeda, K.5    Yagita, H.6    Okumura, K.7    Sato, O.8    Takagi, A.9    Tada, Y.10
  • 53
    • 7444229833 scopus 로고    scopus 로고
    • Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome
    • Chen, Q., S. Tong, M. W. Dewhirst, and F. Yuan. 2004. Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. Mol. Cancer Ther. 3: 1311-1317.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1311-1317
    • Chen, Q.1    Tong, S.2    Dewhirst, M.W.3    Yuan, F.4


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