4-1BB signal stimulates the activation, expansion, and effector functions of γδ T cells in mice and humans

European Journal of Immunology

Volumn 43, Issue 7, 2013, Pages 1839-1848

  Lee, Seung J ^a,b   Kim, Young H ^a   Hwang, Sun H ^a   Kim, Yu I ^a   Han, In S ^b   Vinay, Dass S ^c   Kwon, Byoung S ^a,c  

^a National Cancer Center   (South Korea)

^b University of Ulsan   (South Korea)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

T cells; 4 1BB; IFN ; Listeria monocytogenes

Indexed keywords

CD137 LIGAND; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; CELL DIVISION; CELL EXPANSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; GAMMA DELTA T LYMPHOCYTE; HOST RESISTANCE; IMMUNITY; IMMUNOSTIMULATION; LISTERIOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ΓΔ T CELLS; 4-1BB; IFN-Γ; LISTERIA MONOCYTOGENES;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD137; CELL SEPARATION; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HUMANS; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS;

EID: 84880021335     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242842     Document Type: Article

References (50)

1. Croft, M., Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 2003. 3: 609-620.
2. Watts, T. H., TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 2005. 23: 23-68.
3. Vinay, D. S. and Kwon, B. S., TNF superfamily: costimulation and clinical applications. Cell. Biol. Int. 2009. 33: 453-465.
4. Vinay, D. S. and Kwon, B. S., Role of 4-1BB in immune responses. Semin. Immunol. 1998. 10: 481-489.
5. Garni-Wagner, B. A., Lee, Z. H., Kim, Y. J., Wilde, C., Kang, C. Y. and Kwon, B. S., 4-1BB is expressed on CD45RAhiROhi transitional T cell in humans. Cell. Immunol. 1996. 169: 91-98.
6. Pollok, K. E., Kim, Y. J., Zhou, Z., Hurtado, J., Kim, K. K., Pickard, R. T. and Kwon, B. S., Inducible T cell antigen 4-1BB. Analysis of expression and function. J. Immunol. 1993. 150: 771-781.
7. Futagawa, T., Akiba, H., Kodama, T., Takeda, K., Hosoda, Y., Yagita, H. and Okumura, K., Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int. Immunol. 2002. 14: 275-286.
8. Kwon, B. S. and Weissman, S. M., cDNA sequences of two inducible T-cell genes. Proc. Natl. Acad. Sci. USA 1989. 86: 1963-1967.
9. Wilcox, R. A., Flies, D. B., Zhu, G., Johnson, A. J., Tamada, K., Chapoval, A. I., Strome, S. E. et al., Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J. Clin. Invest. 2002. 109: 651-659.
10. Vinay, D. S. and Kwon, B. S., 4-1BB signaling beyond T cells. Cell. Mol. Immunol. 8: 281-284.
11. Shuford, W. W., Klussman, K., Tritchler, D. D., Loo, D. T., Chalupny, J., Siadak, A. W., Brown, T. J. et al., 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med. 1997. 186: 47-55.
12. Seo, S. K., Choi, J. H., Kim, Y. H., Kang, W. J., Park, H. Y., Suh, J. H., Choi, B. K. et al., 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med. 2004. 10: 1088-1094.
13. Takahashi, C., Mittler, R. S. and Vella, A. T., Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J. Immunol. 1999. 162: 5037-5040.
14. Hayday, A. C., Gamma delta T cells and the lymphoid stress-surveillance response. Immunity 2009. 31: 184-196.
15. Inghirami, G., Zhu, B. Y., Chess, L. and Knowles, D. M., Flow cytometric and immunohistochemical characterization of the gamma/delta T-lymphocyte population in normal human lymphoid tissue and peripheral blood. Am. J. Pathol. 1990. 136: 357-367.
16. Raulet, D. H., The structure, function, and molecular genetics of the gamma/delta T cell receptor. Annu. Rev. Immunol. 1989. 7: 175-207.
17. Haas, W., Pereira, P. and Tonegawa, S., Gamma/delta cells. Annu. Rev. Immunol. 1993. 11: 637-685.
18. Allison, J. P. and Havran, W. L., The immunobiology of T cells with invariant gamma delta antigen receptors. Annu. Rev. Immunol. 1991. 9: 679-705.
19. Hayday, A. C., [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 2000. 18: 975-1026.
20. Hiromatsu, K., Yoshikai, Y., Matsuzaki, G., Ohga, S., Muramori, K., Matsumoto, K., Bluestone, J. A. et al., A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice. J. Exp. Med. 1992. 175: 49-56.
21. Rhodes, K. A., Andrew, E. M., Newton, D. J., Tramonti, D. and Carding, S. R., A subset of IL-10-producing gamma delta T cells protect the liver from Listeria-elicited, CD8(+) T cell-mediated injury. Eur. J. Immunol. 2008. 38: 2274-2283.
22. King, D. P., Hyde, D. M., Jackson, K. A., Novosad, D. M., Ellis, T. N., Putney, L., Stovall, M. Y. et al., Cutting edge: protective response to pulmonary injury requires gamma delta T lymphocytes. J. Immunol. 1999. 162: 5033-5036.
23. Braun, R. K., Ferrick, C., Neubauer, P., Sjoding, M., Sterner-Kock, A., Kock, M., Putney, L. et al., IL-17 producing gammadelta T cells are required for a controlled inflammatory response after bleomycin-induced lung injury. Inflammation 2008. 31: 167-179.
24. Simonian, P. L., Roark, C. L., Wehrmann, F., Lanham, A. M., Born, W. K., O'Brien, R. L. and Fontenot, A. P., IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis. J. Immunol. 2009. 182: 6540-6549.
25. Tripodo, C., Iannitto, E., Florena, A. M., Pucillo, C. E., Piccaluga, P. P., Franco, V. and Pileri, S. A., Gamma-delta T-cell lymphomas. Nat. Rev. Clin. Oncol. 2009. 6: 707-717.
26. Petermann, F., Rothhammer, V., Claussen, M. C., Haas, J. D., Blanco, L. R., Heink, S., Prinz, I. et al., Gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity 33: 351-363.
27. Blink, S. E. and Miller, S. D., The contribution of gammadelta T cells to the pathogenesis of EAE and MS. Curr. Mol. Med. 2009. 9: 15-22.
28. Maloy, K. J., Odermatt, B., Hengartner, H. and Zinkernagel, R. M., Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection. Proc. Natl. Acad. Sci. USA 1998. 95: 1160-1165.
29. Brenner, M. B., McLean, J., Dialynas, D. P., Strominger, J. L., Smith, J. A., Owen, F. L., Seidman, J. G. et al., Identification of a putative second T-cell receptor. Nature 1986. 322: 145-149.
30. Morio, T., Takase, K., Okawa, H., Oguchi, M., Kanbara, M., Hiruma, F., Yoshino, K. et al., The increase of non-MHC-restricted cytotoxic cells (gamma/delta-TCR-bearing T cells or NK cells) and the abnormal differentiation of B cells in Wiskott-Aldrich syndrome. Clin. Immunol. Immunopathol. 1989. 52: 279-290.
31. Vilmer, E., Triebel, F., David, V., Rabian, C., Schumpp, M., Leca, G., Degos, L. et al., Prominent expansion of circulating lymphocytes bearing gamma T-cell receptors, with preferential expression of variable gamma genes after allogeneic bone marrow transplantation. Blood 1988. 72: 841-849.
32. Kreslavsky, T. and von Boehmer, H., Gammadelta TCR ligands and lineage commitment. Semin. Immunol. 2010. 22: 214-221.
33. Chien, Y. H. and Konigshofer, Y., Antigen recognition by gammadelta T cells. Immunol. Rev. 2007. 215: 46-58.
34. Strominger, J. L., The gamma delta T cell receptor and class Ib MHC-related proteins: enigmatic molecules of immune recognition. Cell 1989. 57: 895-898.
35. Kreslavsky, T., Gleimer, M., Garbe, A. I. and von Boehmer, H., Alphabeta versus gammadelta fate choice: counting the T-cell lineages at the branch point. Immunol. Rev. 238: 169-181.
36. Matsuzaki, G., Hiromatsu, K., Yoshikai, Y., Muramori, K. and Nomoto, K., Characterization of T-cell receptor gamma delta T cells appearing at the early phase of murine Listeria monocytogenes infection. Immunology 1993. 78: 22-27.
37. Fujise, S., Matsuzaki, G., Kishihara, K., Kadena, T., Molina, T. and Nomoto, K., The role of p56lck in the development of gamma delta T cells and their function during an infection by Listeria monocytogenes. J. Immunol. 1996. 157: 247-254.
38. Nakamura, T., Matsuzaki, G. and Nomoto, K., The protective role of T-cell receptor Vgamma1+ T cells in primary infection with Listeria monocytogenes. Immunology 1999. 96: 29-34.
39. + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 2010. 15: 419-434.
40. Lee, S. C., Ju, S. A., Pack, H. N., Heo, S. K., Suh, J. H., Park, S. M., Choi, B. K. et al., 4-1BB (CD137) is required for rapid clearance of Listeria monocytogenes infection. Infect. Immun. 2005. 73: 5144-5151.
41. Buchmeier, N. A., Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection. Proc. Natl. Acad. Sci., USA 1985. 82: 7404-7408.
42. Morita, C. T., Jin, C., Sarikonda, G. and Wang, H., Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol. Rev. 2007. 215: 59-76.
43. Thedrez, A., Sabourin, C., Gertner, J., Devilder, M. C., Allain-Maillet, S., Fournie, J. J., Scotet, E. et al., Self/non-self discrimination by human gammadelta T cells: simple solutions for a complex issue? Immunol. Rev. 2007. 215: 123-135.
44. Nedellec, S., Bonneville, M. and Scotet, E., Human Vgamma9Vdelta2 T cells: from signals to functions. Semin. Immunol. 2010. 22: 199-206.
45. Harty, J. T. and Bevan, M. J., Specific immunity to Listeria monocytogenes in the absence of IFN-γ. Immunity 1995. 3: 109-117.
46. Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vlicke, J. et al., Immune response in mice that lack the interferon-γ receptor. Science 1993. 250: 1742-1745.
47. Ribot, J. C., debarros, A. and Silva-Santos, B., Searching for "signal 2": costimulation requirements of gammadelta T cells. Cell. Mol. Life Sci. 2011. 68: 2345-2355.
48. DeBarros, A., Chaves-Ferreira, M., d'Orey, F., Ribot, J. C. and Silva-Santos, B., CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human gammadelta peripheral blood lymphocytes. Eur. J. Immunol. 2011. 41: 195-201.
49. Ribot, J. C., Debarros, A., Mancio-Silva, L., Pamplona, A. and Silva-Santos, B., B7-CD28 costimulatory signals control the survival and proliferation of murine and human gammadelta T cells via IL-2 production. J. Immunol. 2012. 189: 1202-1208.
50. Kwon, B. S., Hurtado, J. C., Lee, Z. H., Kwack, K. B., Seo, S. K., Choi, B. K., Koller, B. H. et al., Immune responses in 4-1BB (CD137)-deficient mice. J. Immunol. 2002. 168: 5483-5490.