메뉴 건너뛰기




Volumn 18, Issue 11, 2010, Pages 2006-2017

T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIBODY; CD3 ANTIBODY; CHIMERIC PROTEIN; CYTOKINE; DISIALOGANGLIOSIDE; GANGLIOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN ANTIBODY; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 78049468066     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2010.185     Document Type: Article
Times cited : (59)

References (47)
  • 1
    • 0028816546 scopus 로고
    • Use of gene-modifed virus-specifc T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation
    • Rooney, CM, Smith, CA, Ng, CY, Loftin, S, Li, C, Krance, RA et al. (1995). Use of gene-modifed virus-specifc T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. Lancet 345: 9-13.
    • (1995) Lancet , vol.345 , pp. 9-13
    • Rooney, C.M.1    Smith, C.A.2    Ng, C.Y.3    Loftin, S.4    Li, C.5    Krance, R.A.6
  • 2
    • 0028594038 scopus 로고
    • Selective reconstitution of CD8+ cytotoxic T lymphocyte responses in immunodefcient bone marrow transplant recipients by the adoptive transfer of T cell clones
    • Riddell, SR, Walter, BA, Gilbert, MJ and Greenberg, PD (1994). Selective reconstitution of CD8+ cytotoxic T lymphocyte responses in immunodefcient bone marrow transplant recipients by the adoptive transfer of T cell clones. Bone Marrow Transplant 14 Suppl 4: S78-S84.
    • (1994) Bone Marrow Transplant , vol.14 , Issue.SUPPL. 4
    • Riddell, S.R.1    Walter, B.A.2    Gilbert, M.J.3    Greenberg, P.D.4
  • 3
    • 0032170108 scopus 로고    scopus 로고
    • Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients
    • Rooney, CM, Smith, CA, Ng, CY, Loftin, SK, Sixbey, JW, Gan, Y et al. (1998). Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92: 1549-1555.
    • (1998) Blood , vol.92 , pp. 1549-1555
    • Rooney, C.M.1    Smith, C.A.2    Ng, C.Y.3    Loftin, S.K.4    Sixbey, J.W.5    Gan, Y.6
  • 4
    • 20144365643 scopus 로고    scopus 로고
    • Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specifc T lymphocytes
    • Straathof, KC, Bollard, CM, Popat, U, Huls, MH, Lopez, T, Morriss, MC et al. (2005). Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specifc T lymphocytes. Blood 105: 1898-1904.
    • (2005) Blood , vol.105 , pp. 1898-1904
    • Straathof, K.C.1    Bollard, C.M.2    Popat, U.3    Huls, M.H.4    Lopez, T.5    Morriss, M.C.6
  • 5
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • Dudley, ME, Wunderlich, JR, Yang, JC, Sherry, RM, Topalian, SL, Restifo, NP et al. (2005). Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 23: 2346-2357.
    • (2005) J Clin Oncol , vol.23 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3    Sherry, R.M.4    Topalian, S.L.5    Restifo, N.P.6
  • 6
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan, RA, Dudley, ME, Wunderlich, JR, Hughes, MS, Yang, JC, Sherry, RM et al. (2006). Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314: 126-129.
    • (2006) Science , vol.314 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3    Hughes, M.S.4    Yang, J.C.5    Sherry, R.M.6
  • 7
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specifc CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee, C, Thompson, JA, Byrd, D, Riddell, SR, Roche, P, Celis, E et al. (2002). Adoptive T cell therapy using antigen-specifc CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci USA 99: 16168-16173.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3    Riddell, S.R.4    Roche, P.5    Celis, E.6
  • 8
    • 10544232277 scopus 로고    scopus 로고
    • Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape
    • Hahne, M, Rimoldi, D, Schröter, M, Romero, P, Schreier, M, French, LE et al. (1996). Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape. Science 274: 1363-1366.
    • (1996) Science , vol.274 , pp. 1363-1366
    • Hahne, M.1    Rimoldi, D.2    Schröter, M.3    Romero, P.4    Schreier, M.5    French, L.E.6
  • 9
    • 27644457376 scopus 로고    scopus 로고
    • TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
    • Thomas, DA and Massagué, J (2005). TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell 8: 369-380.
    • (2005) Cancer Cell , vol.8 , pp. 369-380
    • Thomas, D.A.1    Massagué, J.2
  • 10
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
    • Gorelik, L and Flavell, RA (2001). Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med 7: 1118-1122.
    • (2001) Nat Med , vol.7 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 11
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong, H, Strome, SE, Salomao, DR, Tamura, H, Hirano, F, Flies, DB et al. (2002). Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8: 793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 12
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y, Ishida, M, Tanaka, Y, Okazaki, T, Honjo, T and Minato, N (2002). Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 99: 12293-12297.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 13
    • 4644237613 scopus 로고    scopus 로고
    • Specifc recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel, TJ, Coukos, G, Zou, L, Alvarez, X, Cheng, P, Mottram, P et al. (2004). Specifc recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10: 942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 14
    • 15444377017 scopus 로고    scopus 로고
    • Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • Yu, P, Lee, Y, Liu, W, Krausz, T, Chong, A, Schreiber, H et al. (2005). Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 201: 779-791.
    • (2005) J Exp Med , vol.201 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3    Krausz, T.4    Chong, A.5    Schreiber, H.6
  • 15
    • 20444425695 scopus 로고    scopus 로고
    • Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis
    • Dotti, G, Savoldo, B, Pule, M, Straathof, KC, Biagi, E, Yvon, E et al. (2005). Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood 105: 4677-4684.
    • (2005) Blood , vol.105 , pp. 4677-4684
    • Dotti, G.1    Savoldo, B.2    Pule, M.3    Straathof, K.C.4    Biagi, E.5    Yvon, E.6
  • 16
    • 0036566184 scopus 로고    scopus 로고
    • Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity
    • Bollard, CM, Rössig, C, Calonge, MJ, Huls, MH, Wagner, HJ, Massague, J et al. (2002). Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood 99: 3179-3187.
    • (2002) Blood , vol.99 , pp. 3179-3187
    • Bollard, C.M.1    Rössig, C.2    Calonge, M.J.3    Huls, M.H.4    Wagner, H.J.5    Massague, J.6
  • 17
    • 67349252824 scopus 로고    scopus 로고
    • Genetic manipulation of tumor-specifc cytotoxic T lymphocytes to restore responsiveness to IL-7
    • Vera, JF, Hoyos, V, Savoldo, B, Quintarelli, C, Giordano Attianese, GM, Leen, AM et al. (2009). Genetic manipulation of tumor-specifc cytotoxic T lymphocytes to restore responsiveness to IL-7. Mol Ther 17: 880-888.
    • (2009) Mol Ther , vol.17 , pp. 880-888
    • Vera, J.F.1    Hoyos, V.2    Savoldo, B.3    Quintarelli, C.4    Giordano Attianese, G.M.5    Leen, A.M.6
  • 18
    • 0029069946 scopus 로고
    • Synergistic effects of IL-7 and IL-12 on human T cell activation
    • Mehrotra, PT, Grant, AJ and Siegel, JP (1995). Synergistic effects of IL-7 and IL-12 on human T cell activation. J Immunol 154: 5093-5102.
    • (1995) J Immunol , vol.154 , pp. 5093-5102
    • Mehrotra, P.T.1    Grant, A.J.2    Siegel, J.P.3
  • 19
    • 34250896852 scopus 로고    scopus 로고
    • Autologous designer antigen-presenting cells by gene modifcation of T lymphocyte blasts with IL-7 and IL-12
    • Foster, AE, Leen, AM, Lee, T, Okamura, T, Lu, A, Vera, J et al. (2007). Autologous designer antigen-presenting cells by gene modifcation of T lymphocyte blasts with IL-7 and IL-12. J Immunother 30: 506-516.
    • (2007) J Immunother , vol.30 , pp. 506-516
    • Foster, A.E.1    Leen, A.M.2    Lee, T.3    Okamura, T.4    Lu, A.5    Vera, J.6
  • 20
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, BD and Cantley, LC (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 21
    • 55249097716 scopus 로고    scopus 로고
    • Intracellular signals of T cell costimulation
    • Song, J, Lei, F T, Xiong, X and Haque, R (2008). Intracellular signals of T cell costimulation. Cell Mol Immunol 5: 239-247.
    • (2008) Cell Mol Immunol , vol.5 , pp. 239-247
    • Song, J.1    Lei, F.T.2    Xiong, X.3    Haque, R.4
  • 22
    • 10844280747 scopus 로고    scopus 로고
    • CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway
    • Wu, LX, La Rose, J, Chen, L, Neale, C, Mak, T, Okkenhaug, K et al. (2005). CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway. J Immunol 174: 180-194.
    • (2005) J Immunol , vol.174 , pp. 180-194
    • Wu, L.X.1    La Rose, J.2    Chen, L.3    Neale, C.4    Mak, T.5    Okkenhaug, K.6
  • 23
    • 0028910221 scopus 로고
    • CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
    • Schneider, H, Prasad, KV, Shoelson, SE and Rudd, CE (1995). CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J Exp Med 181: 351-355.
    • (1995) J Exp Med , vol.181 , pp. 351-355
    • Schneider, H.1    Prasad, K.V.2    Shoelson, S.E.3    Rudd, C.E.4
  • 24
    • 59849098801 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells
    • Su, CC, Lin, YP, Cheng, YJ, Huang, JY, Chuang, WJ, Shan, YS et al. (2007). Phosphatidylinositol 3-kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells. J Immunol 179: 4589-4597.
    • (2007) J Immunol , vol.179 , pp. 4589-4597
    • Su, C.C.1    Lin, Y.P.2    Cheng, Y.J.3    Huang, J.Y.4    Chuang, W.J.5    Shan, Y.S.6
  • 26
    • 33947496068 scopus 로고    scopus 로고
    • Vive la Résistance!' - The PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression
    • Wohlfert, EA and Clark, RB (2007). 'Vive la Résistance!'-the PI3K-Akt pathway can determine target sensitivity to regulatory T cell suppression. Trends Immunol 28: 154-160.
    • (2007) Trends Immunol , vol.28 , pp. 154-160
    • Wohlfert, E.A.1    Clark, R.B.2
  • 27
    • 33845709678 scopus 로고    scopus 로고
    • An essential role for Akt1 in dendritic cell function and tumor immunotherapy
    • Park, D, Lapteva, N, Seethammagari, M, Slawin, KM and Spencer, DM (2006). An essential role for Akt1 in dendritic cell function and tumor immunotherapy. Nat Biotechnol 24: 1581-1590.
    • (2006) Nat Biotechnol , vol.24 , pp. 1581-1590
    • Park, D.1    Lapteva, N.2    Seethammagari, M.3    Slawin, K.M.4    Spencer, D.M.5
  • 28
    • 18644362144 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells attenuate the phosphatidylinositol 3-kinase/Akt pathway in antigen-primed immature CD8+ CTLs during functional maturation
    • Kojima, H, Kanno, Y, Hase, H and Kobata, T (2005). CD4+CD25+ regulatory T cells attenuate the phosphatidylinositol 3-kinase/Akt pathway in antigen-primed immature CD8+ CTLs during functional maturation. J Immunol 174: 5959-5967.
    • (2005) J Immunol , vol.174 , pp. 5959-5967
    • Kojima, H.1    Kanno, Y.2    Hase, H.3    Kobata, T.4
  • 29
    • 33847337912 scopus 로고    scopus 로고
    • Tumor evasion of the immune system by converting CD4+CD25-T cells into CD4+CD25+ T regulatory cells: Role of tumor-derived TGF-beta
    • Liu, VC, Wong, LY, Jang, T, Shah, AH, Park, I, Yang, X et al. (2007). Tumor evasion of the immune system by converting CD4+CD25-T cells into CD4+CD25+ T regulatory cells: role of tumor-derived TGF-beta. J Immunol 178: 2883-2892.
    • (2007) J Immunol , vol.178 , pp. 2883-2892
    • Liu, V.C.1    Wong, L.Y.2    Jang, T.3    Shah, A.H.4    Park, I.5    Yang, X.6
  • 31
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    • Haxhinasto, S, Mathis, D and Benoist, C (2008). The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 205: 565-574.
    • (2008) J Exp Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 32
    • 0035888244 scopus 로고    scopus 로고
    • Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes
    • Rossig, C, Bollard, CM, Nuchtern, JG, Merchant, DA and Brenner, MK (2001). Targeting of G(D2)-positive tumor cells by human T lymphocytes engineered to express chimeric T-cell receptor genes. Int J Cancer 94: 228-236.
    • (2001) Int J Cancer , vol.94 , pp. 228-236
    • Rossig, C.1    Bollard, C.M.2    Nuchtern, J.G.3    Merchant, D.A.4    Brenner, M.K.5
  • 33
    • 27744566329 scopus 로고    scopus 로고
    • A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells
    • Pulè, MA, Straathof, KC, Dotti, G, Heslop, HE, Rooney, CM and Brenner, MK (2005). A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells. Mol Ther 12: 933-941.
    • (2005) Mol Ther , vol.12 , pp. 933-941
    • Pulè, M.A.1    Straathof, K.C.2    Dotti, G.3    Heslop, H.E.4    Rooney, C.M.5    Brenner, M.K.6
  • 35
    • 77956627600 scopus 로고    scopus 로고
    • An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies
    • Ramos, CA, Asgari, Z, Liu, E, Yvon, E, Heslop, HE, Rooney, CM et al. (2010). An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies. Stem Cells 28: 1107-1115.
    • (2010) Stem Cells , vol.28 , pp. 1107-1115
    • Ramos, C.A.1    Asgari, Z.2    Liu, E.3    Yvon, E.4    Heslop, H.E.5    Rooney, C.M.6
  • 36
    • 16144363507 scopus 로고    scopus 로고
    • Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells - A mechanism of immune evasion?
    • Strand, S, Hofmann, WJ, Hug, H, Müller, M, Otto, G, Strand, D et al. (1996). Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells-a mechanism of immune evasion? Nat Med 2: 1361-1366.
    • (1996) Nat Med , vol.2 , pp. 1361-1366
    • Strand, S.1    Hofmann, W.J.2    Hug, H.3    Müller, M.4    Otto, G.5    Strand, D.6
  • 39
    • 0035421654 scopus 로고    scopus 로고
    • Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
    • Piccirillo, CA and Shevach, EM (2001). Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 167: 1137-1140.
    • (2001) J Immunol , vol.167 , pp. 1137-1140
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 40
    • 34250193219 scopus 로고    scopus 로고
    • The loss of telomerase activity in highly differentiated CD8+CD28-CD27-T cells is associated with decreased Akt (Ser473) phosphorylation
    • Plunkett, FJ, Franzese, O, Finney, HM, Fletcher, JM, Belaramani, LL, Salmon, M et al. (2007). The loss of telomerase activity in highly differentiated CD8+CD28-CD27-T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol 178: 7710-7719.
    • (2007) J Immunol , vol.178 , pp. 7710-7719
    • Plunkett, F.J.1    Franzese, O.2    Finney, H.M.3    Fletcher, J.M.4    Belaramani, L.L.5    Salmon, M.6
  • 41
    • 2342647439 scopus 로고    scopus 로고
    • PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3
    • Remy, I, Montmarquette, A and Michnick, SW (2004). PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol 6: 358-365.
    • (2004) Nat Cell Biol , vol.6 , pp. 358-365
    • Remy, I.1    Montmarquette, A.2    Michnick, S.W.3
  • 42
    • 34547107052 scopus 로고    scopus 로고
    • Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways
    • Lin, SJ, Chang, C, Ng, AK, Wang, SH, Li, JJ and Hu, CP (2007). Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways. Apoptosis 12: 1659-1670.
    • (2007) Apoptosis , vol.12 , pp. 1659-1670
    • Lin, S.J.1    Chang, C.2    Ng, A.K.3    Wang, S.H.4    Li, J.J.5    Hu, C.P.6
  • 43
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia, M, Stabilini, A and Roncarolo, MG (2005). Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105: 4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 44
    • 33847397525 scopus 로고    scopus 로고
    • Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
    • Crellin, NK, Garcia, RV and Levings, MK (2007). Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood 109: 2014-2022.
    • (2007) Blood , vol.109 , pp. 2014-2022
    • Crellin, N.K.1    Garcia, R.V.2    Levings, M.K.3
  • 45
    • 77953008362 scopus 로고    scopus 로고
    • Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation
    • Pierau, M, Engelmann, S, Reinhold, D, Lapp, T, Schraven, B and Bommhardt, UH (2009). Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J Immunol 183: 6124-6134.
    • (2009) J Immunol , vol.183 , pp. 6124-6134
    • Pierau, M.1    Engelmann, S.2    Reinhold, D.3    Lapp, T.4    Schraven, B.5    Bommhardt, U.H.6
  • 46
    • 0025886953 scopus 로고
    • Adoptive T cell therapy of tumors: Mechanisms operative in the recognition and elimination of tumor cells
    • Greenberg, PD (1991). Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Adv Immunol 49: 281-355.
    • (1991) Adv Immunol , vol.49 , pp. 281-355
    • Greenberg, P.D.1
  • 47
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio, Y and Walsh, K (1999). Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem 274: 16349-16354.
    • (1999) J Biol Chem , vol.274 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.