CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response

Journal of Immunology

Volumn 156, Issue 5, 1996, Pages 1788-1798

  Radvanyi, Laszlo G ^a,b   Shi, Yufang ^c   Vaziri, Homayoun ^b   Sharma, Ajay ^c   Dhala, Ruwaida ^d   Mills, Gordon B ^a,e   Miller, Richard G ^b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c HOLLAND LABORATORY   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL PROTECTION; GENE EXPRESSION REGULATION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; APOPTOSIS; BCL-X PROTEIN; CELL CYCLE; CELL SURVIVAL; FEMALE; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030027748     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. June, C. H., J. A Ledbetter, T. Lindsten, and C. B Thompson. 1989. Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J. Immunol 143.153.
2. Mustelin, T., K. M. Coggeshall, N. Isakov, and A. Altman. 1990 T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation. Science 247.1584.
3. Vandenberghe, P , G J. Freeman, L. M Nadler, M. C. Fletcher, M Kamoun, L A Turka, J A. Ledbetter, C. B. Thompson, and C H. June. 1992. Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells J. Exp. Med. 175:951.
4. Truitt, K E., C. M. Hicks, and J B Imboden. 1994. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat cells. J. Exp. Med. 179:1071.
5. Reiser, H , G. J. Freeman, Z. R. Wolf, C. D. Gimmi, B. Benacerraf, and L. M. Nadler 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc. Natl. Acad Sci. USA 89.271.
6. Freeman, G. J., J G Gribben, V A. Boussious, J. W Ng, V A Restivo, Jr , L A Lombard, G. S. Gray, and L. M. Nadler. 1994. Cloning of B7-2 a CTLA-4 counter-receptor that costimulates human T cell proliferation Science 26:290.
7. Liu, Y., and C. A Janeway 1992. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 cells. Proc Natl Acad. Sci. USA 89:3845.
8. Tan, P., C Anasetti, J. A Hansen, J Melrose, M Brunvand, J Bradshaw, J A Ledbetter, and P S. Linsley. 1993 Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1 J Exp. Med 177:165
9. Jenkins, M. K., C. Chen, G. Jung, D. L. Mueller, and R. H. Schwartz. 1990. Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J. Immunol 144: 16.
10. DeSilva, D. R., K. B. Urdanl, and M. K. Jenkins 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261.
11. Williams, M. E., A H. Lichtman, and A K. Abbas. 1990. Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones. J. Immunol. 144:1208.
12. Jenkins, M K., P. S. Taylor, S. D. Norton, and K. Urdahl. 1991. CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T lymphocytes. J. Immunol. 147:2461.
13. Thompson, C. B., T. Lindsten, J. Ledbetter, S. L. Kunkel, H. A. Young, S. G. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl Acad. Sci. USA 86:1333.
14. Harding, F. A., J G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling costimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
15. Jenkins, M. K. 1994. The ups and downs of T cell costimulation. Immunity 1:443.
16. Russell, J. H., C. L White, D. Y. Loh, and P. Meleedy-Rey. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl. Acad. Sci. USA 88:2151.
17. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis Nature 353:858.
18. Russell, J H., B. J Rush, S. I. Abrams, and R. Wang. 1992. Sensitivity of T cells to anti-CD3-stimulated suicide is independent of functional phenotype. Eur. J. Immunol. 22:1665
19. Radvanyi, L G., G. B. Mills, and R. G Miller. 1993 Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J. Immunol. 150:5704.
20. Mogil, R J, L G Radvanyi, R. Gonzalez-Quintial, R G. Miller, G. B. Mills, A N. Theofilopoulos, and D. R. Green. 1995 Peripheral T cell deletion and associated apoptosis in vivo is defective in young lpr mice. Int. Immunol. 7:1451
21. Baroja, M. L , K. Lorre, F. Van Vaeck, and J. L. Ceuppens 1989. The anti-T cell monoclonal antibody 9.3 (anti-CD28) provides a helper signal and bypasses the need for accessory cells in T cell activation with immobilized anti-CD3 and mitogens. Cell. Immunol. 120:205.
22. Watts, T H., N. Alaverdi, W. F Wade, and P. S. Linsley. 1993. Induction of costimulatory molecule B7 in M12 B lymphomas by cAMP or MHC-restricted T cell interaction. J. Immunol. 150:2192.
23. Strasser, A., A. W. Harris, and S. Cory 1991. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67.889.
24. Strasser, A., A W. Harris, T Jacks, and S. Cory 1994. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independeut mechanisms inhibitable by bcl-2. Cell 79.329.
25. Lowe, S. W., E. M. Schmitt, S. W Smith, B. A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes Nature 362: 847.
26. Gross, J A., E. Callas, and J. P. Allison 1992. Identification and distribution of the costimulatory receptor CD28 in the mouse. J. Immunol. 149:380
27. Karasuyama, H., N. Tohyama, and T. Tada. 1989. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp. Med 169:13.
28. Telford, W. G., L. E. King, and P. J. Fraker 1992. Comparative evaluation of several DNA binding dyes in the detection of apoptosis-associated chromatin degradation by flow cytometry. Cytometry 13:137
29. Brunk, C. F., K. C. Jones, and T W. Jones. 1979. Assay for nanogram quantities of DNA in cellular homogenates Anal. Biochem. 92:497
30. Gillis, S., M. M. Ferm, W. Ou, and K. A. Smith 1978. T cell growth factor, parameters of production and a quantitative microassay for activity. J. Immunol. 120:2027.
31. + Th1 but not Th2 cytokine responses. Int. Immunol. 6:721.
32. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
33. Duke, R. C , and J. J. Cohen. 1986. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res 5:289.
34. Reed, J. 1991. bcl-2 and the regulation of programmed cell death. J. Cell Biol. 124:1.
35. Boise, L H , M. Gonzalez-Garcia, C. E. Postema, L. Ding, T. Lindsten, L A Turka, X. Mao, G. Nunez, and C. B. Thompson. 1993. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death Cell 74:597.
36. Fang, W., J. J. Rivard, D. L. Mueller, and T. W. Behrens. 1994. Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. J. Immunol 153:4388.
37. Yonish-Rouach, E., D. Resnitsky, J. Lotem, L. Sachs, A. Kimchi, and M Oren. 1991 Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6. Nature 352.345.
38. L. Immunity 3.87.
39. Boehme, S. A., and M. J. Lenardo. 1993. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur. J. Immunol. 149:1552
40. Liu, Y., and C. A. Janeway, Jr 1990. Interferon γ plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J. Exp. Med. 172:1735.
41. Liu, Y J., D. Y. Mason, G. D. Johnson, S. Abbot, C. D. Gregory, D L. Hardie, J. Gordon, and I. C M. MacLennan. 1991 Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur J. Immunol 21:1905.
42. L in CD40-mediated rescue from anti-μ-induced apoptosis in WEHI-231 B lymphoma cells. Eur. J. Immunol. 25:1352.
43. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J. Exp. Med. 175:331
44. Akbar, A. N., N Borthwick, M. Salmon, W. Gombert, M Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossy 1993 The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections the role of apoptosis in T cell memory J. Exp. Med. 178:427.
45. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells Nature 362:758.
46. + T cells. Eur. J. Immunol. 23:3306.
47. Critchfield, J. M , M. K. Racke, J. C Zuniga-Pflucker, B. Cannella, C. S Raine, J. Governman, and M. J. Lenardo 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263.1139.
48. Beverly, B., S. M. Kang, M. J. Lenardo, and R. H. Schwartz. 1992. Reversal of in vitro clonal anergy by IL-2 stimulation. Int Immunol. 4:661.
49. Gutierrez-Ramos, J. C , I. Moreno de Alboran, and C. Martinez-A. 1992. In vivo administration of interleukin-2 turns on anergic self-reactive T cells and leads to auto-immune disease. Eur. J. Immunol. 22:2867.
50. Sagerstrom, C. G., E. M. Kerr, J P. Allison, and M. M. Davis. 1993. Activation and differentiation requirements of primary T cells in vitro. Proc. Natl Acad. Sci. USA 90:8987.
51. Croft, M. 1994. Activation of naive, memory and effector T cells. Curr. Opin. Immunol. 6:431.
52. Green, J M., P J Noel, A. I. Sperling, T L. Walunas, G. S Gray, J. A Bluestone, and C. B. Thompson. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1.501.
53. Walunas, T. L., D. J. Lenschow, C Y. Bakker, P. S. Linsley, G. J. Freeman, J M. Green, C. B. Thompson, and J A. Bluestone 1994 CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
54. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell costimulation Immunity 2 555.