The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily

Journal of Biological Chemistry

Volumn 285, Issue 12, 2010, Pages 9202-9210

  Won, Eun Young ^a   Cha, Kiweon ^b   Byun, Jung Sue ^a   Kim, Dong Uk ^a   Shin, Sumi ^c   Ahn, Byungchan ^d   Kim, Young Ho ^c   Rice, Amanda J ^e   Walz, Thomas ^e,f   Kwon, Byoung S ^c   Cho, Hyun Soo ^a  

^a Yonsei University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c National Cancer Center   (South Korea)

^d University of Ulsan   (South Korea)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER IMMUNOTHERAPY; CO-STIMULATORY SIGNAL; ECTODOMAIN; EXTRACELLULAR DOMAINS; HOMOTRIMERS; IMMUNOTHERAPEUTICS; SITE DIRECTED MUTAGENESIS; STRUCTURAL INFORMATION; T LYMPHOCYTES; TUMOR NECROSIS FACTORS;

BINDING ENERGY; ENZYME ACTIVITY; GLYCOPROTEINS; LIGANDS; MACROPHAGES; SCANNING ELECTRON MICROSCOPY; TUMORS;

CRYSTAL STRUCTURE;

CD137 ANTIGEN; CD137 LIGAND; TUMOR NECROSIS FACTOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRON MICROSCOPY; ISOMERIZATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; BINDING SITE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIMERIZATION; FLOW CYTOMETRY; GENETICS; HUMAN; METHODOLOGY; MOLECULAR CLONING; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

4-1BB LIGAND; ANTIGENS, CD137; BINDING SITES; CELL PROLIFERATION; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; FLOW CYTOMETRY; HUMANS; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 77950568379     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.084442     Document Type: Article

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