Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2791-2797

  Finney, Helene M ^a   Lawson, Alastair D G ^a   Bebbington, Christopher R ^a,b   Weir, A Neil C ^a  

^a UCB PHARMA   (Belgium)

^b OXFORD BIOMEDICA UK LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HYBRID PROTEIN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; RECEPTOR; T LYMPHOCYTE RECEPTOR;

ARTICLE; CHIMERA; CYTOKINE PRODUCTION; HUMAN; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; GENES, T-CELL RECEPTOR; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-2; JURKAT CELLS; MEMBRANE PROTEINS; MICE; MUTAGENESIS, INSERTIONAL; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 0032531091     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Elliot, B. E., D. A. Carlow, A.-M. Rodricks, and A. Wade. 1989. Perspectives on the role of MHC antigens in normal and malignant cell development. Adv. Cancer Res. 53:181.
2. Marincola, F. M., P. Shamamian, R. B. Alexander, J. R. Gnarra, R. L. Turetskaya, S. A Nedospasov, T. B. Simonis, J. K. Taubenberger, J. Yannelli, A. Mixon, N. P. Restifo, M. Herlyn, and S. A. Rosenberg. 1994. Loss of HLA haplotype and B locus down-regulation in melanoma cell lines. J. Immunol. 153:1225.
3. Kuwana, Y., Y. Asakura, N. Utsunomiya, M. Nakanishi, Y. Arata, S., Itoh, F. Nagase, and Y. Kurosawa. (1987) Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions. Biochem. Biophys. Res. Commun. 149:960.
4. Gross, G., T. Waks, and Z. Eshhar. 1989. Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc. Natl. Acad. Sci. USA 86:1004.
5. Brocker, T., A. Peter, A. Traunecker, and K. Karjalainen. 1993. New simplified molecular design for functional T cell receptor. Eur. J. Immunol. 23:1435.
6. Eshhar, Z., T. Waks, G. Gross, and D. G. Schindler. 1993. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulin and T-cell receptors. Proc. Natl. Acad. Sci. USA 90:720.
7. Hwu, P., G. E. Shafer, J. Treisman, D. G. Schindler, G. Gross, R. Cowherd, S. A. Rosenberg, and Z. Eshhar. 1993. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor γ chain. J. Exp. Med. 178:361.
8. Stancovski, I., D. G. Schindler, T. Waks, Y. Yarden, M. Sela, and Z. Eshhar. 1993. Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J. Immunol. 151:6577.
9. Moritz, D., W. Wels, J. Mattern, and B. Groner. 1994. Cytotoxic T lymphocytes with grafted recognition specificity for ERBB2-expressing tumor cells. Proc. Natl. Acad. Sci. USA 91:4318.
10. Hwu, P., J. C. Yang, R. Cowherd, J. Treisman, G. E. Shafer, Z. Eshhar, and S. A. Rosenberg. 1995. In vivo antitumor activity of T cells redirected with chimeric antibody/T cell receptor genes. Cancer Res. 55:3369.
11. Brocker, T., M. Riedinger, and K. Karjalainen. 1996. Redirecting the complete T cell receptor/CD3 signaling machinery towards naive antigen via modified T cell receptor. Eur. J. Immunol. 26:1770.
12. Hekele, A., P. Dall, D. Moritz, W. Wels, B. Groner, P. Herlich, and H. Ponta. 1996. Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44V6-specific scFv:ζ-chimera. Int. J. Cancer 68:232.
13. Weijtens, M. E. M., R. A. Willemsen, D. Valerio, K. Stam, and R. L. H. Bolhuis. 1996. Single chain Ig/γ gene-redirected human T lymphocytes produce cytokines, specifically lyse tumor cells, and recycle lytic capacity. J. Immunol. 157: 836.
14. Altenschmidt, U., R. Kahl, D. Moritz, B. S. Schnierle, B. Gerstmayer, W. Wels, and B. Groner. 1996. Cytolysis of tumor cells expressing the neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes. Clin. Cancer Res. 2:1001.
15. Altenschmidt, U., E. Klundt, and B. Groner. 1997. Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression. J. Immunol. 159:5509.
16. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvand, J. Bradshaw, J. A. Ledbetter, and P. S. Linsley. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp Med. 177:165.
17. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
18. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065.
19. Chen, L., S. Ashe, W. A. Brady, I. Hellstrom, K. E. Hellstrom, J. A. Ledbetter, P. McGowan, and P. S. Linsley. 1992. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093.
20. Brocker, T., and K. Karjalainen. 1995. Signals through T cell receptor-ζ chain alone are insufficient to prime resting T lymphocytes. J. Exp. Med. 181:1653.
21. Bierer, B. E., B. P. Sleckman, S. E. Rarnofsky, and S. J. Burakoff. 1989. The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu. Rev. Immunol. 7:579.
22. Janeway, C. A. 1992. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10:645.
23. Alberola-Ila, J., L. Places, D. A. Cantrell, J. Vives, and F. Lozano. 1992. Intracellular events involved in CD5-induced human T cell activation and proliferation. J. Immunol. 148:1287.
24. Vandenberghe, P., G. J. Freeman, L. M. Nadler, M. C. Fletcher, M. Kamoun, A. Turka, J. A. Ledbetter, C. B. Thompson, and C. H. June. 1992. Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. J. Exp. Med. 175:951.
25. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
26. + cytotoxic T lymphocytes in the absence of exogenous help. J. Exp. Med. 177:1791.
27. Rudd, C. E. 1996. Upstream-downstream: CD28 cosignaling pathways and T cell function. Immunity 4:527.
28. Stein, P. H., J. D. Fraser, and A. Weiss. 1994. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3′kinase. Mol. Cell. Biol. 14:3392.
29. Alvarez-Vallina, L., and R. E. Hawkins. 1996. Antigen-specific targeting of CD28-mediated T cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors. Eur. J. Immunol. 26:2304.
30. Huston, J., D. Levinson, M. Mudgett-Hunter, M.-S. Tai, J. Novotny, M. N. Margolies, R. J. Ridge, R. E. Bruccoleri, E. Haber, R. Crea, and H. Oppermann. 1988. Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 85:5879.
31. Press, O. W., D. Shan, J. Howell-Clark, J. Eary, F. R. Appelbaum, D. Matthews, D. J. King, A. M. R. Haines, P. Hamann, L. Hinman, D. Shochat, and I. D. Bernstein. 1996. Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells. Cancer Res. 56:2123.
32. Moritz, D., and B. Groner. 1995. A spacer region between the single chain antibody and the CD3ζ-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity. Gene Ther. 2:539.
33. + T lymphocytes armed with universal T-cell receptors. Blood 84:2878.
34. Andrews, R. G., B. Torok-Storb, and I. D. Bernstein. 1983. Myeloid-associated differentiation antigens on stem cells and their progeny identified by monoclonal antibodies. Blood 62:124.
35. Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest. 5th Ed. National Institutes of Health, Bethesda: National Institutes of Health Publication 91-3242.
36. Weissman, A. M., D. Hou, D. G. Orloff, W. S. Modi, H. Seuanez, S. J. O'Brien, and R. D. Klausner. 1988. Molecular cloning and chromosomal localization of the human T-cell receptor C chain: distinction from the molecular CD3 complex. Proc. Natl. Acad. Sci. USA 85:9709.
37. Moingeon, P., C. C. Stebbins, L. D'Adamio, J. Lucich, and E. L. Reinherz. 1990. Human natural killer cells and mature T lymphocytes express identical CD3 ζ subunits as defined by cDNA cloning and sequence analysis. Eur. J. Immunol. 20:1741.
38. Aruffo, A., and B. Seed. 1987. Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc. Natl. Acad. Sci. USA 84:8573.
39. Stephens, P. E., and M. I. Cockett. 1989. The construction of a highly efficient and versatile set of mammalian expression vectors. Nucleic Acids Res. 17:7110.
40. Mazzoni, A., D. Mezzanzanica, G. Jung, H. Wolf, M. I. Colnaghi, and S. Canevari. 1996. CD3-CD28 costimulation as a means to avoiding T cell pre-activation in bispecific monoclonal antibody-based treatment of ovarian carcinoma. Cancer Res. 56:5443.
41. Renner, C., W. Jung, U. Sahin, R. Denfeld, C. Pohl, L. Tromper, F. Hartmann, V. Diehl, R. van Lier, and M. Pfreundschuh. 1994. Cure of xenografted human tumors by bispecific monoclonal antibodies and human T cells. Science 264:833.
42. Doty, R. T., and E. A. Clark. 1996. Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation. J. Immunol. 157:3270.
43. Bolhuis, R. L. H., H. R. Hoogenboom, and J. W. Gratama. 1996. Targeting of peripheral blood T lymphocytes. Springer Semin. Immunopathol. 18:211.
44. Frank, S. J., L. E. Samelson, and R. D. Klausner. 1990. The structure and signalling functions of the invariant T cell receptor components. Semin. Immunol. 2:89.