메뉴 건너뛰기




Volumn 1, Issue 1, 2014, Pages 64-74

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated

Author keywords

Metabolic stress; Targeted therapy; Tumor Suppressor; Tumor vulnerability

Indexed keywords

PHENFORMIN; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; RIBOSOME RNA; TANESPIMYCIN;

EID: 84931827582     PISSN: None     EISSN: 23523042     Source Type: Journal    
DOI: 10.1016/j.gendis.2014.06.002     Document Type: Review
Times cited : (34)

References (84)
  • 1
    • 0031004175 scopus 로고    scopus 로고
    • Genetic instability in colorectal cancers
    • Lengauer C., Kinzler K.W., Vogelstein B. Genetic instability in colorectal cancers. Nature 1997, 386(6625):623-627.
    • (1997) Nature , vol.386 , Issue.6625 , pp. 623-627
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 2
    • 0033831080 scopus 로고    scopus 로고
    • A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
    • Khuri F.R., Nemunaitis J., Ganly I., et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat Med Aug 2000, 6(8):879-885.
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 879-885
    • Khuri, F.R.1    Nemunaitis, J.2    Ganly, I.3
  • 3
    • 19944363519 scopus 로고    scopus 로고
    • Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
    • O'Shea C.C., Johnson L., Bagus B., et al. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell Dec 2004, 6(6):611-623.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 611-623
    • O'Shea, C.C.1    Johnson, L.2    Bagus, B.3
  • 4
    • 0036645286 scopus 로고    scopus 로고
    • Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
    • Sanchez-Cespedes M., Parrella P., Esteller M., et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res Jul 1 2002, 62(13):3659-3662.
    • (2002) Cancer Res , vol.62 , Issue.13 , pp. 3659-3662
    • Sanchez-Cespedes, M.1    Parrella, P.2    Esteller, M.3
  • 5
    • 0033522144 scopus 로고    scopus 로고
    • Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma
    • Guldberg P., Thor Straten P., Ahrenkiel V., Seremet T., Kirkin A.F., Zeuthen J. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Oncogene Mar 4 1999, 18(9):1777-1780.
    • (1999) Oncogene , vol.18 , Issue.9 , pp. 1777-1780
    • Guldberg, P.1    Thor Straten, P.2    Ahrenkiel, V.3    Seremet, T.4    Kirkin, A.F.5    Zeuthen, J.6
  • 6
    • 77249121152 scopus 로고    scopus 로고
    • Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells
    • McCabe M.T., Powell D.R., Zhou W., Vertino P.M. Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells. Cancer Genet Cytogenet Mar 2010, 197(2):130-141.
    • (2010) Cancer Genet Cytogenet , vol.197 , Issue.2 , pp. 130-141
    • McCabe, M.T.1    Powell, D.R.2    Zhou, W.3    Vertino, P.M.4
  • 7
    • 0038614742 scopus 로고    scopus 로고
    • Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
    • Baas A.F., Boudeau J., Sapkota G.P., et al. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J Jun 16 2003, 22(12):3062-3072.
    • (2003) EMBO J , vol.22 , Issue.12 , pp. 3062-3072
    • Baas, A.F.1    Boudeau, J.2    Sapkota, G.P.3
  • 8
    • 12144287284 scopus 로고    scopus 로고
    • LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    • Lizcano J.M., Goransson O., Toth R., et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J Feb 25 2004, 23(4):833-843.
    • (2004) EMBO J , vol.23 , Issue.4 , pp. 833-843
    • Lizcano, J.M.1    Goransson, O.2    Toth, R.3
  • 9
    • 0033771625 scopus 로고    scopus 로고
    • In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours
    • Rowan A., Churchman M., Jefferey R., Hanby A., Poulsom R., Tomlinson I. In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours. J Pathol Oct 2000, 192(2):203-206.
    • (2000) J Pathol , vol.192 , Issue.2 , pp. 203-206
    • Rowan, A.1    Churchman, M.2    Jefferey, R.3    Hanby, A.4    Poulsom, R.5    Tomlinson, I.6
  • 10
    • 0032495530 scopus 로고    scopus 로고
    • A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
    • Hemminki A., Markie D., Tomlinson I., et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature Jan 8 1998, 391(6663):184-187.
    • (1998) Nature , vol.391 , Issue.6663 , pp. 184-187
    • Hemminki, A.1    Markie, D.2    Tomlinson, I.3
  • 13
    • 80052297991 scopus 로고    scopus 로고
    • Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer
    • Gill R.K., Yang S.H., Meerzaman D., et al. Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer. Oncogene Sep 1 2011, 30(35):3784-3791.
    • (2011) Oncogene , vol.30 , Issue.35 , pp. 3784-3791
    • Gill, R.K.1    Yang, S.H.2    Meerzaman, D.3
  • 14
    • 84893395020 scopus 로고    scopus 로고
    • Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas
    • Fang R., Zheng C., Sun Y., et al. Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas. J Thorac Oncol Feb 2014, 9(2):254-258.
    • (2014) J Thorac Oncol , vol.9 , Issue.2 , pp. 254-258
    • Fang, R.1    Zheng, C.2    Sun, Y.3
  • 15
    • 33746905916 scopus 로고    scopus 로고
    • LKB1 mutation in large cell carcinoma of the lung
    • Zhong D., Guo L., de Aguirre I., et al. LKB1 mutation in large cell carcinoma of the lung. Lung Cancer Sep 2006, 53(3):285-294.
    • (2006) Lung Cancer , vol.53 , Issue.3 , pp. 285-294
    • Zhong, D.1    Guo, L.2    de Aguirre, I.3
  • 16
    • 34547926839 scopus 로고    scopus 로고
    • LKB1 modulates lung cancer differentiation and metastasis
    • Ji H., Ramsey M.R., Hayes D.N., et al. LKB1 modulates lung cancer differentiation and metastasis. Nature Aug 16 2007, 448(7155):807-810.
    • (2007) Nature , vol.448 , Issue.7155 , pp. 807-810
    • Ji, H.1    Ramsey, M.R.2    Hayes, D.N.3
  • 17
    • 84894041496 scopus 로고    scopus 로고
    • Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma
    • Han X., Li F., Fang Z., et al. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun 2014, 5:3261.
    • (2014) Nat Commun , vol.5 , pp. 3261
    • Han, X.1    Li, F.2    Fang, Z.3
  • 18
    • 0034610730 scopus 로고    scopus 로고
    • Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
    • Esteller M., Avizienyte E., Corn P.G., et al. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene Jan 6 2000, 19(1):164-168.
    • (2000) Oncogene , vol.19 , Issue.1 , pp. 164-168
    • Esteller, M.1    Avizienyte, E.2    Corn, P.G.3
  • 19
    • 0033915012 scopus 로고    scopus 로고
    • 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer
    • Trojan J., Brieger A., Raedle J., Esteller M., Zeuzem S. 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. Gut Aug 2000, 47(2):272-276.
    • (2000) Gut , vol.47 , Issue.2 , pp. 272-276
    • Trojan, J.1    Brieger, A.2    Raedle, J.3    Esteller, M.4    Zeuzem, S.5
  • 20
    • 1542322897 scopus 로고    scopus 로고
    • Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis
    • Yu J., Zhang H.Y., Ma Z.Z., Lu W., Wang Y.F., Zhu J.D. Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. Cell Res Oct 2003, 13(5):319-333.
    • (2003) Cell Res , vol.13 , Issue.5 , pp. 319-333
    • Yu, J.1    Zhang, H.Y.2    Ma, Z.Z.3    Lu, W.4    Wang, Y.F.5    Zhu, J.D.6
  • 21
    • 13144290928 scopus 로고    scopus 로고
    • Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    • Yu J., Zhang H., Gu J., et al. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. BMC Cancer Sep 14 2004, 4:65.
    • (2004) BMC Cancer , vol.4 , pp. 65
    • Yu, J.1    Zhang, H.2    Gu, J.3
  • 22
    • 84879879429 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung cancers
    • Lee S.M., Choi J.E., Na Y.K., et al. Genetic and epigenetic alterations of the LKB1 gene and their associations with mutations in TP53 and EGFR pathway genes in Korean non-small cell lung cancers. Lung Cancer Aug 2013, 81(2):194-199.
    • (2013) Lung Cancer , vol.81 , Issue.2 , pp. 194-199
    • Lee, S.M.1    Choi, J.E.2    Na, Y.K.3
  • 23
    • 58649110598 scopus 로고    scopus 로고
    • Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
    • Zheng B., Jeong J.H., Asara J.M., et al. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell Jan 30 2009, 33(2):237-247.
    • (2009) Mol Cell , vol.33 , Issue.2 , pp. 237-247
    • Zheng, B.1    Jeong, J.H.2    Asara, J.M.3
  • 24
    • 62849094740 scopus 로고    scopus 로고
    • Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF
    • Esteve-Puig R., Canals F., Colome N., Merlino G., Recio J.A. Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. PLoS One 2009, 4(3):e4771.
    • (2009) PLoS One , vol.4 , Issue.3 , pp. e4771
    • Esteve-Puig, R.1    Canals, F.2    Colome, N.3    Merlino, G.4    Recio, J.A.5
  • 25
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • El-Mir M.Y., Nogueira V., Fontaine E., Averet N., Rigoulet M., Leverve X. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem Jan 7 2000, 275(1):223-228.
    • (2000) J Biol Chem , vol.275 , Issue.1 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 26
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen M.R., Doran E., Halestrap A.P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J Jun 15 2000, 348(Pt 3):607-614.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 27
    • 84873584845 scopus 로고    scopus 로고
    • LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
    • Shackelford D.B., Abt E., Gerken L., et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell Feb 11 2013, 23(2):143-158.
    • (2013) Cancer Cell , vol.23 , Issue.2 , pp. 143-158
    • Shackelford, D.B.1    Abt, E.2    Gerken, L.3
  • 28
    • 78650606464 scopus 로고    scopus 로고
    • Beta-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
    • Oakhill J.S., Chen Z.P., Scott J.W., et al. beta-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A Nov 9 2010, 107(45):19237-19241.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.45 , pp. 19237-19241
    • Oakhill, J.S.1    Chen, Z.P.2    Scott, J.W.3
  • 29
    • 34147152841 scopus 로고    scopus 로고
    • Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
    • Sanders M.J., Grondin P.O., Hegarty B.D., Snowden M.A., Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J Apr 1 2007, 403(1):139-148.
    • (2007) Biochem J , vol.403 , Issue.1 , pp. 139-148
    • Sanders, M.J.1    Grondin, P.O.2    Hegarty, B.D.3    Snowden, M.A.4    Carling, D.5
  • 30
    • 84892933078 scopus 로고    scopus 로고
    • Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
    • Houde V.P., Ritorto M.S., Gourlay R., et al. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem. J Feb 15 2014, 458(1):41-56.
    • (2014) Biochem. J , vol.458 , Issue.1 , pp. 41-56
    • Houde, V.P.1    Ritorto, M.S.2    Gourlay, R.3
  • 32
    • 84881286031 scopus 로고    scopus 로고
    • Dysregulation of mTOR activity through LKB1 inactivation
    • Zhou W., Marcus A.I., Vertino P.M. Dysregulation of mTOR activity through LKB1 inactivation. Chin J Cancer Aug 2013, 32(8):427-433.
    • (2013) Chin J Cancer , vol.32 , Issue.8 , pp. 427-433
    • Zhou, W.1    Marcus, A.I.2    Vertino, P.M.3
  • 33
    • 84896995354 scopus 로고    scopus 로고
    • Managing lipid metabolism in proliferating cells: New perspective for metformin usage in cancer therapy
    • Lettieri Barbato D., Vegliante R., Desideri E., Ciriolo M.R. Managing lipid metabolism in proliferating cells: New perspective for metformin usage in cancer therapy. Biochim Biophys Acta Apr 2014, 1845(2):317-324.
    • (2014) Biochim Biophys Acta , vol.1845 , Issue.2 , pp. 317-324
    • Lettieri Barbato, D.1    Vegliante, R.2    Desideri, E.3    Ciriolo, M.R.4
  • 34
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw R.J., Kosmatka M., Bardeesy N., et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A Mar 9 2004, 101(10):3329-3335.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.10 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3
  • 35
    • 34247881866 scopus 로고    scopus 로고
    • Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1
    • Nafz J., De-Castro Arce J., Fleig V., Patzelt A., Mazurek S., Rosl F. Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1. Biochem J May 1 2007, 403(3):501-510.
    • (2007) Biochem J , vol.403 , Issue.3 , pp. 501-510
    • Nafz, J.1    De-Castro Arce, J.2    Fleig, V.3    Patzelt, A.4    Mazurek, S.5    Rosl, F.6
  • 36
    • 33847009048 scopus 로고    scopus 로고
    • AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis
    • Kim W.H., Lee J.W., Suh Y.H., et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal Apr 2007, 19(4):791-805.
    • (2007) Cell Signal , vol.19 , Issue.4 , pp. 791-805
    • Kim, W.H.1    Lee, J.W.2    Suh, Y.H.3
  • 37
    • 34247898927 scopus 로고    scopus 로고
    • Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells
    • Kim Y.M., Hwang J.T., Kwak D.W., Lee Y.K., Park O.J. Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. Ann N Y Acad Sci Jan 2007, 1095:496-503.
    • (2007) Ann N Y Acad Sci , vol.1095 , pp. 496-503
    • Kim, Y.M.1    Hwang, J.T.2    Kwak, D.W.3    Lee, Y.K.4    Park, O.J.5
  • 38
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley S.A., Boudeau J., Reid J.L., et al. Complexes between the LKB1 tumor suppressor, STRADalpha/beta and MO25alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003, 2(4):28.
    • (2003) J Biol , vol.2 , Issue.4 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3
  • 39
    • 0035857020 scopus 로고    scopus 로고
    • New drug targets for type 2 diabetes and the metabolic syndrome
    • Moller D.E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature Dec 13 2001, 414(6865):821-827.
    • (2001) Nature , vol.414 , Issue.6865 , pp. 821-827
    • Moller, D.E.1
  • 40
    • 85047689953 scopus 로고
    • 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
    • Corton J.M., Gillespie J.G., Hawley S.A., Hardie D.G. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?. Eur J Biochem Apr 15 1995, 229(2):558-565.
    • (1995) Eur J Biochem , vol.229 , Issue.2 , pp. 558-565
    • Corton, J.M.1    Gillespie, J.G.2    Hawley, S.A.3    Hardie, D.G.4
  • 41
    • 34547870106 scopus 로고    scopus 로고
    • Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells
    • Woollhead A.M., Sivagnanasundaram J., Kalsi K.K., et al. Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells. Br J Pharmacol Aug 2007, 151(8):1204-1215.
    • (2007) Br J Pharmacol , vol.151 , Issue.8 , pp. 1204-1215
    • Woollhead, A.M.1    Sivagnanasundaram, J.2    Kalsi, K.K.3
  • 42
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang S., Houghton P.J. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol Aug 2003, 3(4):371-377.
    • (2003) Curr Opin Pharmacol , vol.3 , Issue.4 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 43
    • 70349378469 scopus 로고    scopus 로고
    • Enhancing mTOR-targeted cancer therapy
    • Wang X., Sun S.Y. Enhancing mTOR-targeted cancer therapy. Expert Opin Ther Targets Oct 2009, 13(10):1193-1203.
    • (2009) Expert Opin Ther Targets , vol.13 , Issue.10 , pp. 1193-1203
    • Wang, X.1    Sun, S.Y.2
  • 44
    • 84892743258 scopus 로고    scopus 로고
    • A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition
    • Cheng H., Liu P., Zhang F., et al. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Res Jan 1 2014, 74(1):15-23.
    • (2014) Cancer Res , vol.74 , Issue.1 , pp. 15-23
    • Cheng, H.1    Liu, P.2    Zhang, F.3
  • 45
    • 84900393562 scopus 로고    scopus 로고
    • Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression
    • Xu C., Fillmore C.M., Koyama S., et al. Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression. Cancer Cell Apr 30 2014.
    • (2014) Cancer Cell
    • Xu, C.1    Fillmore, C.M.2    Koyama, S.3
  • 47
    • 84863736613 scopus 로고    scopus 로고
    • Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
    • Bywater M.J., Poortinga G., Sanij E., et al. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell 2012, 22(1):51-65.
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 51-65
    • Bywater, M.J.1    Poortinga, G.2    Sanij, E.3
  • 48
    • 0037291736 scopus 로고    scopus 로고
    • ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
    • Zhao J., Yuan X., Frodin M., Grummt I. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell Feb 2003, 11(2):405-413.
    • (2003) Mol Cell , vol.11 , Issue.2 , pp. 405-413
    • Zhao, J.1    Yuan, X.2    Frodin, M.3    Grummt, I.4
  • 49
    • 1542343973 scopus 로고    scopus 로고
    • MTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
    • Mayer C., Zhao J., Yuan X., Grummt I. mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev Feb 15 2004, 18(4):423-434.
    • (2004) Genes Dev , vol.18 , Issue.4 , pp. 423-434
    • Mayer, C.1    Zhao, J.2    Yuan, X.3    Grummt, I.4
  • 50
    • 70449584566 scopus 로고    scopus 로고
    • AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply
    • Hoppe S., Bierhoff H., Cado I., et al. AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A Oct 20 2009, 106(42):17781-17786.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.42 , pp. 17781-17786
    • Hoppe, S.1    Bierhoff, H.2    Cado, I.3
  • 51
    • 78650465738 scopus 로고    scopus 로고
    • LKB1 regulated pathways in lung cancer invasion and metastasis
    • Marcus A.I., Zhou W. LKB1 regulated pathways in lung cancer invasion and metastasis. J Thorac Oncol Dec 2010, 5(12):1883-1886.
    • (2010) J Thorac Oncol , vol.5 , Issue.12 , pp. 1883-1886
    • Marcus, A.I.1    Zhou, W.2
  • 52
    • 77953238558 scopus 로고    scopus 로고
    • Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors
    • Carretero J., Shimamura T., Rikova K., et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell Jun 15 2010, 17(6):547-559.
    • (2010) Cancer Cell , vol.17 , Issue.6 , pp. 547-559
    • Carretero, J.1    Shimamura, T.2    Rikova, K.3
  • 53
    • 84879050733 scopus 로고    scopus 로고
    • LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence
    • Kline E.R., Shupe J., Gilbert M.M., Zhou W., Marcus A.I. LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence. J Biol Chem May 1 2013.
    • (2013) J Biol Chem
    • Kline, E.R.1    Shupe, J.2    Gilbert, M.M.3    Zhou, W.4    Marcus, A.I.5
  • 54
    • 84881508779 scopus 로고    scopus 로고
    • Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer
    • Liu Y., Marks K., Cowley G.S., et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discov Aug 2013, 3(8):870-879.
    • (2013) Cancer Discov , vol.3 , Issue.8 , pp. 870-879
    • Liu, Y.1    Marks, K.2    Cowley, G.S.3
  • 55
    • 80052977483 scopus 로고    scopus 로고
    • Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis
    • Kline E.R., Muller S., Pan L., Tighiouart M., Chen Z.G., Marcus A.I. Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis. Head Neck Oct 2011, 33(10):1501-1512.
    • (2011) Head Neck , vol.33 , Issue.10 , pp. 1501-1512
    • Kline, E.R.1    Muller, S.2    Pan, L.3    Tighiouart, M.4    Chen, Z.G.5    Marcus, A.I.6
  • 56
    • 84904038159 scopus 로고    scopus 로고
    • LKB1 when associated with methylatedERa is a marker of bad prognosis in breast cancer
    • Bouchekioua-Bouzaghou K., Poulard C., Rambaud J., et al. LKB1 when associated with methylatedERa is a marker of bad prognosis in breast cancer. Int J Cancer Feb 12 2014.
    • (2014) Int J Cancer
    • Bouchekioua-Bouzaghou, K.1    Poulard, C.2    Rambaud, J.3
  • 57
    • 44949122687 scopus 로고    scopus 로고
    • STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7
    • Dorfman J., Macara I.G. STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7. Mol Biol Cell Apr 2008, 19(4):1614-1626.
    • (2008) Mol Biol Cell , vol.19 , Issue.4 , pp. 1614-1626
    • Dorfman, J.1    Macara, I.G.2
  • 58
    • 84894531752 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway
    • Sanli T., Steinberg G.R., Singh G., Tsakiridis T. AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther Feb 2014, 15(2):156-169.
    • (2014) Cancer Biol Ther , vol.15 , Issue.2 , pp. 156-169
    • Sanli, T.1    Steinberg, G.R.2    Singh, G.3    Tsakiridis, T.4
  • 59
    • 77955917717 scopus 로고    scopus 로고
    • Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells
    • Sanli T., Rashid A., Liu C., et al. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys Sep 1 2010, 78(1):221-229.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , Issue.1 , pp. 221-229
    • Sanli, T.1    Rashid, A.2    Liu, C.3
  • 60
    • 84867045698 scopus 로고    scopus 로고
    • A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation
    • Amatya P.N., Kim H.B., Park S.J., et al. A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation. Biochim Biophys Acta Dec 2012, 1823(12):2099-2108.
    • (2012) Biochim Biophys Acta , vol.1823 , Issue.12 , pp. 2099-2108
    • Amatya, P.N.1    Kim, H.B.2    Park, S.J.3
  • 61
    • 17644362355 scopus 로고    scopus 로고
    • DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM
    • Fernandes N., Sun Y., Chen S., et al. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem Apr 15 2005, 280(15):15158-15164.
    • (2005) J Biol Chem , vol.280 , Issue.15 , pp. 15158-15164
    • Fernandes, N.1    Sun, Y.2    Chen, S.3
  • 62
    • 0036901639 scopus 로고    scopus 로고
    • Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    • Sapkota G.P., Deak M., Kieloch A., et al. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J Dec 1 2002, 368(Pt 2):507-516.
    • (2002) Biochem J , vol.368 , pp. 507-516
    • Sapkota, G.P.1    Deak, M.2    Kieloch, A.3
  • 63
    • 77749233738 scopus 로고    scopus 로고
    • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    • Alexander A., Cai S.L., Kim J., et al. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A Mar 2 2010, 107(9):4153-4158.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.9 , pp. 4153-4158
    • Alexander, A.1    Cai, S.L.2    Kim, J.3
  • 64
    • 77956994837 scopus 로고    scopus 로고
    • Differential localization of ATM is correlated with activation of distinct downstream signaling pathways
    • Alexander A., Walker C.L. Differential localization of ATM is correlated with activation of distinct downstream signaling pathways. Cell Cycle Sep 15 2010, 9(18):3685-3686.
    • (2010) Cell Cycle , vol.9 , Issue.18 , pp. 3685-3686
    • Alexander, A.1    Walker, C.L.2
  • 65
    • 84887383501 scopus 로고    scopus 로고
    • Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair
    • Scott T.L., Rangaswamy S., Wicker C.A., Izumi T. Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair. Antioxid Redox Signal Feb 1 2014, 20(4):708-726.
    • (2014) Antioxid Redox Signal , vol.20 , Issue.4 , pp. 708-726
    • Scott, T.L.1    Rangaswamy, S.2    Wicker, C.A.3    Izumi, T.4
  • 66
    • 84886787846 scopus 로고    scopus 로고
    • Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer
    • Kim H.S., Mendiratta S., Kim J., et al. Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell Oct 24 2013, 155(3):552-566.
    • (2013) Cell , vol.155 , Issue.3 , pp. 552-566
    • Kim, H.S.1    Mendiratta, S.2    Kim, J.3
  • 68
    • 84891748709 scopus 로고    scopus 로고
    • The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
    • Johnson R., Halder G. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov Jan 2014, 13(1):63-79.
    • (2014) Nat Rev Drug Discov , vol.13 , Issue.1 , pp. 63-79
    • Johnson, R.1    Halder, G.2
  • 69
    • 84902513006 scopus 로고    scopus 로고
    • In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival
    • Menzel M., Meckbach D., Weide B., et al. In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival. Pigment Cell Melanoma Res Apr 4 2014.
    • (2014) Pigment Cell Melanoma Res
    • Menzel, M.1    Meckbach, D.2    Weide, B.3
  • 70
    • 53849087493 scopus 로고    scopus 로고
    • Expression of Yes-associated protein in common solid tumors
    • Steinhardt A.A., Gayyed M.F., Klein A.P., et al. Expression of Yes-associated protein in common solid tumors. Hum Pathol Nov 2008, 39(11):1582-1589.
    • (2008) Hum Pathol , vol.39 , Issue.11 , pp. 1582-1589
    • Steinhardt, A.A.1    Gayyed, M.F.2    Klein, A.P.3
  • 71
    • 77953197857 scopus 로고    scopus 로고
    • Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer
    • Wang Y., Dong Q., Zhang Q., Li Z., Wang E., Qiu X. Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer science May 2010, 101(5):1279-1285.
    • (2010) Cancer science , vol.101 , Issue.5 , pp. 1279-1285
    • Wang, Y.1    Dong, Q.2    Zhang, Q.3    Li, Z.4    Wang, E.5    Qiu, X.6
  • 72
    • 84883488932 scopus 로고    scopus 로고
    • LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap
    • Nguyen H.B., Babcock J.T., Wells C.D., Quilliam L.A. LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap. Oncogene Aug 29 2013, 32(35):4100-4109.
    • (2013) Oncogene , vol.32 , Issue.35 , pp. 4100-4109
    • Nguyen, H.B.1    Babcock, J.T.2    Wells, C.D.3    Quilliam, L.A.4
  • 73
    • 84891345748 scopus 로고    scopus 로고
    • A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway
    • Mohseni M., Sun J., Lau A., et al. A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol Jan 2014, 16(1):108-117.
    • (2014) Nat Cell Biol , vol.16 , Issue.1 , pp. 108-117
    • Mohseni, M.1    Sun, J.2    Lau, A.3
  • 74
    • 84862605178 scopus 로고    scopus 로고
    • Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
    • Liu-Chittenden Y., Huang B., Shim J.S., et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev Jun 15 2012, 26(12):1300-1305.
    • (2012) Genes Dev , vol.26 , Issue.12 , pp. 1300-1305
    • Liu-Chittenden, Y.1    Huang, B.2    Shim, J.S.3
  • 75
    • 84896092147 scopus 로고    scopus 로고
    • A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer
    • Jiao S., Wang H., Shi Z., et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell Feb 10 2014, 25(2):166-180.
    • (2014) Cancer Cell , vol.25 , Issue.2 , pp. 166-180
    • Jiao, S.1    Wang, H.2    Shi, Z.3
  • 76
    • 84876563391 scopus 로고    scopus 로고
    • Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
    • Yang W., Soares J., Greninger P., et al. Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res Jan 2013, 41(Database issue):D955-961.
    • (2013) Nucleic Acids Res , vol.41 , Issue.DATABASE ISSUE , pp. D955-961
    • Yang, W.1    Soares, J.2    Greninger, P.3
  • 77
    • 0346057795 scopus 로고    scopus 로고
    • Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37
    • Nony P., Gaude H., Rossel M., Fournier L., Rouault J.P., Billaud M. Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. Oncogene Dec 11 2003, 22(57):9165-9175.
    • (2003) Oncogene , vol.22 , Issue.57 , pp. 9165-9175
    • Nony, P.1    Gaude, H.2    Rossel, M.3    Fournier, L.4    Rouault, J.P.5    Billaud, M.6
  • 78
    • 0037444766 scopus 로고    scopus 로고
    • Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability
    • Boudeau J., Deak M., Lawlor M.A., Morrice N.A., Alessi D.R. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. Biochem J Mar 15 2003, 370(Pt 3):849-857.
    • (2003) Biochem J , vol.370 , pp. 849-857
    • Boudeau, J.1    Deak, M.2    Lawlor, M.A.3    Morrice, N.A.4    Alessi, D.R.5
  • 79
    • 84865213364 scopus 로고    scopus 로고
    • The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity
    • Xu W., Neckers L. The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity. Future Oncol Aug 2012, 8(8):939-942.
    • (2012) Future Oncol , vol.8 , Issue.8 , pp. 939-942
    • Xu, W.1    Neckers, L.2
  • 80
    • 84860407614 scopus 로고    scopus 로고
    • Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1
    • Gaude H., Aznar N., Delay A., et al. Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. Oncogene Mar 22 2012, 31(12):1582-1591.
    • (2012) Oncogene , vol.31 , Issue.12 , pp. 1582-1591
    • Gaude, H.1    Aznar, N.2    Delay, A.3
  • 81
    • 84896521425 scopus 로고    scopus 로고
    • Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways
    • Andrade-Vieira R., Xu Z., Colp P., Marignani P.A. Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways. PLoS One. 2013, 8(2):e56567.
    • (2013) PLoS One. , vol.8 , Issue.2 , pp. e56567
    • Andrade-Vieira, R.1    Xu, Z.2    Colp, P.3    Marignani, P.A.4
  • 82
    • 78650488264 scopus 로고    scopus 로고
    • LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
    • Gao Y., Xiao Q., Ma H., et al. LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A Nov 2 2010, 107(44):18892-18897.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.44 , pp. 18892-18897
    • Gao, Y.1    Xiao, Q.2    Ma, H.3
  • 83
    • 84896031764 scopus 로고    scopus 로고
    • Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
    • Sausville E., Lorusso P., Carducci M., et al. Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors. Cancer Chemother Pharmacol Mar 2014, 73(3):539-549.
    • (2014) Cancer Chemother Pharmacol , vol.73 , Issue.3 , pp. 539-549
    • Sausville, E.1    Lorusso, P.2    Carducci, M.3
  • 84
    • 84883487392 scopus 로고    scopus 로고
    • Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours
    • Seto T., Esaki T., Hirai F., et al. Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours. Cancer Chemother Pharmacol Sep 2013, 72(3):619-627.
    • (2013) Cancer Chemother Pharmacol , vol.72 , Issue.3 , pp. 619-627
    • Seto, T.1    Esaki, T.2    Hirai, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.