Differential localization of ATM is correlated with activation of distinct downstream signaling pathways

Cell Cycle

Volumn 9, Issue 18, 2010, Pages 3709-3710

  Alexander, Angela ^a,b   Walker, Cheryl L ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

AMPK; Apoptosis; ATM; Autophagy; mTORC1; ROS; Signal transduction; Stress; TSC2

Indexed keywords

ATM PROTEIN; HISTONE DEACETYLASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE LKB1; REACTIVE OXYGEN METABOLITE; TUBERIN;

ATAXIA TELANGIECTASIA; AUTOPHAGY; AUTOPHOSPHORYLATION; CELL COMPARTMENTALIZATION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CYTOPLASM; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GENE FUNCTION; GENE MUTATION; GENE REPRESSION; HUMAN; NERVE CELL; PHENOTYPE; PROTEIN LOCALIZATION; SENESCENCE; SHORT SURVEY; SIGNAL TRANSDUCTION; SOMATIC CELL; STRESS;

ATAXIA TELANGIECTASIA;

EID: 77956994837     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.18.13253     Document Type: Short Survey

References (14)

1. McKinnon PJ. ATM and ataxia telangiectasia. EMBO Rep 2004; 5:772-6.
2. Kastan MB, Bartek J. Cell cycle checkpoints and cancer. Nature 2004; 432:316-23.
3. Schneider JG, Finck BN, Ren J, Standley KN, Takagi M, Maclean KH, et al. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metabolism 2006; 4:377-89.
4. Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 2010; 141:970-81.
5. Watters D, Kedar P, Spring K, Bjorkman J, Chen P, Gatei M, et al. Localization of a portion of extranuclear ATM to peroxisomes. J Biol Chem 1999; 274:34277-82.
6. Oricchio E, Saladino C, Iacovelli S, Soddu S, Cundari E. ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity. Cell Cycle 2006; 5:88-92.
7. Lim DS, Kirsch DG, Canman CE, Ahn JH, Ziv Y, Newman LS, et al. ATM binds to beta-adaptin in cytoplasmic vesicles. Proc Natl Acad Sci USA 1998; 95:10146-51.
8. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, et al. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci USA 2010; 107:4153-8.
9. Pospelova TV, Demidenko ZN, Bukreeva EI, Pospelov VA, Gudkov AV, Blagosklonny MV. Pseudo-DNA damage response in senescent cells. Cell Cycle 2009; 8:4112-8.
10. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-5.
11. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304:1500-2.
12. Azad MB, Chen Y, Gibson SB. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 2009; 11:777-90.
13. Barlow C, Ribaut-Barassin C, Zwingman TA, Pope AJ, Brown KD, Owens JW, et al. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. Proc Natl Acad Sci USA 2000; 97:871-6.
14. Oka A, Takashima S. Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development. Neurosci Lett 1998; 252:195-8.