메뉴 건너뛰기




Volumn 32, Issue 35, 2013, Pages 4100-4109

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

Author keywords

growth; Hippo; LKB1; polarity; Yap

Indexed keywords

ADENYLATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN KINASE LKB1; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN;

EID: 84883488932     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.431     Document Type: Article
Times cited : (71)

References (45)
  • 1
    • 4043170088 scopus 로고    scopus 로고
    • Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors
    • Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004; 18: 1909-1925.
    • (2004) Genes Dev , vol.18 , pp. 1909-1925
    • Bilder, D.1
  • 2
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-575.
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 3
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao B, Li L, Lei Q, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 2010; 24: 862-874.
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 4
    • 56749176442 scopus 로고    scopus 로고
    • LKB1; Linking cell structure and tumor suppression
    • Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008; 27: 6908-6919.
    • (2008) Oncogene , vol.27 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 5
    • 80052297991 scopus 로고    scopus 로고
    • Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer
    • Gill RK, Yang SH, Meerzaman D, Mechanic LE, Bowman ED, Jeon HS et al. Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer. Oncogene 2011; 30: 3784-3791.
    • (2011) Oncogene , vol.30 , pp. 3784-3791
    • Gill, R.K.1    Yang, S.H.2    Meerzaman, D.3    Mechanic, L.E.4    Bowman, E.D.5    Jeon, H.S.6
  • 6
    • 12144287284 scopus 로고    scopus 로고
    • LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
    • Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004; 23: 833-843.
    • (2004) EMBO J , vol.23 , pp. 833-843
    • Lizcano, J.M.1    Goransson, O.2    Toth, R.3    Deak, M.4    Morrice, N.A.5    Boudeau, J.6
  • 7
    • 79956088595 scopus 로고    scopus 로고
    • The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
    • van Veelen W, Korsse SE, van de Laar L, Peppelenbosch MP. The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling. Oncogene 2011; 30: 2289-2303.
    • (2011) Oncogene , vol.30 , pp. 2289-2303
    • Van Veelen, W.1    Korsse, S.E.2    Van De Laar, L.3    Peppelenbosch, M.P.4
  • 8
    • 1542777034 scopus 로고    scopus 로고
    • Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
    • Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 2004; 116: 457-466.
    • (2004) Cell , vol.116 , pp. 457-466
    • Baas, A.F.1    Kuipers, J.2    Van Der Wel, N.N.3    Batlle, E.4    Koerten, H.K.5    Peters, P.J.6
  • 9
    • 35548952703 scopus 로고    scopus 로고
    • Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
    • Partanen JI, Nieminen AI, Makela TP, Klefstrom J. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 2007; 104: 14694-14699.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14694-14699
    • Partanen, J.I.1    Nieminen, A.I.2    Makela, T.P.3    Klefstrom, J.4
  • 10
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    • Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 2005; 122: 421-434.
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 11
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010; 19: 491-505.
    • (2010) Dev Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 12
    • 33750614445 scopus 로고    scopus 로고
    • The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    • Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 2006; 16: 2090-2100.
    • (2006) Curr Biol , vol.16 , pp. 2090-2100
    • Willecke, M.1    Hamaratoglu, F.2    Kango-Singh, M.3    Udan, R.4    Chen, C.L.5    Tao, C.6
  • 14
    • 33747591465 scopus 로고    scopus 로고
    • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    • Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 2006; 103: 12405-12410.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12405-12410
    • Overholtzer, M.1    Zhang, J.2    Smolen, G.A.3    Muir, B.4    Li, W.5    Sgroi, D.C.6
  • 15
    • 77954945373 scopus 로고    scopus 로고
    • The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
    • Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 2010; 19: 27-38.
    • (2010) Dev Cell , vol.19 , pp. 27-38
    • Zhang, N.1    Bai, H.2    David, K.K.3    Dong, J.4    Zheng, Y.5    Cai, J.6
  • 16
    • 60749112337 scopus 로고    scopus 로고
    • YAPat the crossroad between transformation and tumor suppression
    • Bertini E, Oka T, Sudol M, Strano S, Blandino G. YAPat the crossroad between transformation and tumor suppression. Cell Cycle 2009; 8: 49-57.
    • (2009) Cell Cycle , vol.8 , pp. 49-57
    • Bertini, E.1    Oka, T.2    Sudol, M.3    Strano, S.4    Blandino, G.5
  • 17
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007; 21: 2747-2761.
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3    Udan, R.S.4    Yang, Q.5    Kim, J.6
  • 18
    • 73549095761 scopus 로고    scopus 로고
    • A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
    • Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev 2010; 24: 72-85.
    • (2010) Genes Dev , vol.24 , pp. 72-85
    • Zhao, B.1    Li, L.2    Tumaneng, K.3    Wang, C.Y.4    Guan, K.L.5
  • 19
    • 84859583470 scopus 로고    scopus 로고
    • Integrating developmental signals: A Hippo in the (path)way
    • Mauviel A, Nallet-Staub F, Varelas X. Integrating developmental signals: a Hippo in the (path)way. Oncogene 2012; 31: 1743-1756.
    • (2012) Oncogene , vol.31 , pp. 1743-1756
    • Mauviel, A.1    Nallet-Staub, F.2    Varelas, X.3
  • 20
    • 0033979731 scopus 로고    scopus 로고
    • Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
    • Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000; 20: 1436-1447.
    • (2000) Mol Cell Biol , vol.20 , pp. 1436-1447
    • Dickson, M.A.1    Hahn, W.C.2    Ino, Y.3    Ronfard, V.4    Wu, J.Y.5    Weinberg, R.A.6
  • 21
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B, Ye X, Yu J, Li L, Li W, Li S et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 2008; 22: 1962-1971.
    • (2008) Genes Dev , vol.22 , pp. 1962-1971
    • Zhao, B.1    Ye, X.2    Yu, J.3    Li, L.4    Li, W.5    Li, S.6
  • 22
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yesassociated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu S, Totty NF, Irwin MS, Sudol M, Downward J. Akt phosphorylates the Yesassociated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell 2003; 11: 11-23.
    • (2003) Mol Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3    Sudol, M.4    Downward, J.5
  • 24
    • 0033376684 scopus 로고    scopus 로고
    • PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
    • Huang H, Potter CJ, Tao W, Li DM, Brogiolo W, Hafen E et al. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 1999; 126: 5365-5372.
    • (1999) Development , vol.126 , pp. 5365-5372
    • Huang, H.1    Potter, C.J.2    Tao, W.3    Li, D.M.4    Brogiolo, W.5    Hafen, E.6
  • 27
    • 77953040994 scopus 로고    scopus 로고
    • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    • Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 2010; 24: 1106-1118.
    • (2010) Genes Dev , vol.24 , pp. 1106-1118
    • Lian, I.1    Kim, J.2    Okazawa, H.3    Zhao, J.4    Zhao, B.5    Yu, J.6
  • 28
    • 65549145048 scopus 로고    scopus 로고
    • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    • Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009; 284: 8023-8032.
    • (2009) J Biol Chem , vol.284 , pp. 8023-8032
    • Thoreen, C.C.1    Kang, S.A.2    Chang, J.W.3    Liu, Q.4    Zhang, J.5    Gao, Y.6
  • 29
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin-and farnesylation-dependent manner
    • Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin-and farnesylation-dependent manner. J Biol Chem 2003; 278: 32493-32496.
    • (2003) J Biol Chem , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4
  • 30
    • 0036778129 scopus 로고    scopus 로고
    • Why size matters: Altering cell size
    • Saucedo LJ, Edgar BA. Why size matters: altering cell size. Curr Opin Genet Dev 2002; 12: 565-571.
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 565-571
    • Saucedo, L.J.1    Edgar, B.A.2
  • 31
    • 20044370885 scopus 로고    scopus 로고
    • Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
    • Sakamoto K, McCarthy A, Smith D, Green KA, Grahame Hardie D, Ashworth A et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 2005; 24: 1810-1820.
    • (2005) EMBO J , vol.24 , pp. 1810-1820
    • Sakamoto, K.1    McCarthy, A.2    Smith, D.3    Green, K.A.4    Grahame Hardie, D.5    Ashworth, A.6
  • 32
    • 80051923057 scopus 로고    scopus 로고
    • Hippo pathway regulation by cell morphology and stress fibers
    • Wada K, Itoga K, Okano T, Yonemura S, Sasaki H. Hippo pathway regulation by cell morphology and stress fibers. Development 2011; 138: 3907-3914.
    • (2011) Development , vol.138 , pp. 3907-3914
    • Wada, K.1    Itoga, K.2    Okano, T.3    Yonemura, S.4    Sasaki, H.5
  • 34
    • 0034928738 scopus 로고    scopus 로고
    • The insert region of RhoA is essential for Rho kinase activation and cellular transformation
    • Zong H, Kaibuchi K, Quilliam LA. The insert region of RhoA is essential for Rho kinase activation and cellular transformation. Mol Cell Biol 2001; 21: 5287-5298.
    • (2001) Mol Cell Biol , vol.21 , pp. 5287-5298
    • Zong, H.1    Kaibuchi, K.2    Quilliam, L.A.3
  • 36
    • 2942729619 scopus 로고    scopus 로고
    • LKB1 tumor suppressor protein: PARtaker in cell polarity
    • Baas AF, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol 2004; 14: 312-319.
    • (2004) Trends Cell Biol , vol.14 , pp. 312-319
    • Baas, A.F.1    Smit, L.2    Clevers, H.3
  • 38
    • 84859167179 scopus 로고    scopus 로고
    • Deregulated MYC expression induces dependence upon AMPK-related kinase 5
    • Liu L, Ulbrich J, Muller J, Wustefeld T, Aeberhard L, Kress TR et al. Deregulated MYC expression induces dependence upon AMPK-related kinase 5. Nature 2012; 483: 608-612.
    • (2012) Nature , vol.483 , pp. 608-612
    • Liu, L.1    Ulbrich, J.2    Muller, J.3    Wustefeld, T.4    Aeberhard, L.5    Kress, T.R.6
  • 39
    • 79961063553 scopus 로고    scopus 로고
    • A cellbased assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription
    • Bao Y, Nakagawa K, Yang Z, Ikeda M, Withanage K, Ishigami-Yuasa M et al. A cellbased assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem 2011; 150: 199-208.
    • (2011) J Biochem , vol.150 , pp. 199-208
    • Bao, Y.1    Nakagawa, K.2    Yang, Z.3    Ikeda, M.4    Withanage, K.5    Ishigami-Yuasa, M.6
  • 40
    • 33947100984 scopus 로고    scopus 로고
    • Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
    • Carretero J, Medina PP, Blanco R, Smit L, Tang M, Roncador G et al. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene 2007; 26: 1616-1625.
    • (2007) Oncogene , vol.26 , pp. 1616-1625
    • Carretero, J.1    Medina, P.P.2    Blanco, R.3    Smit, L.4    Tang, M.5    Roncador, G.6
  • 41
    • 0029128482 scopus 로고
    • Ras-mediated transcription activation: Analysis by transient cotransfection assays
    • Hauser CA, Westwick JK, Quilliam LA. Ras-mediated transcription activation: analysis by transient cotransfection assays. Methods Enzymol 1995; 255: 412-426.
    • (1995) Methods Enzymol , vol.255 , pp. 412-426
    • Hauser, C.A.1    Westwick, J.K.2    Quilliam, L.A.3
  • 42
    • 0042858208 scopus 로고    scopus 로고
    • WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxylterminal fragment of ErbB-4 that translocates to the nucleus
    • Komuro A, Nagai M, Navin NE, Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxylterminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem 2003; 278: 33334-33341.
    • (2003) J Biol Chem , vol.278 , pp. 33334-33341
    • Komuro, A.1    Nagai, M.2    Navin, N.E.3    Sudol, M.4
  • 43
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 44
    • 77951228917 scopus 로고    scopus 로고
    • Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain
    • Heller B, Adu-Gyamfi E, Smith-Kinnaman W, Babbey C, Vora M, Xue Y et al. Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain. J Biol Chem 2010; 285: 12308-12320.
    • (2010) J Biol Chem , vol.285 , pp. 12308-12320
    • Heller, B.1    Adu-Gyamfi, E.2    Smith-Kinnaman, W.3    Babbey, C.4    Vora, M.5    Xue, Y.6
  • 45
    • 79952769108 scopus 로고    scopus 로고
    • The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases
    • Ranahan WP, Han Z, Smith-Kinnaman W, Nabinger SC, Heller B, Herbert BS et al. The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Res 2011; 71: 2203-2211.
    • (2011) Cancer Res , vol.71 , pp. 2203-2211
    • Ranahan, W.P.1    Han, Z.2    Smith-Kinnaman, W.3    Nabinger, S.C.4    Heller, B.5    Herbert, B.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.