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Volumn 197, Issue 2, 2010, Pages 130-141

Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE LKB1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SBNO2; UNCLASSIFIED DRUG;

EID: 77249121152     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2009.11.017     Document Type: Article
Times cited : (28)

References (55)
  • 3
    • 33749070180 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome: clinicopathology and molecular alterations
    • McGarrity T.J., and Amos C. Peutz-Jeghers syndrome: clinicopathology and molecular alterations. Cell Mol Life Sci 63 (2006) 2135-2144
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2135-2144
    • McGarrity, T.J.1    Amos, C.2
  • 4
    • 0033529838 scopus 로고    scopus 로고
    • Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
    • Tiainen M., Ylikorkala A., and Makela T.P. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci U S A 96 (1999) 9248-9251
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 9248-9251
    • Tiainen, M.1    Ylikorkala, A.2    Makela, T.P.3
  • 5
    • 50249143902 scopus 로고    scopus 로고
    • Role of LKB1 in lung cancer development
    • Makowski L., and Hayes D.N. Role of LKB1 in lung cancer development. Br J Cancer 99 (2008) 683-688
    • (2008) Br J Cancer , vol.99 , pp. 683-688
    • Makowski, L.1    Hayes, D.N.2
  • 7
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley S.A., Boudeau J., Reid J.L., Mustard K.J., Udd L., Makela T.P., Alessi D.R., and Hardie D.G. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2 (2003) 28
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 10
    • 34548179000 scopus 로고    scopus 로고
    • Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
    • Kojima Y., Miyoshi H., Clevers H.C., Oshima M., Aoki M., and Taketo M.M. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem 282 (2007) 23532-23540
    • (2007) J Biol Chem , vol.282 , pp. 23532-23540
    • Kojima, Y.1    Miyoshi, H.2    Clevers, H.C.3    Oshima, M.4    Aoki, M.5    Taketo, M.M.6
  • 11
    • 26444610333 scopus 로고    scopus 로고
    • LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes
    • Mehenni H., Lin-Marq N., Buchet-Poyau K., Reymond A., Collart M.A., Picard D., and Antonarakis S.E. LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Hum Mol Genet 14 (2005) 2209-2219
    • (2005) Hum Mol Genet , vol.14 , pp. 2209-2219
    • Mehenni, H.1    Lin-Marq, N.2    Buchet-Poyau, K.3    Reymond, A.4    Collart, M.A.5    Picard, D.6    Antonarakis, S.E.7
  • 12
    • 54749135378 scopus 로고    scopus 로고
    • LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins
    • Zhong D., Liu X., Khuri F.R., Sun S.Y., Vertino P.M., and Zhou W. LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. Cancer Res 68 (2008) 7270-7277
    • (2008) Cancer Res , vol.68 , pp. 7270-7277
    • Zhong, D.1    Liu, X.2    Khuri, F.R.3    Sun, S.Y.4    Vertino, P.M.5    Zhou, W.6
  • 19
    • 0033522144 scopus 로고    scopus 로고
    • Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma
    • Guldberg P., thor Straten P., Ahrenkiel V., Seremet T., Kirkin A.F., and Zeuthen J. Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Oncogene 18 (1999) 1777-1780
    • (1999) Oncogene , vol.18 , pp. 1777-1780
    • Guldberg, P.1    thor Straten, P.2    Ahrenkiel, V.3    Seremet, T.4    Kirkin, A.F.5    Zeuthen, J.6
  • 22
    • 0033676843 scopus 로고    scopus 로고
    • TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers
    • Conway K.E., McConnell B.B., Bowring C.E., Donald C.D., Warren S.T., and Vertino P.M. TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res 60 (2000) 6236-6242
    • (2000) Cancer Res , vol.60 , pp. 6236-6242
    • Conway, K.E.1    McConnell, B.B.2    Bowring, C.E.3    Donald, C.D.4    Warren, S.T.5    Vertino, P.M.6
  • 23
    • 58249112139 scopus 로고    scopus 로고
    • A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation
    • McCabe M.T., Lee E.K., and Vertino P.M. A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Res 69 (2009) 282-291
    • (2009) Cancer Res , vol.69 , pp. 282-291
    • McCabe, M.T.1    Lee, E.K.2    Vertino, P.M.3
  • 27
    • 0042355248 scopus 로고    scopus 로고
    • Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells
    • Qanungo S., Haldar S., and Basu A. Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells. Neoplasia 5 (2003) 367-374
    • (2003) Neoplasia , vol.5 , pp. 367-374
    • Qanungo, S.1    Haldar, S.2    Basu, A.3
  • 28
    • 84873769935 scopus 로고
    • Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer
    • Puck T.T., Marcus P.I., and Cieciura S.J. Clonal growth of mammalian cells in vitro; growth characteristics of colonies from single HeLa cells with and without a feeder layer. J Exp Med 103 (1956) 273-283
    • (1956) J Exp Med , vol.103 , pp. 273-283
    • Puck, T.T.1    Marcus, P.I.2    Cieciura, S.J.3
  • 29
    • 0036250811 scopus 로고    scopus 로고
    • Alu repeats and human genomic diversity
    • Batzer M.A., and Deininger P.L. Alu repeats and human genomic diversity. Nat Rev Genet 3 (2002) 370-379
    • (2002) Nat Rev Genet , vol.3 , pp. 370-379
    • Batzer, M.A.1    Deininger, P.L.2
  • 32
    • 23744493161 scopus 로고    scopus 로고
    • Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences
    • King D.C., Taylor J., Elnitski L., Chiaromonte F., Miller W., and Hardison R.C. Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences. Genome Res 15 (2005) 1051-1060
    • (2005) Genome Res , vol.15 , pp. 1051-1060
    • King, D.C.1    Taylor, J.2    Elnitski, L.3    Chiaromonte, F.4    Miller, W.5    Hardison, R.C.6
  • 33
    • 0035735265 scopus 로고    scopus 로고
    • Computational identification of promoters and first exons in the human genome
    • Davuluri R.V., Grosse I., and Zhang M.Q. Computational identification of promoters and first exons in the human genome. Nat Genet 29 (2001) 412-417
    • (2001) Nat Genet , vol.29 , pp. 412-417
    • Davuluri, R.V.1    Grosse, I.2    Zhang, M.Q.3
  • 34
    • 0036123111 scopus 로고    scopus 로고
    • Computational detection and location of transcription start sites in mammalian genomic DNA
    • Down T.A., and Hubbard T.J. Computational detection and location of transcription start sites in mammalian genomic DNA. Genome Res 12 (2002) 458-461
    • (2002) Genome Res , vol.12 , pp. 458-461
    • Down, T.A.1    Hubbard, T.J.2
  • 37
    • 31544440121 scopus 로고    scopus 로고
    • Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors
    • Korkola J.E., Houldsworth J., Chadalavada R.S., Olshen A.B., Dobrzynski D., Reuter V.E., Bosl G.J., and Chaganti R.S. Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res 66 (2006) 820-827
    • (2006) Cancer Res , vol.66 , pp. 820-827
    • Korkola, J.E.1    Houldsworth, J.2    Chadalavada, R.S.3    Olshen, A.B.4    Dobrzynski, D.5    Reuter, V.E.6    Bosl, G.J.7    Chaganti, R.S.8
  • 38
    • 0037524354 scopus 로고    scopus 로고
    • LKB1, a protein kinase regulating cell proliferation and polarity
    • Boudeau J., Sapkota G., and Alessi D.R. LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett 546 (2003) 159-165
    • (2003) FEBS Lett , vol.546 , pp. 159-165
    • Boudeau, J.1    Sapkota, G.2    Alessi, D.R.3
  • 39
    • 0033876205 scopus 로고    scopus 로고
    • Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome
    • Connolly D.C., Katabuchi H., Cliby W.A., and Cho K.R. Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome. Am J Pathol 156 (2000) 339-345
    • (2000) Am J Pathol , vol.156 , pp. 339-345
    • Connolly, D.C.1    Katabuchi, H.2    Cliby, W.A.3    Cho, K.R.4
  • 40
    • 64549095616 scopus 로고    scopus 로고
    • Mutation of PIK3CA: possible risk factor for cervical carcinogenesis in older women
    • Cui B., Zheng B., Zhang X., Stendahl U., Andersson S., and Wallin K.L. Mutation of PIK3CA: possible risk factor for cervical carcinogenesis in older women. Int J Oncol 34 (2009) 409-416
    • (2009) Int J Oncol , vol.34 , pp. 409-416
    • Cui, B.1    Zheng, B.2    Zhang, X.3    Stendahl, U.4    Andersson, S.5    Wallin, K.L.6
  • 41
    • 0036778597 scopus 로고    scopus 로고
    • The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors
    • Kolomietz E., Meyn M.S., Pandita A., and Squire J.A. The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors. Genes Chromosomes Cancer 35 (2002) 97-112
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 97-112
    • Kolomietz, E.1    Meyn, M.S.2    Pandita, A.3    Squire, J.A.4
  • 42
  • 44
    • 67349251552 scopus 로고    scopus 로고
    • Identification and characterization of a novel MLH1 genomic rearrangement as the cause of HNPCC in a Tunisian family: evidence for a homologous Alu-mediated recombination
    • Aissi-Ben Moussa S., Moussa A., Lovecchio T., Kourda N., Najjar T., Ben Jilani S., El Gaaied A., Porchet N., Manai M., and Buisine M.P. Identification and characterization of a novel MLH1 genomic rearrangement as the cause of HNPCC in a Tunisian family: evidence for a homologous Alu-mediated recombination. Fam Cancer 8 (2009) 119-126
    • (2009) Fam Cancer , vol.8 , pp. 119-126
    • Aissi-Ben Moussa, S.1    Moussa, A.2    Lovecchio, T.3    Kourda, N.4    Najjar, T.5    Ben Jilani, S.6    El Gaaied, A.7    Porchet, N.8    Manai, M.9    Buisine, M.P.10
  • 45
    • 39049177152 scopus 로고    scopus 로고
    • A whole MEN1 gene deletion flanked by Alu repeats in a family with multiple endocrine neoplasia type 1
    • Fukuuchi A., Nagamura Y., Yaguchi H., Ohkura N., Obara T., and Tsukada T. A whole MEN1 gene deletion flanked by Alu repeats in a family with multiple endocrine neoplasia type 1. Jpn J Clin Oncol 36 (2006) 739-744
    • (2006) Jpn J Clin Oncol , vol.36 , pp. 739-744
    • Fukuuchi, A.1    Nagamura, Y.2    Yaguchi, H.3    Ohkura, N.4    Obara, T.5    Tsukada, T.6
  • 46
    • 14644435051 scopus 로고    scopus 로고
    • A multi-exonic BRCA1 deletion identified in multiple families through single nucleotide polymorphism haplotype pair analysis and gene amplification with widely dispersed primer sets
    • Ward B.D., Hendrickson B.C., Judkins T., Deffenbaugh A.M., Leclair B., Ward B.E., and Scholl T. A multi-exonic BRCA1 deletion identified in multiple families through single nucleotide polymorphism haplotype pair analysis and gene amplification with widely dispersed primer sets. J Mol Diagn 7 (2005) 139-142
    • (2005) J Mol Diagn , vol.7 , pp. 139-142
    • Ward, B.D.1    Hendrickson, B.C.2    Judkins, T.3    Deffenbaugh, A.M.4    Leclair, B.5    Ward, B.E.6    Scholl, T.7
  • 48
    • 26944433502 scopus 로고    scopus 로고
    • High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma
    • Hsieh S.Y., Chen W.Y., Yeh T.S., Sheen I.S., and Huang S.F. High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. Oncogene 24 (2005) 6584-6589
    • (2005) Oncogene , vol.24 , pp. 6584-6589
    • Hsieh, S.Y.1    Chen, W.Y.2    Yeh, T.S.3    Sheen, I.S.4    Huang, S.F.5
  • 49
    • 0033728855 scopus 로고    scopus 로고
    • Characterisation of six large deletions in TSC2 identified using long range PCR suggests diverse mechanisms including Alu mediated recombination
    • Dabora S.L., Nieto A.A., Franz D., Jozwiak S., Van Den Ouweland A., and Kwiatkowski D.J. Characterisation of six large deletions in TSC2 identified using long range PCR suggests diverse mechanisms including Alu mediated recombination. J Med Genet 37 (2000) 877-883
    • (2000) J Med Genet , vol.37 , pp. 877-883
    • Dabora, S.L.1    Nieto, A.A.2    Franz, D.3    Jozwiak, S.4    Van Den Ouweland, A.5    Kwiatkowski, D.J.6
  • 55
    • 0035980097 scopus 로고    scopus 로고
    • LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest
    • Marignani P.A., Kanai F., and Carpenter C.L. LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. J Biol Chem 276 (2001) 32415-32418
    • (2001) J Biol Chem , vol.276 , pp. 32415-32418
    • Marignani, P.A.1    Kanai, F.2    Carpenter, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.