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Volumn 6, Issue 6, 2004, Pages 611-623

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ONYX 015; PROTEIN P53; VIRUS RNA;

EID: 19944363519     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2004.11.012     Document Type: Article
Times cited : (314)

References (66)
  • 1
    • 0030916736 scopus 로고    scopus 로고
    • The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10
    • Arai Y., Hosoda F., Kobayashi H., Arai K., Hayashi Y., Kamada N., Kaneko Y., Ohki M. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. Blood. 89:1997;3936-3944
    • (1997) Blood , vol.89 , pp. 3936-3944
    • Arai, Y.1    Hosoda, F.2    Kobayashi, H.3    Arai, K.4    Hayashi, Y.5    Kamada, N.6    Kaneko, Y.7    Ohki, M.8
  • 3
    • 0022263759 scopus 로고
    • Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport
    • Babiss L.E., Ginsberg H.S., Darnell J.E. Jr. Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol. Cell. Biol. 5:1985;2552-2558
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 2552-2558
    • Babiss, L.E.1    Ginsberg, H.S.2    Darnell Jr., J.E.3
  • 4
    • 0023099280 scopus 로고
    • Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection
    • Barker D.D., Berk A.J. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology. 156:1987;107-121
    • (1987) Virology , vol.156 , pp. 107-121
    • Barker, D.D.1    Berk, A.J.2
  • 5
    • 0036655060 scopus 로고    scopus 로고
    • Alternative and aberrant splicing of MDM2 mRNA in human cancer
    • Bartel F., Taubert H., Harris L.C. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell. 2:2002;9-15
    • (2002) Cancer Cell , vol.2 , pp. 9-15
    • Bartel, F.1    Taubert, H.2    Harris, L.C.3
  • 7
    • 0031935821 scopus 로고    scopus 로고
    • Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis
    • Boer J., Bonten-Surtel J., Grosveld G. Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. Mol. Cell. Biol. 18:1998;1236-1247
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1236-1247
    • Boer, J.1    Bonten-Surtel, J.2    Grosveld, G.3
  • 8
    • 0020405893 scopus 로고
    • Assembly of adenovirus major capsid protein is mediated by a nonvirion protein
    • Cepko C.L., Sharp P.A. Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 31:1982;407-415
    • (1982) Cell , vol.31 , pp. 407-415
    • Cepko, C.L.1    Sharp, P.A.2
  • 9
    • 0034665461 scopus 로고    scopus 로고
    • P53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
    • Chao C., Saito S., Kang J., Anderson C.W., Appella E., Xu Y. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J. 19:2000;4967-4975
    • (2000) EMBO J. , vol.19 , pp. 4967-4975
    • Chao, C.1    Saito, S.2    Kang, J.3    Anderson, C.W.4    Appella, E.5    Xu, Y.6
  • 10
    • 0030945245 scopus 로고    scopus 로고
    • P300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis
    • Chiou S.K., White E. p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis. J. Virol. 71:1997;3515-3525
    • (1997) J. Virol. , vol.71 , pp. 3515-3525
    • Chiou, S.K.1    White, E.2
  • 12
    • 0034600839 scopus 로고    scopus 로고
    • Adenovirus-specific translation by displacement of kinase Mnk1 from cap- initiation complex eIF4F
    • Cuesta R., Xi Q., Schneider R.J. Adenovirus-specific translation by displacement of kinase Mnk1 from cap- initiation complex eIF4F. EMBO J. 19:2000;3465-3474
    • (2000) EMBO J. , vol.19 , pp. 3465-3474
    • Cuesta, R.1    Xi, Q.2    Schneider, R.J.3
  • 13
    • 0023114593 scopus 로고
    • Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells
    • Cutt J.R., Shenk T., Hearing P. Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells. J. Virol. 61:1987;543-552
    • (1987) J. Virol. , vol.61 , pp. 543-552
    • Cutt, J.R.1    Shenk, T.2    Hearing, P.3
  • 14
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas M., White E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7:1993;546-554
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 15
    • 0030001373 scopus 로고    scopus 로고
    • Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
    • Dobner T., Horikoshi N., Rubenwolf S., Shenk T. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science. 272:1996;1470-1473
    • (1996) Science , vol.272 , pp. 1470-1473
    • Dobner, T.1    Horikoshi, N.2    Rubenwolf, S.3    Shenk, T.4
  • 16
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • Espinosa J.M., Emerson B.M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell. 8:2001;57-69
    • (2001) Mol. Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 17
    • 0842304525 scopus 로고    scopus 로고
    • Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products
    • Farley D.C., Brown J.L., Leppard K.N. Activation of the early-late switch in adenovirus type 5 major late transcription unit expression by L4 gene products. J. Virol. 78:2004;1782-1791
    • (2004) J. Virol. , vol.78 , pp. 1782-1791
    • Farley, D.C.1    Brown, J.L.2    Leppard, K.N.3
  • 18
    • 0036278859 scopus 로고    scopus 로고
    • Gene quantification using real-time quantitative PCR: An emerging technology hits the mainstream
    • Ginzinger D.G. Gene quantification using real-time quantitative PCR. An emerging technology hits the mainstream Exp. Hematol. 30:2002;503-512
    • (2002) Exp. Hematol. , vol.30 , pp. 503-512
    • Ginzinger, D.G.1
  • 19
    • 0036226061 scopus 로고    scopus 로고
    • Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism
    • Gonzalez R.A., Flint S.J. Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism. J. Virol. 76:2002;4507-4519
    • (2002) J. Virol. , vol.76 , pp. 4507-4519
    • Gonzalez, R.A.1    Flint, S.J.2
  • 20
    • 0031798440 scopus 로고    scopus 로고
    • P53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
    • Goodrum F.D., Ornelles D.A. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection. J. Virol. 72:1998;9479-9490
    • (1998) J. Virol. , vol.72 , pp. 9479-9490
    • Goodrum, F.D.1    Ornelles, D.A.2
  • 21
    • 0032838679 scopus 로고    scopus 로고
    • Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication
    • Goodrum F.D., Ornelles D.A. Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication. J. Virol. 73:1999;7474-7488
    • (1999) J. Virol. , vol.73 , pp. 7474-7488
    • Goodrum, F.D.1    Ornelles, D.A.2
  • 22
    • 0029840632 scopus 로고    scopus 로고
    • Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells
    • Goodrum F.D., Shenk T., Ornelles D.A. Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells. J. Virol. 70:1996;6323-6335
    • (1996) J. Virol. , vol.70 , pp. 6323-6335
    • Goodrum, F.D.1    Shenk, T.2    Ornelles, D.A.3
  • 23
    • 0022381043 scopus 로고
    • Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff
    • Halbert D.N., Cutt J.R., Shenk T. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56:1985;250-257
    • (1985) J. Virol. , vol.56 , pp. 250-257
    • Halbert, D.N.1    Cutt, J.R.2    Shenk, T.3
  • 24
    • 0031697770 scopus 로고    scopus 로고
    • P53-dependent cell death/apoptosis is required for a productive adenovirus infection
    • Hall A.R., Dix B.R., O'Carroll S.J., Braithwaite A.W. p53-dependent cell death/apoptosis is required for a productive adenovirus infection. Nat. Med. 4:1998;1068-1072
    • (1998) Nat. Med. , vol.4 , pp. 1068-1072
    • Hall, A.R.1    Dix, B.R.2    O'Carroll, S.J.3    Braithwaite, A.W.4
  • 25
    • 0142092408 scopus 로고    scopus 로고
    • Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants
    • Hann B., Balmain A. Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants. J. Virol. 77:2003;11588-11595
    • (2003) J. Virol. , vol.77 , pp. 11588-11595
    • Hann, B.1    Balmain, A.2
  • 26
    • 0033022039 scopus 로고    scopus 로고
    • P53-independent and -dependent requirements for E1B-55K in adenovirus type 5 replication
    • Harada J.N., Berk A.J. p53-independent and -dependent requirements for E1B-55K in adenovirus type 5 replication. J. Virol. 73:1999;5333-5344
    • (1999) J. Virol. , vol.73 , pp. 5333-5344
    • Harada, J.N.1    Berk, A.J.2
  • 27
    • 0036720983 scopus 로고    scopus 로고
    • Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery
    • Harada J.N., Shevchenko A., Pallas D.C., Berk A.J. Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery. J. Virol. 76:2002;9194-9206
    • (2002) J. Virol. , vol.76 , pp. 9194-9206
    • Harada, J.N.1    Shevchenko, A.2    Pallas, D.C.3    Berk, A.J.4
  • 28
    • 0025359592 scopus 로고
    • The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species
    • Hayes B.W., Telling G.C., Myat M.M., Williams J.F., Flint S.J. The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species. J. Virol. 64:1990;2732-2742
    • (1990) J. Virol. , vol.64 , pp. 2732-2742
    • Hayes, B.W.1    Telling, G.C.2    Myat, M.M.3    Williams, J.F.4    Flint, S.J.5
  • 29
    • 0031985777 scopus 로고    scopus 로고
    • The tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export
    • Huang W., Flint S.J. The tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export. J. Virol. 72:1998;225-235
    • (1998) J. Virol. , vol.72 , pp. 225-235
    • Huang, W.1    Flint, S.J.2
  • 30
    • 0025857246 scopus 로고
    • Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein
    • Huang J.T., Schneider R.J. Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein. Cell. 65:1991;271-280
    • (1991) Cell , vol.65 , pp. 271-280
    • Huang, J.T.1    Schneider, R.J.2
  • 33
    • 0033831080 scopus 로고    scopus 로고
    • A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
    • Khuri F.R., Nemunaitis J., Ganly I., Arseneau J., Tannock I.F., Romel L., Gore M., Ironside J., MacDougall R.H., Heise C., et al. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat. Med. 6:2000;879-885
    • (2000) Nat. Med. , vol.6 , pp. 879-885
    • Khuri, F.R.1    Nemunaitis, J.2    Ganly, I.3    Arseneau, J.4    Tannock, I.F.5    Romel, L.6    Gore, M.7    Ironside, J.8    MacDougall, R.H.9    Heise, C.10
  • 34
    • 0035346819 scopus 로고    scopus 로고
    • Oncolytic virotherapy for cancer with the adenovirus dl1520 (ONYX-015) Results of phase I and II trials
    • Kirn D. Oncolytic virotherapy for cancer with the adenovirus dl1520 (ONYX-015). Results of phase I and II trials Expert Opin. Biol. Ther. 1:2001;525-538
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 525-538
    • Kirn, D.1
  • 35
    • 0034677567 scopus 로고    scopus 로고
    • The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2
    • Kratzer F., Rosorius O., Heger P., Hirschmann N., Dobner T., Hauber J., Stauber R.H. The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2. Oncogene. 19:2000;850-857
    • (2000) Oncogene , vol.19 , pp. 850-857
    • Kratzer, F.1    Rosorius, O.2    Heger, P.3    Hirschmann, N.4    Dobner, T.5    Hauber, J.6    Stauber, R.H.7
  • 36
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40-transformed cells
    • Lane D.P., Crawford L.V. T antigen is bound to a host protein in SV40-transformed cells. Nature. 278:1979;261-263
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 37
    • 0024456615 scopus 로고
    • The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism
    • Leppard K.N., Shenk T. The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO J. 8:1989;2329-2336
    • (1989) EMBO J. , vol.8 , pp. 2329-2336
    • Leppard, K.N.1    Shenk, T.2
  • 38
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 39
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer D.I., Levine A.J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 17:1979;43-52
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.1    Levine, A.J.2
  • 40
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:2001;402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 41
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
    • Lowe S.W., Ruley H.E. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7:1993;535-545
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 42
    • 1542646349 scopus 로고    scopus 로고
    • Cancer-specific viruses and the development of ONYX-015
    • McCormick F. Cancer-specific viruses and the development of ONYX-015. Cancer Biol. Ther. 2:2003;S157-S160
    • (2003) Cancer Biol. Ther. , vol.2
    • McCormick, F.1
  • 44
    • 0022446817 scopus 로고
    • Hexon trimerization occurring in an assembly-defective, 100K temperature-sensitive mutant of adenovirus 2
    • Morin N., Boulanger P. Hexon trimerization occurring in an assembly-defective, 100K temperature-sensitive mutant of adenovirus 2. Virology. 152:1986;11-31
    • (1986) Virology , vol.152 , pp. 11-31
    • Morin, N.1    Boulanger, P.2
  • 46
    • 0033693231 scopus 로고    scopus 로고
    • Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: A phase II trial
    • Nemunaitis J., Ganly I., Khuri F., Arseneau J., Kuhn J., McCarty T., Landers S., Maples P., Romel L., Randlev B., et al. Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer. A phase II trial Cancer Res. 60:2000;6359-6366
    • (2000) Cancer Res. , vol.60 , pp. 6359-6366
    • Nemunaitis, J.1    Ganly, I.2    Khuri, F.3    Arseneau, J.4    Kuhn, J.5    McCarty, T.6    Landers, S.7    Maples, P.8    Romel, L.9    Randlev, B.10
  • 47
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53. Life, death and cancer Cell Death Differ. 10:2003;431-442
    • (2003) Cell Death Differ. , vol.10 , pp. 431-442
    • Oren, M.1
  • 48
    • 0036147328 scopus 로고    scopus 로고
    • E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein
    • Orlando J.S., Ornelles D.A. E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein. J. Virol. 76:2002;1475-1487
    • (2002) J. Virol. , vol.76 , pp. 1475-1487
    • Orlando, J.S.1    Ornelles, D.A.2
  • 49
    • 0022622023 scopus 로고
    • The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs
    • Pilder S., Moore M., Logan J., Shenk T. The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol. Cell. Biol. 6:1986;470-476
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 470-476
    • Pilder, S.1    Moore, M.2    Logan, J.3    Shenk, T.4
  • 52
    • 0035974901 scopus 로고    scopus 로고
    • Virus-mediated killing of cells that lack p53 activity
    • Raj K., Ogston P., Beard P. Virus-mediated killing of cells that lack p53 activity. Nature. 412:2001;914-917
    • (2001) Nature , vol.412 , pp. 914-917
    • Raj, K.1    Ogston, P.2    Beard, P.3
  • 53
    • 0036828125 scopus 로고    scopus 로고
    • Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520) Phase II viral, immunologic, and clinical endpoints
    • Reid T., Galanis E., Abbruzzese J., Sze D., Wein L.M., Andrews J., Randlev B., Heise C., Uprichard M., Hatfield M., et al. Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520). Phase II viral, immunologic, and clinical endpoints Cancer Res. 62:2002;6070-6079
    • (2002) Cancer Res. , vol.62 , pp. 6070-6079
    • Reid, T.1    Galanis, E.2    Abbruzzese, J.3    Sze, D.4    Wein, L.M.5    Andrews, J.6    Randlev, B.7    Heise, C.8    Uprichard, M.9    Hatfield, M.10
  • 54
    • 0037033736 scopus 로고    scopus 로고
    • ONYX-015: Mechanisms of action and clinical potential of a replication-selective adenovirus
    • Ries S., Korn W.M. ONYX-015. Mechanisms of action and clinical potential of a replication-selective adenovirus Br. J. Cancer. 86:2002;5-11
    • (2002) Br. J. Cancer , vol.86 , pp. 5-11
    • Ries, S.1    Korn, W.M.2
  • 56
    • 0031743945 scopus 로고    scopus 로고
    • Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
    • Rothmann T., Hengstermann A., Whitaker N.J., Scheffner M., zur Hausen H. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells. J. Virol. 72:1998;9470-9478
    • (1998) J. Virol. , vol.72 , pp. 9470-9478
    • Rothmann, T.1    Hengstermann, A.2    Whitaker, N.J.3    Scheffner, M.4    Zur Hausen, H.5
  • 58
    • 0035050154 scopus 로고    scopus 로고
    • Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein
    • Shen Y., Kitzes G., Nye J.A., Fattaey A., Hermiston T. Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K protein. J. Virol. 75:2001;4297-4307
    • (2001) J. Virol. , vol.75 , pp. 4297-4307
    • Shen, Y.1    Kitzes, G.2    Nye, J.A.3    Fattaey, A.4    Hermiston, T.5
  • 59
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr C.J., McCormick F. The RB and p53 pathways in cancer. Cancer Cell. 2:2002;103-112
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 60
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
    • Shieh S.Y., Ahn J., Tamai K., Taya Y., Prives C. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14:2000;289-300
    • (2000) Genes Dev. , vol.14 , pp. 289-300
    • Shieh, S.Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 61
    • 0037130170 scopus 로고    scopus 로고
    • Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
    • Stracker T.H., Carson C.T., Weitzman M.D. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature. 418:2002;348-352
    • (2002) Nature , vol.418 , pp. 348-352
    • Stracker, T.H.1    Carson, C.T.2    Weitzman, M.D.3
  • 62
    • 0032127947 scopus 로고    scopus 로고
    • Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function
    • Thomas A., White E. Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function. Genes Dev. 12:1998;1975-1985
    • (1998) Genes Dev. , vol.12 , pp. 1975-1985
    • Thomas, A.1    White, E.2
  • 63
    • 0033011866 scopus 로고    scopus 로고
    • The replicative capacities of large E1B-null group a and group C adenoviruses are independent of host cell p53 status
    • Turnell A.S., Grand R.J., Gallimore P.H. The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status. J. Virol. 73:1999;2074-2083
    • (1999) J. Virol. , vol.73 , pp. 2074-2083
    • Turnell, A.S.1    Grand, R.J.2    Gallimore, P.H.3
  • 64
    • 0026049728 scopus 로고
    • Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins
    • White E., Cipriani R., Sabbatini P., Denton A. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins. J. Virol. 65:1991;2968-2978
    • (1991) J. Virol. , vol.65 , pp. 2968-2978
    • White, E.1    Cipriani, R.2    Sabbatini, P.3    Denton, A.4
  • 66
    • 0029785142 scopus 로고    scopus 로고
    • Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells
    • Yueh A., Schneider R.J. Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells. Genes Dev. 10:1996;1557-1567
    • (1996) Genes Dev. , vol.10 , pp. 1557-1567
    • Yueh, A.1    Schneider, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.