LKB1 regulated pathways in lung cancer invasion and metastasis

Journal of Thoracic Oncology

Volumn 5, Issue 12, 2010, Pages 1883-1886

  Marcus, Adam I ^a   Zhou, Wei ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adhesion; AMPK; Anoikis; cdc42; Energy; FAK; Invasion; LKB1; Lung cancer; Metastasis; Motility; NSCLC; PAK1; Polarity; STK11

Indexed keywords

ADENYLATE KINASE; METFORMIN; MYOSIN; MYOSIN LIGHT CHAIN; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANOIKIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INVASION; CELL ADHESION; CELL POLARITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE FUNCTION; GENE MUTATION; HUMAN; LUNG METASTASIS; LUNG NON SMALL CELL CANCER; METASTASIS; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR SUPPRESSOR GENE;

AMP-ACTIVATED PROTEIN KINASES; ANOIKIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL POLARITY; HUMANS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 78650465738     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181fbc28a     Document Type: Article

References (48)

1. Carretero J, Medina PP, Pio R, et al. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 2004;23:4037-4040. (Pubitemid 38747933)
2. Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-1075.
3. Sanchez-Cespedes M, Parrella P, Esteller M, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002;62:3659-3662. (Pubitemid 34728843)
4. Jenne DE, Reimann H, Nezu J, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 1998;18:38-43. (Pubitemid 28027876)
5. Alessi DR, Sakamoto K, Bayascas JR. LKB1-dependent signaling pathways. Annu Rev Biochem 2006;75:137-163. (Pubitemid 44118029)
6. Boudeau J, Scott JW, Resta N, et al. Analysis of the LKB1-STRADMO25 complex. J Cell Sci 2004;117:6365-6375.
7. Zeqiraj E, Filippi BM, Deak M, et al. Structure of the LKB1-STRADMO25 complex reveals an allosteric mechanism of kinase activation. Science 2009;326:1707-1711.
8. Lizcano JM, Goransson O, Toth R, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 2004;23:833-843. (Pubitemid 38418750)
9. Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 1998;67:821-855. (Pubitemid 28411146)
10. Mu J, Brozinick JT Jr, Valladares O, et al. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell 2001;7:1085-1094. (Pubitemid 32525754)
11. Hawley SA, Davison M, Woods A, et al. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMPactivated protein kinase. J Biol Chem 1996;271:27879-27887. (Pubitemid 26367365)
12. Stein SC, Woods A, Jones NA, et al. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 2000;345:437-443. (Pubitemid 30099070)
13. Hawley SA, Boudeau J, Reid JL, et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003;2:28. (Pubitemid 37464489)
14. Moller DE. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 2001;414:821-827.
15. Shaw RJ, Kosmatka M, Bardeesy N, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004;101:3329-3335. (Pubitemid 38338195)
16. Ji H, Ramsey MR, Hayes DN, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007;448:807-810. (Pubitemid 47266337)
17. Baas AF, Kuipers J, van der Wel NN, et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 2004;116:457-466. (Pubitemid 38366321)
18. Mirouse V, Swick LL, Kazgan N, et al. LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol 2007;177:387-392. (Pubitemid 46718268)
19. Zhang L, Li J, Young LH, et al. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA 2006;103:17272-17277. (Pubitemid 44788959)
20. Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci USA 2007;104:819-822. (Pubitemid 46154694)
21. Lillie FR. The Development of the Chick. New York: H. Holt and company, 1908.
22. Huber MA, Kraut N, Beug H. Molecular requirements for epithelialmesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17:548-558. (Pubitemid 41267170)
23. Thiery JP. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003;15:740-746.
24. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-454.
25. Roy BC, Kohno T, Iwakawa R, et al. Involvement of LKB1 in epithelialmesenchymal transition (EMT) of human lung cancer cells. Lung Cancer. In press.
26. Etienne-Manneville S. Cdc42-the centre of polarity. J Cell Sci 2004; 117:1291-1300.
27. Zhang S, Schafer-Hales K, Khuri FR, et al. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 2008;68:740-748. (Pubitemid 351206750)
28. Deguchi A, Miyoshi H, Kojima Y, et al. LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain. J Biol Chem 2010;285:18283-18290.
29. Nakano A, Kato H, Watanabe T, et al. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol 2010;12:583-590.
30. Marignani PA, Kanai F, Carpenter CL. LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. J Biol Chem 2001;276: 32415-32418. (Pubitemid 37384677)
31. Tiainen M, Vaahtomeri K, Ylikorkala A, et al. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet 2002;11:1497-1504. (Pubitemid 34679250)
32. Upadhyay S, Liu C, Chatterjee A, et al. LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. Cancer Res 2006;66:7870-7879. (Pubitemid 44299149)
33. Bungard D, Fuerth BJ, Zeng PY, et al. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010;329:1201-1205.
34. Kim MJ, Park IJ, Yun H, et al. AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma. J Biol Chem 2010;285:14617-14627.
35. Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 2008;27:253-261.
36. Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005;6:56-68.
37. Carretero J, Shimamura T, Rikova K, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell 2010;17:547-559.
38. Schaller MD, Borgman CA, Cobb BS, et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 1992;89:5192-5196.
39. Tilghman RW, Slack-Davis JK, Sergina N, et al. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci 2005;118:2613-2623. (Pubitemid 40932887)
40. Zagorska A, Deak M, Campbell DG, et al. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal 2010;3:ra25.
41. Webb DJ, Donais K, Whitmore LA, et al. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 2004;6:154-161. (Pubitemid 38425715)
42. Rennebeck G, Martelli M, Kyprianou N. Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis? Cancer Res 2005;65:11230-11235. (Pubitemid 41821673)
43. Frisch SM, Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol 2001;13:555-562.
44. Cheng H, Liu P, Wang ZC, et al. SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. Sci Signal 2009;2:ra35.
45. Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, et al. Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 9:1092-1099.
46. Gonzalez-Angulo AM, Meric-Bernstam F. Metformin: a therapeutic opportunity in breast cancer. Clin Cancer Res 2010;16:1695-1700.
47. Hadad SM, Fleming S, Thompson AM. Targeting AMPK: a new therapeutic opportunity in breast cancer. Crit Rev Oncol Hematol 2008;67:1-7.
48. Memmott RM, Gills JJ, Hollingshead M, et al. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. Cancer Res 2008;68:580-588. (Pubitemid 351380087)