-
1
-
-
0029156599
-
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
-
Hartley K.O., Gell D., Smith G.C., Zhang H., Divecha N., Connelly M.A., Admon A., Lees-Miller S.P., Anderson C.W., Jackson S.P. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 1995, 82:849-856.
-
(1995)
Cell
, vol.82
, pp. 849-856
-
-
Hartley, K.O.1
Gell, D.2
Smith, G.C.3
Zhang, H.4
Divecha, N.5
Connelly, M.A.6
Admon, A.7
Lees-Miller, S.P.8
Anderson, C.W.9
Jackson, S.P.10
-
3
-
-
0031607707
-
DNA breakage and repair
-
Jeggo P.A. DNA breakage and repair. Adv. Genet. 1998, 38:185-218.
-
(1998)
Adv. Genet.
, vol.38
, pp. 185-218
-
-
Jeggo, P.A.1
-
4
-
-
0033560796
-
The DNA-dependent protein kinase
-
Smith G.C., Jackson S.P. The DNA-dependent protein kinase. Genes Dev. 1999, 13:916-934.
-
(1999)
Genes Dev.
, vol.13
, pp. 916-934
-
-
Smith, G.C.1
Jackson, S.P.2
-
5
-
-
0942268167
-
Repair of DNA double strand breaks by non-homologous end joining
-
Lees-Miller S.P., Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 2003, 85:1161-1173.
-
(2003)
Biochimie
, vol.85
, pp. 1161-1173
-
-
Lees-Miller, S.P.1
Meek, K.2
-
6
-
-
0029827367
-
The Schizosaccharomyces pombe rad3 checkpoint gene
-
Bentley N.J., Holtzman D.A., Flaggs G., Keegan K.S., DeMaggio A., Ford J.C., Hoekstra M., Carr A.M. The Schizosaccharomyces pombe rad3 checkpoint gene. EMBO J. 1996, 15:6641-6651.
-
(1996)
EMBO J.
, vol.15
, pp. 6641-6651
-
-
Bentley, N.J.1
Holtzman, D.A.2
Flaggs, G.3
Keegan, K.S.4
DeMaggio, A.5
Ford, J.C.6
Hoekstra, M.7
Carr, A.M.8
-
7
-
-
0032472330
-
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
-
Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., Friend S.H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 1998, 17:159-169.
-
(1998)
EMBO J.
, vol.17
, pp. 159-169
-
-
Cliby, W.A.1
Roberts, C.J.2
Cimprich, K.A.3
Stringer, C.M.4
Lamb, J.R.5
Schreiber, S.L.6
Friend, S.H.7
-
8
-
-
3242882820
-
PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways
-
Abraham R.T. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst) 2004, 3:883-887.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 883-887
-
-
Abraham, R.T.1
-
9
-
-
0035282062
-
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization
-
Warden S.M., Richardson C., O'Donnell J., Stapleton D., Kemp B.E., Witters L.A. Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem. J. 2001, 354:275-283.
-
(2001)
Biochem. J.
, vol.354
, pp. 275-283
-
-
Warden, S.M.1
Richardson, C.2
O'Donnell, J.3
Stapleton, D.4
Kemp, B.E.5
Witters, L.A.6
-
10
-
-
0030870168
-
Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit
-
Mitchelhill K.I., Michell B.J., House C.M., Stapleton D., Dyck J., Gamble J., Ullrich C., Witters L.A., Kemp B.E. Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit. J. Biol. Chem. 1997, 272:24475-24479.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24475-24479
-
-
Mitchelhill, K.I.1
Michell, B.J.2
House, C.M.3
Stapleton, D.4
Dyck, J.5
Gamble, J.6
Ullrich, C.7
Witters, L.A.8
Kemp, B.E.9
-
11
-
-
0032567252
-
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase
-
Crute B.E., Seefeld K., Gamble J., Kemp B.E., Witters L.A. Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J. Biol. Chem. 1998, 273:35347-35354.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35347-35354
-
-
Crute, B.E.1
Seefeld, K.2
Gamble, J.3
Kemp, B.E.4
Witters, L.A.5
-
12
-
-
0037799908
-
AMPK beta subunit targets metabolic stress sensing to glycogen
-
Polekhina G., Gupta A., Michell B.J., van Denderen B., Murthy S., Feil S.C., Jennings I.G., Campbell D.J., Witters L.A., Parker M.W., Kemp B.E., Stapleton D. AMPK beta subunit targets metabolic stress sensing to glycogen. Curr. Biol. 2003, 13:867-871.
-
(2003)
Curr. Biol.
, vol.13
, pp. 867-871
-
-
Polekhina, G.1
Gupta, A.2
Michell, B.J.3
van Denderen, B.4
Murthy, S.5
Feil, S.C.6
Jennings, I.G.7
Campbell, D.J.8
Witters, L.A.9
Parker, M.W.10
Kemp, B.E.11
Stapleton, D.12
-
13
-
-
33745815985
-
AMP-activated protein kinase signaling in metabolic regulation
-
Long Y.C., Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J. Clin. Invest. 2006, 116:1776-1783.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1776-1783
-
-
Long, Y.C.1
Zierath, J.R.2
-
15
-
-
0033560109
-
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge
-
Hardie D.G., Salt I.P., Hawley S.A., Davies S.P. AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem. J. 1999, 338(Pt 3):717-722.
-
(1999)
Biochem. J.
, vol.338
, Issue.PART 3
, pp. 717-722
-
-
Hardie, D.G.1
Salt, I.P.2
Hawley, S.A.3
Davies, S.P.4
-
16
-
-
85047691317
-
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
-
Scott J.W., Hawley S.A., Green K.A., Anis M., Stewart G., Scullion G.A., Norman D.G., Hardie D.G. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 2004, 113:274-284.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 274-284
-
-
Scott, J.W.1
Hawley, S.A.2
Green, K.A.3
Anis, M.4
Stewart, G.5
Scullion, G.A.6
Norman, D.G.7
Hardie, D.G.8
-
17
-
-
0035542970
-
AMP-activated protein kinase: the energy charge hypothesis revisited
-
Hardie D.G., Hawley S.A. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 2001, 23:1112-1119.
-
(2001)
Bioessays
, vol.23
, pp. 1112-1119
-
-
Hardie, D.G.1
Hawley, S.A.2
-
18
-
-
15044358594
-
New roles for the LKB1->AMPK pathway
-
Hardie D.G. New roles for the LKB1->AMPK pathway. Curr. Opin. Cell Biol. 2005, 17:167-173.
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 167-173
-
-
Hardie, D.G.1
-
19
-
-
20844451123
-
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005, 1:15-25.
-
(2005)
Cell Metab.
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
20
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley S.A., Boudeau J., Reid J.L., Mustard K.J., Udd L., Makela T.P., Alessi D.R., Hardie D.G. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2003, 2:28.
-
(2003)
J. Biol.
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
21
-
-
0041305909
-
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
-
Hong S.P., Leiper F.C., Woods A., Carling D., Carlson M. Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:8839-8843.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 8839-8843
-
-
Hong, S.P.1
Leiper, F.C.2
Woods, A.3
Carling, D.4
Carlson, M.5
-
22
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw R.J., Kosmatka M., Bardeesy N., Hurley R.L., Witters L.A., DePinho R.A., Cantley L.C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:3329-3335.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
23
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A., Johnstone S.R., Dickerson K., Leiper F.C., Fryer L.G., Neumann D., Schlattner U., Wallimann T., Carlson M., Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol. 2003, 13:2004-2008.
-
(2003)
Curr. Biol.
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
24
-
-
23044432463
-
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
-
Hawley S.A., Pan D.A., Mustard K.J., Ross L., Bain J., Edelman A.M., Frenguelli B.G., Hardie D.G. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005, 2:9-19.
-
(2005)
Cell Metab.
, vol.2
, pp. 9-19
-
-
Hawley, S.A.1
Pan, D.A.2
Mustard, K.J.3
Ross, L.4
Bain, J.5
Edelman, A.M.6
Frenguelli, B.G.7
Hardie, D.G.8
-
25
-
-
23844471263
-
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
-
Hurley R.L., Anderson K.A., Franzone J.M., Kemp B.E., Means A.R., Witters L.A. The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J. Biol. Chem. 2005, 280:29060-29066.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29060-29066
-
-
Hurley, R.L.1
Anderson, K.A.2
Franzone, J.M.3
Kemp, B.E.4
Means, A.R.5
Witters, L.A.6
-
26
-
-
23044437445
-
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
-
Woods A., Dickerson K., Heath R., Hong S.P., Momcilovic M., Johnstone S.R., Carlson M., Carling D. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2005, 2:21-33.
-
(2005)
Cell Metab.
, vol.2
, pp. 21-33
-
-
Woods, A.1
Dickerson, K.2
Heath, R.3
Hong, S.P.4
Momcilovic, M.5
Johnstone, S.R.6
Carlson, M.7
Carling, D.8
-
27
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano J.M., Goransson O., Toth R., Deak M., Morrice N.A., Boudeau J., Hawley S.A., Udd L., Makela T.P., Hardie D.G., Alessi D.R. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004, 23:833-843.
-
(2004)
EMBO J.
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
28
-
-
17144474893
-
Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
-
Sakamoto K., Goransson O., Hardie D.G., Alessi D.R. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E310-E317.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
, vol.287
-
-
Sakamoto, K.1
Goransson, O.2
Hardie, D.G.3
Alessi, D.R.4
-
29
-
-
0037067666
-
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
-
Fryer L.G., Parbu-Patel A., Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem. 2002, 277:25226-25232.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25226-25232
-
-
Fryer, L.G.1
Parbu-Patel, A.2
Carling, D.3
-
30
-
-
0024839973
-
Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay
-
Davies S.P., Carling D., Hardie D.G. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur. J. Biochem. 1989, 186:123-128.
-
(1989)
Eur. J. Biochem.
, vol.186
, pp. 123-128
-
-
Davies, S.P.1
Carling, D.2
Hardie, D.G.3
-
31
-
-
33745225026
-
AMP-activated protein kinase-development of the energy sensor concept
-
Hardie D.G., Hawley S.A., Scott J.W. AMP-activated protein kinase-development of the energy sensor concept. J. Physiol. 2006, 574:7-15.
-
(2006)
J. Physiol.
, vol.574
, pp. 7-15
-
-
Hardie, D.G.1
Hawley, S.A.2
Scott, J.W.3
-
32
-
-
79960346497
-
AMPK regulates metabolism and survival in response to ionizing radiation
-
Zannella V.E., Cojocari D., Hilgendorf S., Vellanki R.N., Chung S., Wouters B.G., Koritzinsky M. AMPK regulates metabolism and survival in response to ionizing radiation. Radiother. Oncol. 2011, 99:293-299.
-
(2011)
Radiother. Oncol.
, vol.99
, pp. 293-299
-
-
Zannella, V.E.1
Cojocari, D.2
Hilgendorf, S.3
Vellanki, R.N.4
Chung, S.5
Wouters, B.G.6
Koritzinsky, M.7
-
33
-
-
57649231164
-
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes
-
Cao C., Lu S., Kivlin R., Wallin B., Card E., Bagdasarian A., Tamakloe T., Chu W.M., Guan K.L., Wan Y. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J. Biol. Chem. 2008, 283:28897-28908.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 28897-28908
-
-
Cao, C.1
Lu, S.2
Kivlin, R.3
Wallin, B.4
Card, E.5
Bagdasarian, A.6
Tamakloe, T.7
Chu, W.M.8
Guan, K.L.9
Wan, Y.10
-
34
-
-
5444239709
-
IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner
-
Suzuki A., Kusakai G., Kishimoto A., Shimojo Y., Ogura T., Lavin M.F., Esumi H. IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. Biochem. Biophys. Res. Commun. 2004, 324:986-992.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.324
, pp. 986-992
-
-
Suzuki, A.1
Kusakai, G.2
Kishimoto, A.3
Shimojo, Y.4
Ogura, T.5
Lavin, M.F.6
Esumi, H.7
-
35
-
-
35548999608
-
AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner
-
Sun Y., Connors K.E., Yang D.Q. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner. Mol. Cell. Biochem. 2007, 306:239-245.
-
(2007)
Mol. Cell. Biochem.
, vol.306
, pp. 239-245
-
-
Sun, Y.1
Connors, K.E.2
Yang, D.Q.3
-
36
-
-
10944247187
-
The AMP-activated protein kinase pathway-new players upstream and downstream
-
Hardie D.G. The AMP-activated protein kinase pathway-new players upstream and downstream. J. Cell Sci. 2004, 117:5479-5487.
-
(2004)
J. Cell Sci.
, vol.117
, pp. 5479-5487
-
-
Hardie, D.G.1
-
37
-
-
33846030181
-
A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits
-
Wong K.A., Lodish H.F. A revised model for AMP-activated protein kinase structure: The alpha-subunit binds to both the beta- and gamma-subunits although there is no direct binding between the beta- and gamma-subunits. J. Biol. Chem. 2006, 281:36434-36442.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 36434-36442
-
-
Wong, K.A.1
Lodish, H.F.2
-
38
-
-
33749479230
-
AMP-activated protein kinase: Role in metabolism and therapeutic implications
-
Schimmack G., Defronzo R.A., Musi N. AMP-activated protein kinase: Role in metabolism and therapeutic implications. Diabetes Obes. Metab. 2006, 8:591-602.
-
(2006)
Diabetes Obes. Metab.
, vol.8
, pp. 591-602
-
-
Schimmack, G.1
Defronzo, R.A.2
Musi, N.3
-
39
-
-
33745183847
-
Functions of AMP-activated protein kinase in adipose tissue
-
Daval M., Foufelle F., Ferre P. Functions of AMP-activated protein kinase in adipose tissue. J. Physiol. 2006, 574:55-62.
-
(2006)
J. Physiol.
, vol.574
, pp. 55-62
-
-
Daval, M.1
Foufelle, F.2
Ferre, P.3
-
40
-
-
0346102907
-
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site
-
Adams J., Chen Z.P., Van Denderen B.J., Morton C.J., Parker M.W., Witters L.A., Stapleton D., Kemp B.E. Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci. 2004, 13:155-165.
-
(2004)
Protein Sci.
, vol.13
, pp. 155-165
-
-
Adams, J.1
Chen, Z.P.2
Van Denderen, B.J.3
Morton, C.J.4
Parker, M.W.5
Witters, L.A.6
Stapleton, D.7
Kemp, B.E.8
-
41
-
-
62149105212
-
A role of DNA-PK for the metabolic gene regulation in response to insulin
-
Wong R.H., Chang I., Hudak C.S., Hyun S., Kwan H.Y., Sul H.S. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 2009, 136:1056-1072.
-
(2009)
Cell
, vol.136
, pp. 1056-1072
-
-
Wong, R.H.1
Chang, I.2
Hudak, C.S.3
Hyun, S.4
Kwan, H.Y.5
Sul, H.S.6
-
42
-
-
70350399521
-
Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes
-
Chanda D., Li T., Song K.H., Kim Y.H., Sim J., Lee C.H., Chiang J.Y., Choi H.S. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J. Biol. Chem. 2009, 284:28510-28521.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 28510-28521
-
-
Chanda, D.1
Li, T.2
Song, K.H.3
Kim, Y.H.4
Sim, J.5
Lee, C.H.6
Chiang, J.Y.7
Choi, H.S.8
-
43
-
-
78149500681
-
Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective
-
Wong R.H., Sul H.S. Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective. Curr. Opin. Pharmacol. 2010, 10:684-691.
-
(2010)
Curr. Opin. Pharmacol.
, vol.10
, pp. 684-691
-
-
Wong, R.H.1
Sul, H.S.2
|