Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

Biochemical Journal

Volumn 370, Issue 3, 2003, Pages 849-857

  Boudeau, Jérôme ^a   Deak, Maria ^a   Lawlor, Margaret A ^a   Morrice, Nick A ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Chaperone; Geldanamycin; Peutz Jeghers syndrome; Proteasome; Radicicol; Tumour suppressor

Indexed keywords

DRUG THERAPY; ENZYME INHIBITION; GROWTH KINETICS; MUTAGENESIS; ONCOLOGY;

CELL GROWTH;

ENZYMES;

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLALANYLLEUCINAL; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL 2,6 DICHLOROBENZENE; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 37; DIMETHYL PIMELIMIDATE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; LACTACYSTIN; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PEPSTATIN; PIMELIC ACID DERIVATIVE; PROTEASOME INHIBITOR; PROTEIN KINASE LKB1; PROTEIN SERINE THREONINE KINASE; PROTEOME; RADICICOL; TOSYLLYSYL CHLOROMETHYL KETONE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL GROWTH; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN STABILITY; RAT; REGULATORY MECHANISM;

ANIMALS; BENZOQUINONES; CELL CYCLE PROTEINS; CELL LINE; CHAPERONINS; CYSTEINE ENDOPEPTIDASES; DROSOPHILA PROTEINS; ENZYME INHIBITORS; ENZYME STABILITY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LACTONES; MACROLIDES; MICE; MOLECULAR CHAPERONES; MULTIENZYME COMPLEXES; PEUTZ-JEGHERS SYNDROME; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; QUINONES; RECOMBINANT FUSION PROTEINS;

ANIMALIA;

EID: 0037444766     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021813     Document Type: Article

References (46)

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