Regulation of age-related macular degeneration-like pathology by complement factor H

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 23, 2015, Pages E3040-E3049

  Toomey, Christopher B ^a,b   Kelly, Una ^a   Saban, Daniel R ^a,b   Rickman, Catherine Bowes ^a,b  

^a DUKE UNIVERSITY EYE CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Age related macular degeneration; Complement; Factor H; Lipoprotein; Retinal pigmented epithelium

Indexed keywords

CHOLESTEROL; COMPLEMENT COMPONENT C5A; COMPLEMENT FACTOR H; LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

AGE RELATED MACULAR DEGENERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; BRUCH MEMBRANE; COMPLEMENT ACTIVATION; COMPLEMENT DEFICIENCY; COMPLEMENT SYSTEM; CONTROLLED STUDY; DIET SUPPLEMENTATION; ELECTRORETINOGRAM; ENVIRONMENTAL STRESS; EXPLANT; GENETIC ANALYSIS; HUMAN; HYDROLYSIS; IN VIVO STUDY; INTRAVASCULAR SPACE; LIPID DIET; MALE; MOLECULAR PATHOLOGY; MONOCYTOSIS; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM; VISION; VISUAL IMPAIRMENT; ANIMAL; CHOROID; GENETICS; MACULAR DEGENERATION; METABOLISM; MONOCYTE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINAL PIGMENT EPITHELIUM; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; CHOROID; COMPLEMENT FACTOR H; DIET, HIGH-FAT; MACULAR DEGENERATION; MICE; MICE, TRANSGENIC; MONOCYTES; RETINAL PIGMENT EPITHELIUM;

EID: 84931291540     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424391112     Document Type: Article

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