Identification of factor h-like protein 1 as the predominant complement regulator in Bruch's Membrane: Implications for age-related macular degeneration

Journal of Immunology

Volumn 193, Issue 10, 2014, Pages 4962-4970

  Clark, Simon J ^a,b   Schmidt, Christoph Q ^c   White, Anne M ^a,b   Hakobyan, Svetlana ^d   Morgan, B Paul ^d   Bishop, Paul N ^a,b,e  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF ULM   (Germany)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT FACTOR; COMPLEMENT FACTOR H; FACTOR H LIKE 1 PROTEIN; HEPARAN SULFATE; UNCLASSIFIED DRUG; CFHR1 PROTEIN, HUMAN; COMPLEMENT FACTOR I; PROTEIN BINDING;

AGE RELATED MACULAR DEGENERATION; ARTICLE; BRUCH MEMBRANE; CFH GENE; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FHL 1 GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLYCOSYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; MOLECULAR INTERACTION; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; RISK FACTOR; DRUSEN; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; IMMUNOLOGY; INNATE IMMUNITY; MACULAR DEGENERATION; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; RETINA; SIGNAL TRANSDUCTION;

BRUCH MEMBRANE; COMPLEMENT ACTIVATION; COMPLEMENT C3B INACTIVATOR PROTEINS; COMPLEMENT FACTOR H; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GLYCOSYLATION; HEPARITIN SULFATE; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; MACULAR DEGENERATION; PROTEIN BINDING; PROTEIN TRANSPORT; RETINA; RETINAL DRUSEN; SIGNAL TRANSDUCTION;

EID: 84910115978     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401613     Document Type: Article

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