Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 43, 2013, Pages

  Hu, Peng ^a   Herrmann, Rolf ^a,e   Bednar, Amanda ^a   Saloupis, Peter ^a   Dwyer, Mary A ^b   Yang, Ping ^a   Qi, Xiaoping ^c   Thomas, Russell S ^d   Jaffe, Glenn J ^a   Boulton, Michael E ^c   McDonnell, Donald P ^b   Malek, Goldis ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Oxidized low density lipoprotein; Retinal disease; Retinal pigment epithelium; Toxin metabolism

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CALRETININ; CIGARETTE SMOKE; COLLAGEN TYPE 4; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIOXIN; HIGH DENSITY LIPOPROTEIN; HYDROQUINONE; LIPOFUSCIN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PEANUT AGGLUTININ; PROTEIN KINASE C ALPHA; RHODOPSIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA;

A WAVE; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B WAVE; BINDING AFFINITY; BRUCH MEMBRANE; CELL CULTURE; CELL METABOLISM; CONTROLLED STUDY; DEFENSE MECHANISM; DNA BINDING; ELECTRORETINOGRAM; ELECTRORETINOGRAPHY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN TISSUE; HYPOTHESIS; MACULAR THICKNESS; MALE; MOUSE; NONHUMAN; NULL ALLELE; OPTICAL COHERENCE TOMOGRAPHY; PATHOGENESIS; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETINA MACULA AGE RELATED DEGENERATION; RISK FACTOR; SENESCENCE; SIGNAL TRANSDUCTION; TIGHT JUNCTION; TRANSCRIPTION INITIATION; TRANSMISSION ELECTRON MICROSCOPY; VISION; VISUAL IMPAIRMENT; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

OXIDIZED LOW DENSITY LIPOPROTEIN; RETINAL DISEASE; RETINAL PIGMENT EPITHELIUM; TOXIN METABOLISM;

ADOLESCENT; ADULT; AGING; ANIMALS; BRUCH MEMBRANE; CELL LINE; CHILD; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; FEMALE; HUMANS; LIPOFUSCIN; LIPOPROTEINS, LDL; MACULAR DEGENERATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MIDDLE AGED; PIGMENT EPITHELIUM OF EYE; RECEPTORS, ARYL HYDROCARBON; RNA INTERFERENCE; TIGHT JUNCTIONS; YOUNG ADULT;

EID: 84886420285     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307574110     Document Type: Article

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