Basal linear deposit and large drusen are specific for early age- related maculopathy

Archives of Ophthalmology

Volumn 117, Issue 3, 1999, Pages 329-339

  Curcio, Christine A ^a,b   Millican, C Leigh ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BRUCH MEMBRANE; DRUSEN; ELECTRON MICROSCOPY; FEMALE; HISTOPATHOLOGY; HUMAN; MALE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA FOVEA; RETINA MACULOPATHY; ULTRASTRUCTURE;

EID: 0344791691     PISSN: 00039950     EISSN: None     Source Type: Journal    
DOI: 10.1001/archopht.117.3.329     Document Type: Article

References (67)

1. Bird AC, Bressler NM, Chisholm IH, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367-374.
2. Leibowitz HM, Maunder LR, Milton RC, et al. The Framingham Eye Study Monograph. Surv Ophthalmol. 1980;24(suppl):335-610.
3. Sarks SH. Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol. 1976;60:324-341.
4. Loeffler KU, Lee WR. Basal linear deposit in the human macula. Graefes Arch Clin Exp Ophthalmol. 1986;224:493-501.
5. Feeney-Burns L, Burns RP, Gao C-L. Age-related macular changes in humans over 90 years old. Am J Ophthalmol. 1990;109:265-278.
6. Sarks SH. Drusen and their relationship to senile macular degeneration. Aust J Ophthalmol. 1980;8:117-130.
7. van der Schaft TL, de Bruijn WC, Mooy CM, Ketelaars DA, de Jong PT. Is basal laminar deposit unique for age-related macular degeneration? Arch Ophthalmol. 1991;109:420-425.
8. van der Schaft TL, Mooy CM, de Bruijn WC, et al. Histologic features of the early stages of age-related macular degeneration; Ophthalmology. 1992;99:278-286.
9. Green WR, Enger C. Age-related macular degeneration histopathologic studies: the 1992 Lorenz E. Zimmerman Lecture. Ophthalmology. 1993;100:1519-1535.
10. Rosa RH Jr, Thomas MA, Green WR. Clinicopathologic correlation of submacular membranectomy with retention of good vision in a patient with age-related macular degeneration. Arch Ophthalmol. 1996;114:480-487.
11. Bressler SB, Maguire MG, Bressler NM, Fine SL. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. Arch Ophthaimol. 1990;108:1442-1447.
12. Bressler NM, Munoz B, Maguire MG, et al. Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Arch Ophthalmol. 1995;113:301-308.
13. Klein R, Klein BEK, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy. Ophthalmology. 1997;104:7-21.
14. Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clinicopathological correlation of drusen and retinal pigment epithelial abnormalities in age-related macular degeneration. Retina. 1994;14:130-142.
15. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988;2:552-577.
16. Sarks SH, van Driel D, Maxwell L, Killingsworth M. Softening of drusen and subretinal neovascularization. Trans Ophthalmol Soc U K. 1980;100:414-422.
17. Green WR, Key SN. Senile macular degeneration: a histopathological study. Trans Am Ophthalmol Soc. 1977;75:180-254.
18. Hogan MJ, Alvarado JA, Weddell JE. Histology of the Human Eye. Philadelphia, Pa: WB Saunders Co; 1971:328-363.
19. Feeney-Burns L, Ellersieck MR. Age-related changes in the ultrastructure of Bruch's membrane. Am J Ophthalmol. 1985;100:686-697.
20. Curcio CA, Medeiros NE, Millican CL. The Alabama Age-related Macular Degeneration Grading System for donor eyes. Invest Ophthalmol Vis Sci. 1998;39:1085-1096.
21. Pauleikhoff D, Barondes MJ, Minassian D, Chisholm IH, Bird AC. Drusen as risk factors in age-related macular disease. Am J Ophthalmol. 1990;109:38-43.
22. Klein R, Klein BEK, Linton KLP. Prevalence of age-related maculopathy. Ophthalmology. 1992;99:933-943.
23. Vingerling JR, Dielemans I, Hofman A, et al. The prevalence of age-related maculopathy in the Rotterdam study. Ophthalmology. 1995;102:205-210.
24. Mitchell P, Smith W, Attebo K, Wang JJ. Prevalence of age-related maculopathy in Australia. Ophthalmology. 1995;102:1450-1460.
25. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye. 1994;8:269-283.
26. Hennekens CH, Buring JE. Epidemiology in Medians. Boston, Mass: Little Brown & Co Inc; 1987:327-347.
27. Fisher RA. The logic of inductive reference. J R Stat Soc. 1935;98:39-54.
28. Breslow NE, Day NE. Statistical Methods in Cancer Research. Lyons, France: International Agency for Research on Cancer; 1980.
29. Sahai H, Kurshid A. Statistics in Epidemiology: Methods, Techniques, and Applications. Boca Raton. Fla: CRC Press Inc; 1996.
30. Ishibashi T, Patterson R, Ohnishi Y, et al. Formation of drusen in the human eye. Am J Ophthalmol. 1986;101:342-353.
31. Green WR, Schwartz DM. Aspects histopathologiques. In: Coscas G, ed. Dégénérescences Maculaires Acquises Liées à l'Age et Neovaisseaux SousRétiniens. Newport, NY: Masson Publishing; 1991;5:90-119.
32. Gottsch JD, Bynoe JD, Harlan JB, Rencs EV, Green WR. Light-induced deposits in Bruch's membrane of protoporphyric mice. Arch Ophthalmol. 1993;111:126-129.
33. Katz ML, Robison WG Jr. Age-related changes in the retinal pigment epithelium of pigmented rats. Exp Eye Res. 1984;38:137-151.
34. Kliffen M, Lutgens E, Mooy CM, et al. Apolipoprotein-E3 transgenic mice as an animal model for age-related maculopathy [abstract]. Invest Ophthaimol Vis Sci. 1998;39(suppl):S882.
35. Allikmets R, Shroyer NF, Singh N, et al. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science. 1997;277:1805-1807.
36. Gorin MB, Jackson KE, Ferrell RE, et al. A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. Ophthalmology. 1995;102:246-255.
37. Sarks SM. New vessel formation beneath the retinal pigment epithelium in senile eyes. Br J Ophthalmol. 1973;57:951-965.
38. Kenyon KR, Maumenee AE, Ryan SJ, Whitmore PV, Green WR. Diffuse drusen and associated complications. Am J Ophthalmol. 1985;100:119-123.
39. Sarks SH. Drusen patterns predisposing to geographic atrophy of the retinal pigment epithelium. Aust J Ophthalmol. 1982;99:445-459.
40. Chang TS, Freund KB, de la Cruz Z, Yannuzzi LA, Green WR. Clinicopathologic correlation of choroidal neovascularization demonstrated by indocyanine green angiography in a patient with retention of good vision for almost four years. Retina. 1994; 14:114-124.
41. Gass JDM. Biomicroscopic and histopathologic considerations regarding the feasibility of surgical excision of subfoveal neovascular membranes. Am J Ophthalmol. 1994;118:285-298.
42. Sarks JP, Sarks SH, Killingsworth MC. Morphology of early choroidal neovascularization in age-related macular degeneration: correlation with activity. Eye. 1997;11:515-522.
43. Grossniklaus H, Hutchinson A, Capone A Jr, Woolfson J, Lambert HM. Clinico-pathologic features of surgically excised choroidal neovascular membranes. Ophthalmology. 1994;94:1099-1111.
44. Grossniklaus HE, Green WR. Histopathologic and ultrastructural findings of surgically excised choroidal neovascularization. Arch Ophthalmol. 1998;116:745-749.
45. Spraul CW, Grossniklaus HE. Characteristics of drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration. Arch Ophthalmol. 1997;115:267-273.
46. Killingsworth MC, Sarks JP, Sarks SH. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye. 1990;4:613-621.
47. Dastgheib K, Green WR. Granulomatous reaction to Bruch's membrane in age-related macular degeneration. Arch Ophthalmol. 1994;112:813-818.
48. van der Schaft TL, de Bruijn WC, Mooy CM, de Jong PTVM. Basal laminar deposit in the aging peripheral human retina. Graefes Arch Clin Exp Ophthalmol. 1993;231:470-475.
49. Duvall-Young J, MacDonald MK, McKechnie NM. Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report. Br J Ophthalmol. 1989;73:297-302.
50. Marshall GE, Konstas AGP, Reid GG, Edwards FT, Lee WR. Type IV collagen and laminin in Bruch's membrane and basal linear deposit in the human macula. Br J Ophthalmol. 1992;76:607-614.
51. van der Schaft TL, Mooy CM, de Bruijn WC, Bosman FT, de Jong PTVM. Immunohistochemical light and electron microscopy of basal laminar deposit. Graefes Arch Clin Exp Ophthalmol. 1994;232:40-46.
52. Green WR, McDonnell PJ, Yeo JH. Pathologic features of senile macular degeneration. Ophthalmology. 1985;92:615-627.
53. Loeffler KU, Lee WR. Is basal laminar deposit unique for age-related macular degeneration [letter]? Arch Ophthalmol. 1992;110:15-16.
54. Loeffler KU, Lee WR. Terminology of sub-RPE deposits: do we all speak the same language? Br J Ophthalmol. 1998;82:1104-1105.
55. Killingsworth MC. Age-related components of Bruch's membrane. Graefes Arch Clin Exp Ophthalmol. 1987;225:406-412.
56. Pauleikhoff D, Harper CA, Marshall J, Bird AC. Aging changes in Bruch's membrane: a histochemical and morphological study. Ophthalmology. 1990;97:171-178.
57. Guyton JR. The role of lipoproteins in atherogenesis. In: Longenecker JB, ed. Nutrition and Biotechnology in Heart Disease and Cancer. New York, NY: Plenum Publishing Corp; 1995:29-38.
58. Holz FG, Sheraidah G, Pauleikhoff D, Bird AC. Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane. Arch Ophthalmol. 1994;112:402-406.
59. Pauleikhoff D, Zuels S, Sheraidah GS, et al. Correlation between biochemical composition and fluorescein binding of deposits in Bruch's membrane. Ophthalmology. 1992;99:1548-1553.
60. Haimovici R, Rumelt S, Small DM, Gantz DL, Freddo TF. In situ lipid analysis of drusen and age-related changes in Bruch's membrane, using hot stage polarizing microscopy [abstract]. Invest Ophthalmol Vis Sci. 1997;38(suppl):S93.
61. Bird A. Age-related macular disease. Br J Ophthalmol. 1996;80:2-3.
62. Chen JC, Fitzke FW, Pauleikhoff D, et al. Functional loss in age-related Bruch's membrane change with choroidal perfusion defect. Invest Ophthalmol Vis Sci. 1992;33:334-340.
63. Remulla JFC, Gaudio AR, Miller S, Sandberg MA. Foveal electroretinograms and choroidal perfusion characteristics in fellow eyes of patients with unilateral neovascular age-related macular degeneration. Br J Ophthalmol. 1995;79:558-561.
64. Guyton JR, Klemp KF. Ultrastructural discrimination of lipid droplets and vesicles inatherosclerosis: value of osmium-thiocarbohydrazide-osmium and tannic acid-paraphenylenediamine techniques. J Histochem Cytochem. 1988;36:1319-1328.
65. Guyton JR, Bocan TMA, Schifani TA. Quantitative ultrastructural analysis of perifibrous lipid and its association with elastin in nonatherosclerotic human aorta. Arteriosclerosis. 1985;5:644-652.
66. Bocan TM, Schifani TA, Guyton JR. Ultrastructure of the human aortic fibrolipid lesion: formation of the atherosclerotic lipid-rich core. Am J Pathol. 1986;123: 413-424.
67. Guyton JR, Klemp KF, The lipid-rich core region of human atherosclerotic fibrous plaques: prevalence of small lipid droplets and vesicles by electron microscopy. Am J Pathol. 1989;134:705-717.