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Volumn 14, Issue 5, 2008, Pages 551-557

Functional roles for C5a receptors in sepsis

Author keywords

[No Author keywords available]

Indexed keywords

C512 PROTEIN; COMPLEMENT COMPONENT C5A RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; RECEPTOR ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

EID: 43249098418     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1753     Document Type: Article
Times cited : (330)

References (38)
  • 1
    • 0033052453 scopus 로고    scopus 로고
    • Protective effects of C5a blockade in sepsis
    • Czermak, B.J. et al. Protective effects of C5a blockade in sepsis. Nat. Med. 5, 788-792 (1999).
    • (1999) Nat. Med , vol.5 , pp. 788-792
    • Czermak, B.J.1
  • 2
    • 0026078539 scopus 로고
    • The chemotactic receptor for human C5a anaphylatoxin
    • Gerard, N.P. & Gerard, C. The chemotactic receptor for human C5a anaphylatoxin. Nature 349, 614-617 (1991).
    • (1991) Nature , vol.349 , pp. 614-617
    • Gerard, N.P.1    Gerard, C.2
  • 3
    • 0028201342 scopus 로고    scopus 로고
    • Gerard, C. & Gerard, N.P. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12, 775-808 (1994).
    • Gerard, C. & Gerard, N.P. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 12, 775-808 (1994).
  • 5
    • 33846027130 scopus 로고    scopus 로고
    • Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines
    • Johswich, K. et al. Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. J. Biol. Chem. 281, 39088-39095 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 39088-39095
    • Johswich, K.1
  • 6
    • 0041571471 scopus 로고    scopus 로고
    • C5L2, a nonsignaling C5A binding protein
    • Okinaga, S. et al. C5L2, a nonsignaling C5A binding protein. Biochemistry 42, 9406-9415 (2003).
    • (2003) Biochemistry , vol.42 , pp. 9406-9415
    • Okinaga, S.1
  • 7
    • 0038662716 scopus 로고    scopus 로고
    • The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein
    • Kalant, D. et al. The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. J. Biol. Chem. 278, 11123-11129 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 11123-11129
    • Kalant, D.1
  • 8
    • 21244438039 scopus 로고    scopus 로고
    • C5L2 is a functional receptor for acylation-stimulating protein
    • Kalant, D. et al. C5L2 is a functional receptor for acylation-stimulating protein. J. Biol. Chem. 280, 23936-23944 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 23936-23944
    • Kalant, D.1
  • 9
    • 0034670027 scopus 로고    scopus 로고
    • Cutting edge: Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock
    • Kildsgaard, J. et al. Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock. J. Immunol. 165, 5406-5409 (2000).
    • (2000) J. Immunol , vol.165 , pp. 5406-5409
    • Kildsgaard, J.1
  • 10
    • 0029974609 scopus 로고    scopus 로고
    • A new biologic role for C3a and C3a desArg: Regulation of TNF-alpha and IL-1 beta synthesis
    • Takabayashi, T. et al. A new biologic role for C3a and C3a desArg: regulation of TNF-alpha and IL-1 beta synthesis. J. Immunol. 156, 3455-3460 (1996).
    • (1996) J. Immunol , vol.156 , pp. 3455-3460
    • Takabayashi, T.1
  • 11
    • 28844434626 scopus 로고    scopus 로고
    • An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2
    • Gerard, N.P. et al. An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J. Biol. Chem. 280, 39677-39680 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 39677-39680
    • Gerard, N.P.1
  • 12
    • 84934440946 scopus 로고    scopus 로고
    • C5L2 - an anti-inflammatory molecule or a receptor for acylation stimulating protein (C3a-desArg)?
    • Johswich, K. & Klos, A. C5L2 - an anti-inflammatory molecule or a receptor for acylation stimulating protein (C3a-desArg)? Adv. Exp. Med. Biol. 598, 159-180 (2007).
    • (2007) Adv. Exp. Med. Biol , vol.598 , pp. 159-180
    • Johswich, K.1    Klos, A.2
  • 13
    • 33947110020 scopus 로고    scopus 로고
    • C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
    • Chen, N.J. et al. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature 446, 203-207 (2007).
    • (2007) Nature , vol.446 , pp. 203-207
    • Chen, N.J.1
  • 14
    • 0033709969 scopus 로고    scopus 로고
    • A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells
    • Ohno, M. et al. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol. Immunol. 37, 407-412 (2000).
    • (2000) Mol. Immunol , vol.37 , pp. 407-412
    • Ohno, M.1
  • 15
    • 19944428475 scopus 로고    scopus 로고
    • Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans
    • Huber-Lang, M. et al. Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J. Immunol. 174, 1104-1110 (2005).
    • (2005) J. Immunol , vol.174 , pp. 1104-1110
    • Huber-Lang, M.1
  • 16
    • 1842333302 scopus 로고    scopus 로고
    • Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor
    • Hopken, U.E., Lu, B., Gerard, N.P. & Gerard, C. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J. Exp. Med. 186, 749-756 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 749-756
    • Hopken, U.E.1    Lu, B.2    Gerard, N.P.3    Gerard, C.4
  • 17
    • 0347052898 scopus 로고    scopus 로고
    • C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: Position 69 is the locus that determines agonism or antagonism
    • Otto, M. et al. C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. J. Biol. Chem. 279, 142-151 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 142-151
    • Otto, M.1
  • 18
    • 20444460795 scopus 로고    scopus 로고
    • Evidence for a functional role of the second C5a receptor C5L2
    • Gao, H. et al. Evidence for a functional role of the second C5a receptor C5L2. FASEB J. 19, 1003-1005 (2005).
    • (2005) FASEB J , vol.19 , pp. 1003-1005
    • Gao, H.1
  • 19
    • 33749840453 scopus 로고    scopus 로고
    • Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies
    • Lee, H. et al. Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies. Nat. Biotechnol. 24, 1279-1284 (2006).
    • (2006) Nat. Biotechnol , vol.24 , pp. 1279-1284
    • Lee, H.1
  • 20
    • 0033557752 scopus 로고    scopus 로고
    • In vitro and in vivo dependency of chemokine generation on C5a and TNF-α
    • Czermak, B.J. et al. In vitro and in vivo dependency of chemokine generation on C5a and TNF-α. J. Immunol. 162, 2321-2325 (1999).
    • (1999) J. Immunol , vol.162 , pp. 2321-2325
    • Czermak, B.J.1
  • 21
    • 14844314806 scopus 로고    scopus 로고
    • Identification of complement 5a-like receptor (C5L2) from astrocytes: Characterization of anti-inflammatory properties
    • Gavrilyuk, V. et al. Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties. J. Neurochem. 92, 1140-1149 (2005).
    • (2005) J. Neurochem , vol.92 , pp. 1140-1149
    • Gavrilyuk, V.1
  • 22
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang, H. et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 285, 248-251 (1999).
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1
  • 23
    • 0035882102 scopus 로고    scopus 로고
    • New EMBO members' review: The double life of HMGB1 chromatin protein: architectural factor and extracellular signal
    • Muller, S. et al. New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal. EMBO J. 20, 4337-4340 (2001).
    • (2001) EMBO J , vol.20 , pp. 4337-4340
    • Muller, S.1
  • 24
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze, M.T. & Tracey, K.J. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat. Rev. Immunol. 5, 331-342 (2005).
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 25
    • 33748760336 scopus 로고    scopus 로고
    • Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis
    • Suda, K. et al. Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J. Surg. 30, 1755-1762 (2006).
    • (2006) World J. Surg , vol.30 , pp. 1755-1762
    • Suda, K.1
  • 26
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    • Yang, H. et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. USA 101, 296-301 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 296-301
    • Yang, H.1
  • 27
    • 33745854493 scopus 로고    scopus 로고
    • Role of HMGB1 in apoptosis-mediated sepsis lethality
    • Qin, S. et al. Role of HMGB1 in apoptosis-mediated sepsis lethality. J. Exp. Med. 203, 1637-1642 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1637-1642
    • Qin, S.1
  • 28
    • 17444403917 scopus 로고    scopus 로고
    • C5a negatively regulates Toll-like receptor 4-induced immune responses
    • Hawlisch, H. et al. C5a negatively regulates Toll-like receptor 4-induced immune responses. Immunity 22, 415-426 (2005).
    • (2005) Immunity , vol.22 , pp. 415-426
    • Hawlisch, H.1
  • 29
    • 34347400796 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo
    • Zhang, X. et al. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110, 228-236 (2007).
    • (2007) Blood , vol.110 , pp. 228-236
    • Zhang, X.1
  • 30
    • 0036180753 scopus 로고    scopus 로고
    • Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: Mediation by interleukin-6 from Kupffer cells
    • Koleva, M. et al. Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo: mediation by interleukin-6 from Kupffer cells. Gastroenterology 122, 697-708 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 697-708
    • Koleva, M.1
  • 31
    • 33745712069 scopus 로고    scopus 로고
    • The role of complement in danger sensing and transmission
    • Kohl, J. The role of complement in danger sensing and transmission. Immunol. Res. 34, 157-176 (2006).
    • (2006) Immunol. Res , vol.34 , pp. 157-176
    • Kohl, J.1
  • 32
    • 22544471801 scopus 로고    scopus 로고
    • Complement and Toll-like receptors: Key regulators of adaptive immune responses
    • Hawlisch, H. & Kohl, J. Complement and Toll-like receptors: key regulators of adaptive immune responses. Mol. Immunol. 43, 13-21 (2006).
    • (2006) Mol. Immunol , vol.43 , pp. 13-21
    • Hawlisch, H.1    Kohl, J.2
  • 33
    • 20244373188 scopus 로고    scopus 로고
    • HMGB1 contributes to the development of acute lung injury after hemorrhage
    • Kim, J.Y. et al. HMGB1 contributes to the development of acute lung injury after hemorrhage. Am. J. Physiol. Lung Cell. Mol. Physiol. 288, L958-L965 (2005).
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.288
    • Kim, J.Y.1
  • 34
    • 9144263639 scopus 로고    scopus 로고
    • Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    • Wang, H. et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 10, 1216-1221 (2004).
    • (2004) Nat. Med , vol.10 , pp. 1216-1221
    • Wang, H.1
  • 35
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • Bonaldi, T. et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J. 22, 5551-5560 (2003).
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1
  • 36
    • 4344600286 scopus 로고    scopus 로고
    • C5a initiates the inflammatory cascade in immune complex peritonitis
    • Godau, J. et al. C5a initiates the inflammatory cascade in immune complex peritonitis. J. Immunol. 173, 3437-3445 (2004).
    • (2004) J. Immunol , vol.173 , pp. 3437-3445
    • Godau, J.1
  • 37
    • 19944428796 scopus 로고    scopus 로고
    • Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation
    • Baelder, R. et al. Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J. Immunol. 174, 783-789 (2005).
    • (2005) J. Immunol , vol.174 , pp. 783-789
    • Baelder, R.1
  • 38
    • 0041441084 scopus 로고    scopus 로고
    • High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2
    • Yamada, S., Inoue, K., Yakabe, K., Imaizumi, H. & Maruyama, I. High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2. Clin. Chem. 49, 1535-1537 (2003).
    • (2003) Clin. Chem , vol.49 , pp. 1535-1537
    • Yamada, S.1    Inoue, K.2    Yakabe, K.3    Imaizumi, H.4    Maruyama, I.5


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