Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: Implications for age-related macular degeneration

Journal of Immunology

Volumn 185, Issue 9, 2010, Pages 5486-5494

  Kelly, Una ^a   Yu, Ling ^a   Kumar, Pallavi ^b   Ding, Jin Dong ^a   Jiang, Haixiang ^c   Hageman, Gregory S ^d   Arshavsky, Vadim Y ^a   Frank, Michael M ^c   Hauser, Michael A ^c   Rickman, Catherine Bowes ^a,c  

^a DUKE UNIVERSITY EYE CENTER   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c DUKE UNIVERSITY   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT FACTOR H; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; COMPLEMENT FACTOR H, HUMAN; ISOPROTEIN;

ADULT; AGED; ALLOTYPE; ARTICLE; BRUCH MEMBRANE; CLINICAL ARTICLE; COMPLEMENT ALTERNATIVE PATHWAY; DISEASE ASSOCIATION; FEMALE; HAPLOTYPE; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN VARIANT; RETINA MACULA AGE RELATED DEGENERATION; RISK FACTOR; SULFATION; TISSUE INJURY; VISUAL DISORDER; CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; RETINA MACULA DEGENERATION; TRANSMISSION ELECTRON MICROSCOPY;

ADULT; AGED; AGED, 80 AND OVER; BRUCH MEMBRANE; COMPLEMENT C3B; COMPLEMENT FACTOR H; COMPLEMENT PATHWAY, ALTERNATIVE; FEMALE; HEPARITIN SULFATE; HUMANS; MACULAR DEGENERATION; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; PROTEIN ISOFORMS;

EID: 78149492503     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903596     Document Type: Article

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