The role of complement in age-related macular degeneration: Heparan sulphate, a ZIP code for complement factor H?

Journal of Innate Immunity

Volumn 6, Issue 4, 2014, Pages 407-416

  Langford Smith, Alex ^a   Keenan, Tiarnan D L ^a,b,c   Clark, Simon J ^b,c   Bishop, Paul N ^b,c   Day, Anthony J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

Author keywords

Age related macular degeneration; Complement factor H; Heparan sulphate; Tissue specific immune recognition

Indexed keywords

COMPLEMENT FACTOR H; HEPARAN SULFATE; PROTEIN BINDING;

BRUCH MEMBRANE; COMPLEMENT ACTIVATION; EXTRACELLULAR MATRIX; GENETICS; GLOMERULUS BASEMENT MEMBRANE; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; SULFATION; ANIMAL; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; IMMUNOLOGY; MACULAR DEGENERATION; METABOLISM; PATHOLOGY; PROTEIN DOMAIN; RETINA; AGE RELATED MACULAR DEGENERATION; BINDING AFFINITY; MOLECULAR RECOGNITION;

ANIMALS; BRUCH MEMBRANE; COMPLEMENT ACTIVATION; COMPLEMENT FACTOR H; GENETIC PREDISPOSITION TO DISEASE; HEPARITIN SULFATE; HUMANS; MACULAR DEGENERATION; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RETINA;

EID: 84902651058     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000356513     Document Type: Review

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