NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis

Circulation Research

Volumn 110, Issue 3, 2012, Pages 416-427

  Hanna, Richard N ^a   Shaked, Iftach ^a   Hubbeling, Harper G ^b   Punt, Jennifer A ^b   Wu, Runpei ^a   Herrley, Erica ^a   Zaugg, Claudia ^a   Pei, Hong ^a   Geissmann, Frederic ^c   Ley, Klaus ^a   Hedrick, Catherine C ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b HAVERFORD COLLEGE   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

atherosclerosis; macrophage; monocyte; nuclear receptors; toll like receptors

Indexed keywords

APOENZYME; ARGINASE 1; CD14 ANTIGEN; CD16 ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR; NITRIC OXIDE; NUCLEAR RECEPTOR NUR77; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; ATHEROSCLEROSIS; B LYMPHOCYTE; BONE MARROW CELL; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIETARY INTAKE; DISEASE COURSE; ENZYME INHIBITION; GENE DELETION; GRANULOCYTE; HEMATOPOIETIC CELL; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; DIET; DISEASE MODELS, ANIMAL; GENE DELETION; HUMANS; INFLAMMATION; LIPID METABOLISM; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PHENOTYPE; RECEPTORS, LDL; TOLL-LIKE RECEPTORS;

EID: 84856707159     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.253377     Document Type: Article

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